Targeted delivery of the RGD-labeled biodegradable polymersomes loaded with the hydrophilic drug oxymatrine on cultured hepatic stellate cells and liver fibrosis in rats

European Journal of Pharmaceutical Sciences

Volumn 52, Issue 1, 2014, Pages 180-190

  Yang, Jianhong ^a,b   Hou, Yanhui ^b   Ji, Gangjian ^a   Song, Zhihua ^a   Liu, Yanhua ^b   Dai, Guidong ^b   Zhang, Yajun ^c   Chen, Jianhai ^a  

^a SOUTHERN MEDICAL UNIVERSITY   (China)

^b NINGXIA MEDICAL UNIVERSITY   (China)

^c NORTHWEST UNIVERSITY   (China)

Author keywords

Hepatic fibrosis; HSCs; Oxymatrine; Polymersomes; RGD

Indexed keywords

ARGINYLGLYCYLASPARTIC ACID; COPOLYMER; DRUG CARRIER; MACROGOL; OXYMATRINE; POLYMERSOME; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BILE DUCT; CELL PROLIFERATION; CELLULAR DISTRIBUTION; CONTROLLED STUDY; CYTOTOXICITY TEST; DRUG CYTOTOXICITY; DRUG EFFECT; GLASS TRANSITION TEMPERATURE; HYDROPHILICITY; LIVER CELL; LIVER FIBROSIS; MALE; MOLECULAR WEIGHT; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTON NUCLEAR MAGNETIC RESONANCE; RAT; STELLATE CELL;

CAPROLACTONE (PUBCHEM CID:10401); ETHYLENE GLYCOL (PUBCHEM CID:174); HEPATIC FIBROSIS; HSCS; MALEIMIDE (PUBCHEM CID:10935); OM (PUBCHEM CID:114850); OXYMATRINE; POLYMERSOMES; RGD;

ACTINS; ALKALOIDS; ANIMALS; CELLS, CULTURED; COLLAGEN TYPE I; DRUG CARRIERS; GENE EXPRESSION; HEPATIC STELLATE CELLS; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; LACTONES; LIVER; LIVER CIRRHOSIS; MALE; MALEIMIDES; NANOSTRUCTURES; OLIGOPEPTIDES; POLYESTERS; POLYETHYLENE GLYCOLS; QUINOLIZINES; RATS; RATS, WISTAR;

EID: 84890516562     PISSN: 09280987     EISSN: 18790720     Source Type: Journal    
DOI: 10.1016/j.ejps.2013.11.017     Document Type: Article

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