메뉴 건너뛰기




Volumn 14, Issue 1, 2015, Pages

Glyceraldehyde-derived pyridinium (GLAP) evokes oxidative stress and inflammatory and thrombogenic reactions in endothelial cells via the interaction with RAGE

Author keywords

AGEs; Aptamer; GLAP; Oxidative stress; RAGE

Indexed keywords

ADVANCED GLYCATION END PRODUCT; ADVANCED GLYCATION END PRODUCT RECEPTOR; ADVANCED GLYCATION END PRODUCT RECEPTOR ANTAGONIST; APTAMER; GLYCERALDEHYDE; INTERCELLULAR ADHESION MOLECULE 1; LYSINE; MESSENGER RNA; MONOCYTE CHEMOTACTIC PROTEIN 1; PLASMINOGEN ACTIVATOR INHIBITOR 1; PYRIDINIUM DERIVATIVE; VASCULAR CELL ADHESION MOLECULE 1; AGER PROTEIN, HUMAN; REACTIVE OXYGEN METABOLITE;

EID: 84924289618     PISSN: None     EISSN: 14752840     Source Type: Journal    
DOI: 10.1186/s12933-014-0162-3     Document Type: Article
Times cited : (31)

References (54)
  • 1
    • 0029882358 scopus 로고    scopus 로고
    • Recent progress in advanced glycation and diabetic vascular disease: role of advanced glycation end product receptors
    • Vlassara H, Bucala R: Recent progress in advanced glycation and diabetic vascular disease: role of advanced glycation end product receptors. Diabetes 1996, 45(Suppl 3):S65-S66.
    • (1996) Diabetes , vol.45 , pp. S65-S66
    • Vlassara, H.1    Bucala, R.2
  • 2
    • 0023950461 scopus 로고
    • Advanced glycosylation end products in tissue and the biochemical basis of diabetic complications
    • Brownlee M, Cerami A, Vlassara H: Advanced glycosylation end products in tissue and the biochemical basis of diabetic complications. N Engl J Med 1988, 318:1315-1321.
    • (1988) N Engl J Med , vol.318 , pp. 1315-1321
    • Brownlee, M.1    Cerami, A.2    Vlassara, H.3
  • 3
    • 34548299920 scopus 로고    scopus 로고
    • Novel inhibitors of glycation and AGE formation
    • Rahbar S: Novel inhibitors of glycation and AGE formation. Cell Biochem Biophys 2007, 48:147-157.
    • (2007) Cell Biochem Biophys , vol.48 , pp. 147-157
    • Rahbar, S.1
  • 6
    • 21044443182 scopus 로고    scopus 로고
    • Diabetic vascular complications: pathophysiology, biochemical basis and potential therapeutic strategy
    • Yamagishi S, Imaizumi T: Diabetic vascular complications: pathophysiology, biochemical basis and potential therapeutic strategy. Curr Pharm Des 2005, 11:2279-2299.
    • (2005) Curr Pharm Des , vol.11 , pp. 2279-2299
    • Yamagishi, S.1    Imaizumi, T.2
  • 7
    • 42049109529 scopus 로고    scopus 로고
    • Receptor for advanced glycation end products (RAGE): a novel therapeutic target for diabetic vascular complication
    • Yamagishi S, Nakamura K, Matsui T, Noda Y, Imaizumi T: Receptor for advanced glycation end products (RAGE): a novel therapeutic target for diabetic vascular complication. Curr Pharm Des 2008, 14:487-495.
    • (2008) Curr Pharm Des , vol.14 , pp. 487-495
    • Yamagishi, S.1    Nakamura, K.2    Matsui, T.3    Noda, Y.4    Imaizumi, T.5
  • 8
    • 44449125709 scopus 로고    scopus 로고
    • The role of AGEs in cardiovascular disease
    • Jandeleit-Dahm K, Cooper ME: The role of AGEs in cardiovascular disease. Curr Pharm Des 2008, 14:979-986.
    • (2008) Curr Pharm Des , vol.14 , pp. 979-986
    • Jandeleit-Dahm, K.1    Cooper, M.E.2
  • 11
    • 84856252632 scopus 로고    scopus 로고
    • Serum levels of advanced glycation end products (AGEs) are independent correlates of insulin resistance in nondiabetic subjects
    • Tahara N, Yamagishi S, Matsui T, Takeuchi M, Nitta Y, Kodama N, Mizoguchi M, Imaizumi T: Serum levels of advanced glycation end products (AGEs) are independent correlates of insulin resistance in nondiabetic subjects. Cardiovasc Ther 2012, 30:42-48.
    • (2012) Cardiovasc Ther , vol.30 , pp. 42-48
    • Tahara, N.1    Yamagishi, S.2    Matsui, T.3    Takeuchi, M.4    Nitta, Y.5    Kodama, N.6    Mizoguchi, M.7    Imaizumi, T.8
  • 14
    • 84863499980 scopus 로고    scopus 로고
    • Serum levels of advanced glycation end products (AGEs) are inversely associated with the number and migratory activity of circulating endothelial progenitor cells in apparently healthy subjects
    • Ueda S, Yamagishi S, Matsui T, Noda Y, Ueda S, Jinnouchi Y, Sasaki K, Takeuchi M, Imaizumi T: Serum levels of advanced glycation end products (AGEs) are inversely associated with the number and migratory activity of circulating endothelial progenitor cells in apparently healthy subjects. Cardiovasc Ther 2012, 30:249-254.
    • (2012) Cardiovasc Ther , vol.30 , pp. 249-254
    • Ueda, S.1    Yamagishi, S.2    Matsui, T.3    Noda, Y.4    Ueda, S.5    Jinnouchi, Y.6    Sasaki, K.7    Takeuchi, M.8    Imaizumi, T.9
  • 16
    • 37349025554 scopus 로고    scopus 로고
    • Olmesartan blocks inflammatory reactions in endothelial cells evoked by advanced glycation end products by suppressing generation of reactive oxygen species
    • Yamagishi S, Matsui T, Nakamura K, Inoue H, Takeuchi M, Ueda S, Okuda S, Imaizumi T: Olmesartan blocks inflammatory reactions in endothelial cells evoked by advanced glycation end products by suppressing generation of reactive oxygen species. Ophthalmic Res 2008, 40:10-15.
    • (2008) Ophthalmic Res , vol.40 , pp. 10-15
    • Yamagishi, S.1    Matsui, T.2    Nakamura, K.3    Inoue, H.4    Takeuchi, M.5    Ueda, S.6    Okuda, S.7    Imaizumi, T.8
  • 17
    • 73949118948 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 (GLP-1) inhibits advanced glycation end product (AGE)-induced up-regulation of VCAM-1 mRNA levels in endothelial cells by suppressing AGE receptor (RAGE) expression
    • Ishibashi Y, Matsui T, Takeuchi M, Yamagishi S: Glucagon-like peptide-1 (GLP-1) inhibits advanced glycation end product (AGE)-induced up-regulation of VCAM-1 mRNA levels in endothelial cells by suppressing AGE receptor (RAGE) expression. Biochem Biophys Res Commun 2010, 391:1405-1408.
    • (2010) Biochem Biophys Res Commun , vol.391 , pp. 1405-1408
    • Ishibashi, Y.1    Matsui, T.2    Takeuchi, M.3    Yamagishi, S.4
  • 18
    • 84883084459 scopus 로고    scopus 로고
    • Advanced glycation end products evoke endothelial cell damage by stimulating soluble dipeptidyl peptidase-4 production and its interaction with mannose 6-phosphate/insulin-like growth factor II receptor
    • Ishibashi Y, Matsui T, Maeda S, Higashimoto Y, Yamagishi S: Advanced glycation end products evoke endothelial cell damage by stimulating soluble dipeptidyl peptidase-4 production and its interaction with mannose 6-phosphate/insulin-like growth factor II receptor. Cardiovasc Diabetol 2013, 12:125.
    • (2013) Cardiovasc Diabetol , vol.12 , pp. 125
    • Ishibashi, Y.1    Matsui, T.2    Maeda, S.3    Higashimoto, Y.4    Yamagishi, S.5
  • 19
    • 84899572841 scopus 로고    scopus 로고
    • Advanced glycation end products potentiate citrated plasma-evoked oxidative and inflammatory reactions in endothelial cells by up-regulating protease-activated receptor-1 expression
    • Ishibashi Y, Matsui T, Ueda S, Fukami K, Yamagishi S: Advanced glycation end products potentiate citrated plasma-evoked oxidative and inflammatory reactions in endothelial cells by up-regulating protease-activated receptor-1 expression. Cardiovasc Diabetol 2014, 13:60.
    • (2014) Cardiovasc Diabetol , vol.13 , pp. 60
    • Ishibashi, Y.1    Matsui, T.2    Ueda, S.3    Fukami, K.4    Yamagishi, S.5
  • 20
    • 80052963329 scopus 로고    scopus 로고
    • Sitagliptin augments protective effects of GLP-1 against advanced glycation end product receptor axis in endothelial cells
    • Ishibashi Y, Matsui T, Takeuchi M, Yamagishi S: Sitagliptin augments protective effects of GLP-1 against advanced glycation end product receptor axis in endothelial cells. Horm Metab Res 2011, 43:731-734.
    • (2011) Horm Metab Res , vol.43 , pp. 731-734
    • Ishibashi, Y.1    Matsui, T.2    Takeuchi, M.3    Yamagishi, S.4
  • 21
    • 0025074907 scopus 로고
    • In vitro selection of RNA molecules that bind specific ligands
    • Ellington AD, Szostak JW: In vitro selection of RNA molecules that bind specific ligands. Nature 1990, 346:818-822.
    • (1990) Nature , vol.346 , pp. 818-822
    • Ellington, A.D.1    Szostak, J.W.2
  • 23
    • 80052350022 scopus 로고    scopus 로고
    • A dose ranging phase I/II trial of the von Willebrand factor inhibiting aptamer ARC1779 in patients with congenital thrombotic thrombocytopenic purpura
    • Jilma-Stohlawetz P, Gilbert JC, Gorczyca ME, Knöbl P, Jilma B: A dose ranging phase I/II trial of the von Willebrand factor inhibiting aptamer ARC1779 in patients with congenital thrombotic thrombocytopenic purpura. Thromb Haemost 2011, 106:539-547.
    • (2011) Thromb Haemost , vol.106 , pp. 539-547
    • Jilma-Stohlawetz, P.1    Gilbert, J.C.2    Gorczyca, M.E.3    Knöbl, P.4    Jilma, B.5
  • 24
    • 84888435253 scopus 로고    scopus 로고
    • Blockade by phosphorothioate aptamers of advanced glycation end products-induced damage in cultured pericytes and endothelial cells
    • Higashimoto Y, Matsui T, Nishino Y, Taira J, Inoue H, Takeuchi M, Yamagishi S: Blockade by phosphorothioate aptamers of advanced glycation end products-induced damage in cultured pericytes and endothelial cells. Microvasc Res 2013, 90:64-70.
    • (2013) Microvasc Res , vol.90 , pp. 64-70
    • Higashimoto, Y.1    Matsui, T.2    Nishino, Y.3    Taira, J.4    Inoue, H.5    Takeuchi, M.6    Yamagishi, S.7
  • 26
    • 84893673451 scopus 로고    scopus 로고
    • DNA aptamer raised against advanced glycation end products inhibits neointimal hyperplasia in balloon-injured rat carotid arteries
    • Ojima A, Oda E, Higashimoto Y, Matsui T, Yamagishi S: DNA aptamer raised against advanced glycation end products inhibits neointimal hyperplasia in balloon-injured rat carotid arteries. Int J Cardiol 2014, 171:443-446.
    • (2014) Int J Cardiol , vol.171 , pp. 443-446
    • Ojima, A.1    Oda, E.2    Higashimoto, Y.3    Matsui, T.4    Yamagishi, S.5
  • 27
    • 84897388063 scopus 로고    scopus 로고
    • DNA aptamer raised against advanced glycation end products inhibits melanoma growth in nude mice
    • Ojima A, Matsui T, Maeda S, Takeuchi M, Inoue H, Higashimoto Y, Yamagishi S: DNA aptamer raised against advanced glycation end products inhibits melanoma growth in nude mice. Lab Invest 2014, 94:422-429.
    • (2014) Lab Invest , vol.94 , pp. 422-429
    • Ojima, A.1    Matsui, T.2    Maeda, S.3    Takeuchi, M.4    Inoue, H.5    Higashimoto, Y.6    Yamagishi, S.7
  • 28
    • 0042821521 scopus 로고    scopus 로고
    • Isolation and identification of the 3-hydroxy-5-hydroxymethyl-pyridinium compound as a novel advanced glycation end product on glyceraldehyde-related Maillard reaction
    • Usui T, Hayase F: Isolation and identification of the 3-hydroxy-5-hydroxymethyl-pyridinium compound as a novel advanced glycation end product on glyceraldehyde-related Maillard reaction. Biosci Biotechnol Biochem 2003, 67:930-932.
    • (2003) Biosci Biotechnol Biochem , vol.67 , pp. 930-932
    • Usui, T.1    Hayase, F.2
  • 31
    • 84885655050 scopus 로고    scopus 로고
    • Pigment epithelium-derived factor (PEDF) blocks high glucose-induced inflammatory reactions in endothelial cells through its anti-oxidative properties
    • Nakashima S, Matsui T, Yamagishi S: Pigment epithelium-derived factor (PEDF) blocks high glucose-induced inflammatory reactions in endothelial cells through its anti-oxidative properties. Int J Cardiol 2013, 168:3004-3006.
    • (2013) Int J Cardiol , vol.168 , pp. 3004-3006
    • Nakashima, S.1    Matsui, T.2    Yamagishi, S.3
  • 32
    • 0042121256 scopus 로고    scopus 로고
    • Mfold web server for nucleic acid folding and hybridization prediction
    • Zuker M: Mfold web server for nucleic acid folding and hybridization prediction. Nucleic Acids Res 2013, 31:3406-3415.
    • (2013) Nucleic Acids Res , vol.31 , pp. 3406-3415
    • Zuker, M.1
  • 33
    • 84872598301 scopus 로고    scopus 로고
    • The modelling of blood coagulation using the quartz crystal microbalance
    • Efremov V, Killard AJ, Byrne B, Lakshmanan RS: The modelling of blood coagulation using the quartz crystal microbalance. J Biomech 2013, 46:437-442.
    • (2013) J Biomech , vol.46 , pp. 437-442
    • Efremov, V.1    Killard, A.J.2    Byrne, B.3    Lakshmanan, R.S.4
  • 34
    • 33847208469 scopus 로고    scopus 로고
    • Detection and determination of glyceraldehyde-derived pyridinium-type advanced glycation end products in streptozotocin-induced diabetic rats
    • Usui T, Shimohira K, Watanabe H, Hayase F: Detection and determination of glyceraldehyde-derived pyridinium-type advanced glycation end products in streptozotocin-induced diabetic rats. Biosci Biotechnol Biochem 2007, 71:442-448.
    • (2007) Biosci Biotechnol Biochem , vol.71 , pp. 442-448
    • Usui, T.1    Shimohira, K.2    Watanabe, H.3    Hayase, F.4
  • 36
    • 0034682796 scopus 로고    scopus 로고
    • The receptor for advanced glycation end products is induced by the glycation products themselves and tumor necrosis factor-alpha through nuclear factor-kappa B, and by 17beta-estradiol through Sp-1 in human vascular endothelial cells
    • Tanaka N, Yonekura H, Yamagishi S, Fujimori H, Yamamoto Y, Yamamoto H: The receptor for advanced glycation end products is induced by the glycation products themselves and tumor necrosis factor-alpha through nuclear factor-kappa B, and by 17beta-estradiol through Sp-1 in human vascular endothelial cells. J Biol Chem 2000, 275:25781-25790.
    • (2000) J Biol Chem , vol.275 , pp. 25781-25790
    • Tanaka, N.1    Yonekura, H.2    Yamagishi, S.3    Fujimori, H.4    Yamamoto, Y.5    Yamamoto, H.6
  • 38
    • 34248146103 scopus 로고    scopus 로고
    • Pigment-epithelium-derived factor suppresses expression of receptor for advanced glycation end products in the eye of diabetic rats
    • Yamagishi S, Matsui T, Nakamura K, Yoshida T, Takeuchi M, Inoue H, Yoshida Y, Imaizumi T: Pigment-epithelium-derived factor suppresses expression of receptor for advanced glycation end products in the eye of diabetic rats. Ophthalmic Res 2007, 39:92-97.
    • (2007) Ophthalmic Res , vol.39 , pp. 92-97
    • Yamagishi, S.1    Matsui, T.2    Nakamura, K.3    Yoshida, T.4    Takeuchi, M.5    Inoue, H.6    Yoshida, Y.7    Imaizumi, T.8
  • 39
    • 0032134003 scopus 로고    scopus 로고
    • Absence of monocyte chemoattractant protein-1 reduces atherosclerosis in low density lipoprotein receptor-deficient mice
    • Gu L, Okada Y, Clinton SK, Gerard C, Sukhova GK, Libby P, Rollins BJ: Absence of monocyte chemoattractant protein-1 reduces atherosclerosis in low density lipoprotein receptor-deficient mice. Mol Cell 1998, 2:275-281.
    • (1998) Mol Cell , vol.2 , pp. 275-281
    • Gu, L.1    Okada, Y.2    Clinton, S.K.3    Gerard, C.4    Sukhova, G.K.5    Libby, P.6    Rollins, B.J.7
  • 40
    • 0032572719 scopus 로고    scopus 로고
    • Decreased lesion formation in CCR2-/- mice reveals a role for chemokines in the initiation of atherosclerosis
    • Boring L, Gosling J, Cleary M, Charo IF: Decreased lesion formation in CCR2-/- mice reveals a role for chemokines in the initiation of atherosclerosis. Nature 1998, 394:894-897.
    • (1998) Nature , vol.394 , pp. 894-897
    • Boring, L.1    Gosling, J.2    Cleary, M.3    Charo, I.F.4
  • 41
    • 66949136652 scopus 로고    scopus 로고
    • ICAM-1 signaling in endothelial cells
    • Lawson C, Wolf S: ICAM-1 signaling in endothelial cells. Pharmacol Rep 2009, 61:22-32.
    • (2009) Pharmacol Rep , vol.61 , pp. 22-32
    • Lawson, C.1    Wolf, S.2
  • 42
    • 33947354929 scopus 로고    scopus 로고
    • Vascular cell adhesion molecule-1: a viable therapeutic target for atherosclerosis?
    • Preiss DJ, Sattar N: Vascular cell adhesion molecule-1: a viable therapeutic target for atherosclerosis? Int J Clin Pract 2007, 6:697-701.
    • (2007) Int J Clin Pract , vol.6 , pp. 697-701
    • Preiss, D.J.1    Sattar, N.2
  • 43
    • 84887987862 scopus 로고    scopus 로고
    • Pigment epithelium-derived factor (PEDF) binds to caveolin-1 and inhibits the pro-inflammatory effects of caveolin-1 in endothelial cells
    • Matsui T, Higashimoto Y, Taira J, Yamagishi S: Pigment epithelium-derived factor (PEDF) binds to caveolin-1 and inhibits the pro-inflammatory effects of caveolin-1 in endothelial cells. Biochem Biophys Res Commun 2013, 441:405-410.
    • (2013) Biochem Biophys Res Commun , vol.441 , pp. 405-410
    • Matsui, T.1    Higashimoto, Y.2    Taira, J.3    Yamagishi, S.4
  • 44
    • 33645890286 scopus 로고    scopus 로고
    • Role of advanced glycation end products (AGEs) in thrombogenic abnormalities in diabetes
    • Takenaka K, Yamagishi S, Matsui T, Nakamura K, Imaizumi T: Role of advanced glycation end products (AGEs) in thrombogenic abnormalities in diabetes. Curr Neurovasc Res 2006, 3:73-77.
    • (2006) Curr Neurovasc Res , vol.3 , pp. 73-77
    • Takenaka, K.1    Yamagishi, S.2    Matsui, T.3    Nakamura, K.4    Imaizumi, T.5
  • 45
    • 0031773362 scopus 로고    scopus 로고
    • Advanced glycation endproducts inhibit prostacyclin production and induce plasminogen activator inhibitor-1 in human microvascular endothelial cells
    • Yamagishi S, Fujimori H, Yonekura H, Yamamoto Y, Yamamoto H: Advanced glycation endproducts inhibit prostacyclin production and induce plasminogen activator inhibitor-1 in human microvascular endothelial cells. Diabetologia 1998, 41:1435-1441.
    • (1998) Diabetologia , vol.41 , pp. 1435-1441
    • Yamagishi, S.1    Fujimori, H.2    Yonekura, H.3    Yamamoto, Y.4    Yamamoto, H.5
  • 46
    • 79955480528 scopus 로고    scopus 로고
    • Vildagliptin blocks vascular injury in thoracic aorta of diabetic rats by suppressing advanced glycation end product-receptor axis
    • Matsui T, Nishino Y, Takeuchi M, Yamagishi S: Vildagliptin blocks vascular injury in thoracic aorta of diabetic rats by suppressing advanced glycation end product-receptor axis. Pharmacol Res 2011, 63:383-388.
    • (2011) Pharmacol Res , vol.63 , pp. 383-388
    • Matsui, T.1    Nishino, Y.2    Takeuchi, M.3    Yamagishi, S.4
  • 47
    • 36749040838 scopus 로고    scopus 로고
    • Serum level of advanced glycation end-products (AGEs) is an independent determinant of plasminogen activator inhibitor-1 (PAI-1) in nondiabetic general population
    • Yamagishi S, Adachi H, Takeuchi M, Enomoto M, Furuki K, Matsui T, Nakamura K, Imaizumi T: Serum level of advanced glycation end-products (AGEs) is an independent determinant of plasminogen activator inhibitor-1 (PAI-1) in nondiabetic general population. Horm Metab Res 2007, 39:845-848.
    • (2007) Horm Metab Res , vol.39 , pp. 845-848
    • Yamagishi, S.1    Adachi, H.2    Takeuchi, M.3    Enomoto, M.4    Furuki, K.5    Matsui, T.6    Nakamura, K.7    Imaizumi, T.8
  • 48
    • 0034136370 scopus 로고    scopus 로고
    • Immunological evidence that non-carboxymethyllysine advanced glycation end-products are produced from short chain sugars and dicarbonyl compounds in vivo
    • Takeuchi M, Makita Z, Bucala R, Suzuki T, Koike T, Kameda Y: Immunological evidence that non-carboxymethyllysine advanced glycation end-products are produced from short chain sugars and dicarbonyl compounds in vivo. Mol Med 2000, 6:114-125.
    • (2000) Mol Med , vol.6 , pp. 114-125
    • Takeuchi, M.1    Makita, Z.2    Bucala, R.3    Suzuki, T.4    Koike, T.5    Kameda, Y.6
  • 49
    • 84929108572 scopus 로고    scopus 로고
    • DNA Aptamer Raised Against Advanced Glycation End Products (AGEs) Improves Glycemic Control and Decreases Adipocyte Size in Fructose-Fed Rats by Suppressing AGE-RAGE Axis.
    • Ojima A, Matsui T, Nakamura N, Higashimoto Y, Ueda S, Fukami K, Okuda S, Yamagishi S: DNA Aptamer Raised Against Advanced Glycation End Products (AGEs) Improves Glycemic Control and Decreases Adipocyte Size in Fructose-Fed Rats by Suppressing AGE-RAGE Axis. Horm Metab Res 2014, doi:10.1055/s-0034-1385904
    • (2014) Horm Metab Res
    • Ojima, A.1    Matsui, T.2    Nakamura, N.3    Higashimoto, Y.4    Ueda, S.5    Fukami, K.6    Okuda, S.7    Yamagishi, S.8
  • 51
    • 85047691537 scopus 로고    scopus 로고
    • Inhibition of GAPDH activity by poly(ADP-ribose) polymerase activates three major pathways of hyperglycemic damage in endothelial cells
    • Du X, Matsumura T, Edelstein D, Rossetti L, Zsengellér Z, Szabó C, Brownlee M: Inhibition of GAPDH activity by poly(ADP-ribose) polymerase activates three major pathways of hyperglycemic damage in endothelial cells. J Clin Invest 2003, 112:1049-1057.
    • (2003) J Clin Invest , vol.112 , pp. 1049-1057
    • Du, X.1    Matsumura, T.2    Edelstein, D.3    Rossetti, L.4    Zsengellér, Z.5    Szabó, C.6    Brownlee, M.7
  • 52
    • 84899490902 scopus 로고    scopus 로고
    • Advanced glycation endproducts trigger autophagy in cadiomyocyte via RAGE/PI3K/AKT/mTOR pathway
    • Hou X, Hu Z, Xu H, Xu J, Zhang S, Zhong Y, He X, Wang N: Advanced glycation endproducts trigger autophagy in cadiomyocyte via RAGE/PI3K/AKT/mTOR pathway. Cardiovasc Diabetol 2014, 13:78.
    • (2014) Cardiovasc Diabetol , vol.13 , pp. 78
    • Hou, X.1    Hu, Z.2    Xu, H.3    Xu, J.4    Zhang, S.5    Zhong, Y.6    He, X.7    Wang, N.8
  • 53
    • 84874195515 scopus 로고    scopus 로고
    • Heparanase induced by advanced glycation end products (AGEs) promotes macrophage migration involving RAGE and PI3K/AKT pathway
    • Qin Q, Niu J, Wang Z, Xu W, Qiao Z, Gu Y: Heparanase induced by advanced glycation end products (AGEs) promotes macrophage migration involving RAGE and PI3K/AKT pathway. Cardiovasc Diabetol 2013, 12:37.
    • (2013) Cardiovasc Diabetol , vol.12 , pp. 37
    • Qin, Q.1    Niu, J.2    Wang, Z.3    Xu, W.4    Qiao, Z.5    Gu, Y.6
  • 54
    • 84920053904 scopus 로고    scopus 로고
    • Extracellular matrix is modulated in advanced glycation end products milieu via a RAGE receptor dependent pathway boosted by transforming growth factor-β1.
    • Serban AI, Stanca L, Geicu OI, Munteanu MC, Costache M, Dinischiotu A: Extracellular matrix is modulated in advanced glycation end products milieu via a RAGE receptor dependent pathway boosted by transforming growth factor-β1. J Diabetes 2014, doi:10.1111/1753-0407
    • (2014) J Diabetes
    • Serban, A.I.1    Stanca, L.2    Geicu, O.I.3    Munteanu, M.C.4    Costache, M.5    Dinischiotu, A.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.