메뉴 건너뛰기




Volumn 65, Issue 3, 2015, Pages 651-661

Systolic blood pressure variation and mean heart rate is associated with cognitive dysfunction in patients with high cardiovascular risk

(18)  Böhm, Michael a   Schumacher, Helmut b   Leong, Darryl c   Mancia, Giuseppe d   Unger, Thomas e   Schmieder, Roland f   Custodis, Florian a   Diener, Hans Christoph g   Laufs, Ulrich a   Lonn, Eva c   Sliwa, Karen h   Teo, Koon c   Fagard, Robert i   Redon, Josep j   Sleight, Peter k   Anderson, Craig l   O'Donnell, Martin m   Yusuf, Salim c  


Author keywords

heart rate; hypertension; myocardial infarction; stroke

Indexed keywords

ADULT; AGE; ALCOHOL CONSUMPTION; ARTICLE; ASIAN; BODY MASS; CARDIOVASCULAR RISK; CAUCASIAN; CEREBROVASCULAR ACCIDENT; CLINICAL EVALUATION; COGNITION; COGNITIVE DEFECT; DIABETES MELLITUS; DISEASE ASSOCIATION; EDUCATIONAL STATUS; ETHNIC DIFFERENCE; FEMALE; FOLLOW UP; GLOMERULUS FILTRATION RATE; HEART ATRIUM FIBRILLATION; HEART RATE; HUMAN; INCIDENCE; MAJOR CLINICAL STUDY; MALE; MEDICAL HISTORY; MENTAL DETERIORATION; MINI MENTAL STATE EXAMINATION; PHYSICAL ACTIVITY; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL (TOPIC); SYSTOLIC BLOOD PRESSURE; AGED; BLOOD PRESSURE; CARDIOVASCULAR DISEASES; COGNITION DISORDERS; COMPLICATION; DRUG COMBINATION; HYPERTENSION; MIDDLE AGED; MULTIVARIATE ANALYSIS; PATHOPHYSIOLOGY; PHYSIOLOGY; PREDICTIVE VALUE; RETROSPECTIVE STUDY; RISK FACTOR; VERY ELDERLY;

EID: 84924275551     PISSN: 0194911X     EISSN: 15244563     Source Type: Journal    
DOI: 10.1161/HYPERTENSIONAHA.114.04568     Document Type: Article
Times cited : (78)

References (55)
  • 1
    • 12744273863 scopus 로고    scopus 로고
    • Midlife cardiovascular risk factors and risk of dementia in late life
    • Whitmer RA, Sidney S, Selby J, Johnston SC, Yaffe K. Midlife cardiovascular risk factors and risk of dementia in late life.Neurology.2005;64:277-281. doi: 10.1212/01.WNL.0000149519.47454.F2.
    • (2005) Neurology , vol.64 , pp. 277-281
    • Whitmer, R.A.1    Sidney, S.2    Selby, J.3    Johnston, S.C.4    Yaffe, K.5
  • 2
    • 84858702001 scopus 로고    scopus 로고
    • Blood pressure trajectories from midlife to late life in relation to dementia in women followed for 37 years
    • Joas E, Bäckman K, Gustafson D, Ostling S, Waern M, Guo X, Skoog I. Blood pressure trajectories from midlife to late life in relation to dementia in women followed for 37 years.Hypertension.2012;59:796-801. doi: 10.1161/HYPERTENSIONAHA.111.182204.
    • (2012) Hypertension , vol.59 , pp. 796-801
    • Joas, E.1    Bäckman, K.2    Gustafson, D.3    Ostling, S.4    Waern, M.5    Guo, X.6    Skoog, I.7
  • 3
    • 78149245073 scopus 로고    scopus 로고
    • Role of inflammation in cognitive impairment: Results of observational epidemiological studies and clinical trials
    • Gorelick PB. Role of inflammation in cognitive impairment: results of observational epidemiological studies and clinical trials.Ann N Y Acad Sci.2010;1207:155-162. doi: 10.1111/j.1749-6632.2010.05726.x.
    • (2010) Ann N y Acad Sci , vol.1207 , pp. 155-162
    • Gorelick, P.B.1
  • 4
    • 80052400687 scopus 로고    scopus 로고
    • Vascular contributions to cognitive impairment and dementia: A statement for healthcare professionals from the american heart association/ american stroke association
    • Gorelick PB, Scuteri A, Black SE, et al American Heart Association Stroke Council, Council on Epidemiology and Prevention, Council on Cardiovascular Nursing, Council on Cardiovascular Radiology and Intervention, and Council on Cardiovascular Surgery and Anesthesia. Vascular contributions to cognitive impairment and dementia: a statement for healthcare professionals from the american heart association/ american stroke association. Stroke. 2011;42:2672-2713. doi: 10.1161/STR.0b013e3182299496.
    • (2011) Stroke , vol.42 , pp. 2672-2713
    • Gorelick, P.B.1    Scuteri, A.2    Black, S.E.3
  • 7
    • 84865504561 scopus 로고    scopus 로고
    • Association between annual visit-to-visit blood pressure variability and stroke in postmenopausal women: Data from the Women's Health Initiative
    • Shimbo D, Newman JD, Aragaki AK, LaMonte MJ, Bavry AA, Allison M, Manson JE, Wassertheil-Smoller S. Association between annual visit-to-visit blood pressure variability and stroke in postmenopausal women: data from the Women's Health Initiative. Hypertension.2012;60:625-630. doi: 10.1161/HYPERTENSIONAHA.112.193094.
    • (2012) Hypertension , vol.60 , pp. 625-630
    • Shimbo, D.1    Newman, J.D.2    Aragaki, A.K.3    LaMonte, M.J.4    Bavry, A.A.5    Allison, M.6    Manson, J.E.7    Wassertheil-Smoller, S.8
  • 8
    • 44449129008 scopus 로고    scopus 로고
    • Impact of resting heart rate on outcomes in hypertensive patients with coronary artery disease: Findings from the INternational VErapamil-SR/trandolapril STudy (INVEST)
    • Kolloch R, Legler UF, Champion A, Cooper-Dehoff RM, Handberg E, Zhou Q, Pepine CJ. Impact of resting heart rate on outcomes in hypertensive patients with coronary artery disease: findings from the INternational VErapamil-SR/trandolapril STudy (INVEST).Eur Heart J. 2008;29:1327-1334. doi: 10.1093/eurheartj/ehn123.
    • (2008) Eur Heart J , vol.29 , pp. 1327-1334
    • Kolloch, R.1    Legler, U.F.2    Champion, A.3    Cooper-Dehoff, R.M.4    Handberg, E.5    Zhou, Q.6    Pepine, C.J.7
  • 9
    • 50649089781 scopus 로고    scopus 로고
    • Heart rate as a prognostic risk factor in patients with coronary artery disease and left-ventricular systolic dysfunction (BEAUTIFUL): A subgroup analysis of a randomised controlled trial
    • Fox K, Ford I, Steg PG, Tendera M, Robertson M, Ferrari R; BEAUTIFUL investigators. Heart rate as a prognostic risk factor in patients with coronary artery disease and left-ventricular systolic dysfunction (BEAUTIFUL): a subgroup analysis of a randomised controlled trial.Lancet.2008;372:817-821. doi: 10.1016/S0140-6736(08)61171-X.
    • (2008) Lancet , vol.372 , pp. 817-821
    • Fox, K.1    Ford, I.2    Steg, P.G.3    Tendera, M.4    Robertson, M.5    Ferrari, R.6
  • 11
    • 77956618692 scopus 로고    scopus 로고
    • SHIFT Investigators. Heart rate as a risk factor in chronic heart failure (SHIFT): The association between heart rate and outcomes in a randomised placebo-controlled trial
    • Böhm M, Swedberg K, Komajda M, Borer JS, Ford I, Dubost-Brama A, Lerebours G, Tavazzi L; SHIFT Investigators. Heart rate as a risk factor in chronic heart failure (SHIFT): the association between heart rate and outcomes in a randomised placebo-controlled trial.Lancet.2010;376:886-894. doi: 10.1016/S0140-6736(10)61259-7.
    • (2010) Lancet , vol.376 , pp. 886-894
    • Böhm, M.1    Swedberg, K.2    Komajda, M.3    Borer, J.S.4    Ford, I.5    Dubost-Brama, A.6    Lerebours, G.7    Tavazzi, L.8
  • 12
    • 43249091146 scopus 로고    scopus 로고
    • Heart rate reduction by ivabradine reduces oxidative stress, improves endothelial function, and prevents atherosclerosis in apolipoprotein E-deficient mice
    • Custodis F, Baumhäkel M, Schlimmer N, List F, Gensch C, Böhm M, Laufs U. Heart rate reduction by ivabradine reduces oxidative stress, improves endothelial function, and prevents atherosclerosis in apolipoprotein E-deficient mice. Circulation.2008;117:2377-2387. doi: 10.1161/CIRCULATIONAHA.107.746537.
    • (2008) Circulation , vol.117 , pp. 2377-2387
    • Custodis, F.1    Baumhäkel, M.2    Schlimmer, N.3    List, F.4    Gensch, C.5    Böhm, M.6    Laufs, U.7
  • 15
    • 84869127972 scopus 로고    scopus 로고
    • Impact of resting heart rate on mortality, disability and cognitive decline in patients after ischaemic stroke
    • Böhm M, Cotton D, Foster L, Custodis F, Laufs U, Sacco R, Bath PM, Yusuf S, Diener HC. Impact of resting heart rate on mortality, disability and cognitive decline in patients after ischaemic stroke.Eur Heart J.2012;33:2804-2812. doi: 10.1093/eurheartj/ehs250.
    • (2012) Eur Heart J , vol.33 , pp. 2804-2812
    • Böhm, M.1    Cotton, D.2    Foster, L.3    Custodis, F.4    Laufs, U.5    Sacco, R.6    Bath, P.M.7    Yusuf, S.8    Diener, H.C.9
  • 16
    • 84863834121 scopus 로고    scopus 로고
    • Visit-to-visit blood pressure variations: New independent determinants for cognitive function in the elderly at high risk of cardiovascular disease
    • Nagai M, Hoshide S, Ishikawa J, Shimada K, Kario K. Visit-to-visit blood pressure variations: new independent determinants for cognitive function in the elderly at high risk of cardiovascular disease. J Hypertens. 2012;30:1556-1563. doi: 10.1097/HJH.0b013e3283552735.
    • (2012) J Hypertens , vol.30 , pp. 1556-1563
    • Nagai, M.1    Hoshide, S.2    Ishikawa, J.3    Shimada, K.4    Kario, K.5
  • 18
    • 53049109468 scopus 로고    scopus 로고
    • Telmisartan Randomised AssessmeNt Study in ACE iNtolerant subjects with cardiovascular Disease (TRANSCEND) Investigators, Yusuf S, Teo K, Anderson C, Pogue J, Dyal L, Copland I, Schumacher H, Dagenais G, Sleight P. Effects of the angiotensin-receptor blocker telmisartan on cardiovascular events in high-risk patients intolerant to angiotensinconverting enzyme inhibitors: a randomised controlled trial.Lancet.2008;372:1174-1183.
    • (2008) Lancet , vol.372 , pp. 1174-1183
  • 19
    • 58149142536 scopus 로고    scopus 로고
    • Does a reliable decline in mini mental state examination total score predict dementia? Diagnostic accuracy of two reliable change indices
    • Hensel A, Luck T, Luppa M, Glaesmer H, Angermeyer MC, Riedel-Heller SG. Does a reliable decline in Mini Mental State Examination total score predict dementia? Diagnostic accuracy of two reliable change indices.Dement Geriatr Cogn Disord.2009;27:50-58. doi: 10.1159/000189267.
    • (2009) Dement Geriatr Cogn Disord , vol.27 , pp. 50-58
    • Hensel, A.1    Luck, T.2    Luppa, M.3    Glaesmer, H.4    Angermeyer, M.C.5    Riedel-Heller, S.G.6
  • 20
    • 0032984115 scopus 로고    scopus 로고
    • Variability in annual mini-mental state examination score in patients with probable Alzheimer disease: A clinical perspective of data from the consortium to establish a registry for Alzheimer's Disease
    • Clark CM, Sheppard L, Fillenbaum GG, Galasko D, Morris JC, Koss E, Mohs R, Heyman A. Variability in annual Mini-Mental State Examination score in patients with probable Alzheimer disease: a clinical perspective of data from the Consortium to Establish a Registry for Alzheimer's Disease.Arch Neurol.1999;56:857-862.
    • (1999) Arch Neurol , vol.56 , pp. 857-862
    • Clark, C.M.1    Sheppard, L.2    Fillenbaum, G.G.3    Galasko, D.4    Morris, J.C.5    Koss, E.6    Mohs, R.7    Heyman, A.8
  • 21
    • 0026646174 scopus 로고
    • The mini-mental state examination: A comprehensive review
    • Tombaugh TN, McIntyre NJ. The mini-mental state examination: a comprehensive review. J Am Geriatr Soc. 1992;40:922-935.
    • (1992) J Am Geriatr Soc , vol.40 , pp. 922-935
    • Tombaugh, T.N.1    McIntyre, N.J.2
  • 22
    • 36849080312 scopus 로고    scopus 로고
    • Measuring cognitive change in older adults: Reliable change indices for the mini-mental state examination
    • Hensel A, Angermeyer MC, Riedel-Heller SG. Measuring cognitive change in older adults: reliable change indices for the Mini-Mental State Examination.J Neurol Neurosurg Psychiatry.2007;78:1298-1303. doi: 10.1136/jnnp.2006.109074.
    • (2007) J Neurol Neurosurg Psychiatry , vol.78 , pp. 1298-1303
    • Hensel, A.1    Angermeyer, M.C.2    Riedel-Heller, S.G.3
  • 24
    • 78650022206 scopus 로고    scopus 로고
    • Renin-angiotensin system blockade and cognitive function in patients at high risk of cardiovascular disease: Analysis of data from the ONTARGET and TRANSCEND studies
    • Anderson C, Teo K, Gao P, et al ONTARGET and TRANSCEND Investigators. Renin-angiotensin system blockade and cognitive function in patients at high risk of cardiovascular disease: analysis of data from the ONTARGET and TRANSCEND studies.Lancet Neurol.2011;10:43-53. doi: 10.1016/S1474-4422(10)70250-7.
    • (2011) Lancet Neurol , vol.10 , pp. 43-53
    • Anderson, C.1    Teo, K.2    Gao, P.3
  • 25
    • 0024596532 scopus 로고
    • Flexible regression models with cubic splines
    • Durrleman S, Simon R. Flexible regression models with cubic splines. Stat Med. 1989;8:551-561.
    • (1989) Stat Med , vol.8 , pp. 551-561
    • Durrleman, S.1    Simon, R.2
  • 29
    • 7644223380 scopus 로고    scopus 로고
    • Risk factors for vascular dementia and Alzheimer disease
    • Suppl 1
    • Gorelick PB. Risk factors for vascular dementia and Alzheimer disease.Stroke.2004;35(11 Suppl 1):2620-2622. doi: 10.1161/01.STR.0000143318.70292.47.
    • (2004) Stroke , vol.35 , Issue.11 , pp. 2620-2622
    • Gorelick, P.B.1
  • 31
    • 27744507967 scopus 로고    scopus 로고
    • Illustrating the impact of a time-varying covariate with an extended Kaplan-Meier indicator
    • Snappin S, Iglewicz B. Illustrating the impact of a time-varying covariate with an extended Kaplan-Meier indicator. Am Stat. 2005;4:301-307.
    • (2005) Am Stat , vol.4 , pp. 301-307
    • Snappin, S.1    Iglewicz, B.2
  • 32
    • 67649790352 scopus 로고    scopus 로고
    • Prognostic value of blood pressure in patients with high vascular risk in the ongoing telmisartan alone and in combination with ramipril global endpoint trial study
    • ONTARGET investigators
    • Sleight P, Redon J, Verdecchia P, Mancia G, Gao P, Fagard R, Schumacher H, Weber M, Böhm M, Williams B, Pogue J, Koon T, Yusuf S; ONTARGET investigators. Prognostic value of blood pressure in patients with high vascular risk in the Ongoing Telmisartan Alone and in combination with Ramipril Global Endpoint Trial study.J Hypertens. 2009;27:1360-1369. doi: 10.1097/HJH.0b013e32832d7370.
    • (2009) J Hypertens , vol.27 , pp. 1360-1369
    • Sleight, P.1    Redon, J.2    Verdecchia, P.3    Mancia, G.4    Gao, P.5    Fagard, R.6    Schumacher, H.7    Weber, M.8    Böhm, M.9    Williams, B.10    Pogue, J.11    Koon, T.12    Yusuf, S.13
  • 33
    • 77749245884 scopus 로고    scopus 로고
    • Limitations of the usual blood-pressure hypothesis and importance of variability, instability, and episodic hypertension
    • Rothwell PM. Limitations of the usual blood-pressure hypothesis and importance of variability, instability, and episodic hypertension.Lancet.2010;375:938-948. doi: 10.1016/S0140-6736(10)60309-1.
    • (2010) Lancet , vol.375 , pp. 938-948
    • Rothwell, P.M.1
  • 34
    • 77749251836 scopus 로고    scopus 로고
    • Prognostic significance of visit-to-visit variability, maximum systolic blood pressure, and episodic hypertension
    • Rothwell PM, Howard SC, Dolan E, O'Brien E, Dobson JE, Dahlöf B, Sever PS, Poulter NR. Prognostic significance of visit-to-visit variability, maximum systolic blood pressure, and episodic hypertension.Lancet.2010;375:895-905. doi: 10.1016/S0140-6736(10)60308-X.
    • (2010) Lancet , vol.375 , pp. 895-905
    • Rothwell, P.M.1    Howard, S.C.2    Dolan, E.3    O'Brien, E.4    Dobson, J.E.5    Dahlöf, B.6    Sever, P.S.7    Poulter, N.R.8
  • 35
    • 79551479820 scopus 로고    scopus 로고
    • The relationship between visit-to-visit variability in systolic blood pressure and all-cause mortality in the general population: Findings from NHANES III, 1988 to 1994
    • Muntner P, Shimbo D, Tonelli M, Reynolds K, Arnett DK, Oparil S. The relationship between visit-to-visit variability in systolic blood pressure and all-cause mortality in the general population: findings from NHANES III, 1988 to 1994.Hypertension.2011;57:160-166. doi: 10.1161/HYPERTENSIONAHA.110.162255.
    • (2011) Hypertension , vol.57 , pp. 160-166
    • Muntner, P.1    Shimbo, D.2    Tonelli, M.3    Reynolds, K.4    Arnett, D.K.5    Oparil, S.6
  • 36
    • 84868206012 scopus 로고    scopus 로고
    • Different impacts of blood pressure variability on the progression of cerebral microbleeds and white matter lesions
    • Liu W, Liu R, Sun W, Peng Q, Zhang W, Xu E, Cheng Y, Ding M, Li Y, Hong Z, Wu J, Zeng J, Yao C, Huang Y; CASISP Study Group. Different impacts of blood pressure variability on the progression of cerebral microbleeds and white matter lesions.Stroke.2012;43:2916-2922. doi: 10.1161/STROKEAHA.112.658369.
    • (2012) Stroke , vol.43 , pp. 2916-2922
    • Liu, W.1    Liu, R.2    Sun, W.3    Peng, Q.4    Zhang, W.5    Xu, E.6    Cheng, Y.7    Ding, M.8    Li, Y.9    Hong, Z.10    Wu, J.11    Zeng, J.12    Yao, C.13    Huang, Y.14
  • 37
    • 58549107564 scopus 로고    scopus 로고
    • Cognitive function and hypertension
    • Birns J, Kalra L. Cognitive function and hypertension.J Hum Hypertens.2009;23:86-96. doi: 10.1038/jhh.2008.80.
    • (2009) J Hum Hypertens , vol.23 , pp. 86-96
    • Birns, J.1    Kalra, L.2
  • 38
    • 0032564132 scopus 로고    scopus 로고
    • Prevention of dementia in randomised double-blind placebo-controlled Systolic Hypertension in Europe (Syst-Eur) trial
    • Forette F, Seux ML, Staessen JA, et al. Prevention of dementia in randomised double-blind placebo-controlled Systolic Hypertension in Europe (Syst-Eur) trial. Lancet. 1998;352:1347-1351.
    • (1998) Lancet , vol.352 , pp. 1347-1351
    • Forette, F.1    Seux, M.L.2    Staessen, J.A.3
  • 39
    • 0038669268 scopus 로고    scopus 로고
    • Effects of blood pressure lowering with perindopril and indapamide therapy on dementia and cognitive decline in patients with cerebrovascular disease
    • Tzourio C, Anderson C, Chapman N, Woodward M, Neal B, MacMahon S, Chalmers J; PROGRESS Collaborative Group. Effects of blood pressure lowering with perindopril and indapamide therapy on dementia and cognitive decline in patients with cerebrovascular disease.Arch Intern Med.2003;163:1069-1075. doi: 10.1001/archinte.163.9.1069.
    • (2003) Arch Intern Med , vol.163 , pp. 1069-1075
    • Tzourio, C.1    Anderson, C.2    Chapman, N.3    Woodward, M.4    Neal, B.5    MacMahon, S.6    Chalmers, J.7
  • 41
    • 0029988543 scopus 로고    scopus 로고
    • Is the cognitive function of older patients affected by antihypertensive treatment? Results from 54 months of the Medical Research Council's trial of hypertension in older adults
    • Prince MJ, Bird AS, Blizard RA, Mann AH. Is the cognitive function of older patients affected by antihypertensive treatment? Results from 54 months of the Medical Research Council's trial of hypertension in older adults.BMJ.1996;312:801-805.
    • (1996) BMJ , vol.312 , pp. 801-805
    • Prince, M.J.1    Bird, A.S.2    Blizard, R.A.3    Mann, A.H.4
  • 42
    • 0037534905 scopus 로고    scopus 로고
    • The study on cognition and prognosis in the elderly (SCOPE): Principal results of a randomized double-blind intervention trial
    • Lithell H, Hansson L, Skoog I, Elmfeldt D, Hofman A, Olofsson B, Trenkwalder P, Zanchetti A; SCOPE Study Group. The Study on Cognition and Prognosis in the Elderly (SCOPE): principal results of a randomized double-blind intervention trial.J Hypertens.2003;21:875-886. doi: 10.1097/01.hjh.0000059028.82022.89.
    • (2003) J Hypertens , vol.21 , pp. 875-886
    • Lithell, H.1    Hansson, L.2    Skoog, I.3    Elmfeldt, D.4    Hofman, A.5    Olofsson, B.6    Trenkwalder, P.7    Zanchetti, A.8
  • 44
    • 51449085994 scopus 로고    scopus 로고
    • Effects of aspirin plus extended-release dipyridamole versus clopidogrel and telmisartan on disability and cognitive function after recurrent stroke in patients with ischaemic stroke in the Prevention Regimen for Effectively Avoiding Second Strokes (PRoFESS) trial: A double-blind, active and placebo-controlled study
    • Diener HC, Sacco RL, Yusuf S, et al Prevention Regimen for Effectively Avoiding Second Strokes (PRoFESS) study group. Effects of aspirin plus extended-release dipyridamole versus clopidogrel and telmisartan on disability and cognitive function after recurrent stroke in patients with ischaemic stroke in the Prevention Regimen for Effectively Avoiding Second Strokes (PRoFESS) trial: a double-blind, active and placebo-controlled study.Lancet Neurol.2008;7:875-884. doi: 10.1016/S1474-4422(08)70198-4.
    • (2008) Lancet Neurol , vol.7 , pp. 875-884
    • Diener, H.C.1    Sacco, R.L.2    Yusuf, S.3
  • 45
    • 84864450634 scopus 로고    scopus 로고
    • Visit-to-visit blood pressure variability, carotid atherosclerosis, and cardiovascular events in the European Lacidipine study on Atherosclerosis
    • Mancia G, Facchetti R, Parati G, Zanchetti A. Visit-to-visit blood pressure variability, carotid atherosclerosis, and cardiovascular events in the European Lacidipine Study on Atherosclerosis.Circulation.2012;126:569-578. doi: 10.1161/CIRCULATIONAHA.112.107565.
    • (2012) Circulation , vol.126 , pp. 569-578
    • Mancia, G.1    Facchetti, R.2    Parati, G.3    Zanchetti, A.4
  • 46
    • 77956612624 scopus 로고    scopus 로고
    • SHIFT Investigators. Ivabradine and outcomes in chronic heart failure (SHIFT): A randomised placebo-controlled study
    • Swedberg K, Komajda M, Böhm M, Borer JS, Ford I, Dubost-Brama A, Lerebours G, Tavazzi L; SHIFT Investigators. Ivabradine and outcomes in chronic heart failure (SHIFT): a randomised placebo-controlled study.Lancet.2010;376:875-885. doi: 10.1016/S0140-6736(10)61198-1.
    • (2010) Lancet , vol.376 , pp. 875-885
    • Swedberg, K.1    Komajda, M.2    Böhm, M.3    Borer, J.S.4    Ford, I.5    Dubost-Brama, A.6    Lerebours, G.7    Tavazzi, L.8
  • 48
    • 43249091146 scopus 로고    scopus 로고
    • Heart rate reduction by ivabradine reduces oxidative stress, improves endothelial function, and prevents atherosclerosis in apolipoprotein E-deficient mice
    • Custodis F, Baumhäkel M, Schlimmer N, List F, Gensch C, Böhm M, Laufs U. Heart rate reduction by ivabradine reduces oxidative stress, improves endothelial function, and prevents atherosclerosis in apolipoprotein E-deficient mice. Circulation.2008;117:2377-2387. doi: 10.1161/CIRCULATIONAHA.107.746537.
    • (2008) Circulation , vol.117 , pp. 2377-2387
    • Custodis, F.1    Baumhäkel, M.2    Schlimmer, N.3    List, F.4    Gensch, C.5    Böhm, M.6    Laufs, U.7
  • 50
    • 77956229711 scopus 로고    scopus 로고
    • Heart rate reduction with ivabradine improves erectile dysfunction in parallel to decrease in atherosclerotic plaque load in ApoE-knockout mice
    • Baumhäkel M, Custodis F, Schlimmer N, Laufs U, Böhm M. Heart rate reduction with ivabradine improves erectile dysfunction in parallel to decrease in atherosclerotic plaque load in ApoE-knockout mice.Atherosclerosis.2010;212:55-62. doi: 10.1016/j.atherosclerosis.2010.03.002.
    • (2010) Atherosclerosis , vol.212 , pp. 55-62
    • Baumhäkel, M.1    Custodis, F.2    Schlimmer, N.3    Laufs, U.4    Böhm, M.5
  • 52
  • 53
    • 77957336864 scopus 로고    scopus 로고
    • Cortical oxygen supply during postural hypotension is further decreased in Alzheimer's disease, but unrelated to cholinesterase-inhibitor use
    • van Beek AH, Sijbesma JC, Jansen RW, Rikkert MG, Claassen JA. Cortical oxygen supply during postural hypotension is further decreased in Alzheimer's disease, but unrelated to cholinesterase-inhibitor use.J Alzheimers Dis.2010;21:519-526. doi: 10.3233/JAD-2010-100288.
    • (2010) J Alzheimers Dis , vol.21 , pp. 519-526
    • Van Beek, A.H.1    Sijbesma, J.C.2    Jansen, R.W.3    Rikkert, M.G.4    Claassen, J.A.5
  • 54
    • 84876499366 scopus 로고    scopus 로고
    • Hypotensive syndromes are not associated with cognitive impairment in geriatric patients
    • Schoon Y, Lagro J, Verhoeven Y, Rikkert MO, Claassen J. Hypotensive syndromes are not associated with cognitive impairment in geriatric patients.Am J Alzheimers Dis Other Demen.2013;28:47-53. doi: 10.1177/1533317512466692.
    • (2013) Am J Alzheimers Dis Other Demen , vol.28 , pp. 47-53
    • Schoon, Y.1    Lagro, J.2    Verhoeven, Y.3    Rikkert, M.O.4    Claassen, J.5
  • 55
    • 84859531891 scopus 로고    scopus 로고
    • Increased risk of cognitive and functional decline in patients with atrial fibrillation: Results of the ONTARGET and TRANSCEND studies
    • Marzona I, O'Donnell M, Teo K, Gao P, Anderson C, Bosch J, Yusuf S. Increased risk of cognitive and functional decline in patients with atrial fibrillation: results of the ONTARGET and TRANSCEND studies.CMAJ.2012;184:E329-E336. doi: 10.1503/cmaj.111173.
    • (2012) CMAJ , vol.184 , pp. E329-E336
    • Marzona, I.1    O'Donnell, M.2    Teo, K.3    Gao, P.4    Anderson, C.5    Bosch, J.6    Yusuf, S.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.