Inhibition of kidney proximal tubular glucose reabsorption does not prevent against diabetic nephropathy in type 1 diabetic enos knockout mice

PLoS ONE

Volumn 9, Issue 11, 2014, Pages

  Komala, Muralikrishna Gangadharan ^a   Gross, Simon ^a   Mudaliar, Harshini ^a   Huang, Chunling ^a   Pegg, Katherine ^a   Mather, Amanda ^a   Shen, Sylvie ^a   Pollock, Carol A ^a   Panchapakesan, Usha ^a  

^a UNIVERSITY OF SYDNEY   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

EMPAGLIFLOZIN; ENDOTHELIAL NITRIC OXIDE SYNTHASE; FIBRONECTIN; GLUCOSE TRANSPORTER 1; MONOCYTE CHEMOTACTIC PROTEIN 1; SODIUM GLUCOSE COTRANSPORTER 2; TELMISARTAN; TOLL LIKE RECEPTOR 1; TOLL LIKE RECEPTOR 2; TRANSFORMING GROWTH FACTOR BETA1; ANTIDIABETIC AGENT; BENZHYDRYL DERIVATIVE; BENZIMIDAZOLE DERIVATIVE; BENZOIC ACID DERIVATIVE; CCL2 PROTEIN, MOUSE; GLUCOSE BLOOD LEVEL; GLUCOSIDE; MESSENGER RNA; SLC2A1 PROTEIN, MOUSE; STREPTOZOCIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD PRESSURE MEASUREMENT; BODY WEIGHT; CONTROLLED STUDY; DIABETIC NEPHROPATHY; GENE EXPRESSION; GLOMERULOSCLEROSIS; GLUCOSE BLOOD LEVEL; GLUCOSURIA; HISTOPATHOLOGY; INSULIN DEPENDENT DIABETES MELLITUS; KIDNEY FIBROSIS; KIDNEY PROXIMAL TUBULE; KIDNEY TUBULE ABSORPTION; MALE; MICROALBUMINURIA; MOUSE; NONHUMAN; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; RENAL PROTECTION; TREATMENT RESPONSE; WEIGHT GAIN; WESTERN BLOTTING; ALBUMINURIA; ANALYSIS; ANIMAL; ANTAGONISTS AND INHIBITORS; C57BL MOUSE; CHEMICALLY INDUCED; COMPLICATION; DEFICIENCY; DIABETIC NEPHROPATHIES; DRUG EFFECTS; EXPERIMENTAL DIABETES MELLITUS; GENETICS; KNOCKOUT MOUSE; METABOLISM; PATHOLOGY;

ALBUMINURIA; ANIMALS; BENZHYDRYL COMPOUNDS; BENZIMIDAZOLES; BENZOATES; BLOOD GLUCOSE; CHEMOKINE CCL2; DIABETES MELLITUS, EXPERIMENTAL; DIABETIC NEPHROPATHIES; FIBRONECTINS; GLUCOSE TRANSPORTER TYPE 1; GLUCOSIDES; HYPOGLYCEMIC AGENTS; KIDNEY TUBULES, PROXIMAL; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; NITRIC OXIDE SYNTHASE TYPE III; RNA, MESSENGER; SODIUM-GLUCOSE TRANSPORTER 2; STREPTOZOCIN; TOLL-LIKE RECEPTOR 2; TRANSFORMING GROWTH FACTOR BETA1;

EID: 84924263307     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0108994     Document Type: Article

References (33)

1. Reutens AT, Atkins RC (2011) Epidemiology of diabetic nephropathy. Contrib Nephrol 170: 1-7.
2. Holman RR, Paul SK, Bethel MA, Matthews DR, Neil HA (2008) 10-year follow-up of intensive glucose control in type 2 diabetes. N Engl J Med 359: 1577-1589.
3. Evans M, Bain SC, Hogan S, Bilous RW, Collaborative Study Group p (2012) Irbesartan delays progression of nephropathy as measured by estimated glomerular filtration rate: Post hoc analysis of the Irbesartan Diabetic Nephropathy Trial. Nephrol Dial Transplant 27: 2255-2263.
4. de Boer IH, Rue TC, Hall YN, Heagerty PJ, Weiss NS, et al. (2011) Temporal trends in the prevalence of diabetic kidney disease in the United States. JAMA 305: 2532-2539.
5. Ghosh RK, Ghosh SM, Chawla S, Jasdanwala SA (2011) SGLT2 Inhibitors: A New Emerging Therapeutic Class in the Treatment of Type 2 Diabetes Mellitus. J Clin Pharmacol 0091270011400604 [pii] 10.1177/0091270011400604[doi].
6. Vallon V, Sharma K (2010) Sodium-glucose transport: role in diabetes mellitus and potential clinical implications. Current opinion in nephrology and hypertension 19: 425-431.
7. Mather A, Pollock C (2011) Glucose handling by the kidney. Kidney international Supplement 10.1038/ki.2010.509: S1-6.
8. Mather A, Pollock C (2010) Renal glucose transporters: novel targets for hyperglycemia management. Nature reviews Nephrology 6: 307-311.
9. Ziyadeh FN (2004) Mediators of diabetic renal disease: The case for tgf-Beta as the major mediator. J Am Soc Nephrol 15 Suppl1: S55-57.
10. Holian J, Qi W, Kelly DJ, Zhang Y, Mreich E, et al. (2008) Role of Kruppel-like factor 6 in transforming growth factor-beta1-induced epithelial-mesenchymal transition of proximal tubule cells. American journal of physiology Renal physiology 295: F 1388-1396.
11. Qi W, Twigg S, Chen X, Polhill TS, Poronnik P, et al. (2005) Integrated actions of transforming growth factor-beta1 and connective tissue growth factor in renal fibrosis. American journal of physiology Renal physiology 288: F800-809.
12. Johnson DW, Saunders HJ, Brew BK, Poronnik P, Cook DI, et al. (1998) TGFbeta 1 dissociates human proximal tubule cell growth and Na(+)-H+ exchange activity. Kidney Int 53: 1601-1607.
13. Lin M, Yiu WH, Wu HJ, Chan LY, Leung JC, et al. (2012) Toll-like receptor 4 promotes tubular inflammation in diabetic nephropathy. J Am Soc Nephrol 23: 86-102.
14. Mudaliar H, Pollock C, Komala MG, Chadban S, Wu H, et al. (2013) The role of Toll-like receptor proteins (TLR) 2 and 4 in mediating inflammation in proximal tubules. Am J Physiol Renal Physiol 305: F143-154.
15. Panchapakesan U, Pollock CA, Chen XM (2004) The effect of high glucose and PPAR-gamma agonists on PPAR-gamma expression and function in HK-2 cells. American journal of physiology Renal physiology 287: F528-534.
16. Panchapakesan U, Sumual S, Pollock CA, Chen X (2005) PPARgamma agonists exert antifibrotic effects in renal tubular cells exposed to high glucose. American journal of physiology Renal physiology 289: F1153-1158.
17. Pollock CA, Field MJ, Bostrom TE, Dyne M, Gyory AZ, et al. (1991) Proximal tubular cell sodium concentration in early diabetic nephropathy assessed by electron microprobe analysis. Pflugers Arch 418: 14-17.
18. Pollock CA, Lawrence JR, Field MJ (1991) Tubular sodium handling and tubuloglomerular feedback in experimental diabetes mellitus. Am J Physiol 260: F946-952.
19. Qi W, Chen X, Holian J, Mreich E, Twigg S, et al. (2006) Transforming growth factor-beta1 differentially mediates fibronectin and inflammatory cytokine expression in kidney tubular cells. American journal of physiology Renal physiology 291: F1070-1077.
20. Panchapakesan U, Pegg K, Gross S, Komala MG, Mudaliar H, et al. (2013) Effects of SGLT2 inhibition in human kidney proximal tubular cells- renoprotection in diabetic nephropathy? PLoS One 8: E54442.
21. Brosius FC 3rd, Alpers CE, Bottinger EP, Breyer MD, Coffman TM, et al. (2009) Mouse models of diabetic nephropathy. Journal of the American Society of Nephrology: JASN 20: 2503-2512.
22. Maric C, Sandberg K, Hinojosa-Laborde C (2004) Glomerulosclerosis and tubulointerstitial fibrosis are attenuated with 17beta-estradiol in the aging Dahl salt sensitive rat. J Am Soc Nephrol 15: 1546-1556.
23. Yale JF, Bakris G, Cariou B, Yue D, David-Neto E, et al. (2013) Efficacy and safety of canagliflozin in subjects with type 2 diabetes and chronic kidney disease. Diabetes Obes Metab 15: 463-473.
24. Nagata T, Fukuzawa T, Takeda M, Fukazawa M, Mori T, et al. (2013) Tofogliflozin, a novel sodium-glucose co-transporter 2 inhibitor, improves renal and pancreatic function in db/db mice. Br J Pharmacol 10.1111/bph.12269.
25. Kojima N, Williams JM, Takahashi T, Miyata N, Roman RJ (2013) Effects of a new SGLT2 inhibitor, luseogliflozin, on diabetic nephropathy in T2DN rats. J Pharmacol Exp Ther 345: 464-472.
26. Anderson PW, Zhang XY, Tian J, Correale JD, Xi XP, et al. (1996) Insulin and angiotensin II are additive in stimulating TGF-beta 1 and matrix mRNAs in mesangial cells. Kidney Int 50: 745-753.
27. Sarafidis PA, Ruilope LM (2006) Insulin resistance, hyperinsulinemia, and renal injury: Mechanisms and implications. Am J Nephrol 26: 232-244.
28. Ghezzi C, Wright EM (2012) Regulation of the human Na+-dependent glucose cotransporter hSGLT2. Am J Physiol Cell Physiol 303: C348-354.
29. Vallon V, Rose M, Gerasimova M, Satriano J, Platt KA, et al. (2013) Knockout of Na-glucose transporter SGLT2 attenuates hyperglycemia and glomerular hyperfiltration but not kidney growth or injury in diabetes mellitus. Am J Physiol Renal Physiol 304: F156-167.
30. Vallon V, Gerasimova M, Rose M, Masuda T, Satriano J, et al. (2013) SGLT2 Inhibitor Empagliflozin Reduces Renal Growth and Albuminuria in Proportion to Hyperglycemia and Prevents Glomerular Hyperfiltration in Diabetic Akita Mice. Am J Physiol Renal Physiol 10.1152/ajprenal.00520.2013.
31. Hodgkins KS, Schnaper HW (2012) Tubulointerstitial injury and the progression of chronic kidney disease. Pediatr Nephrol 27: 901-909.
32. Powell DR, DaCosta CM, Gay J, Ding ZM, Smith M, et al. (2013) Improved glycemic control in mice lacking Sglt1 and Sglt2. American journal of physiology Endocrinology and metabolism 304: E117-130.
33. Zhao FQ, Keating AF (2007) Functional properties and genomics of glucose transporters. Curr Genomics 8: 113-128.