-
1
-
-
79952284127
-
Hallmarks of cancer: the next generation
-
Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation. Cell. 2011; 144:646-674.
-
(2011)
Cell
, vol.144
, pp. 646-674
-
-
Hanahan, D.1
Weinberg, R.A.2
-
2
-
-
12444279265
-
On the origin of cancer cells
-
Warburg O. On the origin of cancer cells. Science. 1956; 123:309-314.
-
(1956)
Science
, vol.123
, pp. 309-314
-
-
Warburg, O.1
-
3
-
-
8144228566
-
Why do cancers have high aerobic glycolysis?
-
Gatenby RA, Gillies RJ. Why do cancers have high aerobic glycolysis?. Nat Rev Cancer. 2004; 4:891-899.
-
(2004)
Nat Rev Cancer
, vol.4
, pp. 891-899
-
-
Gatenby, R.A.1
Gillies, R.J.2
-
4
-
-
78249286217
-
Cancer metabolism: the Warburg effect today
-
Ferreira LM. Cancer metabolism: the Warburg effect today. Exp Mol Pathol. 2010; 89:372-380.
-
(2010)
Exp Mol Pathol
, vol.89
, pp. 372-380
-
-
Ferreira, L.M.1
-
5
-
-
2942531063
-
Mitochondrial defects in cancer
-
Carew JS, Huang P. Mitochondrial defects in cancer. Mol Cancer. 2002; 1:9.
-
(2002)
Mol Cancer
, vol.1
, pp. 9
-
-
Carew, J.S.1
Huang, P.2
-
6
-
-
32444441115
-
PKC regulates a farnesyl-electrostatic switch on K-Ras that promotes its association with Bcl-XL on mitochondria and induces apoptosis
-
Bivona TG, Quatela SE, Bodemann BO, Ahearn IM, Soskis MJ, Mor A, Miura J, Wiener HH, Wright L, Saba SG, Yim D, Fein A, Perez de Castro I, Li C, Thompson CB, Cox AD, et al. PKC regulates a farnesyl-electrostatic switch on K-Ras that promotes its association with Bcl-XL on mitochondria and induces apoptosis. Mol Cell. 2006; 21:481-493.
-
(2006)
Mol Cell
, vol.21
, pp. 481-493
-
-
Bivona, T.G.1
Quatela, S.E.2
Bodemann, B.O.3
Ahearn, I.M.4
Soskis, M.J.5
Mor, A.6
Miura, J.7
Wiener, H.H.8
Wright, L.9
Saba, S.G.10
Yim, D.11
Fein, A.12
Perez de Castro, I.13
Li, C.14
Thompson, C.B.15
Cox, A.D.16
-
7
-
-
77952737658
-
Mitochondrial metabolism and ROS generation are essential for Kras-mediated tumorigenicity
-
Weinberg F, Hamanaka R, Wheaton WW, Weinberg S, Joseph J, Lopez M, Kalyanaraman B, Mutlu GM, Budinger GR, Chandel NS. Mitochondrial metabolism and ROS generation are essential for Kras-mediated tumorigenicity. Proc Natl Acad Sci U S A. 2010; 107:8788-8793.
-
(2010)
Proc Natl Acad Sci U S A
, vol.107
, pp. 8788-8793
-
-
Weinberg, F.1
Hamanaka, R.2
Wheaton, W.W.3
Weinberg, S.4
Joseph, J.5
Lopez, M.6
Kalyanaraman, B.7
Mutlu, G.M.8
Budinger, G.R.9
Chandel, N.S.10
-
8
-
-
33748967370
-
Expression of transforming K-Ras oncogene affects mitochondrial function and morphology in mouse fibroblasts
-
Chiaradonna F, Gaglio D, Vanoni M, Alberghina L. Expression of transforming K-Ras oncogene affects mitochondrial function and morphology in mouse fibroblasts. Biochim Biophys Acta. 2006; 1757:1338-1356.
-
(2006)
Biochim Biophys Acta
, vol.1757
, pp. 1338-1356
-
-
Chiaradonna, F.1
Gaglio, D.2
Vanoni, M.3
Alberghina, L.4
-
9
-
-
84856595714
-
K-ras(G12V) transformation leads to mitochondrial dysfunction and a metabolic switch from oxidative phosphorylation to glycolysis
-
Hu Y, Lu W, Chen G, Wang P, Chen Z, Zhou Y, Ogasawara M, Trachootham D, Feng L, Pelicano H, Chiao PJ, Keating MJ, Garcia-Manero G, Huang P. K-ras(G12V) transformation leads to mitochondrial dysfunction and a metabolic switch from oxidative phosphorylation to glycolysis. Cell Res. 2012; 22:399-412.
-
(2012)
Cell Res
, vol.22
, pp. 399-412
-
-
Hu, Y.1
Lu, W.2
Chen, G.3
Wang, P.4
Chen, Z.5
Zhou, Y.6
Ogasawara, M.7
Trachootham, D.8
Feng, L.9
Pelicano, H.10
Chiao, P.J.11
Keating, M.J.12
Garcia-Manero, G.13
Huang, P.14
-
11
-
-
43549084582
-
Proteomic view of mitochondrial function
-
Dimmer KS, Rapaport D. Proteomic view of mitochondrial function. Genome Biol. 2008; 9:209.
-
(2008)
Genome Biol
, vol.9
, pp. 209
-
-
Dimmer, K.S.1
Rapaport, D.2
-
12
-
-
34447312250
-
Human CIA30 is involved in the early assembly of mitochondrial complex I and mutations in its gene cause disease
-
Dunning CJ, McKenzie M, Sugiana C, Lazarou M, Silke J, Connelly A, Fletcher JM, Kirby DM, Thorburn DR, Ryan MT. Human CIA30 is involved in the early assembly of mitochondrial complex I and mutations in its gene cause disease. EMBO J. 2007; 26:3227-3237.
-
(2007)
EMBO J
, vol.26
, pp. 3227-3237
-
-
Dunning, C.J.1
McKenzie, M.2
Sugiana, C.3
Lazarou, M.4
Silke, J.5
Connelly, A.6
Fletcher, J.M.7
Kirby, D.M.8
Thorburn, D.R.9
Ryan, M.T.10
-
13
-
-
27144528747
-
Human mitochondrial complex I assembly is mediated by NDUFAF1
-
Vogel RO, Janssen RJ, Ugalde C, Grovenstein M, Huijbens RJ, Visch HJ, van den Heuvel LP, Willems PH, Zeviani M, Smeitink JA, Nijtmans LG. Human mitochondrial complex I assembly is mediated by NDUFAF1. FEBS J. 2005; 272:5317-5326.
-
(2005)
FEBS J
, vol.272
, pp. 5317-5326
-
-
Vogel, R.O.1
Janssen, R.J.2
Ugalde, C.3
Grovenstein, M.4
Huijbens, R.J.5
Visch, H.J.6
van den Heuvel, L.P.7
Willems, P.H.8
Zeviani, M.9
Smeitink, J.A.10
Nijtmans, L.G.11
-
14
-
-
34248576290
-
Investigation of the complex I assembly chaperones B17.2L and NDUFAF1 in a cohort of CI deficient patients
-
Vogel RO, van den Brand MA, Rodenburg RJ, van den Heuvel LP, Tsuneoka M, Smeitink JA, Nijtmans LG. Investigation of the complex I assembly chaperones B17.2L and NDUFAF1 in a cohort of CI deficient patients. Mol Genet Metab. 2007; 91:176-182.
-
(2007)
Mol Genet Metab
, vol.91
, pp. 176-182
-
-
Vogel, R.O.1
van den Brand, M.A.2
Rodenburg, R.J.3
van den Heuvel, L.P.4
Tsuneoka, M.5
Smeitink, J.A.6
Nijtmans, L.G.7
-
15
-
-
20444464893
-
In vitro modeling of human pancreatic duct epithelial cell transformation defines gene expression changes induced by K-ras oncogenic activation in pancreatic carcinogenesis
-
Qian J, Niu J, Li M, Chiao PJ, Tsao MS. In vitro modeling of human pancreatic duct epithelial cell transformation defines gene expression changes induced by K-ras oncogenic activation in pancreatic carcinogenesis. Cancer Res. 2005; 65:5045-5053.
-
(2005)
Cancer Res
, vol.65
, pp. 5045-5053
-
-
Qian, J.1
Niu, J.2
Li, M.3
Chiao, P.J.4
Tsao, M.S.5
-
16
-
-
0028331587
-
Farnesyltransferase inhibitors: Ras research yields a potential cancer therapeutic
-
Gibbs JB, Oliff A, Kohl NE. Farnesyltransferase inhibitors: Ras research yields a potential cancer therapeutic. Cell. 1994; 77:175-178.
-
(1994)
Cell
, vol.77
, pp. 175-178
-
-
Gibbs, J.B.1
Oliff, A.2
Kohl, N.E.3
-
17
-
-
84861534727
-
Novel role of NOX in supporting aerobic glycolysis in cancer cells with mitochondrial dysfunction and as a potential target for cancer therapy
-
Lu W, Hu Y, Chen G, Chen Z, Zhang H, Wang F, Feng L, Pelicano H, Wang H, Keating MJ, Liu J, McKeehan W, Luo Y, Huang P. Novel role of NOX in supporting aerobic glycolysis in cancer cells with mitochondrial dysfunction and as a potential target for cancer therapy. PLoS Biol. 2012; 10:e1001326.
-
(2012)
PLoS Biol
, vol.10
-
-
Lu, W.1
Hu, Y.2
Chen, G.3
Chen, Z.4
Zhang, H.5
Wang, F.6
Feng, L.7
Pelicano, H.8
Wang, H.9
Keating, M.J.10
Liu, J.11
McKeehan, W.12
Luo, Y.13
Huang, P.14
-
18
-
-
0024376173
-
ras oncogenes in human cancer: a review
-
Bos JL. ras oncogenes in human cancer: a review. Cancer Res. 1989; 49:4682-4689.
-
(1989)
Cancer Res
, vol.49
, pp. 4682-4689
-
-
Bos, J.L.1
-
19
-
-
77951432631
-
The causes of cancer revisited: "mitochondrial malignancy" and ROS-induced oncogenic transformation-why mitochondria are targets for cancer therapy
-
Ralph SJ, Rodriguez-Enriquez S, Neuzil J, Saavedra E, Moreno-Sanchez R. The causes of cancer revisited: "mitochondrial malignancy" and ROS-induced oncogenic transformation-why mitochondria are targets for cancer therapy. Mol Aspects Med. 2010; 31:145-170.
-
(2010)
Mol Aspects Med
, vol.31
, pp. 145-170
-
-
Ralph, S.J.1
Rodriguez-Enriquez, S.2
Neuzil, J.3
Saavedra, E.4
Moreno-Sanchez, R.5
-
20
-
-
17844383964
-
Perturbational profiling of a cell-line model of tumorigenesis by using metabolic measurements
-
Ramanathan A, Wang C, Schreiber SL. Perturbational profiling of a cell-line model of tumorigenesis by using metabolic measurements. Proc Natl Acad Sci U S A. 2005; 102:5992-5997.
-
(2005)
Proc Natl Acad Sci U S A
, vol.102
, pp. 5992-5997
-
-
Ramanathan, A.1
Wang, C.2
Schreiber, S.L.3
-
21
-
-
77955967332
-
Impairment of mitochondrial respiration in mouse fibroblasts byoncogenic H-RASQ61L
-
Yang D, Wang M-T, Tang Y, Chen Y, Jiang H, Jones T, Rao K, Brewer G, Singh KK, Nie D. Impairment of mitochondrial respiration in mouse fibroblasts byoncogenic H-RASQ61L. Cancer Biology & Therapy. 2014; 9:122-133.
-
(2014)
Cancer Biology & Therapy
, vol.9
, pp. 122-133
-
-
Yang, D.1
Wang, M.-T.2
Tang, Y.3
Chen, Y.4
Jiang, H.5
Jones, T.6
Rao, K.7
Brewer, G.8
Singh, K.K.9
Nie, D.10
-
22
-
-
33947129099
-
Cytosolic signaling protein Ecsit also localizes to mitochondria where it interacts with chaperone NDUFAF1 and functions in complex I assembly
-
Vogel RO, Janssen RJRJ, van den Brand MAM, Dieteren CEJ, Verkaart S, Koopman WJH, Willems PHGM, Pluk W, van den Heuvel LPWJ, Smeitink JAM, Nijtmans LGJ. Cytosolic signaling protein Ecsit also localizes to mitochondria where it interacts with chaperone NDUFAF1 and functions in complex I assembly. Genes & Development. 2007; 21:615-624.
-
(2007)
Genes & Development
, vol.21
, pp. 615-624
-
-
Vogel, R.O.1
Janssen, R.J.R.J.2
van den Brand, M.A.M.3
Dieteren, C.E.J.4
Verkaart, S.5
Koopman, W.J.H.6
Willems, P.H.G.M.7
Pluk, W.8
van den Heuvel, L.P.W.J.9
Smeitink, J.A.M.10
Nijtmans, L.G.J.11
-
23
-
-
79961000873
-
Mice Lacking TR4 Nuclear Receptor Develop Mitochondrial Myopathy with Deficiency in Complex, I
-
Liu S, Lee Y-F, Chou S, Uno H, Li G, Brookes P, Massett MP, Wu Q, Chen L-M, Chang C. Mice Lacking TR4 Nuclear Receptor Develop Mitochondrial Myopathy with Deficiency in Complex, I. Molecular Endocrinology. 2011; 25:1301-1310.
-
(2011)
Molecular Endocrinology
, vol.25
, pp. 1301-1310
-
-
Liu, S.1
Lee, Y.-F.2
Chou, S.3
Uno, H.4
Li, G.5
Brookes, P.6
Massett, M.P.7
Wu, Q.8
Chen, L.-M.9
Chang, C.10
-
24
-
-
15244339921
-
Overexpression of a novel superoxide-producing enzyme, NADPH oxidase 1, in adenoma and well differentiated adenocarcinoma of the human colon
-
Fukuyama M, Rokutan K, Sano T, Miyake H, Shimada M, Tashiro S. Overexpression of a novel superoxide-producing enzyme, NADPH oxidase 1, in adenoma and well differentiated adenocarcinoma of the human colon. Cancer Lett. 2005; 221:97-104.
-
(2005)
Cancer Lett
, vol.221
, pp. 97-104
-
-
Fukuyama, M.1
Rokutan, K.2
Sano, T.3
Miyake, H.4
Shimada, M.5
Tashiro, S.6
-
25
-
-
11844272091
-
Increased Nox1 and hydrogen peroxide in prostate cancer
-
Lim SD, Sun C, Lambeth JD, Marshall F, Amin M, Chung L, Petros JA, Arnold RS. Increased Nox1 and hydrogen peroxide in prostate cancer. Prostate. 2005; 62:200-207.
-
(2005)
Prostate
, vol.62
, pp. 200-207
-
-
Lim, S.D.1
Sun, C.2
Lambeth, J.D.3
Marshall, F.4
Amin, M.5
Chung, L.6
Petros, J.A.7
Arnold, R.S.8
-
26
-
-
52649107626
-
Cancer Cell Metabolism: Warburg and Beyond
-
Hsu PP, Sabatini DM. Cancer Cell Metabolism: Warburg and Beyond. Cell. 2008; 134:703-707.
-
(2008)
Cell
, vol.134
, pp. 703-707
-
-
Hsu, P.P.1
Sabatini, D.M.2
-
27
-
-
40749099894
-
Pyruvate kinase M2 is a phosphotyrosine-binding protein
-
Christofk HR, Vander Heiden MG, Wu N, Asara JM, Cantley LC. Pyruvate kinase M2 is a phosphotyrosine-binding protein. Nature. 2008; 452:181-186.
-
(2008)
Nature
, vol.452
, pp. 181-186
-
-
Christofk, H.R.1
Vander Heiden, M.G.2
Wu, N.3
Asara, J.M.4
Cantley, L.C.5
-
28
-
-
84860321700
-
Oncogenic Kras maintains pancreatic tumors through regulation of anabolic glucose metabolism
-
Ying H, Kimmelman AC, Lyssiotis CA, Hua S, Chu GC, Fletcher-Sananikone E, Locasale JW, Son J, Zhang H, Coloff JL, Yan H, Wang W, Chen S, Viale A, Zheng H, Paik JH, et al. Oncogenic Kras maintains pancreatic tumors through regulation of anabolic glucose metabolism. Cell. 2012; 149:656-670.
-
(2012)
Cell
, vol.149
, pp. 656-670
-
-
Ying, H.1
Kimmelman, A.C.2
Lyssiotis, C.A.3
Hua, S.4
Chu, G.C.5
Fletcher-Sananikone, E.6
Locasale, J.W.7
Son, J.8
Zhang, H.9
Coloff, J.L.10
Yan, H.11
Wang, W.12
Chen, S.13
Viale, A.14
Zheng, H.15
Paik, J.H.16
-
29
-
-
0037317228
-
Stop and go extraction tips for matrix-assisted laser desorption/ionization, nanoelectrospray, and LC/MS sample pretreatment in proteomics
-
Rappsilber J, Ishihama Y, Mann M. Stop and go extraction tips for matrix-assisted laser desorption/ionization, nanoelectrospray, and LC/MS sample pretreatment in proteomics. Anal Chem. 2003; 75:663-670.
-
(2003)
Anal Chem
, vol.75
, pp. 663-670
-
-
Rappsilber, J.1
Ishihama, Y.2
Mann, M.3
-
30
-
-
34548178909
-
In-gel digestion for mass spectrometric characterization of proteins and proteomes
-
Shevchenko A, Tomas H, Havlis J, Olsen JV, Mann M. In-gel digestion for mass spectrometric characterization of proteins and proteomes. Nat Protoc. 2006; 1:2856-2860.
-
(2006)
Nat Protoc
, vol.1
, pp. 2856-2860
-
-
Shevchenko, A.1
Tomas, H.2
Havlis, J.3
Olsen, J.V.4
Mann, M.5
-
31
-
-
0036788293
-
Dysfunction of mitochondria in human skeletal muscle in type 2 diabetes
-
Kelley DE, He J, Menshikova EV, Ritov VB. Dysfunction of mitochondria in human skeletal muscle in type 2 diabetes. Diabetes. 2002; 51:2944-2950.
-
(2002)
Diabetes
, vol.51
, pp. 2944-2950
-
-
Kelley, D.E.1
He, J.2
Menshikova, E.V.3
Ritov, V.B.4
-
32
-
-
84879378746
-
Decreased expression of the mitochondrial metabolic enzyme aconitase (ACO2) is associated with poor prognosis in gastric cancer
-
Wang P, Mai C, Wei YL, Zhao JJ, Hu YM, Zeng ZL, Yang J, Lu WH, Xu RH, Huang P. Decreased expression of the mitochondrial metabolic enzyme aconitase (ACO2) is associated with poor prognosis in gastric cancer. Med Oncol. 2013; 30:552.
-
(2013)
Med Oncol
, vol.30
, pp. 552
-
-
Wang, P.1
Mai, C.2
Wei, Y.L.3
Zhao, J.J.4
Hu, Y.M.5
Zeng, Z.L.6
Yang, J.7
Lu, W.H.8
Xu, R.H.9
Huang, P.10
-
33
-
-
0141509869
-
Inhibition of mitochondrial respiration: a novel strategy to enhance drug-induced apoptosis in human leukemia cells by a reactive oxygen species-mediated mechanism
-
Pelicano H, Feng L, Zhou Y, Carew JS, Hileman EO, Plunkett W, Keating MJ, Huang P. Inhibition of mitochondrial respiration: a novel strategy to enhance drug-induced apoptosis in human leukemia cells by a reactive oxygen species-mediated mechanism. J Biol Chem. 2003; 278:37832-37839.
-
(2003)
J Biol Chem
, vol.278
, pp. 37832-37839
-
-
Pelicano, H.1
Feng, L.2
Zhou, Y.3
Carew, J.S.4
Hileman, E.O.5
Plunkett, W.6
Keating, M.J.7
Huang, P.8
|