Decreased expression of the mitochondrial metabolic enzyme aconitase (ACO2) is associated with poor prognosis in gastric cancer

Medical Oncology

Volumn 30, Issue 2, 2013, Pages

  Wang, Peng ^a   Mai, Cong ^a   Wei, Yong Li ^b   Zhao, Jing Jing ^a   Hu, Yu Min ^a   Zeng, Zhao Lei ^a   Yang, Jing ^a   Lu, Wen Hua ^a   Xu, Rui Hua ^a   Huang, Peng ^a  

^a SUN YAT SEN UNIVERSITY CANCER CENTER   (China)

^b AFFILIATED HOSPITAL OF SHANDONG UNIVERSITY OF TRADITIONAL CHINESE MEDICINE   (China)

Author keywords

Cancer metabolism; Gastric cancer; Mitochondrial aconitase (ACO2); Prognosis

Indexed keywords

ACONITATE HYDRATASE; MITOCHONDRIAL ENZYME; ACO2 PROTEIN, HUMAN; MESSENGER RNA; MITOCHONDRIAL PROTEIN; TUMOR MARKER;

ADULT; ARTICLE; CANCER PATIENT; CANCER PROGNOSIS; CANCER SURVIVAL; CLINICAL CLASSIFICATION; COMPARATIVE STUDY; CONTROLLED STUDY; DIFFERENTIATION; DOWN REGULATION; FEMALE; FROZEN SECTION; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MALE; PRIORITY JOURNAL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STOMACH CANCER; TISSUE SECTION; WESTERN BLOTTING; AGED; BIOSYNTHESIS; DRUG ANTAGONISM; ENZYMOLOGY; FOLLOW UP; GENE EXPRESSION REGULATION; GENETICS; MIDDLE AGED; PROGNOSIS; STOMACH TUMOR; SURVIVAL RATE;

ACONITATE HYDRATASE; AGED; FEMALE; FOLLOW-UP STUDIES; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MALE; MIDDLE AGED; MITOCHONDRIAL PROTEINS; PROGNOSIS; RNA, MESSENGER; STOMACH NEOPLASMS; SURVIVAL RATE; TUMOR MARKERS, BIOLOGICAL;

EID: 84879378746     PISSN: 13570560     EISSN: 1559131X     Source Type: Journal    
DOI: 10.1007/s12032-013-0552-5     Document Type: Article

References (30)

1. Danaei G, Vander Hoorn S, Lopez AD, Murray CJ, Ezzati M. Causes of cancer in the world: comparative risk assessment of nine behavioural and environmental risk factors. Lancet. 2005;366(9499):1784-93.
2. Siegel R, Naishadham D, Jemal A. Cancer statistics, 2012. CA Cancer J Clin. 2012;62(1):10-29.
3. Nagini S. Carcinoma of the stomach: a review of epidemiology, pathogenesis, molecular genetics and chemoprevention. World J Gastrointest Oncol. 2012;4(7):156-69.
4. Yasui W, Oue N, Aung PP, Matsumura S, Shutoh M, Nakayama H. Molecular-pathological prognostic factors of gastric cancer: a review. Gastric Cancer. 2005;8(2):86-94.
5. Chen CN, Lin JJ, Chen JJ, Lee PH, Yang CY, Kuo ML, et al. Gene expression profile predicts patient survival of gastric cancer after surgical resection. J Clin Oncol. 2005;23(29):7286-95.
6. Hippo Y, Taniguchi H, Tsutsumi S, Machida N, Chong JM, Fukayama M, et al. Global gene expression analysis of gastric cancer by oligonucleotide microarrays. Cancer Res. 2002;62(1):233-40.
7. Lee HS, Cho SB, Lee HE, Kim MA, Kim JH, Park do J, et al. Protein expression profiling and molecular classification of gastric cancer by the tissue array method. Clin Cancer Res. 2007;13(14):4154-63.
8. Beinert H, Kennedy MC. Aconitase, a two-faced protein: enzyme and iron regulatory factor. FASEB J. 1993;7(15):1442-9.
9. Gruer MJ, Artymiuk PJ, Guest JR. The aconitase family: three structural variations on a common theme. Trends Biochem Sci. 1997;22(1):3-6.
10. Robbins AH, Stout CD. Structure of activated aconitase: formation of the [4Fe-4S] cluster in the crystal. Proc Natl Acad Sci USA. 1989;86(10):3639-43.
11. Haile DJ, Rouault TA, Tang CK, Chin J, Harford JB, Klausner RD. Reciprocal control of RNA-binding and aconitase activity in the regulation of the iron-responsive element binding protein: role of the iron-sulfur cluster. Proc Natl Acad Sci USA. 1992;89(16):7536-40.
12. Tong WH, Rouault TA. Metabolic regulation of citrate and iron by aconitase: role of iron-sulfur cluster biogenesis. Biometals. 2007;20(3-4):549-64.
13. Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation. Cell. 2011;144(5):646-74.
14. Warburg O. On the origin of cancer cells. Science. 1956;123(3191):309-14.
15. Warburg O. On respiratory impairment in cancer cells. Science. 1956;124(3215):269-70.
16. Kroemer G, Pouyssegur J. Tumor cell metabolism: cancer's Achilles' heel. Cancer Cell. 2008;13(6):472-82.
17. Semenza GL. Regulation of cancer cell metabolism by hypoxia-inducible factor 1. Semin Cancer Biol. 2009;19(1):12-6.
18. Cai Z, Zhao JS, Li JJ, Peng DN, Wang XY, Chen TL, et al. A combined proteomics and metabolomics profiling of gastric cardia cancer reveals characteristic dysregulations in glucose metabolism. Mol Cell Proteomics. 2010;9(12):2617-28.
19. Laiho P, Hienonen T, Mecklin JP, Jarvinen H, Karhu A, Launonen V, et al. Mutation and LOH analysis of ACO2 in colorectal cancer: no evidence of biallelic genetic inactivation. J Med Genet. 2003;40(5):e73.
20. Bota DA, Davies KJ. Lon protease preferentially degrades oxidized mitochondrial aconitase by an ATP-stimulated mechanism. Nat Cell Biol. 2002;4(9):674-80.
21. Szatrowski TP, Nathan CF. Production of large amounts of hydrogen peroxide by human tumor cells. Cancer Res. 1991;51(3):794-8.
22. Toyokuni S, Okamoto K, Yodoi J, Hiai H. Persistent oxidative stress in cancer. FEBS Lett. 1995;358(1):1-3.
23. Chen XJ, Wang X, Butow RA. Yeast aconitase binds and provides metabolically coupled protection to mitochondrial DNA. Proc Natl Acad Sci USA. 2007;104(34):13738-43.
24. Shadel GS, Mitochondrial DNA. aconitase 'wraps' it up. Trends Biochem Sci. 2005;30(6):294-6.
25. Chen XJ, Wang X, Kaufman BA, Butow RA. Aconitase couples metabolic regulation to mitochondrial DNA maintenance. Science. 2005;307(5710):714-7.
26. Sudarshan S, Sourbier C, Kong HS, Block K, Valera Romero VA, Yang Y, et al. Fumarate hydratase deficiency in renal cancer induces glycolytic addiction and hypoxia-inducible transcription factor 1 alpha stabilization by glucose-dependent generation of reactive oxygen species. Mol Cell Biol. 2009;29(15):4080-90.
27. Bi X, Lin Q, Foo TW, Joshi S, You T, Shen HM, et al. Proteomic analysis of colorectal cancer reveals alterations in metabolic pathways: mechanism of tumorigenesis. Mol Cell Proteomics. 2006;5(6):1119-30.
28. Robey IF, Stephen RM, Brown KS, Baggett BK, Gatenby RA, Gillies RJ. Regulation of the Warburg effect in early-passage breast cancer cells. Neoplasia. 2008;10(8):745-56.
29. Deberardinis RJ, Sayed N, Ditsworth D, Thompson CB. Brick by brick: metabolism and tumor cell growth. Curr Opin Genet Dev. 2008;18(1):54-61.
30. Lunt SY, Vander Heiden MG. Aerobic glycolysis: meeting the metabolic requirements of cell proliferation. Annu Rev Cell Dev Biol. 2011;27:441-64.