GEA 3162 decomposes to co-generate nitric oxide and superoxide and induces apoptosis in human neutrophils via a peroxynitrite-dependent mechanism

British Journal of Pharmacology

Volumn 143, Issue 1, 2004, Pages 179-185

  Taylor, Emma L ^a   Rossi, Adriano G ^a   Shaw, Catherine A ^b   Dal Rio, Francesco P ^b   Haslett, Christopher ^a   Megson, Ian L ^b  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

^b UNIVERSITY OF EDINBURGH   (United Kingdom)

Author keywords

Apoptosis; GEA 3162; Neutrophil; Nitric oxide; Peroxynitrite

Indexed keywords

3 (3,4 DICHLOROPHENYL) 1,2,3,4 OXATRIAZOLE 5 IMINE; COPPER ZINC SUPEROXIDE DISMUTASE; DIETHYLAMINE DIAZENIUMDIOLATE; DIHYDRORHODAMINE 123; DNA FRAGMENT; FLUORESCENT DYE; LINSIDOMINE; NITRIC OXIDE; NITRIC OXIDE DONOR; PEROXYNITRITE; SUPEROXIDE; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CELL STRUCTURE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG DECOMPOSITION; DRUG MECHANISM; ELECTROCHEMICAL DETECTION; ELECTRON SPIN RESONANCE; HUMAN; HUMAN CELL; NEUTROPHIL; NORMAL HUMAN; OXIDATION; PRIORITY JOURNAL; SPECTROFLUOROMETRY;

APOPTOSIS; CELL SEPARATION; ELECTROCHEMISTRY; ELECTRON SPIN RESONANCE SPECTROSCOPY; FLUORESCENT DYES; HUMANS; MOLSIDOMINE; NEUTROPHILS; NITRIC OXIDE; NITRIC OXIDE DONORS; PEROXYNITROUS ACID; RHODAMINES; SUPEROXIDES; TRIAZOLES;

EID: 4644268638     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0705909     Document Type: Article

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