MicroRNA-204-5p–mediated regulation of SIRT1 contributes to the delay of epithelial cell cycle traversal in diabetic corneas

Investigative Ophthalmology and Visual Science

Volumn 56, Issue 3, 2015, Pages 1493-1504

  Gao, Jing ^a,b   Wang, Ye ^b   Zhao, Xiaowen ^b   Chen, Peng ^b   Xie, Lixin ^a,b  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^b SHANDONG EYE INSTITUTE   (China)

Author keywords

Cell cycle; Corneal wound healing; Diabetic keratopathy; MiRNA; SIRT1

Indexed keywords

CYCLIN D1; MICRORNA; MICRORNA 204 5P; PROTEIN P16; SIRTUIN 1; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; SIRT1 PROTEIN, MOUSE;

ANIMAL CELL; ARTICLE; BIOINFORMATICS; CELL CULTURE; CELL CYCLE ARREST; CELL GROWTH; CELL VIABILITY; CONTROLLED STUDY; CORNEA EPITHELIUM; DIABETIC RETINOPATHY; EPITHELIUM CELL; FLOW CYTOMETRY; GENE EXPRESSION REGULATION; GENETIC TRANSFECTION; LUCIFERASE ASSAY; MOUSE; MTT ASSAY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; WESTERN BLOTTING; WOUND HEALING; ANIMAL; BIOLOGY; C57BL MOUSE; CELL CYCLE; CORNEA DISEASE; DIABETES MELLITUS; EXPERIMENTAL DIABETES MELLITUS; GENETICS; INBRED MOUSE STRAIN; PATHOPHYSIOLOGY; PHYSIOLOGY;

ANIMALS; CELL CYCLE; COMPUTATIONAL BIOLOGY; CORNEAL DISEASES; DIABETES COMPLICATIONS; DIABETES MELLITUS, EXPERIMENTAL; EPITHELIAL CELLS; EPITHELIUM, CORNEAL; FLOW CYTOMETRY; GENE EXPRESSION REGULATION; MICE, INBRED C57BL; MICE, INBRED STRAINS; MICRORNAS; REAL-TIME POLYMERASE CHAIN REACTION; SIRTUIN 1; WOUND HEALING;

EID: 84924245051     PISSN: 01460404     EISSN: 15525783     Source Type: Journal    
DOI: 10.1167/iovs.14-15913     Document Type: Article

References (32)

1. American Diabetes Association. Diagnosis and classification of diabetes mellitus. Diabetes Care. 2010;33(suppl 1):S62–S69.
2. Schultz RO, Van Horn DL, Peters MA, Klewin KM, Schutten WH. Diabetic keratopathy. Trans Am Ophthalmol Soc. 1981; 79:180–199.
3. Foulks GN, Thoft RA, Perry HD, Tolentino FI. Factors related to corneal epithelial complications after closed vitrectomy in diabetics. Arch Ophthalmol. 1979;97:1076–1078.
4. Gopinathan U, Garg P, Fernandes M, Sharma S, Athmanathan S, Rao GN. The epidemiological features and laboratory results of fungal keratitis: a 10-year review at a referral eye care center in South India. Cornea. 2002;21:555–559.
5. Schultz RO, Peters MA, Sobocinski K, Nassif K, Schultz KJ. Diabetic keratopathy as a manifestation of peripheral neuropathy. Am J Ophthalmol. 1983;96:368–371.
6. Bikbova G, Oshitari T, Tawada A, Yamamoto S. Corneal changes in diabetes mellitus. Curr Diab Rev. 2012;8:294–302.
7. Hossain P, Sachdev A, Malik RA. Early detection of diabetic peripheral neuropathy with corneal confocal microscopy. Lancet. 2005;366:1340–1343.
8. Wang Y, Zhao X, Shi D, et al. Overexpression of SIRT1 promotes high glucose-attenuated corneal epithelial wound healing via p53 regulation of the IGFBP3/IGF-1R/AKT pathway. Invest Ophthalmol Vis Sci. 2013;54:3806–3814.
9. Houtkooper RH, Pirinen E, Auwerx J. Sirtuins as regulators of metabolism and healthspan. Nature Rev Mol Cell Biol. 2012; 13:225–238.
10. Brooks CL, Gu W. How does SIRT1 affect metabolism, senescence and cancer? Nature Rev Cancer. 2009;9:123–128.
11. Menghini R, Casagrande V, Cardellini M, et al. MicroRNA 217 modulates endothelial cell senescence via silent information regulator 1. Circulation. 2009;120:1524–1532.
12. Bartel DP. MicroRNAs: target recognition and regulatory functions. Cell. 2009;136:215–233.
13. Hua YJ, Tang ZY, Tu K, et al. Identification and target prediction of miRNAs specifically expressed in rat neural tissue. BMC Genomics. 2009;10:214.
14. Mortuza R, Feng B, Chakrabarti S. miR-195 regulates SIRT1- mediated changes in diabetic retinopathy. Diabetologia. 2014; 57:1037–1046.
15. Wang Y, Li W, Zang X, et al. MicroRNA-204-5p regulates epithelial-to-mesenchymal transition during human posterior capsule opacification by targeting SMAD 4. Invest Ophthalmol Vis Sci. 2013;54:323–332.
16. Karali M, Peluso I, Marigo V, Banfi S. Identification and characterization of microRNAs expressed in the mouse eye. Invest Ophthalmol Vis Sci. 2007;48:509–515.
17. Ron D. Proteotoxicity in the endoplasmic reticulum: lessons from the Akita diabetic mouse. J Clin Invest. 2002;109:443–445.
18. Barber AJ, Antonetti DA, Kern TS, et al. The Ins2Akita mouse as a model of early retinal complications in diabetes. Invest Ophthalmol Vis Sci. 2005;46:2210–2218.
19. Xu KP, Li Y, Ljubimov AV, Yu FS. High glucose suppresses epidermal growth factor receptor/phosphatidylinositol 3- kinase/Akt signaling pathway and attenuates corneal epithelial wound healing. Diabetes. 2009;58:1077–1085.
20. Kawakita T, Shimmura S, Hornia A, Higa K, Tseng SC. Stratified epithelial sheets engineered from a single adult murine corneal/limbal progenitor cell. J Cell Mol Med. 2008;12: 1303–1316.
21. Wang Y, Li W, Wang Y, Huang Y. Growth inhibition of human lens epithelial cells by short hairpin RNA in transcription factor forkhead box E3 (FOXE3). Graefe’s Arch Clin Exp Ophthalmol. 2012;250:999–1007.
22. Ryan DG, Oliveira-Fernandes M, Lavker RM. MicroRNAs of the mammalian eye display distinct and overlapping tissue specificity. Mol Vis. 2006;12:1175–1184.
23. Hoffmann A, Huang Y, Suetsugu-Maki R, et al. Implication of the miR-184 and miR-204 competitive RNA network in control of mouse secondary cataract. Mol Med. 2012;18:528–538.
24. Zhang L, Wang X, Chen P. MiR-204 down regulates SIRT1 and reverts SIRT1-induced epithelial-mesenchymal transition, anoikis resistance and invasion in gastric cancer cells. BMC Cancer. 2013;13:290.
25. Yamakuchi M, Ferlito M, Lowenstein CJ. miR-34a repression of SIRT1 regulates apoptosis. Proc Natl Acad Sci U S A. 2008; 105:13421–13426.
26. Ramachandran D, Roy U, Garg S, Ghosh S, Pathak S, Kolthur- Seetharam U. Sirt1 and mir-9 expression is regulated during glucose-stimulated insulin secretion in pancreatic beta-islets. FEBS J. 2011;278:1167–1174.
27. Strum JC, Johnson JH, Ward J, et al. MicroRNA 132 regulates nutritional stress-induced chemokine production through repression of SirT 1. Mol Endocr. 2009;23:1876–1884.
28. Jaliffa C, Ameqrane I, Dansault A, et al. Sirt1 involvement in rd10 mouse retinal degeneration. Invest Ophthalmol Vis Sci. 2009;50:3562–3572.
29. Alves LF, Fernandes BF, Burnier JV, et al. Expression of SIRT1 in ocular surface squamous neoplasia. Cornea. 2012;31:817–819.
30. Chung EH, Hutcheon AE, Joyce NC, Zieske JD. Synchronization of the G1/S transition in response to corneal debridement. Invest Ophthalmol Vis Sci. 1999;40:1952–1958.
31. Lee Y, Dominy JE, Choi YJ, et al. Cyclin D1-Cdk4 controls glucose metabolism independently of cell cycle progression. Nature. 2014;510:547–551.
32. Janzen V, Forkert R, Fleming HE, et al. Stem-cell ageing modified by the cyclin-dependent kinase inhibitor p16INK4a. Nature. 2006;443:421–426.