NIH Consensus Development Project on Criteria for Clinical Trials in Chronic Graft-versus-Host Disease: II. The 2014 Pathology Working Group Report

Biology of Blood and Marrow Transplantation

Volumn 21, Issue 4, 2015, Pages 589-603

  Shulman, Howard M ^a   Cardona, Diana M ^b   Greenson, Joel K ^c   Hingorani, Sangeeta ^a,d,e   Horn, Thomas ^f   Huber, Elisabeth ^g   Kreft, Andreas ^h   Longerich, Thomas ⁱ   Morton, Thomas ^d   Myerson, David ^a,d   Prieto, Victor G ^j   Rosenberg, Avi ^k   Treister, Nathaniel ^l   Washington, Kay ^m   Ziemer, Mirjana ⁿ   Pavletic, Steven Z ^k   Lee, Stephanie J ^a   Flowers, Mary E D ^a   Schultz, Kirk R ^o   Jagasia, Madan ^p   Martin, Paul J ^a   Vogelsang, Georgia B ^q   Kleiner, David E ^j   more..

^a USA   (United States)

^b DUKE UNIVERSITY MEDICAL CENTER   (United States)

^c UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^d UNIVERSITY OF WASHINGTON   (United States)

^e SEATTLE CHILDREN S HOSPITAL   (United States)

^f MASSACHUSETTS GENERAL HOSPITAL   (United States)

^g UNIVERSITY OF REGENSBURG   (Germany)

^h UNIVERSITY MEDICAL CENTER MAINZ   (Germany)

ⁱ UNIVERSITY HOSPITAL RWTH AACHEN   (Germany)

^j UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^k NATIONAL CANCER INSTITUTE   (United States)

^l BRIGHAM AND WOMEN S HOSPITAL   (United States)

^m VANDERBILT UNIVERSITY   (United States)

ⁿ UNIVERSITY HOSPITAL LEIPZIG   (Germany)

^o UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^p VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

^q JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

more..

Author keywords

Allogeneic hematopoietic cell transplantation; Chronic graft versus host disease; Consensus; Diagnosis; Histology; Pathology

Indexed keywords

ACUTE GRAFT VERSUS HOST DISEASE; ARTICLE; BIOPSY; BRONCHIECTASIS; BRONCHIOLITIS OBLITERANS; BRONCHIOLITIS OBLITERANS ORGANIZING PNEUMONIA; CHRONIC GRAFT VERSUS HOST DISEASE; CHRONIC KIDNEY DISEASE; CLINICAL FEATURE; CLINICAL TRIAL (TOPIC); CONCURRENT INFECTION; CONSENSUS DEVELOPMENT; DIAGNOSTIC VALUE; EYE; FEMALE GENITAL SYSTEM; GASTROINTESTINAL BIOPSY; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HISTOLOGY; HISTOPATHOLOGY; HUMAN; INTESTINE; KIDNEY; KIDNEY DISEASE; LIVER; LIVER BIOPSY; LUNG; MOUTH CAVITY; MOUTH MUCOSA; NATIONAL HEALTH ORGANIZATION; OROPHARYNX; PROCESS DEVELOPMENT; PULMONARY VENO-OCCLUSIVE DISEASE; REPRODUCIBILITY; RESPIRATORY TRACT DISEASE; SKIN; SKIN BIOPSY; ENTEROPATHY; FEMALE; GRAFT VERSUS HOST REACTION; LIVER DISEASE; MALE; METABOLISM; MOUTH DISEASE; PATHOLOGY; SKIN DISEASE;

BIOLOGICAL MARKER;

BIOMARKERS; CLINICAL TRIALS AS TOPIC; FEMALE; GRAFT VS HOST DISEASE; HUMANS; INTESTINAL DISEASES; LIVER DISEASES; MALE; MOUTH DISEASES; SKIN DISEASES;

EID: 84924234213     PISSN: 10838791     EISSN: 15236536     Source Type: Journal    
DOI: 10.1016/j.bbmt.2014.12.031     Document Type: Article

References (148)

1. Sale G., Shulman H., Hackman R. Pathology of hematopoietic cell transplantation. Thomas' Hematopoietic Cell Transplantation 2004, 286-299. Blackwell Publishing Ltd., Oxford, UK. 3rd ed. K. Blume, S. Forman, F. Appelbaum (Eds.).
2. Shulman H.M., Sullivan K.M., Weiden P.L., et al. Chronic graft-versus-host syndrome in man. A long-term clinicopathologic study of 20 Seattle patients. Am J Med 1980, 69:204-217.
3. Snover D. The pathology of acute GVHD. Graft-versus-host disease: immunology, pathophysiology, and treatment 1990, 337-353. Marcel Dekker, Inc., New York, NY. 1st ed. S. Burakoff, H. Deeg, J. Ferrara, K. Atkinson (Eds.).
4. Shulman H. Pathology of chronic GVHD. Graft-versus-host disease: immunology, pathophysiology, and treatment 1990, 587-614. Marcel Dekker, Inc., New York, NY. 1st ed. S. Burakoff, H. Deeg, J. Ferrara, K. Atkinson (Eds.).
5. Wagner J., Murphy G. Pathology and pathogenesis of cutaneous graft-vs.-host disease. Graft-vs-host disease 2003, 229-255. Marcel Dekker, New York, NY. 3rd ed. J. Ferrara, K. Cooke, H. Deeg (Eds.).
6. Liu C., Crawford J. Graft-versus-host disease of the liver. Graft-vs-Host Disease 2003, 257-278. Marcel Dekker, New York, NY. 3rd ed. J. Ferrara, K. Cooke, H. Deeg (Eds.).
7. Heymer B., Bunjes D., Friedrich W. Clinical and diagnostic pathology of graft-versus-host disease 2002, Springer. 1st. ed.
8. Ziemer M. Graft-versus-host disease of the skin and adjacent mucous membranes. JGerman Soc Dermatol 2013, 11:477-495.
9. Flowers M.E., Inamoto Y., Carpenter P.A., et al. Comparative analysis of risk factors for acute graft-versus-host disease and for chronic graft-versus-host disease according to National Institutes of Health consensus criteria. Blood 2011, 117:3214-3219.
10. Shulman H.M., Kleiner D., Lee S.J., et al. Histopathologic diagnosis of chronic graft-versus-host disease: National Institutes of Health Consensus Development Project on Criteria for Clinical Trials in Chronic Graft-versus-Host Disease: II. Pathology Working Group Report. Biol Blood Marrow Transplant 2006, 12:31-47.
11. Nishiwaki S., Terakura S., Ito M., et al. Impact of macrophage infiltration of skin lesions on survival after allogeneic stem cell transplantation: a clue to refractory graft-versus-host disease. Blood 2009, 114:3113-3116.
12. Levine J.E., Huber E., Hammer S.T., et al. Low Paneth cell numbers at onset of gastrointestinal graft-versus-host disease identify patients at high risk for nonrelapse mortality. Blood 2013, 122:1505-1509.
13. Biedermann B.C., Sahner S., Gregor M., et al. Endothelial injury mediated by cytotoxic T lymphocytes and loss of microvessels in chronic graft versus host disease. Lancet 2002, 359:2078-2083.
14. Dietrich S., Falk C.S., Benner A., et al. Endothelial vulnerability and endothelial damage are associated with risk of graft-versus-host disease and response to steroid treatment. Biol Blood Marrow Transplant 2013, 19:22-27.
15. Luft T., Dietrich S., Falk C., et al. Steroid-refractory GVHD: T-cell attack within a vulnerable endothelial system. Blood 2011, 118:1685-1692.
16. Palomo M., Diaz-Ricart M., Carbo C., et al. Endothelial dysfunction after hematopoietic stem cell transplantation: role of the conditioning regimen and the type of transplantation. Biol Blood Marrow Transplant 2010, 16:985-993.
17. Schmid P.M., Bouazzaoui A., Doser K., et al. Endothelial dysfunction and altered mechanical and structural properties of resistance arteries in a murine model of GVHD. Biol Blood Marrow Transplant 2014, 20:1493-1500.
18. Filipovich A.H., Weisdorf D., Pavletic S., et al. National Institutes of Health consensus development project on criteria for clinical trials in chronic graft-versus-host disease: I. Diagnosis and staging working group report. Biol Blood Marrow Transplant 2005, 11:945-956.
19. Jacobsohn D.A., Montross S., Anders V., Vogelsang G.B. Clinical importance of confirming or excluding the diagnosis of chronic graft-versus-host disease. Bone Marrow Transplant 2001, 28:1047-1051.
20. Bolanos-Meade J., Anders V., Wisell J., et al. Grover's Disease after Bone Marrow Transplantation. Biol Blood Marrow Transplant 2007, 13:1116-1117.
21. Patel A.R., Turner M.L., Baird K., et al. Voriconazole-induced phototoxicity masquerading as chronic graft-versus-host disease of the skin in allogeneic hematopoietic cell transplant recipients. Biol Blood Marrow Transplant 2009, 15:370-376.
22. Ponec R.J., Hackman R.C., McDonald G.B. Endoscopic and histologic diagnosis of intestinal graft-versus-host disease after marrow transplantation. Gastrointest Endosc 1999, 49:612-621.
23. Shulman H.M., Sharma P., Amos D., et al. Acoded histologic study of hepatic graft-versus-host disease after human bone marrow transplantation. Hepatology 1988, 8:463-470.
24. Stechschulte D.J., Fishback J.L., Emami A., Bhatia P. Secondary biliary cirrhosis as a consequence of graft-versus-host disease. Gastroenterology 1990, 98:223-225.
25. Strasser S.I., Shulman H.M., Flowers M.E., et al. Chronic graft-versus-host disease of the liver: presentation as an acute hepatitis. Hepatology 2000, 32:1265-1271.
26. Hubscher S.G., Buckels J.A., Elias E., et al. Vanishing bile-duct syndrome following liver transplantation-is it reversible?. Transplantation 1991, 51:1004-1010.
27. Shulman H.M., McDonald G.B., Matthews D., et al. An analysis of hepatic venocclusive disease and centrilobular hepatic degeneration following bone marrow transplantation. Gastroenterology 1980, 79:1178-1191.
28. Green R.M., Beier D., Gollan J.L. Regulation of hepatocyte bile salt transporters by endotoxin and inflammatory cytokines in rodents. Gastroenterology 1996, 111:193-198.
29. Barshes N.R., Myers G.D., Lee D., et al. Liver transplantation for severe hepatic graft-versus-host disease: an analysis of aggregate survival data. Liver Transpl 2005, 11:525-531.
30. Balistreri W.F. What every hepatologist needs to know about pediatric liver disease. Postgraduate Course - Liver disease in the 21st century: clinico-pathologic correlates Program and abstracts of the 54th Annual Meeting of the American Association for the Study of Liver Diseases 2003, 143-155. American Association for the Study of Liver Diseases, Boston, MA. B.R. Bacon, Z.D. Goodman, E.M. Brunt (Eds.).
31. Lerner K.G., Kao G.F., Storb R., et al. Histopathology of graft-vs.-host reaction (GvHR) in human recipients of marrow from HL-A-matched sibling donors. Transplant Proc 1974, 6:367-371.
32. Hill J.A., Zerr D., Sedlak R.H., et al. Hepatitis due to human herpesvirus 6 after hematopoietic stem cell transplantation. Biol Blood Marrow Transplant 2014, 20:S228-S229.
33. Kamble R.T., Selby G.B., Mims M., et al. Iron overload manifesting as apparent exacerbation of hepatic graft-versus-host disease after allogeneic hematopoietic stem cell transplantation. Biol Blood Marrow Transplant 2006, 12:506-510.
34. Sucak G.T., Yegin Z.A., Ozkurt Z.N., et al. The role of liver biopsy in the workup of liver dysfunction late after SCT: is the role of iron overload underestimated?. Bone Marrow Transplant 2008, 42:461-467.
35. Lefkowitch J.H., Lobritto S.J., Brown R.S., et al. Ground-glass, polyglucosan-like hepatocellular inclusions: a "new" diagnostic entity. Gastroenterology 2006, 131:713-718.
36. Wisell J., Boitnott J., Haas M., et al. Glycogen pseudoground glass change in hepatocytes. Am J Surg Pathol 2006, 30:1085-1090.
37. Bejarano P.A., Garcia M.T., Rodriguez M.M., et al. Liver glycogen bodies: ground-glass hepatocytes in transplanted patients. Virchows Archiv 2006, 449:539-545.
38. O'Shea A.M., Wilson G.J., Ling S.C., et al. Lafora-like ground-glass inclusions in hepatocytes of pediatric patients: a report of two cases. Pediatr Dev Pathol 2007, 10:351-357.
39. Lunz J.G., Contrucci S., Ruppert K., et al. Replicative senescence of biliary epithelial cells precedes bile duct loss in chronic liver allograft rejection: increased expression of p21(WAF1/Cip1) as a disease marker and the influence of immunosuppressive drugs. Am J Pathol 2001, 158:1379-1390.
40. Malard F., Bossard C., Brissot E., et al. Increased Th17/Treg ratio in chronic liver GVHD. Bone Marrow Transplant 2014, 49:539-544.
41. Ali S.A., Shah V., McKinnon R., et al. Frequent expression of C4d in hepatic graft-versus-host disease: potential clue for diagnosis and distinguishing acute and chronic form. Transplant Immunol 2010, 23:77-80.
42. Akpek G., Boitnott J.K., Lee L.A., et al. Hepatitic variant of graft-versus-host disease after donor lymphocyte infusion. Blood 2002, 100:3903-3907.
43. Lefkowitch J.H., Schiff E.R., Davis G.L., et al. Pathological diagnosis of chronic hepatitis C: a multicenter comparative study with chronic hepatitis B. The Hepatitis Interventional Therapy Group. Gastroenterology 1993, 104:595-603.
44. Cooksley W.G., McIvor C.A. Fibrosing cholestatic hepatitis and HBV after bone marrow transplantation. Biomed Pharmacother 1995, 49:117-124.
45. Evans A.T., Loeb K.R., Shulman H.M., et al. Fibrosing cholestatic hepatitis C following hematopoietic cell transplantation: report of three fatal cases. Am J Surg Pathol 2015, 39:212-220.
46. Barba P., Martino R., Perez-Simon J.A., et al. Incidence, characteristics and risk factors of marked hyperbilirubinemia after allogeneic hematopoietic cell transplantation with reduced-intensity conditioning. Bone Marrow Transplant 2012, 47:1343-1349.
47. Kagoya Y., Takahashi T., Nannya Y., et al. Hyperbilirubinemia after hematopoietic stem cell transplantation: comparison of clinical and pathologic findings in 41 autopsied cases. Clin Transplant 2011, 25:E552-557.
48. Arora M., Klein J.P., Weisdorf D.J., et al. Chronic GVHD risk score: a Center for International Blood and Marrow Transplant Research analysis. Blood 2011, 117:6714-6720.
49. Gooley T.A., Rajvanshi P., Schoch H.G., McDonald G.B. Serum bilirubin levels and mortality after myeloablative allogeneic hematopoietic cell transplantation. Hepatology 2005, 41:345-352.
50. Leisenring W.M., Martin P.J., Petersdorf E.W., et al. An acute graft-versus-host disease activity index to predict survival after hematopoietic cell transplantation with myeloablative conditioning regimens. Blood 2006, 108:749-755.
51. Pidala J., Chai X., Kurland B.F., et al. Analysis of gastrointestinal and hepatic chronic grant-versus-host disease manifestations on major outcomes: a chronic graft-versus-host disease consortium study. Biol Blood Marrow Transplant 2013, 19:784-791.
52. Quaglia A., Duarte R., Patch D., et al. Histopathology of graft versus host disease of the liver. Histopathology 2007, 50:727-738.
53. Duarte R.F., Delgado J., Shaw B.E., et al. Histologic features of the liver biopsy predict the clinical outcome for patients with graft-versus-host disease of the liver. Biol Blood Marrow Transplant 2005, 11:805-813.
54. Akpek G., Chinratanalab W., Lee L.A., et al. Gastrointestinal involvement in chronic graft-versus-host disease: a clinicopathologic study. Biol Blood Marrow Transplant 2003, 9:46-51.
55. Epstein R.J., McDonald G.B., Sale G.E., et al. The diagnostic accuracy of the rectal biopsy in acute graft-versus-host disease: a prospective study of thirteen patients. Gastroenterology 1980, 78:764-771.
56. Gomez A.J., Kambham N. Clinicopathologic assessment of grade 1 acute gastrointestinal graft versus host disease: diagnostic threshold of crypt apoptotic bodies. Mod Pathol 2014, 27:203A.
57. Lin J., Fan R., Zhao Z., et al. Is the presence of 6 or fewer crypt apoptotic bodies sufficient for diagnosis of graft versus host disease? A decade of experience at a single institution. Am J Surg Pathol 2013, 37:539-547.
58. Cardona D.M., Shealy M., Bentley R., Veras E. An analysis of the application and reproducibility of the NIH consensus guidelines for the histologic diagnosis of gastrointestinal acute graft versus host disease. Mod Pathol 2012, 25:155-156A.
59. Nguyen T., Park J.Y., Scudiere J.R., Montgomery E. Mycophenolic acid (cellcept and myofortic) induced injury of the upper GI tract. Am J Surg Pathol 2009, 33:1355-1363.
60. Al-Absi A.I., Cooke C.R., Wall B.M., et al. Patterns of injury in mycophenolate mofetil-related colitis. Transplant Proc 2010, 42:3591-3593.
61. Papadimitriou J.C., Cangro C.B., Lustberg A., et al. Histologic features of mycophenolate mofetil-related colitis: a graft-versus-host disease-like pattern. Int J Surg Pathol 2003, 11:295-302.
62. Parfitt J.R., Jayakumar S., Driman D.K. Mycophenolate mofetil-related gastrointestinal mucosal injury: variable injury patterns, including graft-versus-host disease-like changes. Am J Surg Pathol 2008, 32:1367-1372.
63. Patra S., Vij M., Sukanya B., Kapoor D. Mycophenolate mofetil-induced colitis with graft versus host disease-like features in a liver transplant recipient. Indian J Pathol Microbiol 2012, 55:506-508.
64. Selbst M.K., Ahrens W.A., Robert M.E., et al. Spectrum of histologic changes in colonic biopsies in patients treated with mycophenolate mofetil. Mod Pathol 2009, 22:737-743.
65. Daneshpouy M., Socie G., Lemann M., et al. Activated eosinophils in upper gastrointestinal tract of patients with graft-versus-host disease. Blood 2002, 99:3033-3040.
66. Shealy M.J., de Ridder G.G., McCall S.J., et al. The role of eosinophils and neuroendocrine cell nests in the assessment of gastrointestinal biopsies in bone marrow transplant patients. Mod Pathol 2014, 2014:203A.
67. Star K.V., Ho V.T., Wang H.H., Odze R.D. Histologic features in colon biopsies can discriminate mycophenolate from GVHD-induced colitis. Am J Surg Pathol 2013, 37:1319-1328.
68. Leino D.G., Greenson J.K. Can we distinguish mycophenolate-induced colitis from colonic graft-versus-host diseaes?. Mod Pathol 2012, 25:167-168A.
69. Welch D.C., Wirth P.S., Goldenring J.R., et al. Gastric graft-versus-host disease revisited: does proton pump inhibitor therapy affect endoscopic gastric biopsy interpretation?. Am J Surg Pathol 2006, 30:444-449.
70. Ferrara J.L., Harris A.C., Greenson J.K., et al. Regenerating islet-derived 3-alpha is a biomarker of gastrointestinal graft-versus-host disease. Blood 2011, 118:6702-6708.
71. Melson J., Jakate S., Fung H., et al. Crypt loss is a marker of clinical severity of acute gastrointestinal graft-versus-host disease. Am J Hematol 2007, 82:881-886.
72. Herrera A.F., Soriano G., Bellizzi A.M., et al. Cord colitis syndrome in cord-blood stem-cell transplantation. NEngl J Med 2011, 365:815-824.
73. Milano F., Shulman H.M., Guthrie K.A., et al. Late onset colitis after cord blood transplant is consistent with graft-versus-host disease: results of a blinded histopathological review. Biol Blood Marrow Transplant 2014, 20:1008-1013.
74. Shimoji S., Kato K., Eriguchi Y., et al. Evaluating the association between histological manifestations of cord colitis syndrome with GVHD. Bone Marrow Transplant 2013, 48:1249-1252.
75. Crowell K.R., Patel R.A., Fluchel M., et al. Endoscopy in the diagnosis of intestinal graft-versus-host disease: is lower endoscopy with biopsy as effective in diagnosis as upper endoscopy combined with lower endoscopy?. Pediatr Blood Cancer 2013, 60:1798-1800.
76. Shidham V.B., Chang C.C., Shidham G., et al. Colon biopsies for evaluation of acute graft-versus-host disease (A-GVHD) in allogeneic bone marrow transplant patients. BMC Gastroenterol 2003, 3:5.
77. Andrulis M., Dietrich S., Longerich T., et al. Loss of endothelial thrombomodulin predicts response to steroid therapy and survival in acute intestinal graft-versus-host disease. Haematologica 2012, 97:1674-1677.
78. Kreisel W., Dahlberg M., Bertz H., et al. Endoscopic diagnosis of acute intestinal GVHD following allogeneic hematopoietic SCT: a retrospective analysis in 175 patients. Bone Marrow Transplant 2012, 47:430-438.
79. Abraham J., Janin A., Gornet J.M., et al. Clinical severity scores in gastrointestinal graft-versus-host disease. Transplantation 2014, 97:965-971.
80. Nydegger A., Catto-Smith A.G., Tiedemann K., Hardikar W. Diagnosis of gastrointestinal graft-versus-host disease-is rectal biopsy enough?. Pediatr Blood Cancer 2007, 48:561-566.
81. Ross W.A., Ghosh S., Dekovich A.A., et al. Endoscopic biopsy diagnosis of acute gastrointestinal graft-versus-host disease: rectosigmoid biopsies are more sensitive than upper gastrointestinal biopsies. Am J Gastroenterol 2008, 103:982-989.
82. Roy J., Snover D., Weisdorf S., et al. Simultaneous upper and lower endoscopic biopsy in the diagnosis of intestinal graft-versus-host disease. Transplantation 1991, 51:642-646.
83. Thompson B., Salzman D., Steinhauer J., et al. Prospective endoscopic evaluation for gastrointestinal graft-versus-host disease: determination of the best diagnostic approach. Bone Marrow Transplant 2006, 38:371-376.
84. Yeh S.P., Liao Y.M., Hsu C.H., et al. Gastric bleeding due to graft-vs-host disease: discrepancy between endoscopic and histologic assessment. Am J Clin Pathol 2004, 122:919-925.
85. Lord J.D., Hackman R.C., Gooley T.A., et al. Blood and gastric FOXP3+ T cells are not decreased in human gastric graft-versus-host disease. Biol Blood Marrow Transplant 2011, 17:486-496.
86. Hymes S.R., Turner M.L., Champlin R.E., Couriel D.R. Cutaneous manifestations of chronic graft-versus-host disease. Biol Blood Marrow Transplant 2006, 12:1101-1113.
87. Hillen U., Hausermann P., Massi D., et al. Consensus on performing skin biopsies, laboratory workup, evaluation of tissue samples and reporting of the results in patients with suspected cutaneous graft-versus-host disease. JEur Acad Dermatol Venereol 2014, [Epub ahead of print]. 10.1111/jdv.12737.
88. Ziemer M., Haeusermann P., Janin A., et al. Histopathological diagnosis of graft-versus-host disease of the skin - an interobserver comparison. JEur Acad Dermatol Venereol 2014, 28:915-924.
89. Horn T.D., Bauer D.J., Vogelsang G.B., Hess A.D. Reappraisal of histologic features of the acute cutaneous graft-versus-host reaction based on an allogeneic rodent model. JInvest Dermatol 1994, 103:206-210.
90. Fitzpatrick J. Patterns in dermatopathology. Pathology of the skin 2000, 113-130. McGraw-Hill, New York, NY. E. Farmer, A. Hood (Eds.).
91. Marra D.E., McKee P.H., Nghiem P. Tissue eosinophils and the perils of using skin biopsy specimens to distinguish between drug hypersensitivity and cutaneous graft-versus-host disease. JAm Acad Dermatol 2004, 51:543-546.
92. Li N., Guthrie K.A., Storer B.E., et al. Keratinocyte dysplasia in hematopoietic stem cell transplantation recipients in the day-28-to-84 posttransplantation period. Biol Blood Marrow Transplant 2012, 18:1281-1286.
93. Vassallo C., Brazzelli V., Alessandrino P.E., et al. Normal-looking skin in oncohaematological patients after allogenic bone marrow transplantation is not normal. Br J Dermatol 2004, 151:579-586.
94. White J.M., Devereux S., Pagliuca A., et al. Koebnerizing sclerodermatous graft-versus-host disease caused by donor lymphocyte infusion and interferon-alpha. Br J Dermatol 2006, 155:621-623.
95. Janin A., Socie G., Devergie A., et al. Fasciitis in chronic graft-versus-host disease. A clinicopathologic study of 14 cases. Ann Intern Med 1994, 120:993-998.
96. Kaffenberger B.H., Zuo R.C., Gru A., et al. Graft-versus-host disease-associated angiomatosis: a clinicopathologically distinct entity. JAm Acad Dermatol 2014, 71:745-753.
97. Greinix H.T., Volc-Platzer B., Rabitsch W., et al. Successful use of extracorporeal photochemotherapy in the treatment of severe acute and chronic graft-versus-host disease. Blood 1998, 92:3098-3104.
98. Nash R.A., McSweeney P.A., Crofford L.J., et al. High-dose immunosuppressive therapy and autologous hematopoietic cell transplantation for severe systemic sclerosis: long-term follow-up of the US multicenter pilot study. Blood 2007, 110:1388-1396.
99. Verrecchia F., Laboureau J., Verola O., et al. Skin involvement in scleroderma-where histological and clinical scores meet. Rheumatology 2007, 46:833-841.
100. Fleming J.N., Shulman H.M., Nash R.A., et al. Cutaneous chronic graft-versus-host disease does not have the abnormal endothelial phenotype or vascular rarefaction characteristic of systemic sclerosis. PLoS One 2009, 4:e6203.
101. Aschwanden M., Halter J.P., Walker U.A., et al. Nail fold capillaroscopy differs widely between systemic sclerosis and chronic graft vs host disease of the skin. Rheumatology 2011, 50:1168-1169.
102. Hofstee H.M., de Waal T.T., Zweegman S., et al. Nailfold capillary abnormalities in sclerodermatous chronic GVHD. Bone Marrow Transplant 2013, 48:1574-1577.
103. Sale G.E., Shulman H.M., Schubert M.M., et al. Oral and ophthalmic pathology of graft versus host disease in man: predictive value of the lip biopsy. Hum Pathol 1981, 12:1022-1030.
104. Nakhleh R.E., Miller W., Snover D.C. Significance of mucosal vs salivary gland changes in lip biopsies in the diagnosis of chronic graft-vs-host disease. Arch Pathol Lab Med 1989, 113:932-934.
105. Horn T.D., Rest E.B., Mirenski Y., et al. The significance of oral mucosal and salivary gland pathology after allogeneic bone marrow transplantation. Arch Dermatol 1995, 131:964-965.
106. Soares T.C., Correa M.E., Cintra G.F., et al. The impact of morphological and immunohistological changes in minor salivary glands on the health of the oral cavity in HSCT patients. Bone Marrow Transplant 2013, 48:1525-1529.
107. Alborghetti M.R., Correa M.E., Adam R.L., et al. Late effects of chronic graft-vs.-host disease in minor salivary glands. JOral Pathol Med 2005, 34:486-493.
108. Imanguli M.M., Atkinson J.C., Mitchell S.A., et al. Salivary gland involvement in chronic graft-versus-host disease: prevalence, clinical significance, and recommendations for evaluation. Biol Blood Marrow Transplant 2010, 16:1362-1369.
109. Devic I., Shi M., Schubert M.M., et al. Proteomic analysis of saliva from patients with oral chronic graft-versus-host disease. Biol Blood Marrow Transplant 2014, 20:1048-1055.
110. Jagasia M., Greinix H., Arora M., et al. National Institutes of Health Consensus Development Project on Criteria for Clinical Trials in Chronic Graft-versus-Host Disease: I. The 2014 Diagnosis and Staging Working Group Report. Biol Blood Marrow Transplant 2015, 21:389-401.
111. Curtis R.E., Metayer C., Rizzo J.D., et al. Impact of chronic GVHD therapy on the development of squamous-cell cancers after hematopoietic stem-cell transplantation: an international case-control study. Blood 2005, 105:3802-3811.
112. Treister N.S., Woo S.B., O'Holleran E.W., et al. Oral chronic graft-versus-host disease in pediatric patients after hematopoietic stem cell transplantation. Biol Blood Marrow Transplant 2005, 11:721-731.
113. Spiryda L.B., Laufer M.R., Soiffer R.J., Antin J.A. Graft-versus-host disease of the vulva and/or vagina: diagnosis and treatment. Biol Blood Marrow Transplant 2003, 9:760-765.
114. Hirst L.W., Jabs D.A., Tutschka P.J., et al. The eye in bone marrow transplantation. I. Clinical study. Arch Ophthalmol 1983, 101:580-584.
115. Jabs D.A., Hirst L.W., Green W.R., et al. The eye in bone marrow transplantation. II. Histopathology. Arch Ophthalmol 1983, 101:585-590.
116. Ogawa Y., Kuwana M., Yamazaki K., et al. Periductal area as the primary site for T-cell activation in lacrimal gland chronic graft-versus-host disease. Invest Ophthalmol Vis Sci 2003, 44:1888-1896.
117. West R.H., Szer J., Pedersen J.S. Ocular surface and lacrimal disturbances in chronic graft-versus-host disease: the role of conjunctival biopsy. Aust N Z J Ophthalmol 1991, 19:187-191.
118. Jabs D.A., Wingard J., Green W.R., et al. The eye in bone marrow transplantation. III. Conjunctival graft-vs-host disease. Arch Ophthal 1989, 107:1343-1348.
119. Saito T., Shinagawa K., Takenaka K., et al. Ocular manifestation of acute graft-versus-host disease after allogeneic peripheral blood stem cell transplantation. Int J Hematol 2002, 75:332-334.
120. Kim S.K. Ocular graft versus host disease. Cornea 2004, 879-885. Mosby, St. Louis. 2nd ed. J.H. Krachmer, M.J. Mannis, E.J. Holland (Eds.).
121. Yousem S.A., Berry G.J., Cagle P.T., et al. Revision of the 1990 working formulation for the classification of pulmonary allograft rejection: Lung Rejection Study Group. JHeart Lung Transplant 1996, 15:1-15.
122. Saito K., Morita M., Enomoto K. Bronchiolitis obliterans with pemphigus vulgaris and Castleman's disease of hyaline-vascular type: an autopsy case analyzed by computer-aided 3-D reconstruction of the airway lesions. Hum Pathol 1997, 28:1310-1312.
123. Colby T.V. Bronchiolitis Pathologic considerations. Am J Clin Pathol 1998, 109:101-109.
124. King T.E.J. Bronchiolitis. Interstitial lung disease 1998, 645-684. Decker, London. M.I. Schwartz, T.E.J. King (Eds.).
125. Uhlving H.H., Andersen C.B., Christensen I.J., et al. Biopsy-verified bronchiolitis obliterans and other non-infectious lung pathologies after allogeneic hematopoietic stem cell transplantation. Biol Blood Marrow Transplant 2015, 21:531-538.
126. Holbro A., Lehmann T., Girsberger S., et al. Lung histology predicts outcome of bronchiolitis obliterans syndrome after hematopoietic stem cell transplantation. Biol Blood Marrow Transplant 2013, 19:973-980.
127. Barker A.F., Bergeron A., Rom W.N., Hertz M.I. Obliterative bronchiolitis. NEngl J Med 2014, 370:1820-1828.
128. Galban C.J., Boes J.L., Bule M., et al. Parametric response mapping as an indicator of bronchiolitis obliterans syndrome after hematopoietic stem cell transplantation. Biol Blood Marrow Transplant 2014, 20:1592-1598.
129. Freudenberger T.D., Madtes D.K., Curtis J.R., et al. Association between acute and chronic graft-versus-host disease and bronchiolitis obliterans organizing pneumonia in recipients of hematopoietic stem cell transplants. Blood 2003, 102:3822-3828.
130. Chang A., Hingorani S., Kowalewska J., et al. Spectrum of renal pathology in hematopoietic cell transplantation: a series of 20 patients and review of the literature. Clin J Am Soc Nephrol 2007, 2:1014-1023.
131. Abboud I., Peraldi M.N., Hingorani S. Chronic kidney diseases in long-term survivors after allogeneic hematopoietic stem cell transplantation: monitoring and management guidelines. Sem Hematol 2012, 49:73-82.
132. Niscola P., Tendas A., Luo X.D., et al. The management of membranous glomerulopathy in allogeneic stem cells transplantation: updated literature. Cardiovasc Hematol Agents Med Chem 2013, 11:67-76.
133. Hingorani S., Gooley T., Pao E., et al. Urinary cytokines after HCT: evidence for renal inflammation in the pathogenesis of proteinuria and kidney disease. Bone Marrow Transplant 2014, 49:403-409.
134. Hingorani S., Finn L.S., Pao E., et al. Urinary elafin and kidney injury in hematopoietic cell transplant recipients. Clin J Am Soc Nephrol 2015, 10:12-20.
135. Ferrara J.L. Pathogenesis of acute graft-versus-host disease: cytokines and cellular effectors. JHematother Stem Cell Res 2000, 9:299-306.
136. Rao P.S. Nephrotic syndrome in patients with peripheral blood stem cell transplant. Am J Kidney Dis 2005, 45:780-785.
137. Brukamp K., Doyle A.M., Bloom R.D., et al. Nephrotic syndrome after hematopoietic cell transplantation: do glomerular lesions represent renal graft-versus-host disease?. Clin J Am Soc Nephrol 2006, 1:685-694.
138. Chan G.S., Lam M.F., Au W.Y., et al. IgA nephropathy complicating graft-versus-host disease, another nephropathy causing nephrotic syndrome after bone marrow transplantation. Histopathology 2004, 45:648-651.
139. Chien Y.H., Lin K.H., Lee T.Y., et al. Nephrotic syndrome in a bone marrow transplant recipient without chronic graft-versus-host disease. JFormos Med Assoc 2000, 99:503-506.
140. Nouri-Majelan N., Sanadgol H., Ghafari A., et al. Antineutrophil cytoplasmic antibody-associated glomerulonephritis in chronic graft-versus-host disease after allogeneic hematopoietic stem cell transplantation. Transplant Proc 2005, 37:3213-3215.
141. Oliveira J.S., Bahia D., Franco M., et al. Nephrotic syndrome as a clinical manifestation of graft-versus-host disease (GVHD) in a marrow transplant recipient after cyclosporine withdrawal. Bone Marrow Transplant 1999, 23:99-101.
142. Suehiro T., Masutani K., Yokoyama M., et al. Diffuse proliferative glomerulonephritis after bone marrow transplantation. Clin Nephrol 2002, 58:231-237.
143. El-Seisi S., Gupta R., Clase C.M., et al. Renal pathology at autopsy in patients who died after hematopoietic stem cell transplantation. Biol Blood Marrow Transplant 2003, 9:683-688.
144. Kusumi E., Kami M., Hara S., et al. Postmortem examination of the kidney in allogeneic hematopoietic stem cell transplantation recipients: possible involvement of graft-versus-host disease. Int J Hematol 2008, 87:225-230.
145. Allen J.A., Greenberg S.A., Amato A.A. Dermatomyositis-like muscle pathology in patients with chronic graft-versus-host disease. Muscle Nerve 2009, 40:643-647.
146. Montoro J., Hernandez-Boluda J.C., Arbona C., Solano C. Polymyositis after donor lymphocyte infusion. Int J Hematol 2012, 96:386-389.
147. Rackley C., Schultz K.R., Goldman F.D., et al. Cardiac manifestations of graft-versus-host disease. Biol Blood Marrow Transplant 2005, 11:773-780.
148. Stift J., Baba H.A., Huber E., et al. Consensus on the histopathological evaluation of liver biopsies from patients following allogeneic hematopoietic cell transplantation. Virchows Archiv 2014, 464:175-190.