Loss of endothelial thrombomodulin predicts response to steroid therapy and survival in acute intestinal graft-versus-host disease

Haematologica

Volumn 97, Issue 11, 2012, Pages 1674-1677

  Andrulis, Mindaugas ^a   Dietrich, Sascha ^b,c   Longerich, Thomas ^a   Koschny, Ronald ^c   Burian, Maria ^c   Schmitt Gräf, Annette ^d   Schirmacher, Peter ^a   Ho, Anthony D ^c   Dreger, Peter ^c   Luft, Thomas ^b,c  

^a UNIVERSITY HOSPITAL HEIDELBERG   (Germany)

^b GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^c UNIVERSITY OF HEIDELBERG   (Germany)

^d UNIVERSITY OF FREIBURG   (Germany)

Author keywords

Acute GvHD; Allogeneic stem cell transplantation; Cytotoxic T cells; Endothelial cells; Steroid resistance; Thrombomodulin; TIA 1

Indexed keywords

CD34 ANTIGEN; STEROID; THROMBOMODULIN;

ACUTE GRAFT VERSUS HOST DISEASE; ALLOGENEIC STEM CELL TRANSPLANTATION; ARTICLE; COLON BIOPSY; CONTROLLED STUDY; DISEASE SEVERITY; DRUG MEGADOSE; ENDOTHELIUM CELL; GASTROINTESTINAL DISEASE; HISTOLOGY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LYMPHOCYTIC INFILTRATION; MAJOR CLINICAL STUDY; MORBIDITY; MORTALITY; OBSERVATIONAL STUDY; OVERALL SURVIVAL; PROTEIN DEFICIENCY; PROTEIN EXPRESSION; RETROSPECTIVE STUDY; SURVIVAL RATE; TREATMENT RESPONSE;

DISEASE-FREE SURVIVAL; ENDOTHELIUM, VASCULAR; FEMALE; GRAFT VS HOST DISEASE; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HUMANS; INTESTINAL DISEASES; MALE; MIDDLE AGED; RETROSPECTIVE STUDIES; STEROIDS; SURVIVAL RATE; THROMBOMODULIN; TRANSPLANTATION, HOMOLOGOUS;

EID: 84868522373     PISSN: 03906078     EISSN: 15928721     Source Type: Journal    
DOI: 10.3324/haematol.2011.061051     Document Type: Article

References (23)

1. Bolanos-Meade J, Vogelsang GB. Novel strategies for steroid-refractory acute graftversus-host disease. Curr Opin Hematol. 2005;12(1):40-4.
2. Levine JE, Logan B, Wu J, Alousi AM, Ho V, Bolanos-Meade J, et al. Graft-versus-host disease treatment: predictors of survival. Biol Blood Marrow Transplant. 2010;16(12): 1693-9.
3. Ferrara JL, Levine JE, Reddy P, Holler E. Graftversus-host disease. Lancet. 2009;373 (9674):1550-61.
4. Holler E, Kolb HJ, Hiller E, Mraz W, Lehmacher W, Gleixner B, et al. Microangiopathy in patients on cyclosporine prophylaxis who developed acute graft-versus-host disease after HLA-identical bone marrow transplantation. Blood. 1989;73(7): 2018-24.
5. Nurnberger W, Michelmann I, Burdach S, Gobel U. Endothelial dysfunction after bone marrow transplantation: increase of soluble thrombomodulin and PAI-1 in patients with multiple transplant-related complications. Ann Hematol. 1998;76(2):61-5.
6. Penack O, Socie G, van den Brink MR. The importance of neovascularization and its inhibition for allogeneic hematopoietic stem cell transplantation. Blood. 2011;117(16): 4181-9.
7. Luft T, Dietrich S, Falk CS, Benner A, Conzelmann M, Hess M, et al. Steroid-refractory GVHD: T-cell attack within a vulnerable endothelial system. Blood. 2011; 118(6):1685-92.
8. Testa S, Manna A, Porcellini A, Maffi F, Morstabilini G, Denti N, et al. Increased plasma level of vascular endothelial glycoprotein thrombomodulin as an early indicator of endothelial damage in bone marrow transplantation. Bone Marrow Transplant. 1996;18(2):383-8.
9. Isermann B, Sood R, Pawlinski R, Zogg M, Kalloway S, Degen JL, et al. The thrombomodulin-protein C system is essential for the maintenance of pregnancy. Nat Med. 2003;9(3):331-7.
10. Labarrere CA, Pitts D, Halbrook H, Faulk WP. Natural anticoagulant pathways in normal and transplanted human hearts. J Heart Lung Transplant. 1992;11(2 Pt 1):342-7.
11. Richter KK, Fink LM, Hughes BM, Sung CC, Hauer-Jensen M. Is the loss of endothelial thrombomodulin involved in the mechanism of chronicity in late radiation enteropathy? Radiother Oncol. 1997;44(1):65-71.
12. Boehme MW, Autschbach F, Zuna I, Scherbaum WA, Stange E, Raeth U, et al. Elevated serum levels and reduced immunohistochemical expression of thrombomodulin in active ulcerative colitis. Gastroenterology. 1997;113(1):107-17.
13. Faioni EM, Ferrero S, Fontana G, Gianelli U, Ciulla MM, Vecchi M, et al. Expression of endothelial protein C receptor and thrombomodulin in the intestinal tissue of patients with inflammatory bowel disease. Crit Care Med. 2004;32(5 Suppl):S266-70.
14. Sullivan K. Graft-versus-host-disease. In: Thomas ED, ed. Hematopoietic Cell Transplantation. Boston MA: Blackwell Science, 1999:515-36.
15. Epstein RJ, McDonald GB, Sale GE, Shulman HM, Thomas ED. The diagnostic accuracy of the rectal biopsy in acute graft-versus-host disease: a prospective study of thirteen patients. Gastroenterology. 1980;78(4):764-71.
16. Lerner KG, Kao GF, Storb R, Buckner CD, Clift RA, Thomas ED. Histopathology of graft-vs.-host reaction (GvHR) in human recipients of marrow from HL-A-matched sibling donors. Transplant Proc. 1974;6(4): 367-71.
17. Washington K, Jagasia M. Pathology of graftversus-host disease in the gastrointestinal tract. Hum Pathol. 2009;40(7):909-17.
18. Scrucca L, Santucci A, Aversa F. Competing risk analysis using R: an easy guide for clinicians. Bone Marrow Transplant. 2007;40 (4):381-7.
19. Scrucca L, Santucci A, Aversa F. Regression modeling of competing risk using R: an in depth guide for clinicians. Bone Marrow Transplant. 2010;45(9):1388-95.
20. Gratwohl A, Stern M, Brand R, Apperley J, Baldomero H, de Witte T, et al. Risk score for outcome after allogeneic hematopoietic stem cell transplantation: a retrospective analysis. Cancer. 2009;115(20):4715-26.
21. Biedermann BC. Vascular endothelium and graft-versus-host disease. Best Pract Res Clin Haematol. 2008;21(2):129-38.
22. Ertault-Daneshpouy M, Leboeuf C, Lemann M, Bouhidel F, Ades L, Gluckman E, et al. Pericapillary hemorrhage as criterion of severe human digestive graft-versus-host disease. Blood. 2004;103(12):4681-4.
23. Labarrere CA, Faulk WP. Microvascular perturbations in human allografts: analogies in preeclamptic placentae. Am J Reprod Immunol. 1992;27(3-4):109-16.