Frequent expression of C4d in hepatic graft-versus-host disease: Potential clue for diagnosis and distinguishing acute and chronic form

Transplant Immunology

Volumn 23, Issue 1-2, 2010, Pages 77-80

  Ali, Sharif A ^a,b   Shah, Veena ^a   McKinnon, Rick ^b   Van Harn, Meredith ^b   Janakiraman, Nalini ^b  

^a Department of Pathology and Laboratory Medicine ^*  (United States)

^b HENRY FORD HOSPITAL   (United States)

Author keywords

C4d; Graft vs host disease; Liver

Indexed keywords

BUSULFAN; CARMUSTINE; COMPLEMENT COMPONENT C4D; CYCLOPHOSPHAMIDE; CYTARABINE; ETOPOSIDE; FLUDARABINE; MELPHALAN; THIOTEPA; ANTIBODY; COMPLEMENT C4D; COMPLEMENT COMPONENT C4B; PEPTIDE FRAGMENT;

ACUTE GRAFT VERSUS HOST DISEASE; ACUTE GRANULOCYTIC LEUKEMIA; ACUTE LYMPHOBLASTIC LEUKEMIA; ADULT; ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANTATION; ANTIBODY PRODUCTION; APLASTIC ANEMIA; ARTICLE; CHRONIC GRAFT VERSUS HOST DISEASE; CHRONIC LYMPHATIC LEUKEMIA; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; GRAFT VERSUS HOST REACTION; HODGKIN DISEASE; HUMAN; HUMAN TISSUE; HUMORAL IMMUNITY; IMMUNOPATHOGENESIS; LIVER BIOPSY; LIVER HILUS; LIVER SINUSOID; MALE; MYELOABLATIVE CONDITIONING; MYELODYSPLASTIC SYNDROME; NONHODGKIN LYMPHOMA; PILOT STUDY; PRIORITY JOURNAL; PROTEIN EXPRESSION; ACUTE DISEASE; BLOOD; CHRONIC DISEASE; GENE EXPRESSION REGULATION; GRAFT VS HOST DISEASE; LIVER; LIVER TRANSPLANTATION; METABOLISM; MIDDLE AGED; PATHOPHYSIOLOGY;

ACUTE DISEASE; ADULT; ANTIBODIES; CHRONIC DISEASE; COMPLEMENT C4B; FEMALE; GENE EXPRESSION REGULATION; GRAFT VS HOST DISEASE; HUMANS; LIVER; LIVER TRANSPLANTATION; MALE; MIDDLE AGED; PEPTIDE FRAGMENTS;

EID: 77953807830     PISSN: 09663274     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.trim.2010.03.002     Document Type: Article

References (17)

1. Billingham R.E. The biology of graft-versus-host reactions. Harvey Lect 1966, 62:21-78.
2. Martin P.J., Schoch G., Fisher L., Byers V., Anasetti C., Appelbaum F.R., et al. A retrospective analysis of therapy for acute graft-versus-host disease: initial treatment. Blood 1990, 76(8):1464-1472.
3. Shulman H.M., Sharma P., Amos D., Fenster L.F., McDonald G.B. A coded histologic study of hepatic graft-versus-host disease after human bone marrow transplantation. Hepatology 1988, 8(3):463-470.
4. Nickeleit V., Mihatsch M.J. Kidney transplants, antibodies and rejection: is C4d a magic marker?. Nephrol Dial Transplant 2003, 18(11):2232-2239.
5. Zhang P.L., Wilkerson M.L., Schworer C.M. C4d staining is a valuable marker in identifying chronic GVHD in colonic biopsies following BMT. Bone Marrow Transplant 2008, 42(3):209-211.
6. Martelius T., Halme L., Arola J., Hockerstedt K., Lautenschlager I. Vascular deposition of complement C4d is increased in liver allografts with chronic rejection. Transpl Immunol 2009, 21(4):244-246.
7. Lorho R., Turlin B., Aqodad N., Triki N., de Lajarte-Thirouard A.S., Camus C., et al. C4d: a marker for hepatic transplant rejection. Transplant Proc 2006, 38(7):2333-2334.
8. Bu X., Zheng Z., Yu Y., Zeng L., Jiang Y. Significance of C4d deposition in the diagnosis of rejection after liver transplantation. Transplant Proc 2006, 38(5):1418-1421.
9. Schmeding M., Dankof A., Krenn V., Krukemeyer M.G., Koch M., Spinelli A., et al. C4d in acute rejection after liver transplantation - a valuable tool in differential diagnosis to hepatitis C recurrence. Am J Transplant 2006, 6(3):523-530.
10. Glucksberg H., Storb R., Fefer A., Buckner C.D., Neiman P.E., Clift R.A., et al. Clinical manifestations of graft-versus-host disease in human recipients of marrow from HL-A-matched sibling donors. Transplantation 1974, 18(4):295-304.
11. Shulman H.M., Sale G.E., Lerner K.G., Barker E.A., Weiden P.L., Sullivan K., et al. Chronic cutaneous graft-versus-host disease in man. Am J Pathol 1978, 91(3):545-570.
12. Ishak K.G.B.A., Bianchi L., et al. Histological grading and staging of chronic hepatitis. J Hepatol 1995, 22. 696-699.
13. Searle J.W., ea IsDiMR, Burt A.D., Portmann B.C., Ishak K.S., Anthony P. Pathology of the Liver 2002, Churchill, Livingston. 4th ed.
14. Patriarca F., Skert C., Sperotto A., Zaja F., Falleti E., Mestroni R., et al. The development of autoantibodies after allogeneic stem cell transplantation is related with chronic graft-vs-host disease and immune recovery. Exp Hematol 2006, 34(3):389-396.
15. Canninga-van Dijk M.R., van der Straaten H.M., Fijnheer R., Sanders C.J., van den Tweel J.G., Verdonck L.F. Anti-CD20 monoclonal antibody treatment in 6 patients with therapy-refractory chronic graft-versus-host disease. Blood 2004, 104(8):2603-2606.
16. Ratanatharathorn V., Ayash L., Reynolds C., Silver S., Reddy P., Becker M., et al. Treatment of chronic graft-versus-host disease with anti-CD20 chimeric monoclonal antibody. Biol Blood Marrow Transplant 2003, 9(8):505-511.
17. Ratanatharathorn V., Carson E., Reynolds C., Ayash L.J., Levine J., Yanik G., et al. Anti-CD20 chimeric monoclonal antibody treatment of refractory immune-mediated thrombocytopenia in a patient with chronic graft-versus-host disease. Ann Intern Med 2000, 133(4):275-279.