The role of liver biopsy in the workup of liver dysfunction late after SCT: Is the role of iron overload underestimated?

Bone Marrow Transplantation

Volumn 42, Issue 7, 2008, Pages 461-467

  Sucak, G T ^a   Yegin, Z A ^a   Ozkurt Z N ^a   AkI, S Z ^a   Karakan, T ^a   Akyol, G ^a  

^a GAZI UNIVERSITY   (Turkey)

Author keywords

[No Author keywords available]

Indexed keywords

ACICLOVIR; ALLOPURINOL; AMPHOTERICIN; BUSULFAN; CARMUSTINE; CITALOPRAM; CORTICOSTEROID; COTRIMOXAZOLE; CYCLOPHOSPHAMIDE; CYCLOSPORIN A; CYTARABINE; DEFIBROTIDE; ESTROGEN; ETOPOSIDE; FERRITIN; FLUCONAZOLE; FLUDARABINE; GESTAGEN; IMATINIB; IMMUNOSUPPRESSIVE AGENT; LAMIVUDINE; LIVER ENZYME; MELPHALAN; METHOTREXATE; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; THYMOCYTE ANTIBODY; TRANSFERRIN; UNINDEXED DRUG; VALACICLOVIR; VORICONAZOLE;

ADOLESCENT; ADULT; ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANTATION; ARTICLE; BLOOD TRANSFUSION; CLINICAL ARTICLE; CONTROLLED STUDY; DIAGNOSTIC ACCURACY; DIAGNOSTIC VALUE; DIFFERENTIAL DIAGNOSIS; ENZYME BLOOD LEVEL; FEMALE; FERRITIN BLOOD LEVEL; GRAFT VERSUS HOST REACTION; HEMATOLOGIC MALIGNANCY; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IRON OVERLOAD; LIVER BIOPSY; LIVER CELL; LIVER DYSFUNCTION; LIVER VENOOCCLUSIVE DISEASE; MALE; PRIORITY JOURNAL; REGRESSION ANALYSIS; RETROSPECTIVE STUDY; WHOLE BODY RADIATION;

ADULT; ANTINEOPLASTIC AGENTS; BIOPSY; FEMALE; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HODGKIN DISEASE; HUMANS; IRON OVERLOAD; LEUKEMIA; LIVER; LIVER DISEASES; MALE; MIDDLE AGED; MULTIPLE MYELOMA; RETROSPECTIVE STUDIES; TRANSPLANTATION, HOMOLOGOUS; YOUNG ADULT;

EID: 54349087055     PISSN: 02683369     EISSN: 14765365     Source Type: Journal    
DOI: 10.1038/bmt.2008.193     Document Type: Article

References (40)

1. Armand P, Kim HT, Cutler CS, Ho VT, Koreth J, Alyea EP et al. Prognostic impact of elevated pretransplant serum ferritin in patients undergoing myeloablative stem cell transplantation. Blood 2007; 109: 4586-4588.
2. Iqbal M, Creger RJ, Fox RM, Cooper BW, Jacobs G, Stellato TA et al. Laparoscopic liver biopsy to evaluate hepatic dysfunction in patients with hematologic malignancies: A useful tool to effect changes in management. Bone Marrow Transplant 1996; 17: 655-662.
3. Ho GT, Parker A, MacKenzie JF, Morris AJ, Stanley AJ. Abnormal liver function tests following bone marrow transplantation: Aetiology and role of liver biopsy. Eur J Gastroenterol Hepatol 2004; 16: 157-162.
4. Strasser SI, Sullivan KM, Myerson D, Spurgeon CL, Storer B, Schoch HG et al. Cirrhosis of the liver in long term marrow transplant survivors. Blood 1999; 93: 3259-3266.
5. El Sayed MH, El-Haddad A, Fahmy OA, Salama II, Mahmoud HK. Liver disease is a major cause of mortality following allogeneic bone marrow transplantation. Eur J Gastroenterol Hepatol 2004; 16: 1347-1354.
6. Tomas JF, Pinilla I, Garcia-Buey ML, Garcia A, Figuera A, Gomez-Garcia de Soria V et al. Long term liver dysfunction after allogeneic bone marrow transplantation: Clinical features and course in 61 patients. Bone Marrow Transplant 2000; 26: 649-655.
7. McDonald GB. Review article: Management of hepatic disease following haematopoietic cell transplant. Aliment Pharmacol Ther 2006; 24 441-452.
8. Choi SW, Islam S, Greenson JK, Levine J, Hutchinson R, Yanik G et al. The use of laparoscopic liver biopsies in pediatric patients with hepatic dysfunction following allogeneic hematopoietic stem cell transplantation. Bone Marrow Transplant 2005; 36: 891-896.
9. Ma SY, Au WY, Ng IOL, Lie AKW, Leung AYH, Liang RHS et al. Role of liver biopsy in the management of liver dysfunction after hematopoietic stem cell transplantation in a hepatitis B virus prevalent patient population. Transplantation 2003; 76: 169-176.
10. Harrison P, Neilson JR, Marwah SS, Madden L, Bareford D, Milligan DW. Role of non transferrin bound iron in iron overload and liver dysfunction in long term survivors of acute leukaemia and bone marrow transplantation. J Clin Pathol 1996; 49: 853-856.
11. Veneri D, Franchini M, Zanetti F, Krampera M, Matteis G, Pizzolo G. Iron overload in acute myeloid leukemia patients is not related to HFE and TFR2 gene mutations. Haematologica 2003; 88: 1069-1070.
12. Kim BK, Chung KW, Sun HS, Suh JG, Min WS, Kang CS et al. Liver disease during the first posttransplant year in bone marrow transplantation recipients: Retrospective study. Bone Marrow Transplant 2000; 26: 193-197.
13. Kusumi E, Kami M, Kanda Y, Murasbige N, Seki K, Fujiwara M et al. Hepatic injury following reduced intensity unrelated cord blood transplantation for adult patients with hematological diseases. Biol Blood Marrow Transplant 2006; 12: 1302-1309.
14. Azar N, Valla D, Abdel-Samad I, Hoang C, Fretz C, Sutton L et al. Liver dysfunction in allogeneic bone marrow transplantation recipients. Transplantation 1996; 62: 56-61.
15. Özdoǧan O, Ratip S, Al Ahdab Y, Dane F, Al Ahdab H, Imeryüz N et al. Causes and risk factors for liver injury following bone marrow transplantation. J Clin Gastroenterol 2003; 36: 421-426.
16. Subbarao G, Haut PR, Johnson CS, Gowan D, Molleston JP. Incidence, etiology and risk factors for liver dysfunction in children following hematopoietic stem cell transplantation. Pediatr Transplant 2006; 10: 682-689.
17. Chahal P, Levy C, Litzow MR, Lindor KD. Utility of liver biopsy in bone marrow transplant patients. J Gastroenterol Hepatol 2008; 23 222-225.
18. Evens AM, Mehta J, Gordon LI. Rust and corrosion in hematopoietic stem cell transplantation: The problem of iron and oxidative stress. Bone Marrow Transplant 2004; 34: 561-571.
19. Miceli MH, Dong L, Grazziutti ML, Fassas A, Thertulien R, Van Rhee F et al. Iron overload is a major risk factor for severe infection after autologous stem cell transplantation: A study of 367 myeloma patients. Bone Marrow Transplant 2006; 37: 857-864.
20. Lichtman SM, Attivissimo L, Goldman IS, Schuster MW, Buchbinder A. Secondary hemochromatosis as a long term complication of the treatment of hematologic malignancies. Am J Hematol 1999; 61: 262-264.
21. Strasser SI, Kowdley KV, Sale GE, McDonald GB. Iron overload in bone marrow transplant recipients. Bone Marrow Transplant 1998; 22 167-173.
22. Poli G. Pathogenesis of liver fibrosis: Role of oxidative stress. Mol Aspects Med 2000; 21: 49-98.
23. Allen KJ, Gurrin LC, Constantine CC, Osborne NJ, Delatycki MB, Nicoll AJ et al. Iron overload-related disease in HFE hereditary hemochromatosis. N Engl J Med 2008; 358: 221-230.
24. McKay PJ, Murphy JA, Cameron S, Burnett AK, Camphell M, Tansey P et al. Iron overload and liver dysfunction after allogeneic and autologous bone marrow transplantation. Bone Marrow Transplant 1996; 17: 63-66.
25. Waalen J, Felliti VJ, Gelbart T, Beutler E. Screening for hemachromatosis by measuring ferritin levels: A more effective approach. Blood 2008; 111: 3373-3376.
26. Kamble RT, Selby GB, Mims M, Kharfan-Dabaja MA, Özer H, George JN. Iron overload manifesting as apparent exacerbation of hepatic graft versus host disease after allogeneic hematopoietic stem cell transplantation. Biol Blood Marrow Transplant 2006; 12: 506-510.
27. Socie G, Salooja N, Cohen A, Rovelli A, Carreras E, Locasciulli A et al. Nonmalignant late effects after allogeneic stem cell transplantation. Blood 2003; 101: 3373-3385.
28. Dürken M, Nielsen P, Knobel S, Finckh B, Herrnring C, Dresow B et al. Nontransferrin-bound iron in serum of patients receiving bone marrow transplants. Free Rad Biol Med 1997; 22: 1159-1163.
29. Sahlstedt L, Ebeling F, Von Bonsdorff L, Parkkinen J, Ruutu T. Non-transferrin bound iron during allogeneic stem cell transplantation. Br J Haematol 2001; 113: 836-838.
30. Gordon LI, Brown SG, Tallman MS, Rademaker AW, Weitzman SA, Lazarus HM et al. Sequential changes in serum iron and ferritin in patients undergoing high dose chemotherapy and radiation with autologous bone marrow transplantation: Possible implications for treatment related toxicity. Free Rad Biol Med 1995; 18: 383-389.
31. Morado M, Ojeda E, Garcia Bustos J, Aguado MJ, Arrieta R, Quevedo E et al. Serum ferritin as a risk factor for veno-occlusive disease of the liver. Prospective cohort study. Hematology 2000; 6: 505-512.
32. Maertens J, Demuynck H, Verbeken EK, Zachee P, Verhoef GEG, Vandenberghe P et al. Mucormycosis in allogeneic bone marrow transplant recipients: Report of five cases and review of the role of iron overload in the pathogenesis. Bone Marrow Transplant 1999; 24: 307-312.
33. Altes A, Remacha AF, Sadra P, Sancho FJ, Sureda A, Martino R et al. Frequent severe liver iron overload after stem cell transplantation and its possible association with invasive aspergillosis. Bone Marrow Transplant 2004; 34: 505-509.
34. Altes A, Remacha AF, Sadra P, Baiget M, Sureda A, Martino R et al. Early clinical impact of iron overload in stem cell transplantation. A prospective study. Ann Hematol 2007; 86: 443-447.
35. Angelucci E, Muretto P, Nicolucci A, Baronciani D, Erer B, Gaziev J et al. Effects of iron overload and hepatitis C virus positivity in determining progression of liver fibrosis in thalassemia following bone marrow transplantation. Blood 2002; 100: 17-21.
36. Kallianpur AR, Hall LD, Yadav M, Christman BW, Dittus RS, Haines JL et al. Increased prevalance of the HFE C282Y Hemochromatosis allele in women with breast cancer. Cancer Epidemiol 2004; 13: 205-212.
37. Barton JC, Bertoli LF, Acton RT. HFE C282Y and H63D in adults with malignancies in a community medical oncology practice. BMC Cancer 2004; 4: 1-8.
38. Carreras E. Risk assessment in haematopoietic stem cell transplantation: the liver as a risk factor. Best Pract Res Clin Haematol 2007; 20: 231-246.
39. Varkonyi J, Tarkovacs G, Karadi I, Andrikovics H, Varga Fe, Varga Fa et al. High incidence of hemochromatosis gene mutations in the myelodysplastic syndrome: The Budapest study on 50 patients. Acta Haematol 2003; 109: 64-67.
40. Ko C, Siddaiah N, Berger J, Gish R, Brandhagen D, Sterling RK et al. Prevalence of hepatic iron overload and association with hepatocellular cancer in end-stage liver disease: Results from the National Hemochromatosis Transplant Registry. Liver Int 2007; 27: 1394-1401.