Conceptualizing and measuring potentially inappropriate drug therapy

Journal of Clinical Pharmacy and Therapeutics

Volumn 40, Issue 2, 2015, Pages 167-176

  Santos, A P A L ^a   Silva, D T ^a   Alves Conceicao V ^a   Antoniolli, A R ^a   Lyra, D P ^a  

^a FEDERAL UNIVERSITY OF SERGIPE   (Brazil)

Author keywords

elderly; evaluation tools; potentially inappropriate drug therapy

Indexed keywords

PRESCRIPTION DRUG;

DRUG UTILIZATION; EVALUATION STUDY; HEALTH PRACTITIONER; HOSPITALIZATION; HUMAN; INAPPROPRIATE PRESCRIBING; MEDICAL PRACTICE; MORBIDITY; MORTALITY; POTENTIALLY INAPPROPRIATE DRUG THERAPY; PRESCRIPTION; REVIEW; SYSTEMATIC REVIEW; AGED; CLINICAL PRACTICE; FACTUAL DATABASE; HEALTH CARE QUALITY; POLYPHARMACY; STATISTICS AND NUMERICAL DATA;

AGED; DATABASES, FACTUAL; DRUG UTILIZATION; HUMANS; INAPPROPRIATE PRESCRIBING; POLYPHARMACY; PRACTICE PATTERNS, PHYSICIANS'; QUALITY INDICATORS, HEALTH CARE;

EID: 84924218716     PISSN: 02694727     EISSN: 13652710     Source Type: Journal    
DOI: 10.1111/jcpt.12246     Document Type: Review

References (142)

1. Nations U,. Life expectancy at birth. Charting the progress of the population. Sales No. E.99.XIII.9: Nations U, 2000.
2. INE. População e Sociedade. Lisboa: INE, 2007.
3. Brekke M, Rognstad R, Straand J, Furu K, Gjelstad S, Bjørner T, Dalen I,. Pharmacologically inappropriate prescriptions for elderly patients in general practice: how common? Scand J Prim Health Care, 2008; 26: 80-85.
4. Soares MA, Fernandez-Llimos F, Cabrita J, et al,. Critérios de avaliação de prescrição de medicamentos potencialmente inapropriados: Uma Revisão Sistemática. Acta Med Port, 2011; 24: 775-784.
5. Beers MH, Baran RW, Frenia K,. Drugs and the elderly, Part 1: the problems facing managed care. Am J Manag Care, 2000; 6: 1313-1320.
6. Chang CB, Chan DC,. Comparison of published explicit criteria for potentially inappropriate medications in older adults. Drugs Aging, 2010; 27: 947-957.
7. Lin HY, Liao CC, Cheng SH, Wang PC, Hsueh YS,. Association of potentially inappropriate medication use with adverse outcomes in ambulatory elderly patients with chronic diseases: experience in a Taiwanese medical setting. Drugs Aging, 2008; 14: 49-59.
8. Bakken MS, Ranhoff AH, Engeland A, Ruths S,. Inappropriate prescribing for older people admitted to an intermediate-care nursing home unit and hospital wards. Scand J Prim Health Care, 2012; 30: 169-175.
9. Ribeiro AQ, Araújo CMC, Acurcio FA, Magalhães SMS, Chaimowicz F,. Quality assessment of drug use in the elderly: a review of available evaluation methods. Cien Saúde Colet, 2005; 10: 1037-1045.
10. Clyne B, Bradley MC, Smith SM, et al,. Effectiveness of medicines review with web-based pharmaceutical treatment algorithms in reducing potentially inappropriate prescribing in older people in primary care: a cluster randomized trial (OPTI-SCRIPT study protocol). Trials, 2013; 14: 72.
11. Cahir C, Fahey T, Teeling M, Teljeur C, Feely J, Bennett K,. Potentially inappropriate prescribing and cost outcomes for older people: a national population study. Br J Clin Pharmacol, 2010; 69: 543-552.
12. Albert SM, Colombi A, Hanlon J,. Potentially inappropriate medications and risk of hospitalization in retirees. Drugs Aging, 2010; 27: 407-415.
13. Holguín E, Orozco JG,. Medicaciõn potencialmente inapropiada en ancianos en un hospital de cuarto nivel en Bogotá. Univ Méd Bogotá (Colombia), 2011; 52: 149-168.
14. Bryant LJM, Coster G, Gamble GD, McCormick RN,. The general practitioner-pharmacist collaboration (GPPC) study: a randomised controlled trial of clinical medication reviews in community pharmacy. Int J Pharm Pract, 2011; 19: 94-105.
15. Walsh EK, Cussen K., "Take Ten Minutes": a dedicated ten minute medication review reduces polypharmacy in the elderly. Ir Med J, 2010; 103: 236-238.
16. Steinman MA, Rosenthal GE, Landefeld CS, Bertenthal D, Kaboli PJ,. Agreement between drugs-to-avoid criteria and expert assessments of problematic prescribing. Arch Intern Med, 2009; 169: 1326-1332.
17. Mandavi, Tiwari P, Kapur V,. Inappropriate drug prescribing identified among Indian elderly hospitalized patients. Int J Risk Saf Med, 2007; 19: 111-116.
18. Spinewine A, Swine C, Dhillon S, Lambert P, Nachega JB, Wilmotte L, Tulkens PM,. Effect of a collaborative approach on the quality of prescribing for geriatric inpatients: a randomized, controlled trial. J Am Geriatr Soc, 2007; 55: 658-665.
19. Crotty M, Rowett D, Spurling L, Giles LC, Phillips PA,. Does the addition of a pharmacist transition coordinator improve evidence-based medication management and health outcomes in older adults moving from the hospital to a long-term care facility? Results of a randomized, controlled trial. Am J Geriatr Pharmacother, 2004; 2: 257-264.
20. Gallagher PF, O'Connor MN, O'Mahony D,. Prevention of potentially inappropriate prescribing for elderly patients: a randomized controlled trial using STOPP/START criteria. Clin Pharmacol Ther, 2011; 89: 845-854.
21. Bregnhøj L, Thirstrup S, Kristensen MB, Bjerrum L, Sonne J,. Combined intervention programme reduces inappropriate prescribing in elderly patients exposed to polypharmacy in primary care. Eur J Clin Pharmacol, 2008; 65: 199-207.
22. Bregnhøj L, Thirstrup S, Kristensen MB, Sonne J,. Reliability of a modified medication appropriateness index in primary care. Eur J Clin Pharmacol, 2005; 61: 769-773.
23. Blozik E, Born AM, Stuck AE, Benninger U, Gillmann G, Clough-Gorr KM,. Reduction of inappropriate medications among older nursing-home residents: a nurse-led, pre/post-design, intervention study. Drugs Aging, 2010; 27: 1009-1017.
24. Hanlon JT, Weinberger M, Samsa GP, et al,. A randomized, controlled trial of a clinical pharmacist intervention to improve inappropriate prescribing in elderly outpatients with polypharmacy. Am J Med, 1996; 100: 428-437.
25. Hanlon JT, Schmader KE, Samsa GP, et al,. A method for assessing drug therapy appropriateness. J Clin Epidemiol, 1992; 45: 1045-1051.
26. Terrell KM, Heard K, Miller DK,. Prescribing to older ED patients. Am J Emerg Med, 2006; 24: 468-478.
27. Lam MP, Cheung BM,. The use of STOPP/START criteria as a screening tool for assessing the appropriateness of medications in the elderly population. Expert Rev Clin Pharmacol, 2012; 5: 187-197.
28. Hanlon JT, Shimp LA, Semla TP,. Recent advances in geriatrics: drug-related problems in the elderly. Ann Pharmacother, 2000; 34: 360-365.
29. Beers MH, Ouslander JG, Rollingher I, Reuben DB, Brooks J, Beck JC,. Explicit criteria for determining inappropriate medication use in nursing home residents. UCLA Division of Geriatric Medicine. Arch Intern Med, 1991; 151: 1825-1832.
30. Guaraldo L, Cano FG, Damasceno GS, Rozenfeld S,. Inappropriate medication use among the elderly: a systematic review of administrative databases. BMC Geriatr, 2011; 30: 11-79.
31. Ryan C, O'Mahony D, Kennedy J, Weedle P, Byrne S,. Potentially inappropriate prescribing in an Irish elderly population in primary care. Br J Clin Pharmacol, 2009; 68: 936-947.
32. Nascimento MMG, Pereira ML, Souza ACS, Ribeiro Dias-Junior CAC,. Potential drug therapy problems on an elderly nursing home population. Lat Am J Pharm, 2011; 30: 1985-1990.
33. Regueiro M, Mendy N, Cañás M, Farina HO, Nagel P,. Uso de medicamentos en adultos mayores no institucionalizados. Rev Peru Med Exp Salud Publica, 2011; 28: 643-647.
34. Conejos MMD, Sánchez CM, Delgado SE, Machucaa IS, Gonzalez-Blazquezc S, Errasquind BM, Cruz-Jentoftd AJ,. Potentially inappropriate drug prescription in older subjects across health care settings. Eur Geriatr Med, 2010; 1: 9-14.
35. Hamilton H, Gallagher P, Ryan C, Byrne S, O'Mahony D,. Potentially inappropriate medications defined by STOPP criteria and the risk of adverse drug events in older hospitalized patients. Arch Intern Med, 2011; 171: 1013-1019.
36. Gallagher P, O'Mahony D,. STOPP (Screening tool o folder persons′ potentially inappropriate prescription): application to acutely ill elderly patients and comparison with Beer′s criteria. Age Ageing, 2008; 37: 673-679.
37. Chang CB, Chen JH, Wen CJ, et al,. Potentially inappropriate medications in geriatric outpatients with polypharmacy: application of six sets of published explicit criteria. Br J Clin Pharmacol, 2011; 72: 482-489.
38. Denzin NK,. The research act. Englewood Cliffs, NJ: Prentice Hall, 1989.
39. Flick UEV, Kardorff I,. Triangulation in qualitative research. In:, Flick U, Kardorff E, and, Steinke I, Camp Quality Res, 2005; 1: 178-183.
40. Straand J, Rokstad KS,. Elderly patients in general practice: diagnoses, drugs and inappropriate prescriptions. A report from the More e Romsdal Prescription Study. Fam Pract, 1999; 16: 380-388.
41. Maio V, Del Canale S, Abouzaid S, GAP Investigators. Using explicit criteria to evaluate the quality of prescribing in elderly Italian outpatients: a cohort study. J Clin Pharm Ther, 2010; 35: 219-229.
42. Rancourt C, Moisan J, Baillargeon L, Verreault R, Laurin D, Gregoire JP,. Potentially inappropriate prescriptions for older patients in long-term care. BMC Geriatr, 2004; 4: 9.
43. Higashi T, Shekelle PG, Solomon D,. The quality of pharmacologic care for vulnerable older patients. Ann Intern Med, 2004; 140: 714-720.
44. Maio V, Yuen EJ, Novielli K, Smith KD, Louis DZ,. Potentially inappropriate medication prescribing for elderly outpatients in Emilia Romagna, Italy. Drugs Aging, 2006; 23: 915-924.
45. García-Gollarte F, Baleriola-Júlvez J, Ferrero-Lõpez I, Cruz-Jentoft AJ,. Inappropriate drug prescription at nursing home admission. J Am Med Dir Assoc, 2012; 13: 9-15.
46. Liu CL, Peng LN, Chen YT, Lin MH, Liu LK, Chen LK,. Potentially inappropriate prescribing (IP) for elderly medical inpatients in Taiwan: a hospital-based study. Arch Gerontol Geriatr, 2012; 55: 148-151.
47. Pyszka LL, Seys Ranola TM, Milhans SM,. Identification of inappropriate prescribing in geriatrics at a Veterans Affairs hospital using STOPP/START screening tools. Consult Pharm, 2010; 25: 365-373.
48. Barry PJ, Gallagher P, Ryan C, O'mahony D,. START (screening tool to alert doctors to the right treatment)-an evidence-based screening tool to detect prescribing omissions in elderly patients. Age Ageing, 2007; 36: 632-638.
49. Holmes DR Jr, Hodgson PK, Nishimura RA, Simari RD,. Manuscript preparation and publication. Circulation, 2009; 120: 906-913.
50. Fick DM, Cooper JW, Wande WE, Waller JL, Maclean JR, Beers MH,. Updaring the Beers criteria for potentially inappropriate medication use in older adults: results of a US consensus panel of experts. Arch Intern Med, 2003; 163: 2716-2724.
51. Laroche ML, Charmes JP, Nouaille Y, Picard N, Merle L,. Is inappropriate medication use a major cause of adverse drug reactions in the elderly? Br J Clin Pharmacol, 2007; 63: 177-186.
52. von Elm E, Altman DG, Egger M, Pocock SJ, Gøtzsche PC, Vandenbroucke JP,. Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: guidelines for reporting observational studies. BMJ, 2007; 335: 806-808.
53. Stuart B, Kamal-Bahl S, Briesacher B, et al,. Trends in the prescription of inappropriate drugs for the elderly between 1995 and 1999. Am J Geriatr Pharmacother, 2003; 1: 61-74.
54. Dhalla IA, Anderson GM, Mamdani MM, Bronskill SE, Sykora K, Rochon PA,. Inappropriate prescribing before and after nursing home admission. J Am Geriatr Soc, 2002; 50: 995-1000.
55. Bradley MC, Fahey T, Cahir C, Bennett K, O'Reilly D, Parsons C, Hughes CM,. Potentially inappropriate prescribing and cost outcomes for older people: a cross-sectional study using the Northern Ireland Enhanced Prescribing Database. Eur J Clin Pharmacol, 2012; 68: 1425-1433.
56. Shah RB, Gajjar BM, Desai SV,. Evaluation of the appropriateness of prescribing in geriatric patients using Beers criteria and Phadke's criteria and comparison thereof. J Pharmacol Pharmacother, 2011; 2: 248-252.
57. Zaveri HG, Mansuri SM, Patel VJ,. Use of potentially inappropriate medicines in elderly: a prospective study in medicine out-patient department of a tertiary care teaching hospital. Indian J Pharmacol, 2010; 42: 95-98.
58. Ryan C, O'Mahony D, Kennedy J, Weedle P, Barry P, Gallagher P, Byrne S,. Appropriate prescribing in the elderly: an investigation of two screening tools, Beers criteria considering diagnosis and independent of diagnosis and improved prescribing in the elderly tool to identify inappropriate use of medicines in the elderly in primary care in Ireland. J Clin Pharm Ther, 2009; 34: 369-376.
59. Pugh MJ, Hanlon JT, Zeber JE, Bierman A, Cornell J, Berlowitz DR,. Assessing potentially inappropriate prescribing in the elderly Veterans Affairs population using the HEDIS 2006 quality measure. J Manag Care Pharm, 2006; 12: 537-545.
60. Stafford AC, Alswayan MS, Tenni PC,. Inappropriate prescribing in older residents of Australian care homes. J Clin Pharm Ther, 2011; 36: 33-44.
61. Bregnhøj L, Thirstrup S, Brandt M, Bjerrum L, Sonne J,. Prevalence of inappropriate prescribing in primary care. Pharm World Sci, 2007; 29: 109-111.
62. Barry PJ, O'Keefe N, O'Connor KA, O'Mahony D,. Inappropriate prescribing in the elderly: a comparison of the Beers criteria and the improved prescribing in the elderly tool (IPET) in acutely ill elderly hospitalized patients. J Clin Pharm Ther, 2006; 31: 617-626.
63. Nassur BA, Braun V, Devens LT, Morelato RL,. Avaliação dos medicamentos inapropriados utilizados por idosos admitidos em hospital geral filantrõpico. Rev Soc Bras Clin Med, 2010; 8: 208-211.
64. Bongue B, Laroche ML, Gutton S, Colvez A, Gueguen R, Moulin JJ, Merle L,. Potentially inappropriate drug prescription in the elderly in France: a population-based study from the French National Insurance Healthcare system. Eur J Clin Pharmacol, 2011; 67: 1291-1299.
65. Woelfel JA, Patel RA, Walberg MP, Amaral MM,. Use of potentially inappropriate medications in an ambulatory medicare population. Consult Pharm, 2011; 26: 913-919.
66. Varallo FR, Capucho HC, Planeta CS, Mastroianni Pde C,. Safety assessment of potentially inappropriate medications (PIM) use in older people and the factors associated with hospital admission. J Pharm Pharm Sci, 2011; 14: 283-290.
67. Leikola S, Dimitrow M, Lyles A, PitkÓ"lÓ" K, Airaksinen M,. Potentially inappropriate medication use among Finnish non-institutionalized people aged ≥65 years. Drugs Aging, 2011; 28: 227-236.
68. Kölzsch M, Kopke K, Fischer T, et al,. Prescribing of inappropriate medication in nursing home residents in Germany according to a French consensus list: a cross-sectional cohort study. Pharmacoepidemiol Drug Saf, 2011; 20: 12-19.
69. Harugeri A, Joseph J, Parthasarathi G, Ramesh M, Guido S,. Potentially inappropriate medication use in elderly patients: a study of prevalence and predictors in two teaching hospitals. J Postgrad Med, 2010; 56: 186-191.
70. Shiyanbola OO, Farris KB,. Concerns and beliefs about medicines and inappropriate medications: an internet-based survey on risk factors for self-reported adverse drug events among older adults. Am J Geriatr Pharmacother, 2010; 8: 245-257.
71. Fu AZ, Tang AS, Wang N, Du DT, Jiang JZ,. Effect of medicare part d on potentially inappropriate medication use by older adults. J Am Geriatr Soc, 2010; 58: 944-949.
72. Pattanaworasate W, Emmerton L, Pulver L, Winckel K,. Comparison of prescribing criteria in hospitalised Australian elderly. Pharm Pract (Granada), 2010; 8: 132-138.
73. Akazawa M, Imai H, Igarashi A, Tsutani K,. Potentially inappropriate medication use in elderly Japanese patients. Am J Geriatr Pharmacother, 2010; 8: 146-160.
74. Holguín-Hernández E, Orozco-Díaz JG,. Medicaciõn potencialmente inapropriada en ancianos en un hospital de primer nivel, Bogotá 2007. Rev Salud Pública (Bogota), 2010; 12: 287-299.
75. Kamuhabwa AR, Lugina R,. Pattern of drug use among elderly patients in public and private hospitals in Dar-as Salaam. East Afr J Public Health, 2010; 7: 44-48.
76. Castelino RL, Hilmer SN, Bajorek BV, Nishtala P, Chen TF,. Drug burden index and potentially inappropriate medications in community-dwelling older people: the impact of home medicines review. Drugs Aging, 2010; 27: 135-148.
77. Bongue B, Naudin F, Laroche ML, et al,. Trends of the potentially inappropriate medication consumption over 10 years in older adults in the East of France. Pharmacoepidemiol Drug Saf, 2009; 18: 1125-1133.
78. Lai HY, Hwang SJ, Chen YC, Chen TJ, Lin MH, Chen LK,. Prevalence of the prescribing of potentially inappropriate medications at ambulatory care visits by elderly patients covered by the Taiwanese National Health Insurance Program. Clin Ther, 2009; 31: 1859-1870.
79. Buck MD, Atreja A, Brunker CP, et al,. Potentially inappropriate medication prescribing in outpatient practices: prevalence and patient characteristics based on electronic health records. Am J Geriatr Pharmacother, 2009; 7: 84-92.
80. Chen YC, Hwang SJ, Lai HY, et al,. Potentially inappropriate medication for emergency department visits by elderly patients in Taiwan. Pharmacoepidemiol Drug Saf, 2009; 18: 53-61.
81. Wawruch M, Fialova D, Zikavska M, Chen TJ, Lin MH, Chen LK, Lee CH,. Factors influencing the use of potentially inappropriate medication in older patients in Slovakia. J Clin Pharm Ther, 2008; 33: 381-392.
82. Rothberg MB, Pekow PS, Liu F, et al,. Potentially inappropriate medication use in hospitalized elders. J Hosp Med, 2008; 3: 91-102.
83. Pugh MJV, Rosen AK, Montez-Rath M, et al,. Potentially inappropriate prescribing for the elderly: effects of geriatric care at the patient and health care system level. Med Care, 2008; 46: 167-173.
84. Landi F, Russo A, Liperoti R, et al,. Impact of inappropriate drug use on physical performance among a frail elderly population living in the community. Eur J Clin Pharmacol, 2007; 63: 791-799.
85. Bierman AR, Pugh MJV, Dhalla I, Amuan M, Fincke BG, Rosen A, Berlowitz DR,. Sex differences in inappropriate prescribing among elderly veterans. Am J Geriatr Pharmacother, 2007; 5: 147-161.
86. Lapane KL, Hughes CM, Quilliam BJ,. Does incorporating medications in the surveyors' interpretive guidelines reduce the use of potentially inappropriate medications in nursing homes? J Am Geriatr Soc, 2007; 55: 667-673.
87. Davis RG, Hepfinger CA, Sauer KA, Wilhardt MS,. Retrospective evaluation of medication appropriateness recommendations for home-based primary care veterans. Am J Geriatr Pharmacother, 2007; 5: 40-47.
88. Page RL II, Ruscin JM,. The risk of adverse drug events and hospital-related morbidity and mortality among older adults with potentially inappropriate medication use. Am J Geriatr Pharmacother, 2006; 4: 297-305.
89. Moral EG, Suárez-Varela MTM, Esteban JAH, Perez Suanes AM,. Inappropriate multiple medication and prescribing of drugs in immobile elderly patients living in the community. Aten Primaria, 2006; 38: 476-482.
90. Wawruch M, Zikavska M, Wsolova L, et al,. Perception of potentially inappropriate medication in elderly patients by Slovak physicians. Pharmacoepidemiol Drug Saf, 2006; 15: 829-834.
91. Saab YB, Hachem A, Sinno S, El-Moalem H,. Inappropriate medication use in elderly Lebanese outpatients: prevalence and risk factors. Drugs Aging, 2006; 23: 743-752.
92. Martins SO, Soares MA, Foppe van Mil JW, Cabrita J,. Inappropriate drug use by Portuguese elderly outpatients-effect of the Beers criteria update. Pharm World Sci, 2006; 28: 296-301.
93. Zuckerman IH, Langenberg P, Baumgarten M, Orwig D, Byrns PJ, Simoni-Wastila L, Magaziner J,. Inappropriate drug use and risk of transition to nursing homes among community-dwelling older adults. Med Care, 2006; 44: 722-730.
94. Cannon KT, Choi MM, Zuniga MA,. Potentially inappropriate medication use in elderly patients receiving home health care: a retrospective data analysis. Am J Geriatr Pharmacother, 2006; 4: 134-143.
95. Laroche ML, Charmes JP, Nouaille Y, Fourrier A, Merle L,. Impact of hospitalisation in an acute medical geriatric unit on potentially inappropriate medication use. Drugs Aging, 2006; 23: 49-59.
96. Niwata S, Yamada Y, Ikegami N,. Prevalence of inappropriate medication using Beers criteria in Japanese long-term care facilities. BMC Geriatr, 2006; 6: 1.
97. Azoulay L, Zargarzadeh A, Salahshouri Z, Oraichi D, Berard A,. Inappropriate medication prescribing in community-dwelling elderly people living in Iran. Eur J Clin Pharmacol, 2005; 61: 913-919.
98. Blalock SJ, Byrd JE, Hansen RA, et al,. Factors associated with potentially inappropriate drug utilization in a sample of rural community-dwelling older adults. Am J Geriatr Pharmacother, 2005; 3: 168-179.
99. Onder G, Landi F, Liperoti R, Fialova D, Gambassi G, Bernabei R,. Impact of inappropriate drug use among hospitalized older adults. Eur J Clin Pharmacol, 2005; 61: 453-459.
100. Ay P, Akici A, Harmanci H,. Drug utilization and potentially inappropriate drug use in elderly residents of a community in Istanbul, Turkey. Int J Clin Pharmacol Ther, 2005; 43: 195-202.
101. Fialová D, Topinková E, Gambassi G, et al,. Potentially inappropriate medication use among elderly home care patients in Europe. JAMA, 2005; 293: 1348-1358.
102. Perri M III, Menon AM, Deshpande AD, et al,. Adverse outcomes associated with inappropriate drug use in nursing homes. Ann Pharmacother, 2005; 39: 405-411.
103. Steven R, Simon SR, Chan KA, Soumerai SB, Soumerai SB, Waller JL, Maclean JR, Beers MH,. Potentially inappropriate medication use by elderly persons in U.S. Health Maintenance Organizations, 2000-2001. J Am Geriatr Soc, 2005; 53: 227-232.
104. Viswanathan H, Bharmal M, Thomas J III,. Prevalence and correlates of potentially inappropriate prescribing among ambulatory older patients in the year 2001: comparison of three explicit criteria. Clin Ther, 2005; 27: 88-99.
105. RigJen SK, Perera S, Jachna C, Shireman TI, Eng M,. Comparison of the association between disease burden and inappropriate medication use across three cohorts of older adults. Am J Geriatr Pharmacother, 2004; 2: 239-247.
106. Caterino JM, Emond JA, Camargo CA Jr,. Inappropriate medication administration to the acutely ill elderly: a nationwide emergency department study, 1992-2000. J Am Geriatr Soc, 2004; 52: 1847-1855.
107. Chang CM, Liu PY, Yang YH, Yang YC, Wu CF, Lu FH,. Potentially inappropriate drug prescribing among first-visit elderly outpatients in Taiwan. Ann Pharmacother, 2004; 24: 848-855.
108. Fillenbaum GG, Hanlon JT, Landerman LR, et al,. Impact of Inappropriate drug use on health services utilization among representative older community-dwelling residents. Am J Geriatr Pharmacother, 2004; 2: 92-101.
109. Vlahovic-Palcevski V, Bergman U,. Quality of prescribing for the elderly in Croatia-computerized pharmacy data can be used to screen for potentially inappropriate prescribing. Eur J Clin Pharmacol, 2004; 60: 217-220.
110. Gray SL, Hedrick SC, Rhinard EE, Sales AE, Sullivan JH, Tornatore JB, Curtis MP,. Potentially inappropriate medication use in community residential care facilities. Ann Pharmacother, 2003; 37: 988-993.
111. Onder G, Landi F, Cesari M, Gambassi G, Carbonin P, Bernabei R,. Inappropriate medication use among hospitalized older adults in Italy: results from the Italian Group of Pharmacoepidemiology in the Elderly. Eur J Clin Pharmacol, 2003; 59: 157-162.
112. Kassam R, Martin LG, Farris KB,. Reliability of a modified medication appropriateness index in community pharmacies. Ann Pharmacother, 2003; 37: 40-46.
113. Hanlon JT, Fillenbaum GG, Kuchibhatla M, et al,. Impact of inappropriate drug use on mortality and functional status in representative community dwelling elders. Med Care, 2002; 40: 166-176.
114. Zhan C, Sangl J, Bierman AS, Miller MR, Friedman B, Wickizer SW, Meyer GS,. Potentially inappropriate medication use in the community-dwelling elderly. JAMA, 2001; 286: 2823-2829.
115. Chin MH, Wang LC, Jin L, et al,. Appropriateness of medication selection for older persons in an urban academic emergency department. Acad Emerg Med, 1999; 6: 1232-1242.
116. Stuijt CCM, Franssen EJF, Egber ACG, Hudson SA,. Appropriateness of prescribing among elderly patients in a Dutch residential home: observational study of outcomes after a pharmacist-led medication review. Drugs Aging, 2008; 25: 947-954.
117. Steinman MA, Landefeld CS, Rosenthal GE, Berthenthal D, Sen S, Kaboli PJ,. Polypharmacy and prescribing quality in older people. J Am Geriatr Soc, 2006; 54: 1516-1523.
118. Goltz L, Kullak-Ublick GA, Kirch W,. Potentially inappropriate prescribing for elderly outpatients in Germany: a retrospective claims data analysis. Int J Clin Pharmacol Ther, 2012; 50: 185-194.
119. Amann U, Schmedt N, Garbe E,. Prescribing of potentially inappropriate medications for the elderly. Dtsch Arztebl Int, 2012; 109: 69-75.
120. Nyborg G, Straand J, Brekk M,. Inappropriate prescribing for the elderly-a modern epidemic? Eur J Clin Pharmacol, 2012; 68: 1085-1094.
121. Garcia-Ramos SE, Garcia-Poza P, Ramos-Diaz F,. Evaluaciõn de las prescripciones inapropiadas según los critérios de Beers en los servicios de cardiología y neumología hospitalários. Rev Calid Asist, 2012; 27: 169-174.
122. Luo R, Scullin C, Mullan AMP, Scott MG, McElnay JC,. Comparison of tools for the assessment of inappropriate prescribing in hospitalized older people. J Eval Clin Pract, 2012; 18: 1196-1202.
123. Mera F, Mestre D, Almeda J, Ferrera A, Formigac F, Farrerasd SR,. Paciente anciano y medicaciõn crõnica inapropiada en la comunidad ¿somos conscientes de ello? Rev Esp Geriatr Gerontol, 2011; 46: 125-130.
124. Dedhiya SD, Hancock E, Craig BA, Doebbeling CC, Thomas J 3rd,. Incident use and outcomes associated with potentially inappropriate medication use in older adults. Am J Geriatr Pharmacother, 2010; 8: 562-570.
125. Sakuma M, Morimoto T, Matsui K, et al,. Epidemiology of potentially inappropriate medication use in elderly patients in Japanese acute care hospitals. Pharmacoepidemiol Drug Saf, 2011; 20: 386-392.
126. Ruggiero C, Dell'Aquila G, Gasperini B, et al,. Potentially inappropriate drug prescriptions and risk of hospitalization among older, Italian, nursing home residents: the Ulisse project. Drugs Aging, 2010; 27: 747-758.
127. Starner CI, Norman SA, Reynolds RG, Gleason PP,. Effect of a retrospective drug utilization review on potentially inappropriate prescribing in the elderly. Am J Geriatr Pharmacother, 2009; 7: 11-19.
128. Radosevic N, Gantumur M, Vlahovic-Palcevski V,. Potentially inappropriate prescribing to hospitalized patients. Pharmacoepidemiol Drug Saf, 2008; 17: 733-737.
129. Hustey FM, Wallis N, Miller J,. Inappropriate prescribing in an older ED population. Am J Emerg Med, 2007; 25: 804-807.
130. Maio V, Hartmann CW, Poston S, Liu-Chen X, Diamond J, Arenson C,. Potentially inappropriate prescribing for elderly patients in 2 outpatient settings. Am J Med Qual, 2006; 21: 162-168.
131. van der Hooft CS, Jong GW, Dieleman JP, Verhamme KMC, van der Cammen T, Stricker BHC, Sturkenboom MCJM,. Inappropriate drug prescribing in older adults: the updated 2002 Beers criteria-a population-based cohort study. Br J Clin Pharmacol, 2005; 60: 137-144.
132. Rochon PA, Lane CJ, Bronskill SE, et al,. Potentially inappropriate prescribing in Canada relative to the US. Drugs Aging, 2004; 21: 939-947.
133. Goulding MR,. Inappropriate medication prescribing for elderly ambulatory care patients. Arch Intern Med, 2004; 164: 305-312.
134. Hanlon JT, Schmader KE, Boult C, et al,. Use of inappropriate prescription drugs by older people. J Am Geriatr Soc, 2002; 50: 26-34.
135. Aparasu RR, Sitzman SJ,. Inappropriate prescribing for elderly outpatients. Am J Health Syst Pharm, 1999; 56: 433-439.
136. Gallagher P, Lang PO, Cherubini A, et al,. Prevalence of potentially inappropriate prescribing in an acutely ill population of older patients admitted to six European hospitals. Eur J Clin Pharmacol, 2011; 67: 1175-1188.
137. De Wilde S, Carey IM, Harris T, Richards N, Victor C, Hilton SR, Cook DG,. Trends in potentially inappropriate prescribing amongst older UK primary care patients. Pharmacoepidemiol Drug Saf, 2007; 16: 658-667.
138. Barnett MJ, Perry PJ, Langstaff JD, Kaboli PJ,. Comparison of rates of potentially inappropriate medication use according to the Zhan criteria for VA versus private sector medicare HMOs. J Manag Care Pharm, 2006; 12: 362-370.
139. Roth MT, Ivey JL,. Self-reported medication use in community-residing older adults: a pilot study. Am J Geriatr Pharmacother, 2005; 3: 196-204.
140. Lane CJ, Bronskill SE, Sykora K, et al,. Potentially inappropriate prescribing in Ontario community-dwelling older adults and nursing home residents. J Am Geriatr Soc, 2004; 52: 861-866.
141. Raji MA, Ostir GV, Markides KS, Espino DV, Goodwin JS,. Potentially inappropriate medication use by elderly Mexican Americans. Ann Pharmacother, 2003; 37: 1197-1202.
142. Carey IM, De Wilde S, Harris T, Victor C, Richards N, Hilton SR, Cook DG,. What factors predict potentially inappropriate primary care prescribing in older people: analysis of UK primary care patient record database. Drugs Aging, 2008; 25: 693-706.