Faecal shedding of antimicrobial-resistant Clostridium difficile strains by dogs

Journal of Small Animal Practice

Volumn 56, Issue 3, 2015, Pages 190-195

  Alvarez Perez S ^a   Blanco, J L ^a   Pelaez T ^b,c   Lanzarot, M P ^a   Harmanus, C ^d   Kuijper, E ^d   Garcia M E ^a  

^a UNIVERSIDAD COMPLUTENSE DE MADRID   (Spain)

^b HOSPITAL GENERAL UNIVERSITARIO GREGORIO MARAÑÓN   (Spain)

^c SCHOOL OF MEDICINE   (Spain)

^d LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMALIA; BACTERIA (MICROORGANISMS); CANIS FAMILIARIS; CLOSTRIDIUM DIFFICILE;

ANTIINFECTIVE AGENT;

ANIMAL; ANTIBIOTIC RESISTANCE; ASYMPTOMATIC DISEASE; BACTERIAL SHEDDING; DOG; DOG DISEASE; DRUG EFFECTS; ENTEROCOLITIS, PSEUDOMEMBRANOUS; FECES; FEMALE; GENETICS; MALE; MICROBIAL SENSITIVITY TEST; MICROBIOLOGY; PEPTOCLOSTRIDIUM DIFFICILE; RIBOTYPING; VETERINARY;

ANIMALS; ANTI-BACTERIAL AGENTS; ASYMPTOMATIC DISEASES; BACTERIAL SHEDDING; CLOSTRIDIUM DIFFICILE; DOG DISEASES; DOGS; DRUG RESISTANCE, BACTERIAL; ENTEROCOLITIS, PSEUDOMEMBRANOUS; FECES; FEMALE; MALE; MICROBIAL SENSITIVITY TESTS; RIBOTYPING;

EID: 84924199147     PISSN: 00224510     EISSN: 17485827     Source Type: Journal    
DOI: 10.1111/jsap.12311     Document Type: Article

References (37)

1. Alcalá, L., Martín, A., Marín, M., et al. (2012) The undiagnosed cases of Clostridium difficile infection in a whole nation: where is the problem? Clinical Microbiology and Infection 18, E204-E213
2. Álvarez-Pérez, S., Blanco, J. L., Bouza, E., et al. (2009) Prevalence of Clostridium difficile in diarrhoeic and non-diarrhoeic piglets. Veterinary Microbiology 137, 302-305
3. Álvarez-Pérez, S., Blanco, J. L., Martínez-Nevado, E., et al. (2014) Shedding of Clostridium difficile PCR ribotype 078 by zoo animals, and report of an unstable metronidazole-resistant isolate from a zebra foal (Equus quagga burchellii). Veterinary Microbiology 169, 218-222
4. Álvarez-Pérez, S., Blanco, J. L., Peláez, T., et al. (2013) High prevalence of the epidemic Clostridium difficile PCR ribotype 078 in Iberian free-range pigs. Research in Veterinary Science 95, 358-361
5. Bartlett, J. G. & Gerding, D. N. (2008) Clinical recognition and diagnosis of Clostridium difficile infection. Clinical Infectious Diseases 46, S12-S18
6. Bauer, M. P., Notermans, D. W., van Benthem, B. H., et al. (2011) Clostridium difficile infection in Europe: a hospital-based survey. Lancet 377, 63-73
7. Bidet, P., Lalande, V., Salauze, B., et al. (2000) Comparison of PCR ribotyping, arbitrarily primed PCR, and pulsed-field gel electrophoresis for typing Clostridium difficile. Journal of Clinical Microbiology 38, 2484-2487
8. Blanco, J. L., Álvarez-Pérez, S. & García, M. E. (2013) Is Clostrium difficile prevalence in animals underestimated? Veterinary Journal 197, 694-698
9. Clinical and Laboratory Standards Institute (CLSI). (2007) Methods for Antimicrobial Susceptibility Testing of Anaerobic Bacteria. Approved standard M11-A7. 7th edn. Wayne, PA: CLSI
10. Drudy, D., Quinn, T., O'Mahony, R., et al. (2006) High-level resistance to moxifloxacin and gatifloxacin associated with a novel mutation in gyrB in toxin-A-negative, toxin-B-positive Clostridium difficile. Journal of Antimicrobial Chemotherapy 58, 1264-1267
11. Goorhuis, A., Bakker, D., Corver, J., et al. (2008) Emergence of Clostridium difficile infection due to a new hypervirulent strain, polymerase chain reaction ribotype 078. Clinical Infectious Diseases 47, 1162-1170
12. Guardabassi, L., Schwarz, S., Lloyd, D. H. (2004) Pet animals as reservoirs of antimicrobial-resistant bacteria. Journal of Antimicrobial Chemotherapy 54, 321-332
13. Hensgens, M. P., Keessen, E. C., Squire, M. M., et al. (2012) Clostridium difficile infection in the community: a zoonotic disease? Clinical Microbiology and Infection 18, 635-645
14. Janezic, S., Ocepek, M., Zidaric, V., et al. (2012) Clostridium difficile genotypes other than ribotype 078 that are prevalent among human, animal and environmental isolates. BMC Microbiology 12, 48
15. Keessen, E. C., Gaastra, W. & Lipman, L. J. (2011) Clostridium difficile infection in human and animals, differences and similarities. Veterinary Microbiology 153, 205-217
16. Keessen, E. C. & Lipman, L. J. (2012) Clostridium difficile transmission risks for humans through diseased animals and symptomless but colonized animals. Wiener Tierärztliche Monatsschrift 99, 286-297
17. Khanna, S., Pardi, D. S., Aronson, S. L., et al. (2012) The epidemiology of community-acquired Clostridium difficile infection: a population-based study. American Journal of Gastroenterology 107, 89-95
18. Lawhon, S. D., Taylor, A., Fajt, V. R. (2013) Frequency of resistance in obligate anaerobic bacteria isolated from dogs, cats, and horses to antimicrobial agents. Journal of Clinical Microbiology 51, 3804-3810
19. Lefebvre, S. L., Arroyo, L. G., Weese, J. S. (2006a) Epidemic Clostridium difficile strain in hospital visitation dog. Emerging Infectious Diseases 12, 1036-1037
20. Lefebvre, S. L., Waltner-Toews, D., Peregrine, A. S., et al. (2006b) Prevalence of zoonotic agents in dogs visiting hospitalized people in Ontario: implications for infection control. Journal of Hospital Infection 62, 458-466
21. Marks, S. L. & Kather, E. J. (2003) Antimicrobial susceptibilities of canine Clostridium difficile and Clostridium perfringens isolates to commonly utilized antimicrobial drugs. Veterinary Microbiology 94, 39-45
22. Marks, S. L. (2007) Bacterial-associated diarrhoea in dogs and cats. Proceedings of the 32nd Annual World Small Animal Veterinary Association (WSAVA) Congress. 23-27 August, Sydney, Australia
23. Peláez, T., Alcalá, L., Blanco, J. L., et al. (2013) Characterisation of swine isolates of Clostridium difficile in Spain: a potential source of hypervirulent multidrug resistant strains? Anaerobe 22, 45-49
24. Peláez, T., Cercenado, E., Alcalá, L., et al. (2008) Metronidazole resistance in Clostridium difficile is heterogeneous. Journal of Clinical Microbiology 46, 3028-3032
25. Pirš, T., Avberšek, J., Zdovc, I., et al. (2013) Antimicrobial susceptibility of animal and human isolates of Clostridium difficile by broth microdilution. Journal of Medical Microbiology 62, 1478-1485
26. Schneeberg, A., Rupnik, M., Neubauer, H., et al. (2012) Prevalence and distribution of Clostridium difficile PCR ribotypes in cats and dogs from animal shelters in Thuringia, Germany. Anaerobe 18, 484-488
27. Songer, J. G., Trinh, H. T., Killgore, G. E., et al. (2009) Clostridium difficile in retail meat products, USA, 2007. Emerging Infectious Diseases 15, 819-821
28. Stubbs, S., Rupnik, M., Gibert, M., et al. (2000) Production of actin-specific ADP-ribosyltransferase (binary toxin) by strains of Clostridium difficile. FEMS Microbiology Letters 186, 307-312
29. Thakur, S., Putnam, M., Fry, P. R., et al. (2010) Prevalence of antimicrobial resistance and association with toxin genes in Clostridium difficile in commercial swine. American Journal of Veterinary Research 71, 1189-1194
30. Walk, S. T., Micic, D., Jain, R., et al. (2012) Clostridium difficile ribotype does not predict severe infection. Clinical Infectious Diseases 55, 1661-1668
31. Weese, J. S., Staempfli, H. R., Prescott, J. F., et al. (2001) The roles of Clostridium difficile and enterotoxigenic Clostridium perfringens in diarrhea in dogs. Journal of Veterinary Internal Medicine 15, 374-378
32. Weese, J. S. & Armstrong, J. (2003) Outbreak of Clostridium difficile-associated disease in a small animal veterinary teaching hospital. Journal of Veterinary Internal Medicine 17, 813-816
33. Weese, J. S., Finley, R., Reid-Smith, R. R., et al. (2010a) Evaluation of Clostridium difficile in dogs and the household environment. Epidemiology and Infection 138, 1100-1104
34. Weese, J. S., Wakeford, T., Reid-Smith, R., et al. (2010b) Longitudinal investigation of Clostridium difficile shedding in piglets. Anaerobe 16, 501-504
35. Wetterwik, K. J., Trowald-Wigh, G., Fernström, L. L., et al. (2013) Clostridium difficile in faeces from healthy dogs and dogs with diarrhea. Acta Veterinaria Scandinavica 55, 23
36. World Health Organization. (1998) Use of quinolones in food animals and potential impact on human health. Report of a WHO meeting, Geneva. http://whqlibdoc.who.int/hq/1998/WHO_EMC_ZDI_98.10.pdf. Accessed 6 May 2014
37. Zidaric, V., Pardon, B., Dos Vultos, T., et al. (2012) Different antibiotic resistance and sporulation properties within multiclonal Clostridium difficile PCR ribotypes 078, 126, and 033 in a single calf farm. Applied and Environmental Microbiology 78, 8515-8522