Clostridium difficile transmission risks for humans through diseased animals and symptomless but colonized animals

Wiener Tierarztliche Monatsschrift

Volumn 99, Issue 11-12, 2012, Pages 286-297

  Keessen, E C ^a   Lipman, L J A ^a  

^a UTRECHT UNIVERSITY   (Netherlands)

Author keywords

C. diff cile; Food microbiology; Occupational disease; Zoonosis

Indexed keywords

EID: 84875207636     PISSN: 0043535X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (125)

1. AL SAIF, N., BRAZIER, J. S. (1996): The distribution of Clostridium difficile in the environment of South Wales. J Med Microbiol 45, 133-137. (Pubitemid 26291483)
2. ALVAREZ-PEREZ, S., BLANCO, J. L., BOUZA, E., ALBA, P., GIBERT, X., MALDONADO, J., GARCIA, M. E. (2009): Prevalence of Clostridium difficile in diarrhoeic and non-diarrhoeic piglets. Vet Microbiol 137, 302-305.
3. ARFONS, L., RAY, A. J., DONSKEY, C. J. (2005): Clostridium difficile infection among health care workers receiving antibiotic therapy. Clin Infect Dis 40, 1384-1385. (Pubitemid 40570259)
4. ARROYO, L. G., STAMPFLI, H. R., WEESE, J. S. (2006): Potential role of Clostridium difficile as a cause of duodenitis-proximal jejunitis in horses. J Med Microbiol 55, 605-608.
5. ARROYO, L. G., STAEMPFLI, H., WEESE, J. S. (2007): Molecular analysis of Clostridium difficile isolates recovered from horses with diarrhoea. Vet Microbiol 120, 179-183. (Pubitemid 46149211)
6. ARROYO, L. G., WEESE, J. S., STAEMPFLI, H. R. (2004): Experimental Clostridium difficile enterocolitis in foals. J Vet Intern Med 18, 734-738. (Pubitemid 39406879)
7. AVBERSEK, J., JANEZIC, S., PATE, M., RUPNIK, M., ZIDARIC, V., LOGAR, K., VENGUST, M., ZEMLJIC, M., PIRS, T., OCEPEK, M. (2009): Diversity of Clostridium difficile in pigs and other animals in Slovenia. Anaerobe 15, 252-255.
8. BAKRI, M. M., BROWN, D. J., BUTCHER, J. P., SUTHERLAND, A. D. (2009): Clostridium difficile in ready-to-eat salads, Scotland. Emerg Infect Dis 15, 817-818.
9. BARTLETT, J. G., MOON, N., CHANG, T. W., TAYLOR, N., ONDERDONK, A. B. (1978): Role of Clostridium difficile in antibiotic-associated pseudomembranous colitis. Gastroenterology 75, 778-782. (Pubitemid 9040959)
10. BAUER, M. P., NOTERMANS, D. W., VAN BENTHEM, B. H., BRAZIER, J. S., WILCOX, M. H., RUPNIK, M., MONNET, D. L., VAN DISSEL, J. T., KUIJPER, E. J., ECDIS STUDY GROUP (2011): Clostridium difficile infection in Europe: a hospital-based survey. Lancet 377, 63-73.
11. BAUER, M. P., VAN DISSEL, J. T. (2009a): Alternative strategies for Clostridium difficile infection. Int J Antimicrob Ag 33(Suppl 1), S51-6.
12. BAUER, M. P., VEENENDAAL, D., VERHOEF, L., BLOEMBERGEN, P., VAN DISSEL, J. T., KUIJPER, E. J. (2009b): Clinical and microbiological characteristics of community-onset Clostridium difficile infection in The Netherlands. Clin Microbiol Infect 15, 1087-1092.
13. BAVERUD, V., GUSTAFSSON, A., FRANKLIN, A., ASPAN, A., GUNNARSSON, A. (2003): Clostridium difficile: prevalence in horses and environment, and antimicrobial susceptibility. Equine Vet J 35, 465-471. (Pubitemid 38698708)
14. BAVERUD, V., GUSTAFSSON, A., FRANKLIN, A., LINDHOLM, A., GUNNARSSON, A. (1997): Clostridium difficile associated with acute colitis in mature horses treated with antibiotics. Equine Vet J 29, 279-284. (Pubitemid 127519409)
15. BIGNARDI, G. E., SETTLE, C. (2008): Different ribotypes in community-acquired Clostridium difficile. J Hosp Infect 70, 96-98.
16. BOBULSKY, G. S., AL-NASSIR, W. N., RIGGS, M. M., SETHI, A. K., DONSKEY, C. J. (2008): Clostridium difficile skin contamination in patients with C. difficile-associated disease. Clin Infect Dis 46, 447-450. (Pubitemid 351263530)
17. BORRIELLO, S. P., HONOUR, P., TURNER, T., BARCLAY, F. (1983): Household pets as a potential reservoir for Clostridium difficile infection. J Clin Pathol 36, 84-87. (Pubitemid 13177657)
18. BOUTTIER, S., BARC, M. C., FELIX, B., LAMBERT, S., COLLIGNON, A., BARBUT, F. (2010): Clostridium difficile in ground meat, France. Emerg Infect Dis 16, 733-735.
19. BOUZA, E., MARTIN, A., VAN DEN BERG, R. J., KUIJPER, E. J. (2008): Laboratory-acquired Clostridium difficile polymerase chain reaction ribotype 027: a new risk for laboratory workers? Clin Inf Dis 47, 1493-1494.
20. BRAKOVICH, B., BONHAM, E., VANBRACKLE, L. (2012): War on the spore: Clostridium difficile disease among patients in a longterm acute care hospital. J Healthc Qual, doi: 10.1111/j.1945-1474.2011.00182.x.
21. CHOUICHA, N., MARKS, S. L. (2006): Evaluation of five enzyme immunoassays compared with the cytotoxicity assay for diagnosis of Clostridium difficile-associated diarrhoea in dogs. J Vet Diagnost Invest 18, 182-188.
22. CLOOTEN, J., KRUTH, S., ARROYO, L., WEESE, J. S. (2008): Prevalence and risk factors for Clostridium difficile colonization in dogs and cats hospitalized in an intensive care unit. Vet Microbiol 129, 209-214.
23. COHEN, S. H., GERDING, D. N., JOHNSON, S., KELLY, C. P., LOO, V. G., MCDONALD, L. C., PEPIN, J., WILCOX, M. H., SOCIETY FOR HEALTHCARE EPIDEMIOLOGY OF AMERICA, INFECTIOUS DISEASES SOCIETY OF AMERICA (2010): Clinical practice guidelines for Clostridium difficile infection in adults: 2010 update by the society for healthcare epidemiology of America (SHEA) and the infectious diseases society of America (IDSA). Infect Cont Hosp Ep 31, 431-455.
24. CROBACH, M. J. T., DEKKERS, O. M., WILCOX, M. H., KUIJPER, E. J. (2009): European Society of Clinical Microbiology and Infectious Diseases (ESCMID): Data review and recommendations for diagnosing Clostridium difficile-infection (CDI). Clin Microbiol Infect 15, 1053-1066.
25. CRUMP, J. A., BRADEN, C. R., DEY, M. E., HOEKSTRA, R. M., RICKELMAN-APISA, J. M., BALDWIN, D. A., DE FIJTER, S. J., NOWICKI, S. F., KOCH, E. M., BANNERMAN, T. L., SMITH, F. W., SARISKY, J. P., HOCHBERG, N., MEAD, P. S. (2003): Outbreaks of Escherichia coli O157 infections at multiple county agricultural fairs: a hazard of mixing cattle, concession stands and children. Epidemiol Infect 131, 1055-1062. (Pubitemid 38195577)
26. CRUMP, J. A., SULKA, A. C., LANGER, A. J., SCHABEN, C., CRIELLY, A. S., GAGE, R., BAYSINGER, M., MOLL, M., WITHERS, G., TONEY, D. M., HUNTER, S. B., HOEKSTRA, R. M., WONG, S. K., GRIFFIN, P. M., VAN GILDER, T. J. (2002): An outbreak of Escherichia coli O157:H7 infections among visitors to a dairy farm. New Eng J Med 347, 555-560.
27. DE BOER, E., ZWARTKRUIS-NAHUIS, A., HEUVELINK, A. E., HARMANUS, C., KUIJPER, E. J. (2011): Prevalence of Clostridium difficile in retailed meat in the Netherlands. Int J Food Microbiol 144, 561-564.
28. DEBAST, S. B., VAN LEENGOED, L. A., GOORHUIS, A., HARMANUS, C., KUIJPER, E. J., BERGWERFF, A. A. (2009): Clostridium difficile PCR ribotype 078 toxinotype V found in diarrhoeal pigs identical to isolates from affected humans. Environ Microbiol 11, 505-511.
29. DUBBERKE, E. R., RESKE, K. A., NOBLE-WANG, J., THOMPSON, A., KILLGORE, G., MAYFIELD, J., CAMINS, B., WOELTJE, K., MCDONALD, J. R., MCDONALD, L. C., FRASER, V. J. (2007): Prevalence of Clostridium difficile environmental contamination and strain variability in multiple health care facilities. Am J Inf Cont 35, 315-318. (Pubitemid 46907328)
30. DURSO, L. M., REYNOLDS, K., BAUER, N., JR, KEEN, J. E. (2005): Shiga-toxigenic Escherichia coli O157:H7 infections among livestock exhibitors and visitors at a Texas County Fair. Vector Borne Zoonotic Dis 5, 193-201. (Pubitemid 41149692)
31. EASTWOOD, K., ELSE, P., CHARLETT, A., WILCOX, M. (2009): Comparison of nine commercially available Clostridium difficile toxin detection assays, a real-time PCR assay for C. difficile tcdB, and a glutamate dehydrogenase detection assay to cytotoxin testing and cytotoxigenic culture methods. J Clin Microbiol 47, 3211-3217.
32. FREEMAN, J., BAUER, M. P., BAINES, S. D., CORVER, J., FAWLEY, W. N., GOORHUIS, B., KUIJPER, E. J., WILCOX, M. H. (2010): The changing epidemiology of Clostridium difficile infections. Clin Microbiol Rev 23, 529-549.
33. FRIEDMAN, C. R., TORIGIAN, C., SHILLAM, P. J., HOFFMAN, R. E., HELTZEL, D., BEEBE, J. L., MALCOLM, G., DEWITT, W. E., HUTWAGNER, L., GRIFFIN, P. M. (1998): An outbreak of salmonellosis among children attending a reptile exhibit at a zoo. J Pediatr 132, 802v807.
34. GERDING, D. N. (2009): Clostridium difficile 30 years on: what has, or has not, changed and why? Int J Antimicrob Ag 33(Suppl 1), S2-8.
35. GERDING, D. N., MUTO, C. A., OWENS, R. C., JR (2008): Measures to control and prevent Clostridium difficile infection. Clin Inf Dis 46(Suppl 1), S43-49. (Pubitemid 351323664)
36. GOORHUIS, A., BAKKER, D., CORVER, J., DEBAST, S. B., HARMANUS, C., NOTERMANS, D. W., BERGWERFF, A. A., DEKKER, F. W., KUIJPER, E. J. (2008): Emergence of Clostridium difficile infection due to a new hypervirulent strain, polymerase chain reaction ribotype 078. Clin Inf Dis 47, 1162-1170.
37. GOULD, L. H., LIMBAGO, B. (2010): Clostridium difficile in food and domestic animals: a new foodborne pathogen? Clin Inf Dis 51, 577-582.
38. HAMMITT, M. C., BUESCHEL, D. M., KEEL, M. K., GLOCK, R. D., CUNEO, P., DEYOUNG, D. W., REGGIARDO, C., TRINH, H. T., SONGER, J. G. (2008): A possible role for Clostridium difficile in the etiology of calf enteritis. Vet Microbiol 127, 343-352. (Pubitemid 351173516)
39. HARVEY, R. B., NORMAN, K. N., ANDREWS, K., HUME, M. E., SCANLAN, CM., CALLAWAY, T. R., ANDERSON, R. C., NISBET, D. J. (2011): Clostridium difficile in poultry and poultry meat. Foodborne Pathogens and Disease 8, 1321-1323.
40. HELL, M., INDRA, A., HUHULESCU, S., ALLERBERGER, F. (2009): Clostridium difficile Infection in a health care worker. Clin Inf Dis 48, 1329.
41. HENSGENS, M. P., KEESSEN, E. C., SQUIRE, M. M., RILEY, T. V., KOENE, M. G., DE BOER, E., LIPMAN, L. J., KUIJPER, E. J.; on behalf of European Society of Clinical Microbiology and Infectious Diseases Study Group for Clostridium difficile (ESGCD) (2012): Clostridium difficile infection in the community: a zoonotic disease? Clin Inf Dis 18, 635-645.
42. HOFFER, E., HAECHLER, H., FREI, R., STEPHAN, R. (2010): Low occurrence of Clostridium difficile in fecal samples of healthy calves and pigs at slaughter and in minced meat in Switzerland. J Food Protect 73, 973-975.
43. HOPMAN, N. E., KEESSEN, E. C., HARMANUS, C., SANDERS, I. M., VAN LEENGOED, L. A., KUIJPER, E. J., LIPMAN, L. J. (2011): Acquisition of Clostridium difficile by piglets. Vet Microbiol 149, 186-192.
44. HUHULESCU, S., KISS, R., BRETTLECKER, M., CERNY, R. J., HESS, C., WEWALKA, G., ALLERBERGER, F. (2009): Etiology of acute gastroenteritis in three sentinel general practices, Austria 2007. Infection 37, 103-108.
45. INDRA, A., LASSNIG, H., BALIKO, N., MUCH, P., FIEDLER, A., HUHULESCU, S., ALLERBERGER, F. (2009): Clostridium difficile: a new zoonotic agent? Wien Klin Wochenschr 121, 91-95.
46. JOBSTL, M., HEUBERGER, S., INDRA, A., NEPF, R., KOFER, J., WAGNER, M. (2010): Clostridium difficile in raw products of animal origin. Int Journal Food Microbiol 138, 172-175.
47. KATO, H., KITA, H., KARASAWA, T., MAEGAWA, T., KOINO, Y., TAKAKUWA, H., SAIKAI, T., KOBAYASHI, K., YAMAGISHI, T., NAKAMURA, S. (2001): Colonisation and transmission of Clostridium difficile in healthy individuals examined by PCR ribotyping and pulsed-field gel electrophoresis. J Med Microbiol 50, 720-727. (Pubitemid 32664902)
48. KEEL, K., BRAZIER, J. S., POST, K. W., WEESE, S., SONGER, J. G. (2007): Prevalence of PCR Ribotypes among Clostridium difficile Isolates from Pigs, Calves, and Other Species. J Clin Microbiol 45, 1963-1964. (Pubitemid 46933933)
49. KEESSEN, E. C., LEENGOED, L. A., BAKKER, D., VAN DEN BRINK, K. M., KUIJPER, E. J., LIPMAN, L. J. (2010): Prevalence of Clostridium difficile in swine thought to have Clostridium difficile infections (CDI) in eleven swine operations in the netherlands. Tijdschr Diergeneeskd 135, 134-137.
50. KEESSEN, E. C., DONSWIJK, C. J., HOL, S. P., HERMANUS, C., KUIJPER, E. J., LIPMAN, L. J. (2011a): Aerial dissemination of Clostridium difficile on a pig farm and its environment. Environ Res 111, 1027-1032.
51. KEESSEN, E. C., HOPMAN, N. E., VAN LEENGOED, L. A., VAN ASTEN, A. J., HERMANUS, C., KUIJPER, E. J., LIPMAN, L. J. (2011b): Evaluation of four different diagnostic tests to detect Clostridium difficile in piglets. J Clin Microbiol 49, 1816-1821.
52. KEESSEN, E. C., VAN DEN BERKT, A. J., HAASJES, N. H., HERMANUS, C., KUIJPER, E. J., LIPMAN, L. J. (2011c): The relation between farm specific factors and prevalence of Clostridium difficile in slaughter pigs. Vet Microbiol 154, 130-134.
53. KELLY, C. P., LAMONT, J. T. (1998): Clostridium difficile infection. Annual Review of Medicine 49, 375-390. (Pubitemid 28197461)
54. KIM, J., SMATHERS, S. A., PRASAD, P., LECKERMAN, K. H., COFFIN, S., ZAOUTIS, T. (2008): Epidemiological features of Clostridium difficile-associated disease among inpatients at children's hospitals in the United States, 2001-2006. Pediatrics 122, 1266-1270.
55. KOENE, M. G., MEVIUS, D., WAGENAAR, J. A., HARMANUS, C., HENSGENS, M. P., MEETSMA, A. M., PUTIRULAN, F. F., VAN BERGEN, M. A., KUIJPER, E. J. (2011): Clostridium difficile in Dutch animals: their presence, characteristics and similarities with human isolates. Clin Inf Dis, doi: 10.1111/j.1469-0691.2011. 03651.x
56. KUIJPER, E. J., COIGNARD, B., BRAZIER, J. S., SUETENS, C., DRUDY, D., WIUFF, C., PITUCH, H., REICHERT, P., SCHNEIDER, F., WIDMER, A. F., OLSEN, K. E., ALLERBERGER, F., NOTERMANS, D. W., BARBUT, F., DELMEE, M., WILCOX, M., PEARSON, A., PATEL, B. C., BROWN, D. J., FREI, R., AKERLUND, T., POXTON, I. R., TULL, P. (2007): Update of Clostridium difficile-associated disease due to PCR ribotype 027 in Europe. Euro surveillance: bulletin europeen sur les maladies transmissibles = European communicable disease bulletin 12, E1-2.
57. KUIJPER, E. J., COIGNARD, B., TULL, P., ESCMID STUDY GROUP FOR Clostridium difficile, EU MEMBER STATES, EUROPEAN CENTRE FOR DISEASE PREVENTION AND CONTROL (2006): Emergence of Clostridium difficile-associated disease in North America and Europe. Clin Inf Dis 12(Suppl 6), 2-18.
58. KUIJPER, E. J., VAN DISSEL, J. T. (2008): Spectrum of Clostridium difficile infections outside health care facilities. CMAJ: Can Med Assoc J 179, 747-748.
59. LANZAS, C., DUBBERKE, E. R., LU, Z., RESKE, K. A., GROHN, Y. T. (2011): Epidemiological model for Clostridium difficile transmission in healthcare settings. Infect Cont Hosp Ep 32, 553-561.
60. LAWLEY, T. D., CLARE, S., WALKER, A. W., GOULDING, D., STABLER, R. A., CROUCHER, N., MASTROENI, P., SCOTT, P., RAISEN, C., MOTTRAM, L., FAIRWEATHER, N. F., WREN, B. W., PARKHILL, J., DOUGAN, G. (2009): Antibiotic treatment of Clostridium difficile carrier mice triggers a supershedder state, spore-mediated transmission, and severe disease in immunocompromised hosts. Infect Immun 77, 3661-3669.
61. LEFEBVRE, S. L., REID-SMITH, R. J., WALTNER-TOEWS, D., WEESE, J. S. (2009): Incidence of acquisition of methicillin-resistant Staphylococcus aureus, Clostridium difficile, and other health-care-associated pathogens by dogs that participate in animal-assisted interventions. J Am Vet Med Assoc 234, 1404-1417.
62. LIMBAGO, B. M., LONG, CM., THOMPSON, A. D., KILLGORE, G. E., HANNETT, G. E., HAVILL, N. L., MICKELSON, S., LATHROP, S., JONES, T. F., PARK, M. M., HARRIMAN, K. H., GOULD, L. H., MCDONALD, L. C., ANGULO, F. J. (2009): Clostridium difficile strains from community-associated infections. J Clin Microbiol 47, 3004-3007.
63. LOO, V. G., POIRIER, L., MILLER, M. A., OUGHTON, M., LIBMAN, M. D., MICHAUD, S., BOURGAULT, A. M., NGUYEN, T., FRENETTE, C., KELLY, M., VIBIEN, A., BRASSARD, P., FENN, S., DEWAR, K., HUDSON, T. J., HORN, R., RENE, P., MONCZAK, Y., DASCAL, A. (2005): A predominantly clonal multi-institutional outbreak of Clostridium difficile-associated diarrhoea with high morbidity and mortality. New England J Med 353, 2442-2449. (Pubitemid 41770165)
64. MADEWELL, B. R., BEA, J. K., KRAEGEL, S. A., WINTHROP, M., TANG, Y. J., SILVA, J., JR (1999): Clostridium difficile: a survey of fecal carriage in cats in a veterinary medical teaching hospital. J Vet Diagnost Invest 11, 50-54. (Pubitemid 129693011)
65. MADEWELL, B. R., TANG, Y. J., JANG, S., MADIGAN, J. E., HIRSH, D. C., GUMERLOCK, P. H., SILVA, J., JR (1995): Apparent outbreaks of Clostridium difficile-associated diarrhoea in horses in a veterinary medical teaching hospital. J Vet Diagnost Invest 7, 343-346.
66. MAGDESIAN, K. G., DUJOWICH, M., MADIGAN, J. E., HANSEN, L. M., HIRSH, D. C., JANG, S. S. (2006): Molecular characterization of Clostridium difficile isolates from horses in an intensive care unit and association of disease severity with strain type. J Am Vet Med Assoc 228, 751-755. (Pubitemid 43352519)
67. MARKS, S. L., KATHER, E. J., KASS, P. H., MELLI, A. C. (2002): Genotypic and phenotypic characterization of Clostridium perfringens and Clostridium difficile in diarrheic and healthy dogs. J Vet Intern Med 16, 533-540. (Pubitemid 135747431)
68. MARSH, J. W., TULENKO, M. M., SHUTT, K. A., THOMPSON, A. D., WEESE, J. S., SONGER, J. G., LIMBAGO, B. M., HARRISON, L. H. (2011): Multi-locus variable number tandem repeat analysis for investigation of the genetic association of Clostridium difficile isolates from food, food animals and humans. Anaerobe 17, 156-160.
69. MCDONALD, L. C., COIGNARD, B., DUBBERKE, E., SONG, X., HORAN, T., KUTTY, P. K., AD HOC Clostridium difficile SURVEILLANCE WORKING GROUP (2007): Recommendations for surveillance of Clostridium difficile-associated disease. Infect Control Hosp Ep 28, 140-145. (Pubitemid 46374153)
70. MCDONALD, L. C., KILLGORE, G. E., THOMPSON, A., OWENS, R. C., JR, KAZAKOVA, S. V., SAMBOL, S. P., JOHNSON, S., GERDING, D. N. (2005): An epidemic, toxin gene-variant strain of Clostridium difficile. New England J Med 353, 2433-2441. (Pubitemid 41770164)
71. MCNAMARA, S. E., ABDUJAMILOVA, N., SOMSEL, P., GORDONCILLO, M. J., DEDECKER, J. M., BARTLETT, P. C. (2010): Carriage of Clostridium difficile and Other Enteric Pathogens Among a 4-H Avocational Cohort. Zoonoses and Public Health 58, 192-199.
72. MEADER, E., MAYER, M. J., GASSON, M. J., STEVERDING, D., CARDING, S. R., NARBAD, A. (2010): Bacteriophage treatment significantly reduces viable Clostridium difficile and prevents toxin production in an In vitro model system. Anaerobe 16, 549-554.
73. MERRIGAN, M. M., SAMBOL, S. P., JOHNSON, S., GERDING, D. N. (2003): Prevention of fatal Clostridium difficile-associated disease during continuous administration of clindamycin in hamsters. J Inf Dis 188, 1922-1927. (Pubitemid 38064879)
74. METCALF, D., AVERY, B. P., JANECKO, N., MATIC, N., REID-SMITH, R., WEESE, J. S. (2011): Clostridium difficile in seafood and fish. Anaerobe 17, 85-86.
75. METCALF, D., REID-SMITH, R. J., AVERY, B. P., WEESE, J. S. (2010): Prevalence of Clostridium difficile in retail pork. Can Vet J 1, 873-876.
76. NORMAN, K. N., HARVEY, R. B., SCOTT, H. M., HUME, M. E., ANDREWS, K., BRAWLEY, A. D. (2009): Varied prevalence of Clostridium difficile in an integrated swine operation. Anaerobe 15, 256-260.
77. OTTER, J. A., YEZLI, S., FRENCH, G. L. (2011): The role played by contaminated surfaces in the transmission of nosocomial pathogens. Infect Cont Hosp Ep 32, 687-699.
78. OUGHTON, M. T., LOO, V. G., DENDUKURI, N., FENN, S., LIBMAN, M. D. (2009): Hand hygiene with soap and water is superior to alcohol rub and antiseptic wipes for removal of Clostridium difficile. Infect Cont Hosp Ep 30, 939-944.
79. OZAKI, E., KATO, H., KITA, H., KARASAWA, T., MAEGAWA, T., KOINO, Y., MATSUMOTO, K., TAKADA, T., NOMOTO, K., TANAKA, R., NAKAMURA, S. (2004): Clostridium difficile colonization in healthy adults: transient colonization and correlation with enterococcal colonization. J Med Microbiol 53, 167-172. (Pubitemid 38223698)
80. PEPIN, J., VALIQUETTE, L., ALARY, M. E., VILLEMURE, P., PELLETIER, A., FORGET, K., PEPIN, K., CHOUINARD, D. (2004): Clostridium difficile-associated diarrhoea in a region of Quebec from 1991 to 2003: a changing pattern of disease severity. Can Med Assoc J 171, 466-472. (Pubitemid 39179608)
81. PERRIN, J., BUOGO, C., GALLUSSER, A., BURNENS, A. P., NICOLET, J. (1993): Intestinal carriage of Clostridium difficile in neonate dogs. J Vet Med B 40, 222-226.
82. PLANCHE, T., AGHAIZU, A., HOLLIMAN, R., RILEY, P., POLONIECKI, J., BREATHNACH, A., KRISHNA, S. (2008): Diagnosis of Clostridium difficile infection by toxin detection kits: a systematic review. Lancet Inf Dis 8, 777-784.
83. RAMESH, V., FRALICK, J. A., ROLFE, R. D. (1999): Prevention of Clostridium difficile-induced ileocecitis with bacteriophage. Anaerobe 5(2), 69-78. (Pubitemid 29431598)
84. RIGGS, M. M., SETHI, A. K., ZABARSKY, T. F., ECKSTEIN, E. C., JUMP, R. L., DONSKEY, C. J. (2007): Asymptomatic carriers are a potential source for transmission of epidemic and nonepidemic Clostridium difficile strains among long-term care facility residents. Clin Inf Dis 45, 992-998. (Pubitemid 47580347)
85. RILEY, T. V., ADAMS, J. E., O'NEILL, G. L., BOWMAN, R. A. (1991): Gastrointestinal carriage of Clostridium difficile in cats and dogs attending veterinary clinics. Epidemiol Infect 107, 659-665.
86. RODRIGUEZ-PALACIOS, A., REID-SMITH, R. J., STAEMPFLI, H. R., WEESE, J. S. (2010): Clostridium difficile survives minimal temperature recommended for cooking ground meats. Anaerobe 16, 540-542.
87. RODRIGUEZ-PALACIOS, A., REID-SMITH, R. J., STAEMPFLI, H. R., DAIGNAULT, D., JANECKO, N., AVERY, B. P., MARTIN, H., THOMSPON, A. D., MCDONALD, L. C., LIMBAGO, B., WEESE, J. S. (2009): Possible seasonality of Clostridium difficile in retail meat, Canada. Emerging infectious diseases 15, 802-805.
88. RODRIGUEZ-PALACIOS, A., STAMPFLI, H. R., DUFFIELD, T., PEREGRINE, A. S., TROTZ-WILLIAMS, L. A., ARROYO, L. G., BRAZIER, J. S., WEESE, J. S. (2006): Clostridium difficile PCR ribotypes in calves, Canada. Emerg Infect Dis 12, 1730-1736. (Pubitemid 44674250)
89. RODRIGUEZ-PALACIOS, A., STAEMPFLI, H. R., DUFFIELD, T., WEESE, J. S. (2007): Clostridium difficile in retail ground meat, Canada. Emerg Infect Dis 13, 485-487. (Pubitemid 46348139)
90. ROHDE, C. L., BARTOLINI, V., JONES, N. (2009): The use of probiotics in the prevention and treatment of antibiotic-associated diarrhoea with special interest in Clostridium difficile-associated diarrhoea. Nutr Clin Pract 24, 33-40.
91. ROUPHAEL, N. G., O'DONNELL, J. A., BHATNAGAR, J., LEWIS, F., POLGREEN, P. M., BEEKMANN, S., GUARNER, J., KILLGORE, G. E., COFFMAN, B., CAMPBELL, J., ZAKI, S. R., MCDONALD, L. C. (2008): Clostridium difficile-associated diarrhoea: an emerging threat to pregnant women. Am J Obstet Gynecol 198, 635. e1-635.e6.
92. RUBY, R., MAGDESIAN, K. G., KASS, P. H. (2009): Comparison of clinical, microbiologic, and clinicopathologic findings in horses positive and negative for Clostridium difficile infection. J Am Vet Med Assoc 234, 777-784.
93. RUPNIK, M. (2007): Is Clostridium difficile-associated infection a potentially zoonotic and foodborne disease? Clin Microbiol Infect 13, 457-459. (Pubitemid 46563496)
94. RUPNIK, M. (2010): Clostridium difficile: (re) emergence of zoonotic potential. Clin Inf Dis 51, 583-584.
95. RUPNIK, M., WILCOX, M. H., GERDING, D. N. (2009): Clostridium difficile infection: new developments in epidemiology and pathogenesis. Nat Rev Microbiol 7, 526-536.
96. RUTALA, W. A., STIEGEL, M. M., SARUBBI, F. A., WEBER, D. J. (1997): Susceptibility of antibiotic-susceptible and antibioticresistant hospital bacteria to disinfectants. Infect Cont Hosp Ep 18, 417-421. (Pubitemid 127470991)
97. SAMBOL, S. P., MERRIGAN, M. M., TANG, J. K., JOHNSON, S., GERDING, D. N. (2002): Colonization for the prevention of Clostridium difficile disease in hamsters. J Inf Dis 186, 1781-1789. (Pubitemid 35463511)
98. SETHI, A. K., AL-NASSIR, W. N., NERANDZIC, M. M., BOBULSKY, G. S., DONSKEY, C. J. (2010): Persistence of skin contamination and environmental shedding of Clostridium difficile during and after treatment of C. difficile infection. Infect Cont Hosp Ep 31, 21-27.
99. SIMANGO, C. (2006): Prevalence of Clostridium difficile in the environment in a rural community in Zimbabwe. Transactions of the Royal Society of Tropical Medicine and Hygiene 100, 1146-1150. (Pubitemid 44478721)
100. SIMANGO, C., MWAKURUDZA, S. (2008): Clostridium difficile in broiler chickens sold at market places in Zimbabwe and their antimicrobial susceptibility. Int J Food Microbiol 124, 268-270.
101. SMITH, K. E., STENZEL, S. A., BENDER, J. B., WAGSTROM, E., SODERLUND, D., LEANO, F. T., TAYLOR, C. M., BELLE-ISLE, P. A., DANILA, R. (2004): Outbreaks of enteric infections caused by multiple pathogens associated with calves at a farm day camp. Pediatric Infect Dis J 23, 1098-1104. (Pubitemid 40812755)
102. SONGER, J. G. (2010): Clostridia as agents of zoonotic disease. Vet Microbiol 140, 399-404.
103. SONGER, J. G., ANDERSON, M. A. (2006): Clostridium difficile: an important pathogen of food animals. Anaerobe 12, 1-4. (Pubitemid 41774737)
104. SONGER, J. G., JONES, R., ANDERSON, M. A., BARBARA, A. J., POST, K. W., TRINH, H. T. (2007): Prevention of porcine Clostridium difficile-associated disease by competitive exclusion with nontoxigenic organisms. Vet Microbiol 124, 358-361. (Pubitemid 47268670)
105. SONGER, J. G., TRINH, H. T., KILLGORE, G. E., THOMPSON, A. D., MCDONALD, L. C., LIMBAGO, B. M. (2009): Clostridium difficile in retail meat products, USA, 2007. Emerg Infect Dis 15, 819-821.
106. STRUBLE, A. L., TANG, Y. J., KASS, P. H., GUMERLOCK, P. H., MADEWELL, B. R., SILVA, J., JR (1994): Fecal shedding of Clostridium difficile in dogs: a period prevalence survey in a veterinary medical teaching hospital. J Vet Diagnost Invest 6, 342-347.
107. TONNA, I., WELSBY, P. D. (2005): Pathogenesis and treatment of Clostridium difficile infection. Postgrad Med J 81, 367-369. (Pubitemid 40834901)
108. VON ABERCRON, S. M., KARLSSON, F., WIGH, G. T., WIERUP, M., KROVACEK, K. (2009): Low occurrence of Clostridium difficile in retail ground meat in Sweden. J Food Protect 72, 1732-1734.
109. WALKER, A. S., EYRE, D. W., WYLLIE, D. H., DINGLE, K. E., HARDING, R. M., O'CONNOR, L., GRIFFITHS, D., VAUGHAN, A., FINNEY, J., WILCOX, M. H., CROOK, D. W., PETO, T. E. (2012): Characterisation of Clostridium difficile hospital ward-based transmission using extensive epidemiological data and molecular typing. PLoS Med 9, e1001172.
110. WANG, H., SUN, X., ZHANG, Y., LI, S., CHEN, K., SHI, L., NIE, W., KUMAR, R., TZIPORI, S., WANG, J., SAVIDGE, T., FENG, H. (2012): A chimeric toxin vaccine protects against primary and recurrent Clostridium difficile infection. Infect Immun 80, 2678-2688.
111. WEBER, A., KROTH, P., HEIL, G. (1989): The occurrence of Clostridium difficile in fecal samples of dogs and cats. J Vet Med B 36, 568-576.
112. WEBER, D. J., RUTALA, W. A. (2011): The role of the environment in transmission of Clostridium difficile infection in healthcare facilities. Infect Cont Hosp Ep 32, 207-209.
113. WEESE, J. S. (2010): Clostridium difficile in food-innocent bystander or serious threat? Clin Microbiol Infect 16, 3-10.
114. WEESE, J. S., ARMSTRONG, J. (2003): Outbreak of Clostridium difficile-associated disease in a Small Animal Veterinary Teaching Hospital. J Vet Intern Med 17, 813-816. (Pubitemid 38002205)
115. WEESE, J. S., AVERY, B. P., ROUSSEAU, J., REID-SMITH, R. J. (2009): Detection and enumeration of Clostridium difficile in retail beef and pork. Appl Env Microbiol 75, 5009-5011.
116. WEESE, J. S., FINLEY, R., REID-SMITH, R. R., JANECKO, N., ROUSSEAU, J. (2010): Evaluation of Clostridium difficile in dogs and the household environment. Epidemiol Infect 138, 1100-1104.
117. WEESE, J. S., REID-SMITH, R. J., AVERY, B. P., ROUSSEAU, J. (2010): Detection and characterization of Clostridium difficile in retail chicken. Lett Appl Microbiol 50, 362-365.
118. WEESE, J. S., STAEMPFLI, H. R., PRESCOTT, J. F. (2001): A prospective study of the roles of Clostridium difficile and enterotoxigenic Clostridium perfringens in equine diarrhoea. Equine Vet J 33, 403-409. (Pubitemid 33644661)
119. WEESE, J. S., STAEMPFLI, H. R., PRESCOTT, J. F., KRUTH, S. A., GREENWOOD, S. J., WEESE, H. E. (2001): The roles of Clostridium difficile and enterotoxigenic Clostridium perfringens in diarrhoea in dogs. J Vet Intern Med 15, 374-378. (Pubitemid 33722449)
120. WEESE, J. S., WEESE, H. E., BOURDEAU, T. L., STAEMPFLI, H. R. (2001): Suspected Clostridium difficile-associated diarrhoea in two cats. J Am Vet Med Assoc 218, 1436-1439. (Pubitemid 33664469)
121. WHEELER, J. G., SETHI, D., COWDEN, J. M., WALL, P. G., RODRIGUES, L. C., TOMPKINS, D. S., HUDSON, M. J., RODERICK, P. J. (1999): Study of infectious intestinal disease in England: rates in the community, presenting to general practice, and reported to national surveillance. The Infectious Intestinal Disease Study Executive. BMJ 318, 1046-1050. (Pubitemid 29191897)
122. WILCOX, M. H., FAWLEY, W. N. (2000): Hospital disinfectants and spore formation by Clostridium difficile. Lancet 356, 1324.
123. WILCOX, M. H., MOONEY, L., BENDALL, R., SETTLE, C. D., FAWLEY, W. N. (2008): A case-control study of community-associated Clostridium difficile infection. J Antimicrob Chemother 62, 388-396. (Pubitemid 351984787)
124. WILSON, K. H., SILVA, J., FEKETY, F. R. (1982): Fluorescent-antibody test for detection of Clostridium difficile in stool specimens. J Clin Microbiol 16, 464-468. (Pubitemid 12050036)
125. ZIDARIC, V., ZEMLJIC, M., JANEZIC, S., KOCUVAN, A., RUPNIK, M. (2008): High diversity of Clostridium difficile genotypes isolated from a single poultry farm producing replacement laying hens. Anaerobe 14, 325-327.