Meconium aspiration syndrome: Possible pathophysiological mechanisms and future potential therapies

Neonatology

Volumn 107, Issue 3, 2015, Pages 225-230

  Haakonsen Lindenskov, Paal Helge ^b   Castellheim, Albert ^a   Saugstad, Ola Didrik ^b   Mollnes, Tom Eirik ^b,c,d,e,f  

^a QUEEN SILVIA CHILDREN'S HOSPITAL   (Sweden)

^b OSLO UNIVERSITY HOSPITAL   (Norway)

^c UNIVERSITY OF OSLO   (Norway)

^d NORDLAND HOSPITAL   (Norway)

^e UNIVERSITY OF TROMSØ   (Norway)

^f NORWEGIAN UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Norway)

Author keywords

Complement system; Inflammation; Meconium aspiration syndrome

Indexed keywords

ARACHIDONIC ACID; C REACTIVE PROTEIN; CD14 ANTIGEN; COMPLEMENT COMPONENT C3; COMPLEMENT COMPONENT C5A; INTERLEUKIN 10; INTERLEUKIN 1BETA; INTERLEUKIN 6; INTERLEUKIN 8; LUNG SURFACTANT; NITRIC OXIDE; PATTERN RECOGNITION RECEPTOR; PHOSPHOLIPASE A2; PROSTAGLANDIN; REACTIVE OXYGEN METABOLITE; TOLL LIKE RECEPTOR 4; TUMOR NECROSIS FACTOR; CYTOKINE; TOLL LIKE RECEPTOR;

ADAPTIVE IMMUNITY; APOPTOSIS; COMPLEMENT ACTIVATION; COMPLEMENT SYSTEM; CYTOKINE RELEASE; GRAM NEGATIVE BACTERIUM; HUMAN; INNATE IMMUNITY; LEUKOCYTE ACTIVATION; LUNG ALVEOLUS CELL; LUNG ALVEOLUS MACROPHAGE; LUNG LAVAGE; MECONIUM; MECONIUM ASPIRATION; NEWBORN; NEWBORN SEPSIS; NONHUMAN; PATHOPHYSIOLOGY; PATTERN RECOGNITION; PNEUMONIA; PRIORITY JOURNAL; PULMONARY HYPERTENSION; RESPIRATORY BURST; REVIEW; ANIMAL; IMMUNOLOGY; INFLAMMATION; LUNG; MECONIUM ASPIRATION SYNDROME;

ANIMALIA;

ANIMALS; COMPLEMENT ACTIVATION; CYTOKINES; HUMANS; IMMUNITY, INNATE; INFANT, NEWBORN; INFLAMMATION; LUNG; MECONIUM; MECONIUM ASPIRATION SYNDROME; TOLL-LIKE RECEPTORS;

EID: 84924184287     PISSN: 16617800     EISSN: 16617819     Source Type: Journal    
DOI: 10.1159/000369373     Document Type: Review

References (40)

1. Vain NE, Szyld EG, Prudent LM, Wiswell TE, Aguilar AM, Vivas NI: Oropharyngeal and nasopharyngeal suctioning of meconium-stained neonates before delivery of their shoulders: multicentre, randomised controlled trial. Lancet 2004; 364:597-602.
2. Katz VL, Bowes WA Jr: Meconium aspiration syndrome: reflections on a murky subject. Am J Obstet Gynecol 1992; 166:171-183.
3. Fischer C, Rybakowski C, Ferdynus C, Sagot P, Gouyon JB: A population-based study of meconium aspiration syndrome in neonates born between 37 and 43 weeks of gestation. Int J Pediatr 2012; 2012: 321545.
4. Wiswell TE: Meconium aspiration syndrome; in Donn SM, Sinha SK (eds): Manual of Neonatal Respiratory Care. New York, Springer, 2012, pp 555-564.
5. Van Ierland Y, de Beaufort AJ: Why does me-conium cause meconium aspiration syndrome? Current concepts of MAS pathophys-iology. Early Hum Dev 2009; 85:617-620.
6. Vidyasagar D, Zagariya A: Studies of meconi-um-induced lung injury: inflammatory cyto-kine expression and apoptosis. J Perinatol 2008; 28(suppl 3):S102-S107.
7. Kaapa PO: Meconium aspiration syndrome (MAS)-where do we go? Research perspectives. Early Hum Dev 2009; 85:627-629.
8. Mollnes TE, Castellheim A, Lindenskov PH, Salvesen B, Saugstad OD: The role of complement in meconium aspiration syndrome. J Perinatol 2008; 28(suppl 3):S116-S119.
9. Tyler DC, Murphy J, Cheney FW: Mechanical and chemical damage to lung tissue caused by meconium aspiration. Pediatrics 1978; 62: 454-459.
10. Lindenskov PH, Castellheim A, Aamodt G, Saugstad OD: Meconium induced IL-8 production and intratracheal albumin alleviated lung injury in newborn pigs. Pediatr Res 2005; 57:371-377.
11. Zagariya A, Bhat R, Navale S, Vidyasagar D: Cytokine expression in meconium-induced lungs. Indian J Pediatr 2004; 71:195-201.
12. Kytola J, Kaapa P, Uotila P: Meconium aspiration stimulates cyclooxygenase-2 and nitric oxide synthase-2 expression in rat lungs. Pe-diatr Res 2003; 53:731-736.
13. Hofer N, Muller W, Resch B: Non-infectious conditions and gestational age influence C-reactive protein values in newborns during the first 3 days of life. Clin Chem Lab Med 2011; 49:297-302.
14. De Beaufort AJ, Pelikan DM, Elferink JG, Berger HM: Effect of interleukin 8 in meco-nium on in-vitro neutrophil chemotaxis. Lancet 1998; 352:102-105.
15. Yamada T, Minakami H, Matsubara S, Yat-suda T, Kohmura Y, Sato I: Meconium-stained amniotic fluid exhibits chemotactic activity for polymorphonuclear leukocytes in vitro. J Reprod Immunol 2000; 46:21-30.
16. De Beaufort AJ, Bakker AC, van Tol MJ, Poorthuis BJ, Schrama AJ, Berger HM: Meco-nium is a source of pro-inflammatory substances and can induce cytokine production in cultured A549 epithelial cells. Pediatr Res 2003; 54:491-495.
17. Salvesen B, Fung M, Saugstad OD, Mollnes TE: Role of complement and CD14 in meco-nium-induced cytokine formation. Pediatrics 2008; 121:e496-e505.
18. Salvesen B, Nielsen EW, Harboe M, Saugstad OD, Mollnes TE: Mechanisms of complement activation and effects of C1-inhibitor on the meconium-induced inflammatory reaction in human cord blood. Mol Immunol 2009; 46:688-694.
19. Salvesen B, Stenvik J, Rossetti C, Saugstad OD, Espevik T, Mollnes TE: Meconium-in-duced release of cytokines is mediated by the TRL4/MD-2 complex in a CD14-dependent manner. Mol Immunol 2010; 47:1226-1234.
20. Squires KA, De Paoli AG, Williams C, Dar-gaville PA: High-frequency oscillatory ventilation with low oscillatory frequency in pulmonary interstitial emphysema. Neonatology 2013; 104:243-249.
21. Zagariya A, Sierzputovska M, Navale S, Vidyasagar D: Role of meconium and hypox-ia in meconium aspiration-induced lung injury in neonatal rabbits. Mediators Inflamm 2010; 2010:204831.
22. Okazaki K, Kondo M, Kato M, Kakinuma R, Nishida A, Noda M, Taniguchi K, Kimura H: Serum cytokine and chemokine profiles in neonates with meconium aspiration syndrome. Pediatrics 2008; 121:e748-e753.
23. Ricklin D, Hajishengallis G, Yang K, Lambris JD: Complement: a key system for immune surveillance and homeostasis. Nat Immunol 2010; 11:785-797.
24. Castellheim A, Pharo A, Fung M, Saugstad OD, Mollnes TE: Complement C5a is a key mediator of meconium-induced neutrophil activation. Pediatr Res 2005; 57:242-247.
25. Bergamini CM, Gambetti S, Dondi A, Cervel-lati C: Oxygen, reactive oxygen species and tissue damage. Curr Pharm Des 2004; 10: 1611-1626.
26. Shingu M, Nonaka S, Nishimukai H, Nobu-naga M, Kitamura H, Tomo-Oka K: Activation of complement in normal serum by hydrogen peroxide and hydrogen peroxide-related oxygen radicals produced by activated neutrophils. Clin Exp Immunol 1992; 90:72-78.
27. Clark P, Duff P: Inhibition of neutrophil oxi-dative burst and phagocytosis by meconium. Am J Obstet Gynecol 1995; 173:1301-1305.
28. Soukka HR, Ahotupa M, Ruutu M, Kaapa PO: Meconium stimulates neutrophil oxidative burst. Am J Perinatol 2002; 19:279-284.
29. Holopainen R, Aho H, Laine J, Peuravuori H, Soukka H, Kaapa P: Human meconium has high phospholipase A2 activity and induces cellular injury and apoptosis in piglet lungs. Pediatr Res 1999; 46:626-632.
30. Abraham E: NF-kappaB activation. Crit Care Med 2000; 28:N100-N104.
31. Medzhitov R: Origin and physiological roles of inflammation. Nature 2008; 454:428-435.
32. Janeway CA Jr, Medzhitov R: Innate immune recognition. Annu Rev Immunol 2002; 20: 197-216.
33. Lappegard KT, Christiansen D, Pharo A, Thorgersen EB, Hellerud BC, Lindstad J, Nielsen EW, Bergseth G, Fadnes D, Abraha-msen TG, Hoiby EA, Schejbel L, Garred P, Lambris JD, Harboe M, Mollnes TE: Human genetic deficiencies reveal the roles of complement in the inflammatory network: lessons from nature. Proc Natl Acad Sci USA 2009; 106:15861-15866.
34. Mollnes TE, Brekke OL, Fung M, Fure H, Christiansen D, Bergseth G, Videm V, Lappegard KT, Kohl J, Lambris JD: Essential role of the C5a receptor in E. Coli-induced oxidative burst and phagocytosis revealed by a novel lepirudin-based human whole blood model of inflammation. Blood 2002; 100: 1869-1877.
35. Barratt-Due A, Pischke SE, Brekke OL, Thorgersen EB, Nielsen EW, Espevik T, Hu-ber-Lang M, Mollnes TE: Bride and groom in systemic inflammation-the bells ring for complement and Toll in cooperation. Immu-nobiology 2012; 217:1047-1056.
36. Mollnes TE, Christiansen D, Brekke OL, Es-pevik T: Hypothesis: combined inhibition of complement and CD14 as treatment regimen to attenuate the inflammatory response. Adv Exp Med Biol 2008; 632:253-263.
37. Romero R, Yoon BH, Chaemsaithong P, Cor-tez J, Park CW, Gonzalez R, Behnke E, Hassan SS, Chaiworapongsa T, Yeo L: Bacteria and endotoxin in meconium-stained amniotic fluid at term: could intra-amniotic infection cause meconium passage? J Matern Fetal Neonatal Med 2014; 27:775-788.
38. Castellheim A, Lindenskov PH, Pharo A, Fung M, Saugstad OD, Mollnes TE: Meconi-um is a potent activator of complement in human serum and in piglets. Pediatr Res 2004; 55:310-318.
39. Castellheim A, Lindenskov PH, Pharo A, Aamodt G, Saugstad OD, Mollnes TE: Meco-nium aspiration syndrome induces complement-associated systemic inflammatory response in newborn piglets. Scand J Immunol 2005; 61:217-225.
40. Lindenskov PH, Castellheim A, Aamodt G, Saugstad OD, Mollnes TE: Complement activation reflects severity of meconium aspiration syndrome in newborn pigs. Pediatr Res 2004; 56:810-817.