Meconium aspiration stimulates cyclooxygenase-2 and nitric oxide synthase-2 expression in rat lungs

Pediatric Research

Volumn 53, Issue 5, 2003, Pages 731-736

  Kytölä, Jaakko ^a   Kääpä, Pekka ^a   Uotila, Pekka ^a  

^a UNIVERSITY OF TURKU   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; DEXAMETHASONE; ENDOTHELIAL NITRIC OXIDE SYNTHASE; INDOMETACIN; INDUCIBLE NITRIC OXIDE SYNTHASE; ISOENZYME; MESSENGER RNA; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; OXYGEN; PROSTAGLANDIN; SODIUM CHLORIDE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ARTIFICIAL VENTILATION; BIOSYNTHESIS; CONTROLLED STUDY; DRUG EFFECT; ENZYME ACTIVATION; ENZYME INDUCTION; GENE EXPRESSION REGULATION; HEMODYNAMICS; IMMUNOHISTOCHEMISTRY; LUNG ALVEOLUS MACROPHAGE; MALE; MECONIUM ASPIRATION; NONHUMAN; NORTHERN BLOTTING; PNEUMONIA; PRIORITY JOURNAL; PROSTAGLANDIN SYNTHESIS; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; RAT; RESPIRATORY EPITHELIUM; TISSUE DISTRIBUTION; TISSUE LEVEL; UPREGULATION; VASCULAR ENDOTHELIUM;

AGE FACTORS; ANIMALS; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITORS; CYCLOOXYGENASE INHIBITORS; HUMANS; INDOMETHACIN; INFANT, NEWBORN; ISOENZYMES; LUNG; MALE; MECONIUM ASPIRATION SYNDROME; MEMBRANE PROTEINS; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE II; NITRIC OXIDE SYNTHASE TYPE III; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; RATS; RATS, SPRAGUE-DAWLEY; RESPIRATORY MUCOSA; RNA, MESSENGER;

EID: 0242432422     PISSN: 00313998     EISSN: None     Source Type: Journal    
DOI: 10.1203/01.PDR.0000059222.68800.1B     Document Type: Article

References (33)

1. Davey AM, Becker JD, Davis JM 1993 Meconium aspiration syndrome: physiological and inflammatory changes in a newbom piglet model. Pediatr Pulmonol 16:101-108
2. Tyler DC, Murphy J, Cheney FW 1978 Mechanical and chemical damage to lung tissue caused by meconium aspiration. Pediatrics 62:454-459
3. Holopainen R, Soukka H, Halkola L, Kääpä P 1998 Meconium aspiration induces a concentration-dependent pulmonary hypertensive response in newbom piglets. Pediatr Pulmonol 25:107-113
4. Cleary GM, Wiswell TE 1998 Meconium-stained amniotic fluid and the meconium aspiration syndrome. An update. Pediatr Clin North Am 45:511-529
5. Kojima T, Hattori K, Fujiwara T, Sasai-Takedatsu M, Kobayashi Y 1994 Meconium-induced lung injury mediated by activation of alveolar macrophages. Life Sci 54:1559-1562
6. de Beaufort AJ, Pelikan DM, Elferink JG, Berger HM 1998 Effect of interleukin 8 in meconium on in-vitro neutrophil chemotaxis. Lancet 352:102-105
7. Vane JR, Bakhle YS, Botting RM 1998 Cyclooxygenases 1 and 2. Annu Rev Pharmacol Toxicol 38:97-120
8. Feng L, Xia Y, Garcia GE, Hwang D, Wilson CB 1995 Involvement of reactive oxygen intermediates in cyclooxygenase-2 expression induced by interleukin-1, tumor necrosis factor-alpha, and lipopolysaccharide. J Clin Invest 95:1669-1675
9. Hempel SL, Monick MM, Hunninghake GW 1994 Lipopolysaccharide induces prostaglandin H synthase-2 protein and mRNA in human alveolar macrophages and blood monocytes. J Clin Invest 93:391-396
10. Mitchell JA, Belvisi MG, Akarasereenont P, Robbins RA, Kwon OJ, Croxtall J, Barnes PJ, Vane JR 1994 Induction of cyclo-oxygenase-2 by cytokines in human pulmonary epithelial cells: regulation by dexamethasone. Br J Pharmacol 113:1008-1014
11. Kytölä J, Uotila P, Kääpä P 1999 Meconium stimulates cyclooxygenase-2 expression in rat lungs. Prostaglandins Leukot Essent Fatty Acids 60:107-110
12. Nathan C 1992 Nitric oxide as a secretory product of mammalian cells. FASEB J 6:3051-3064
13. Kristof AS, Goldberg P, Laubach V, Hussain SN 1998 Role of inducible nitric oxide synthase in endotoxin-induced acute lung injury. Am J Respir Crit Care Med 158:1883-1889
14. Moncada S, Palmer RM, Higgs EA 1991 Nitric oxide: physiology, pathophysiology, and pharmacology. Pharmacol Rev 43:109-142
15. Ziegler JW, Ivy DD, Kinsella JP, Abman SH 1995 The role of nitric oxide, endothelin, and prostaglandins in the transition of the pulmonary circulation. Clin Perinatol 22:387-403
16. Tetsuka T, Daphna Iken D, Srivastava SK, Baier LD, DuMaine J, Morrison AR 1994 Cross-talk between cyclooxygenase and nitric oxide pathways: prostaglandin E2 negatively modulates induction of nitric oxide synthase by interleukin 1. Proc Natl Acad Sci U S A 91:12168-12172
17. Chomczynski P, Sacchi N 1987 Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem 162:156-159
18. Fort P, Marty L, Piechaczyk M, el Sabrouty S, Dani C, Jeanteur P, Blanchard JM 1985 Various rat adult tissues express only one major mRNA species from the glyceraldehyde-3-phosphate-dehydrogenase multigenic family. Nucleic Acids Res 13:1431-1442
19. Lee SH, Soyoola E, Chanmugam P, Hart S, Sun W, Zhong H, Liou S, Simmons D, Hwang D 1992 Selective expression of mitogen-inducible cyclooxygenase in macrophages stimulated with lipopolysaccharide. J Biol Chem 267:25934-25938
20. Vidyasagar D, Bhat R, Uhal B, Navale S, Zagariya A 1999 The TNF-a, IL-1-b, IL-6, INF-g, PGE-2 and IL-10 expression in meconium aspirated newborn lungs. Pediatr Res 45:325A
21. Soukka H, Viinikka L, Kääpä P 1998 Involvement of thromboxane A2 and prostacyclin in the early pulmonary hypertension after porcine meconium aspiration. Pediatr Res 44:838-842
22. Uotila PJ, Kääpä PO 1998 Cyclooxygenase-2 expression in human monocytes stimulated by meconium. Lancet 351:878
23. Maier JA, Hla T, Maciag T 1990 Cyclooxygenase is an immediate-early gene induced by interleukin-1 in human endothelial cells. J Biol Chem 265:10805-10808
24. Chida M, Voelkel NF 1996 Effects of acute and chronic hypoxia on rat lung cyclooxygenase. Am J Physiol 270:L872-L878
25. Mitchell JA, Akarasereenont P, Thiemermann C, Flower RJ, Vane JR 1993 Selectivity of nonsteroidal antiinflammatory drugs as inhibitors of constitutive and inducible cyclooxygenase. Proc Natl Acad Sci U S A 90:11693-11697
26. Newton R, Seybold J, Kuitert LM, Bergmann M, Barnes PJ 1998 Repression of cyclooxygenase-2 and prostaglandin E2 release by dexamethasone occurs by transcriptional and post-transcriptional mechanisms involving loss of polyadenylated mRNA. J Biol Chem 273:32312-32321
27. Robbins RA, Barnes PJ, Springall DR, Warren JB, Kwon OJ, Buttery LD, Wilson AJ, Geller DA, Polak JM 1994 Expression of inducible nitric oxide in human lung epithelial cells. Biochem Biophys Res Commun 203:209-218
28. Haddad IY, Pataki G, Hu P, Galliani C, Beckman JS, Matalon S 1994 Quantitation of nitrotyrosine levels in lung sections of patients and animals with acute lung injury. J Clin Invest 94:2407-2413
29. Di Rosa M, Radomski M, Carnuccio R, Moncada S 1990 Glucocorticoids inhibit the induction of nitric oxide synthase in macrophages. Biochem Biophys Res Commun 172:1246-1252
30. Liu S, Adcock IM, Old RW, Barnes PJ, Evans TW 1993 Lipopolysaccharide treatment in vivo induces widespread tissue expression of inducible nitric oxide synthase mRNA. Biochem Biophys Res Commun 196:1208-1213
31. Holopainen R, Aho H, Halkola L, Kääpä P 2001 Dexamethasone treatment attenuates pulmonary injury in experimental meconium aspiration. Pediatr Res 49:1-7
32. Perkins DJ, Kniss DA 1999 Blockade of nitric oxide formation down-regulates cyclooxygenase-2 and decreases PGE2 biosynthesis in macrophages. J Leukoc Biol 65:792-799
33. Wu C-C, Croxtall JD, Perretti M, Bryant CE, Thiemermann C, Flower RJ, Vane JR 1995 Lipocortin 1 mediates the inhibition by dexamethasone of the induction by endotoxin of nitric oxide synthase in the rat. Proc Natl Acad Sci U S A 92:3473-3477