Rectifier of aberrant mRNA splicing recovers tRNA modification in familial dysautonomia

Proceedings of the National Academy of Sciences of the United States of America

Volumn 112, Issue 9, 2015, Pages 2764-2769

  Yoshida, Mayumi ^a   Kataoka, Naoyuki ^a   Miyauchi, Kenjyo ^b   Ohe, Kenji ^a   Iida, Kei ^a   Yoshida, Suguru ^c   Nojima, Takayuki ^d   Okuno, Yukiko ^a   Onogi, Hiroshi ^a,e   Usui, Tomomi ^c   Takeuchi, Akihide ^a   Hosoya, Takamitsu ^c   Suzuki, Tsutomu ^b   Hagiwara, Masatoshi ^a  

^a KYOTO UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

^c TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

^d UNIVERSITY OF OXFORD   (United Kingdom)

^e KinoPharma Inc   (Japan)

Author keywords

Neurodegenerative disease; RNA disease; Small molecules; Splicing; TRNA modification

Indexed keywords

INHIBITOR OF KAPPA LIGHT POLYPEPTIDE GENE ENHANCER IN B CELL KINASE COMPLEX ASSOCIATED PROTEIN; MESSENGER RNA PRECURSOR; TRANSFER RNA; UNCLASSIFIED DRUG; CARRIER PROTEIN; FUSED HETEROCYCLIC RINGS; IKBKAP PROTEIN, HUMAN;

ARTICLE; CELL GROWTH; CONTROLLED STUDY; CYTOPLASM; DNA FLANKING REGION; DYSAUTONOMIA; EXON; FIBROBLAST; GENE EXPRESSION; HUMAN; HUMAN CELL; INTRON; OPEN READING FRAME; POINT MUTATION; PRIORITY JOURNAL; RECTIFIER OF ABERRANT SPLICING; RNA SPLICING; STOP CODON; CHEMISTRY; DRUG EFFECTS; DYSAUTONOMIA, FAMILIAL; GENETICS; HELA CELL LINE; METABOLISM; MUTATION;

CARRIER PROTEINS; DYSAUTONOMIA, FAMILIAL; HELA CELLS; HETEROCYCLIC COMPOUNDS, 3-RING; HUMANS; INTRONS; MUTATION; RNA SPLICING; RNA, TRANSFER;

EID: 84924144421     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1415525112     Document Type: Article

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