Prognostic value of the MicroRNA regulators Dicer and Drosha in non-small-cell lung cancer: Co-expression of Drosha and miR-126 predicts poor survival

BMC Clinical Pathology

Volumn 14, Issue 1, 2015, Pages

  Lønvik, Kenneth ^a,b   Wsørbye, Sveinung ^a   Nilsen, Marit N ^b   Paulssen, Ruth H ^c  

^a UNIVERSITY HOSPITAL OF NORTH NORWAY   (Norway)

^b Department of Medical Biology ^*  (Norway)

^c UNIVERSITY OF TROMSØ   (Norway)

Author keywords

Dicer; Drosha; Immunohistochemistry; MicroRNA; miR 126; NSCLC

Indexed keywords

DICER; DROSHA PROTEIN; ESTERASE; MICRORNA 126; UNCLASSIFIED DRUG;

ARTICLE; CANCER PROGNOSIS; CANCER STAGING; CANCER SURVIVAL; CELL NUCLEUS; CYTOPLASM; DISEASE SPECIFIC SURVIVAL; FEMALE; FOLLOW UP; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; MAJOR CLINICAL STUDY; MALE; NON SMALL CELL LUNG CANCER; OVERALL SURVIVAL; PROTEIN EXPRESSION; TISSUE MICROARRAY;

EID: 84924125880     PISSN: None     EISSN: 14726890     Source Type: Journal    
DOI: 10.1186/1472-6890-14-45     Document Type: Article

References (51)

1. Jemal A, Siegel R, Xu J, Ward E: Cancer Statistics 2010. CA Cancer J Clin 2010, 60(4):277-300.
2. Zhang W-C, Liu J, Xu X, Wang G: The role of microRNAs in lung cancer progression. Med Oncol 2013, 30:675-683.
3. Saito M, Schetter AJ, Mollerup S, Kohno T, Skaug V, Bowman ED, Mathé EA, Takenoshita S, Yokota J, Haugen A, Harris CC: The association of microRNA expression with prognosis and progression in early-stage, non-small cell lung adenocarcinoma: a retrospective analysis of three cohorts. Clin Cancer Res 2011, 17:1875-1882.
4. Malleter M, Jacquot C, Rousseau B, Tomasoni C, Juge M, Pineau A, Sakanian V, Roussakis C: miRNAs, a potential target in the treatment of Non-Small-Cell Lung Carcinomas. Gene 2012, 506:355-359.
5. Raponi M, Dossey L, Jatkoe T, Wu X, Chen G, Fan H, Beer DG: MicroRNA classifiers for predicting prognosis of squamous cell lung cancer. Cancer Res 2009, 69:5776-5783.
6. Lin PY, Lu SL, Yang PC: MicroRNAs in lung cancer. Br J Cancer 2010, 103:1144-1148.
7. Yang J, Lan H, Huang X, Liu B, Tong Y: MicroRNA-126 inhibits tumor cell growth and its expression level correlates with poor survival in nonsmall cell lung cancer patients. PLoS One 2012, 7:e42978.
8. Wang R, Wang ZX, Yang JS, Pan X, De W, Chen LB: MicroRNA-451 functions as a tumor suppressor in human non-small cell lung cancer by targeting ras-related protein 14 (RAB14). Oncogene 2011, 30:2644-2658.
9. Jang JS, Jeon HS, Sun Z, Aubry MC, Tang H, Park CH, Rakhshan F, Schutz DA, Kolbert CP, Lupu R, Park JY, Harris CC, Yang P, Jen J: Increased mir-708 expression in NSCLC and its association with poor survival in lung adenocarcinoma from never smokers. Clin Cancer Res 2012, 18:3658-3667.
10. Ma L, Huang Y, Zhu W, Zhou S, Zhou J, Zeng F, Lin X, Zhang Y, Yu J: An integrated analysis of miRNA and mRNA expressions in non-small cell lung cancers. PLoS One 2011, 6:e26502.
11. Dønnem T, Fenton CG, Lønvik K, Berg T, Eklo K, Andersen S, Stenvold H, Al-Shibli K, Al-Saad S, Bremnes R, Busund LT: MicroRNA signatures in tumor tissue related to angiogenesis in non-small cell lung cancer. PLoS One 2012, 7: e:29671.
12. Tan X, Qin W, Zhang L, Hang J, Li B, Zhang C, Wan J, Zhou F, Shao K, Sun Y, Wu J, Zhang X, Qui B, Li N, Shi S, Feng X, Zhao S, Wang Z, Zhao X, Chen Z, Mitchelson K, Cheng J, Guo Y, He J: A 5-microRNA signature for lung squamous cell carcinoma diagnosis and hsa-miR-31 for prognosis. Clin Cancer Res 2011, 17:6802-6811.
13. Boeri M, Verri C, Conte D, Roz L, Modena P, Facchinetti F, Calabrò E, Croce CM, Pastorino U, Sozzi G: MicroRNA signatures in tissues and plasma predict development and prognosis of computed tomography detected lung cancer. Proc Natl Acad Sci U S A 2011, 108:3713-3718.
14. Tavazoie SF, Alarcon C, Oskarsson T, Padua D, Wang Q, Bos PD, Gerald WL, Massagué J: Endogenous human microRNAs that suppress breast cancer metastasis. Nature 2008, 451:147-152.
15. Ebrahimi F, Gopalan V, Smith RA, Lam A. K.-Y: miR-126 in human cancers: Clinical roles and current perspectives. Exp Mol Pathol 2014, 96:98-107.
16. Cho WC, Chow AS, Au JS: Restoration of tumor-repressor hsa-miR-145 inhibits cancer cell growth in lung adenocarcinoma patients with epidermal growth factor receptor mutation. Eur J Cancer 2008, 45:22197-22206.
17. Agudo J, Ruzo A, Tung N, Salmon H, Leboeuf M, Hashimoto D, Becker C, Garrett-Sinha LA, Baccarini A, Merad M, Brown BD: The miR-216-VEGFR2 axis controls the innate response to pathogen-associated nucleic acids. Nature Immunol 2014, 15:54-62.
18. Zhu X, Li L, Hui L, Chen H, Wang X, Shen H, Xu W: miR-126 enhances the sensitivity of non-small cell lung cancer cells to anticancer agents by targeting vascular endothelial growth factor A. Acta Biochim Biophys Sin 2012, 44:519-526.
19. Dønnem T, Lonvik K, Eklo K, Berg T, Sorbye SW, Al-Shibli K, Al-Saad S, Andersen S, Stenvold H, Bremnes R, Busund LT: Independent and tissuespecific prognostic impact of miR-126 in non-small cell lung cancer. Cancer 2011, 117:3193-3200.
20. Chen H, Miao R, Fan J, Han Z, Wu J, Qui G, Tang H, Peng Z: Decreased expression of mir-126 correlates with metastatic recurrence of hepatocellular carcinoma. Clin Exp Metastasis 2013, 30:651-658.
21. Tomasetti M, Staffolani S, Nocchi L, Neuzil J, Strafella E, Manzella N, Mariotti L, Bracci M, Valentino M, Amati M, Santarelli L: Clinical significance of circulating mir-126 quantification in malignant mesothelioma patients. Clin Biochem 2012, 45:575-581.
22. Meister J, Schmidt MHH: miR-126 and miR-126: New players in Cancer. Sci World J 2010, 10:2090-2100.
23. Davis BN, Hata A: Regulation of microRNA biogenesis: a myriad of mechanisms. Cell Commun Signal 2009, 7:18.
24. Suarez Y, Fernandez-Hernando C, Yu J, Gerber SA, Harrison KD, Pober JS, Iruela-Arispe ML, Merkenschlager M, Sessa WC: Dicer-dependent endothelial microRNAs are necessary for postnatal angiogenesis. Proc Natl Acad Sci U S A 2008, 105:14082-14087.
25. Yang JS, Lai EC: Alternative miRNA biogenesis pathways and the interpretation of core miRNA pathway mutants. Mol Cell 2011, 43:892-903.
26. Macrae IJ, Zhou K, Li F, Repic A, Brooks AN, Cande WZ, Adams PD, Doudna JA: Structural basis for double-stranded RNA processing by Dicer. Science 2006, 311:834-838.
27. Lin RJ, Lin YC, Chen J, Kuo HH, Chen YY, Diccianni MB, London WB, Chang CH, Yu AL: MicroRNA signature and expression of dicer and drosha can predict prognosis and delineate risk groups in neuroblastoma. Cancer Res 2010, 70:7841-7850.
28. Karube Y, Tanaka H, Osada H, Tomida S, Tatematsu Y, Yanagisawa K, Yatabe Y, Takamizawa J, Miyoshi S, Mitsudomi T, Takahashi T: Reduced expression of Dicer associated with poor prognosis in lung cancer patients. Cancer Sci 2005, 96(2):111-115.
29. Merritt WM, Lin YG, Han LY, Kamat AA, Spannuth WA, Schmandt R, Urbauer D, Pennachio LA, Cheng JF, Nick AM, Deavers MT, Mourad-Zeidan A, Wang H, Mueller P, Lenburg ME, Gray JW, Mok S, Birrer MJ, Lopez-Berestein G, Coleman RL, Bar-Eli M, Sood AK: Dicer, Drosha and outcomes in patients with ovarian cancer. N Engl J Med 2008, 359:2641-2650.
30. Grelier G, Voirin N, Ay AS, Cox DG, Chabaud S, Treilleux I, Léon-Goddard S, Rimokh R, Mikaelian I, Venoux C, Puisieux A, Lasset C, Moyret-Lalle C: Prognostic value of Dicer expression in human breast cancers and association with the mesenchymal phenotype. Br J Cancer 2009, 101:673-683.
31. Chiosea S, Jelezcova E, Chandran U, Luo J, Mantha G, Sobol RW, Dacic S: Overexpression of Dicer in precursor lesions of lung adenocarcinoma. Cancer Res 2007, 67:2345-2350.
32. Guo X, Liao Q, Chen P, Li X, Xiong W, Ma J, Li X, Luo Z, Tang H, Deng M, Zheng Y, Wang R, Zhang W, Li G: The microRNA-processing enzymes: Drosha and Dicer can predict prognosis of nasopharyngeal carcinoma. J Cancer Res Clin Oncol 2012, 138:49-56.
33. Oken MM, Creech RH, Tormey DC, Horton J, Davis TE, McFadden ET, Carbone PP: Toxicity and response criteria of the Eastern Cooperative Oncology Group. Am J Clin Oncol 1982, 5:649-655.
34. Goldstraw P: The 7th Edition of TNM in Lung Cancer: what now? J Thorac Oncol 2009, 4:671-673.
35. World Health Organization: Histological Typing of Lung and Pleural Tumours. 3rd edition. Geneva, Switzerland: Springer-Verlag; 1999.
36. Sørbye SW, Kilvær TK, Valkow A, Dønnem T, Smeland E, Al-Shibli K, Bremnes RM, Busund LT: Prognostic impact of Jab1, p16, p21, p62, ki67 and Skp2 in soft tissue sarcomas. PLoS One 2012, 7:e47068.
37. Nuovo GJ, Elton TS, Nana-Sinkam P, Volinia S, Croce CM, Schmittgen TD: A methodology for the combined in situ analyses of the precursor and mature forms of microRNAs and correlation with their putative targets. Nat Protoc 2009, 4:107-115.
38. Dønnem T, Al-Saad S, Al-Shibli K, Delghandi MP, Persson M, Nilsen MN, Busund LT, Bremnes RM: Inverse prognostic impact of angiogenic marker expression in tumor cells versus stromal cells in non small cell lung cancer. Clin Cancer Res 2007, 13:6649-6657.
39. Davis-Dusenbery BN, Hata A: MicroRNA in cancer: the involvement of aberrant microRNA biogenesis regulatory pathways. Genes Cancer 2011, 1:1100-1114.
40. Zhu DX, Fan L, Lu RN, Fang C, Shen WY, Zou ZJ, Wang YH, Zhu HY, Miao KR, Liu P, Xu W, Li JY: Downregulated dicer expression predicts poor prognosis in chronic lymphocytic leukemia. Cancer Sci 2012, 103:875-881
41. Faber C, Horst D, Hlubek F, Kirchner T: Overexpression of dicer predicts poor survival in colorectal cancer. Eur J Cancer 2011, 47:1414-1419
42. Shu G-S, Yang Z-L, Liu DC: Immounohistochemical study of Dicer and Drosha expression in the benign and malignant lesions of gallbladder and their clinicopathological significances. Pathol Res Pract 2012, 208:392-397
43. Vaksman O, Hetland TE, Trope CG, Reich R, Davidson B: Argonaute, Dicer, and Drosha are up-regulated along tumor progression in serious ovarian carcinoma. Hum Pathol 2012, 43:2062-2069.
44. Sassen S, Miska EA, Caldas C: MicroRNA - implications for cancer. Virchows Arch 2008, 451:1-10.
45. Anand S, Cheresh DA: MicroRNA-mediated regulation of the angiogenic switch. Curr Opin Hematol 2011, 18:171-176.
46. Chen CC, Zhou SH: Mesenchymal stem cells overexpressing miR-126 enhance ischemic angiogenesis via the AKT/ERK-related pathway. Cardiol J 2011, 18:675-681
47. Dønnem T, Eklo K, Berg T, Sørbye SW, Lønvik K, Al-Saad S, Al-Shibli K, Stenvold H, Bremnes RM, Busund LT: Prognostic Impact of MiR-155 in non-small Cell Lung cancer evaluated by in Situ Hybridization. J Transl Med 2011, 9:6.
48. Kuehlbacher A, Ubrich C, Zeiher AM, Dimmler S: Role of Dicer and Drosha for endothelial microRNA expression and angiogenesis. Circ Res 2011, 101:59-69
49. Palermo EI, De Campos SG, Campos M, Nogueira De Souza N, Guerreiro IDC, Carvalho AL, Marques MMC: Mechanisms and role of microRNA deregulation in cancer onset and progression. Gen Mol Biol 2011, 34:363-370.
50. Farazi TA, Spitzer JI, Morozow P, Tusch T: miRNAs in human cancer. J Pathol 2011, 223:102-115.
51. Cheloufi S, Dos Santos CO, Chong MM, Hannon GJ: A dicer-independent miRNA biogenesis pathway that requires Ago catalysis. Nature 2010, 465:584-589.