Bioactivity-guided fractionation of an antidiarrheal Chinese herb Rhodiola kirilowii (Regel) Maxim reveals (-)-epicatechin-3-gallate and (-)-epigallocatechin-3-gallate as inhibitors of cystic fibrosis transmembrane conductance regulator

PLoS ONE

Volumn 10, Issue 3, 2015, Pages

  Chen, Lei ^a   Yu, Bo ^a   Zhang, Yaofang ^b   Gao, Xin ^c   Zhu, Liang ^b   Ma, Tonghui ^a,b   Yang, Hong ^a  

^a LIAONING NORMAL UNIVERSITY   (China)

^b DALIAN MEDICAL UNIVERSITY   (China)

^c YANBIAN UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CATECHIN; CHLORIDE CHANNEL BLOCKING AGENT; CHOLERA TOXIN; CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR; EPICATECHIN; EPICATECHIN GALLATE; EPIGALLOCATECHIN; EPIGALLOCATECHIN GALLATE; ANTIDIARRHEAL AGENT; CFTR PROTEIN, HUMAN; CFTR PROTEIN, RAT; HERBACEOUS AGENT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIDIARRHEAL ACTIVITY; ARTICLE; CHINESE HERB; COLON MUCOSA; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG ISOLATION; DRUG STRUCTURE; EX VIVO STUDY; FRACTIONATION; IC50; INTESTINE FLUID; INTRALUMINAL DRUG ADMINISTRATION; MALE; MOUSE; NONHUMAN; RAT; RHODIOLA KIRILOWII; STRUCTURE ACTIVITY RELATION; ANALOGS AND DERIVATIVES; ANIMAL; ANTAGONISTS AND INHIBITORS; CELL LINE; CHEMISTRY; GENETICS; HUMAN; ISOLATION AND PURIFICATION; METABOLISM; RHODIOLA; WISTAR RAT;

MUS; RATTUS; RHODIOLA KIRILOWII;

ANIMALS; ANTIDIARRHEALS; CATECHIN; CELL LINE; CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR; DRUGS, CHINESE HERBAL; HUMANS; MICE; RATS; RATS, WISTAR; RHODIOLA;

EID: 84924090087     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0119122     Document Type: Article

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