CFTR inhibitors for treating diarrheal disease

Clinical Pharmacology and Therapeutics

Volumn 92, Issue 3, 2012, Pages 287-290

  Thiagarajah, J R ^a,b   Verkman, A S ^a,c  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 THIAZOLIDINONE DERIVATIVE; 5 NITRO 2 (3 PHENYLPROPYLAMINO)BENZOIC ACID; CALCIUM ACTIVATED POTASSIUM CHANNEL; CHLORIDE CHANNEL; CYCLIC AMP; EFENAMIC ACID; ENTEROTOXIN; GLIBENCLAMIDE; THIAZOLIDONE; TRANSMEMBRANE CONDUCTANCE REGULATOR; UNCLASSIFIED DRUG;

ARTICLE; CYSTIC FIBROSIS; DIARRHEA; DRUG SCREENING; DRUG STRUCTURE; HUMAN; IC 50; INTESTINE FLUID; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; SECRETION; SECRETORY DIARRHEA;

ANIMALS; ANTIDIARRHEALS; BIOLOGICAL TRANSPORT; CHLORIDE CHANNELS; CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR; DIARRHEA; ENTEROTOXINS; HUMANS; INTESTINES;

EID: 84865412093     PISSN: 00099236     EISSN: 15326535     Source Type: Journal    
DOI: 10.1038/clpt.2012.114     Document Type: Article

References (5)

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4. Snyder, D., Tradtrantip, L., Yao, C., Kurth, M.J. & Verkman, A.S. Potent, metabolically stable pyrimido-pyrrolo-quinoxolindione CFTR inhibitor for polycystic kidney disease. J. Med. Chem. 54, 5468-5477 (2011).
5. Sonawane, N.D., Zhao, D., Zegarra-Moran, O., Galietta, L.J. & Verkman, A.S. Lectin conjugates as potent, nonabsorbable CFTR inhibitors for reducing intestinal fuid secretion in cholera. Gastroenterology 132, 1234-1244 (2007). (Pubitemid 46627584)