Elevated expression of LAG-3, but not PD-1, is associated with impaired iNKT cytokine production during chronic HIV-1 infection and treatment

Retrovirology

Volumn 12, Issue 1, 2015, Pages

  Juno, Jennifer A ^a   Stalker, Andrew T ^a   Waruk, Jillian L M ^b   Oyugi, Julius ^a,c   Kimani, Makobu ^a,c   Plummer, Francis A ^a   Kimani, Joshua ^a,c   Fowke, Keith R ^a,c  

^a UNIVERSITY OF MANITOBA   (Canada)

^b National HIV and Retrovirology Laboratories   (Canada)

^c UNIVERSITY OF NAIROBI   (Kenya)

Author keywords

CD223; Exhaustion; HIV; Immune dysfunction; iNKT cells; LAG 3 protein human

Indexed keywords

ALPHA2 INTERFERON; CD40 LIGAND; CD69 ANTIGEN; GAMMA INTERFERON; HLA DR ANTIGEN; INTERLEUKIN 10; INTERLEUKIN 4; INTERLEUKIN 6; LYMPHOCYTE ACTIVATION GENE 3 PROTEIN; LYMPHOCYTE ANTIGEN; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; MACROPHAGE INFLAMMATORY PROTEIN 1BETA; PROGRAMMED DEATH 1 RECEPTOR; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; CD223 ANTIGEN; CYTOKINE; LEUKOCYTE ANTIGEN; PDCD1 PROTEIN, HUMAN;

ADULT; AFRICAN; ARTICLE; CD4 LYMPHOCYTE COUNT; CD8+ T LYMPHOCYTE; CONTROLLED STUDY; CORRELATIONAL STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; DISEASE COURSE; EX VIVO STUDY; FEMALE; FLOW CYTOMETRY; HIGHLY ACTIVE ANTIRETROVIRAL THERAPY; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; INNATE IMMUNITY; KENYA; MAJOR CLINICAL STUDY; NATURAL KILLER CELL; PROSTITUTION; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; PROTEIN FUNCTION; T LYMPHOCYTE ACTIVATION; T LYMPHOCYTE SUBPOPULATION; UPREGULATION; COHORT ANALYSIS; GENE EXPRESSION; HOST PATHOGEN INTERACTION; HUMAN IMMUNODEFICIENCY VIRUS 1; IMMUNOLOGY; METABOLISM; MIDDLE AGED; NATURAL KILLER T CELL; NORMAL HUMAN;

HUMAN IMMUNODEFICIENCY VIRUS 1;

ADULT; ANTIGENS, CD; COHORT STUDIES; CYTOKINES; FEMALE; GENE EXPRESSION; HEALTHY VOLUNTEERS; HIV INFECTIONS; HIV-1; HOST-PATHOGEN INTERACTIONS; HUMANS; KENYA; MIDDLE AGED; NATURAL KILLER T-CELLS; PROGRAMMED CELL DEATH 1 RECEPTOR; SEX WORKERS; UP-REGULATION;

EID: 84924089423     PISSN: None     EISSN: 17424690     Source Type: Journal    
DOI: 10.1186/s12977-015-0142-z     Document Type: Article

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