Impairment of CD1d-restricted natural killer T cells in chronic HIV type 1 clade C infection

AIDS Research and Human Retroviruses

Volumn 27, Issue 5, 2011, Pages 501-509

  Mureithi, Marianne W ^a,b   Cohen, Kristen ^b   Moodley, Ramona ^a   Poole, Danielle ^a,b   Mncube, Zenele ^a   Kasmar, Anne ^c   Moody, D Branch ^c   Goulder, Philip J R ^a,d   Walker, Bruce D ^a,b,e   Altfeld, Marcus ^a,b   Ndung'u, Thumbi ^a,b,f  

^a UNIVERSITY OF KWAZULU NATAL   (South Africa)

^b MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^c BRIGHAM AND WOMEN S HOSPITAL   (United States)

^d UNIVERSITY OF OXFORD   (United Kingdom)

^e HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^f UNIVERSITY OF KWAZULU NATAL   (South Africa)

Author keywords

[No Author keywords available]

Indexed keywords

CD1D ANTIGEN; GAMMA INTERFERON; INTERLEUKIN 4; TUMOR NECROSIS FACTOR ALPHA;

ADULT; ARTICLE; CD4 LYMPHOCYTE COUNT; CD8+ T LYMPHOCYTE; CELL COMPARTMENTALIZATION; CELL FUNCTION; CONTROLLED STUDY; CYTOKINE PRODUCTION; DISEASE COURSE; EFFECTOR CELL; FLOW CYTOMETRY; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1 INFECTION; MAJOR CLINICAL STUDY; NATURAL KILLER T CELL; PERIPHERAL BLOOD MONONUCLEAR CELL; PHENOTYPE; PRIORITY JOURNAL; T LYMPHOCYTE ACTIVATION;

ADULT; ANTIGENS, CD1D; CD4 LYMPHOCYTE COUNT; CHRONIC DISEASE; CROSS-SECTIONAL STUDIES; FLOW CYTOMETRY; GENOTYPE; HIV INFECTIONS; HIV-1; HUMANS; LYMPHOCYTE SUBSETS; MOLECULAR TYPING; NATURAL KILLER T-CELLS; RNA, VIRAL; SOUTH AFRICA;

EID: 79955760869     PISSN: 08892229     EISSN: None     Source Type: Journal    
DOI: 10.1089/aid.2010.0237     Document Type: Article

References (35)

1. Li D and Xu XN: NKT cells in HIV-1 infection. Cell Res 2008;18:817-822.
2. Kasmar AvR and Moody BD: The evolved functions of CD1 during infection. Curr Opin Immunol 2009;21:397-403.
3. Godfrey DI, et al.: Antigen recognition by CD1d-restricted NKT T cell receptors. Semin Immunol 2010;22:61-67.
4. Bendelac A, et al.: The biology of NKT cells. Annu Rev Immunol 2007;25:297-336. (Pubitemid 46697911)
5. Mattarollo SR, et al.: Secretion of IFN-gamma but not IL-17 by CD1d-restricted NKT cells enhances rejection of skin grafts expressing epithelial cell-derived antigen. J Immunol 2010;184:5663-5669.
6. Carnaud C, et al.: Cutting edge: Cross-talk between cells of the innate immune system: NKT cells rapidly activate NK cells. J Immunol 1999;163:4647-4650. (Pubitemid 29501223)
7. Hermans IF, et al.: NKT cells enhance CD4+ and CD8+ T cell responses to soluble antigen in vivo through direct interaction with dendritic cells. J Immunol 2003;171:5140-5147. (Pubitemid 37432797)
8. Diana J and Lehuen A: NKT cells: Friend or foe during viral infections? Eur J Immunol 2009;39:3283-3291.
9. Moll M, et al.: Severe functional impairment and elevated PD- 1 expression in CD1d-restricted NKT cells retained during chronic HIV-1 infection. Eur J Immunol 2009;39:902-911.
10. Fernandez CS, et al.: Peripheral NKT cells in simian immunodeficiency virus-infected macaques. J Virol 2009;83:1617-1624.
11. Motsinger A, et al.: CD1d-restricted human natural killer T cells are highly susceptible to human immunodeficiency virus 1 infection. J Exp Med 2002;195:869-879. (Pubitemid 34286758)
12. Sandberg JK, et al.: Selective loss of innate CD4(+) V alpha 24 natural killer T cells in human immunodeficiency virus infection. J Virol 2002;76:7528-7534. (Pubitemid 34760975)
13. Moll M, et al.: Expansion of CD1d-restricted NKT cells in patients with primary HIV-1 infection treated with interleukin- 2. Blood 2006;107:3081-3083.
14. Vasan S, et al.: Function of NKT cells, potential anti-HIV effector cells, are improved by beginning HAART during acute HIV-1 infection. Int Immunol 2007;19:943-951. (Pubitemid 47386920)
15. Chen N, et al.: HIV-1 down-regulates the expression of CD1d via Nef. Eur J Immunol 2006;36:278-286. (Pubitemid 43257450)
16. Cho S, et al.: Impaired cell surface expression of human CD1d by the formation of an HIV-1 Nef/CD1d complex. Virology 2005;337:242-252. (Pubitemid 40798992)
17. Moll M, et al.: Inhibition of lipid antigen presentation in dendritic cells by HIV-1 Vpu interference with CD1d recycling from endosomal compartments. Blood 2010;116:1876-1884.
18. Puren AJ: The HIV-1 epidemic in South Africa. Oral Dis 2002;8(Suppl 2):27-31. (Pubitemid 41758936)
19. Vasan S and Tsuji M: A double-edged sword: The role of NKT cells in malaria and HIV infection and immunity. Semin Immunol 2010;22:87-96.
20. Deeks SG and Walker BD: The immune response to AIDS virus infection: Good, bad, or both? J Clin Invest 2004;113: 808-810. (Pubitemid 38544138)
21. Giorgi JV, et al.: Elevated levels of CD38+ CD8+ T cells in HIV infection add to the prognostic value of low CD4+ T cell levels: Results of 6 years of follow-up. The Los Angeles Center, Multicenter AIDS Cohort Study. J Acquir Immune Defic Syndr 1993;6:904-912. (Pubitemid 23207458)
22. Appay V, et al.: Accelerated immune senescence and HIV-1 infection. Exp Gerontol 2007;42:432-437. (Pubitemid 46561182)
23. Brenchley JM, et al.: Expression of CD57 defines replicative senescence and antigen-induced apoptotic death of CD8+ T cells. Blood 2003;101:2711-2720. (Pubitemid 36857634)
24. Balato A, et al.: Natural killer T cells: An unconventional Tcell subset with diverse effector and regulatory functions. J Invest Dermatol 2009;129:1628-1642.
25. Gumperz JE, et al.: Functionally distinct subsets of CD1drestricted natural killer T cells revealed by CD1d tetramer staining. J Exp Med 2002;195:625-636. (Pubitemid 34461507)
26. van der Vliet HJ, et al.: Selective decrease in circulating V alpha 24+V beta 11+ NKT cells during HIV type 1 infection. J Immunol 2002;168:1490-1495.
27. Ndhlovu LC, et al.: Lower numbers of circulating natural killer T (NK T) cells in individuals with human T lymphotropic virus type 1 (HTLV-1) associated neurological disease. Clin Exp Immunol 2009;158:294-299.
28. Cummings JS, et al.: Impacts of HIV infection on Vgamma2Vdelta2 T cell phenotype and function: A mechanism for reduced tumor immunity in AIDS. J Leukoc Biol 2008; 84:371-379.
29. Snyder-Cappione JE, et al.: Lower cytokine secretion ex vivo by natural killer T cells in HIV-infected individuals is associated with higher CD161 expression. AIDS 2009;23:1965-1970.
30. Fahey JL, et al.: Prognostic significance of plasma markers of immune activation, HIV viral load and CD4 T-cell measurements. AIDS 1998;12:1581-1590. (Pubitemid 28418327)
31. Shin Y, et al.: NKT cell-dependent regulation of secondary antigen-specific, conventional CD4+ T cell immune responses. J Immunol 2010;184:5589-5594.
32. Gorochov G, et al.: Perturbation of CD4+ and CD8+ T-cell repertoires during progression to AIDS and regulation of the CD4+ repertoire during antiviral therapy. Nat Med 1998;4:215-221. (Pubitemid 28137377)
33. van der Vliet HJ, et al.: Cutting edge: Rapid recovery of NKT cells upon institution of highly active antiretroviral therapy for HIV-1 infection. J Immunol 2006;177:5775-5778. (Pubitemid 44628789)
34. Sutherland JS, et al.: High granulocyte/lymphocyte ratio and paucity of NKT cells defines TB disease in a TB-endemic setting. Tuberculosis (Edinb) 2009;89:398-404.
35. Barral P, et al.: CD169(+) macrophages present lipid antigens to mediate early activation of iNKT cells in lymph nodes. Nat Immunol 2010;11:303-312.