Transgene-derived overexpression of miR-17-92 in CD8+ T-cells confers enhanced cytotoxic activity

Biochemical and Biophysical Research Communications

Volumn 458, Issue 3, 2015, Pages 549-554

  Kosaka, Akemi ^a,b   Ohkuri, Takayuki ^a,b   Ikeura, Maki ^b   Kohanbash, Gary ^a,b   Okada, Hideho ^a,b  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF PITTSBURGH CANCER INSTITUTE   (United States)

Author keywords

Antigen specific CD8+ T cells; Cytotoxicity; IFN ; miRNA 17 92; TGFBR2

Indexed keywords

GAMMA INTERFERON; HERMES ANTIGEN; MICRORNA; MICRORNA 17 92; T LYMPHOCYTE RECEPTOR; TRANSFORMING GROWTH FACTOR BETA1; TRANSFORMING GROWTH FACTOR BETA2; TUMOR ANTIGEN; UNCLASSIFIED DRUG; MELANOCYTE PROTEIN PMEL 17; MIRN17-92 MICRORNA, MOUSE; PMEL PROTEIN, HUMAN; PROTEIN SERINE THREONINE KINASE; TRANSFORMING GROWTH FACTOR BETA RECEPTOR; TRANSFORMING GROWTH FACTOR-BETA TYPE II RECEPTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTIGEN SPECIFICITY; ARTICLE; CD8+ T LYMPHOCYTE; CELL SURFACE; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOTOXICITY; GENE OVEREXPRESSION; MEMORY CELL; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; T LYMPHOCYTE ACTIVATION; TRANSGENE; TUMOR IMMUNITY; ADOPTIVE IMMUNOTHERAPY; ANIMAL; C57BL MOUSE; GENETICS; HUMAN; IMMUNOLOGY; LYMPHOCYTE ACTIVATION; METABOLISM; TRANSGENIC MOUSE; UPREGULATION;

MUS; MUS MUSCULUS;

ANIMALS; ANTIGENS, CD44; CD8-POSITIVE T-LYMPHOCYTES; GP100 MELANOMA ANTIGEN; HUMANS; IMMUNOTHERAPY, ADOPTIVE; INTERFERON-GAMMA; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MICRORNAS; PROTEIN-SERINE-THREONINE KINASES; RECEPTORS, TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA1; TRANSGENES; UP-REGULATION;

EID: 84924072159     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2015.02.003     Document Type: Article

References (53)

1. X. Qian, X. Wang, and H. Jin Cell transfer therapy for cancer: past, present, and future J. Immunol. Res. 2014 2014 525913
2. T.R. Mosmann, H. Cherwinski, and M.W. Bond Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins J. Immunol. 136 1986 2348 2357
3. L.L. Carter, and R.W. Dutton Type 1 and type 2: a fundamental dichotomy for all T-cell subsets Curr. Opin. Immunol. 8 1996 336 342
4. J. Zhu, and W.E. Paul Heterogeneity and plasticity of T helper cells Cell. Res. 20 2010 4 12
5. K.L. Knutson, and M.L. Disis Tumor antigen-specific T helper cells in cancer immunity and immunotherapy Cancer Immunol. Immunother. 54 2005 721 728
6. M.A. Hallett, K.T. Venmar, and B. Fingleton Cytokine stimulation of epithelial cancer cells: the similar and divergent functions of IL-4 and IL-13 Cancer Res. 72 2012 6338 6343
7. T. Nitta, M. Hishii, and K. Sato Selective expression of interleukin-10 gene within glioblastoma multiforme Brain Res. 649 1994 122 128
8. S. Wojtowicz-Praga Reversal of tumor-induced immunosuppression by TGF-beta inhibitors Invest. New. Drugs 21 2003 21 32
9. H. Nishikawa, and S. Sakaguchi Regulatory T cells in tumor immunity Int. J. Cancer 127 2010 759 767
10. M.J. McGeachy Th17 memory cells: live long and proliferate J. Leukoc. Biol. 94 2013 921 926
11. B. Yang, H. Kang, and A. Fung The role of interleukin 17 in tumour proliferation, angiogenesis, and metastasis Mediat. Inflamm. 2014 2014 623759
12. C. Zhang MicroRNomics: a newly emerging approach for disease biology Physiol. Genomics 33 2008 139 147
13. L. He, J.M. Thomson, and M.T. Hemann A microRNA polycistron as a potential human oncogene Nature 435 2005 828 833
14. Y. Hayashita, H. Osada, and Y. Tatematsu A polycistronic microRNA cluster, miR-17-92, is overexpressed in human lung cancers and enhances cell proliferation Cancer Res. 65 2005 9628 9632
15. H. Matsubara, T. Takeuchi, and E. Nishikawa Apoptosis induction by antisense oligonucleotides against miR-17-5p and miR-20a in lung cancers overexpressing miR-17-92 Oncogene 26 2007 6099 6105
16. C.H. Lawrie MicroRNA expression in lymphoma Expert Opin. Biol. Ther. 7 2007 1363 1374
17. C. Xiao, L. Srinivasan, and D.P. Calado Lymphoproliferative disease and autoimmunity in mice with increased miR-17-92 expression in lymphocytes Nat. Immunol. 9 2008 405 414
18. K. Sasaki, G. Kohanbash, and A. Hoji miR-17-92 expression in differentiated T cells - implications for cancer immunotherapy J. Transl. Med. 8 2010 17
19. M. Ohno, T. Ohkuri, and A. Kosaka Expression of miR-17-92 enhances anti-tumor activity of T-cells transduced with the anti-EGFRvIII chimeric antigen receptor in mice bearing human GBM xenografts J. Immunother. Cancer 1 2013 21
20. E. Tu, P.Z. Chia, and W. Chen TGFbeta in T cell biology and tumor immunity: angel or devil? Cytokine Growth Factor Rev. 25 2014 423 435
21. H.Y. Lin, X.F. Wang, and E. Ng-Eaton Expression cloning of the TGF-beta type II receptor, a functional transmembrane serine/threonine kinase Cell 68 1992 775 785
22. S. Volinia, G.A. Calin, and C.G. Liu A microRNA expression signature of human solid tumors defines cancer gene targets Proc. Natl. Acad. Sci. U. S. A. 103 2006 2257 2261
23. P. Mestdagh, A.K. Bostrom, and F. Impens The miR-17-92 microRNA cluster regulates multiple components of the TGF-beta pathway in neuroblastoma Mol. Cell. 40 2010 762 773
24. M. Merkerova, A. Vasikova, and M. Belickova MicroRNA expression profiles in umbilical cord blood cell lineages Stem Cells Dev. 19 2010 17 26
25. F. Nishimura, J.E. Dusak, and J. Eguchi Adoptive transfer of type 1 CTL mediates effective anti-central nervous system tumor response: critical roles of IFN-inducible protein-10 Cancer Res. 66 2006 4478 4487
26. O. Bannard, M. Kraman, and D. Fearon Pathways of memory CD8+ T-cell development Eur. J. Immunol. 39 2009 2083 2087
27. K. Murali-Krishna, and R. Ahmed Cutting edge: naive T cells masquerading as memory cells J. Immunol. 165 2000 1733 1737
28. A.W. Goldrath, L.Y. Bogatzki, and M.J. Bevan Naive T cells transiently acquire a memory-like phenotype during homeostasis-driven proliferation J. Exp. Med. 192 2000 557 564
29. B.K. Cho, V.P. Rao, and Q. Ge Homeostasis-stimulated proliferation drives naive T cells to differentiate directly into memory T cells J. Exp. Med. 192 2000 549 556
30. A.J. Litterman, D.M. Zellmer, and K.L. Grinnen Profound impairment of adaptive immune responses by alkylating chemotherapy J. Immunol. 190 2013 6259 6268
31. Q.T. Ostrom, H. Gittleman, and P. Farah CBTRUS statistical report: primary brain and central nervous system tumors diagnosed in the United States in 2006-2010 Neuro Oncol. 15 Suppl 2 2013 ii1 56
32. I. Jovcevska, N. Kocevar, and R. Komel Glioma and glioblastoma - how much do we (not) know? Mol. Clin. Oncol. 1 2013 935 941
33. J.T. Pribila, A.C. Quale, and K.L. Mueller Integrins and T cell-mediated immunity Annu. Rev. Immunol. 22 2004 157 180
34. K. Sasaki, X. Zhu, and C. Vasquez Preferential expression of very late antigen-4 on type 1 CTL cells plays a critical role in trafficking into central nervous system tumors Cancer Res. 67 2007 6451 6458
35. X. Zhu, F. Nishimura, and K. Sasaki Toll like receptor-3 ligand poly-ICLC promotes the efficacy of peripheral vaccinations with tumor antigen-derived peptide epitopes in murine CNS tumor models J. Transl. Med. 5 2007 10
36. T.F. Gajewski, S.R. Woo, and Y. Zha Cancer immunotherapy strategies based on overcoming barriers within the tumor microenvironment Curr. Opin. Immunol. 25 2013 268 276
37. T. Chanmee, P. Ontong, and K. Konno Tumor-associated macrophages as major players in the tumor microenvironment Cancers (Basel) 6 2014 1670 1690
38. N. Malhotra, and J. Kang SMAD regulatory networks construct a balanced immune system Immunology 139 2013 1 10
39. M.O. Li, and R.A. Flavell TGF-beta, T-cell tolerance and immunotherapy of autoimmune diseases and cancer Expert Rev. Clin. Immunol. 2 2006 257 265
40. S.H. Wrzesinski, Y.Y. Wan, and R.A. Flavell Transforming growth factor-beta and the immune response: implications for anticancer therapy Clin. Cancer. Res. 13 2007 5262 5270
41. B.S. Kwon, C. Chintamaneni, and C.A. Kozak A melanocyte-specific gene, Pmel 17, maps near the silver coat color locus on mouse chromosome 10 and is in a syntenic region on human chromosome 12 Proc. Natl. Acad. Sci. U. S. A. 88 1991 9228 9232
42. W.W. Overwijk, A. Tsung, and K.R. Irvine gp100/pmel 17 is a murine tumor rejection antigen: induction of "self"-reactive, tumoricidal T cells using high-affinity, altered peptide ligand J. Exp. Med. 188 1998 277 286
43. A.E. Nel T-cell activation through the antigen receptor. Part 1: signaling components, signaling pathways, and signal integration at the T-cell antigen receptor synapse J. Allergy Clin. Immunol. 109 2002 758 770
44. A. Taguchi, K. Yanagisawa, and M. Tanaka Identification of hypoxia-inducible factor-1 alpha as a novel target for miR-17-92 microRNA cluster Cancer Res. 68 2008 5540 5545
45. M. Sitkovsky, and D. Lukashev Regulation of immune cells by local-tissue oxygen tension: HIF1 alpha and adenosine receptors Nat. Rev. Immunol. 5 2005 712 721
46. A.K. Neumann, J. Yang, and M.P. Biju Hypoxia inducible factor 1 alpha regulates T cell receptor signal transduction Proc. Natl. Acad. Sci. U. S. A. 102 2005 17071 17076
47. H.K. Eltzschig, L.F. Thompson, and J. Karhausen Endogenous adenosine produced during hypoxia attenuates neutrophil accumulation: coordination by extracellular nucleotide metabolism Blood 104 2004 3986 3992
48. H. Kojima, H. Gu, and S. Nomura Abnormal B lymphocyte development and autoimmunity in hypoxia-inducible factor 1alpha -deficient chimeric mice Proc. Natl. Acad. Sci. U. S. A. 99 2002 2170 2174
49. D. Lukashev, B. Klebanov, and H. Kojima Cutting edge: hypoxia-inducible factor 1alpha and its activation-inducible short isoform I.1 negatively regulate functions of CD4+ and CD8+ T lymphocytes J. Immunol. 177 2006 4962 4965
50. J. Guo, W. Lu, and L.A. Shimoda Enhanced interferon-gamma gene expression in T Cells and reduced ovalbumin-dependent lung eosinophilia in hypoxia-inducible factor-1-alpha-deficient mice Int. Arch. Allergy Immunol. 149 2009 98 102
51. M. Thiel, C.C. Caldwell, and S. Kreth Targeted deletion of HIF-1alpha gene in T cells prevents their inhibition in hypoxic inflamed tissues and improves septic mice survival PLoS One 2 2007 e853
52. R.M. Prins, S.K. Odesa, and L.M. Liau Immunotherapeutic targeting of shared melanoma-associated antigens in a murine glioma model Cancer Res. 63 2003 8487 8491
53. D. Usharauli, A. Perez-Diez, and P. Matzinger The JAM test and its daughter P-JAM: simple tests of DNA fragmentation to measure cell death and stasis Nat. Protoc. 1 2006 672 682