Disturbance of oligodendrocyte function plays a key role in the pathogenesis of schizophrenia and major depressive disorder

BioMed Research International

Volumn 2015, Issue , 2015, Pages

  Miyata, Shingo ^a   Hattori, Tsuyoshi ^b,c   Shimizu, Shoko ^a,c   Ito, Akira ^c   Tohyama, Masaya ^a,d  

^a KINKI UNIVERSITY   (Japan)

^b KANAZAWA UNIVERSITY GRADUATE SCHOOL OF MEDICAL SCIENCE   (Japan)

^c OSAKA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^d OSAKA GENERAL MEDICAL CENTER   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

3 PHOSPHOINOSITIDE DEPENDENT PROTEIN KINASE; CELL ADHESION MOLECULE; CORTICOSTERONE; DISC1 BINDING ZINC FINGER PROTEIN; DISRUPTED IN SCHIZOPHRENIA 1 PROTEIN; MESSENGER RNA; MYELIN; PHOSPHOINOSITIDE DEPENDENT PROTEIN KINASE 1; PLATELET DERIVED GROWTH FACTOR; SERUM AND GLUCOCORTICOID REGULATED KINASE 1; UNCLASSIFIED DRUG; ZINC FINGER PROTEIN; DISC1 PROTEIN, HUMAN; DNA BINDING PROTEIN; IMMEDIATE EARLY PROTEIN; NERVE PROTEIN; PROTEIN SERINE THREONINE KINASE; SERUM-GLUCOCORTICOID REGULATED KINASE; TRANSCRIPTION FACTOR; ZNF365 PROTEIN, HUMAN;

ARTICLE; CELL FUNCTION; CELL LINEAGE; CELL MATURATION; CELL STRESS; CELL STRUCTURE; CORTICOSTERONE BLOOD LEVEL; GENE SILENCING; HEK293 CELL LINE; HUMAN; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; MAJOR DEPRESSION; MENTAL STRESS; MOLECULAR PATHOLOGY; MYELINATION; NERVE CELL DIFFERENTIATION; NEUROPATHOLOGY; NONHUMAN; OLIGODENDROCYTE PRECURSOR CELL; OLIGODENDROGLIA; PERINATAL PERIOD; POSTNATAL DEVELOPMENT; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; RISK FACTOR; SCHIZOPHRENIA; SIGNAL TRANSDUCTION; UPREGULATION; WHITE MATTER; BIOSYNTHESIS; BLOOD; CELL DIFFERENTIATION; DEPRESSIVE DISORDER, MAJOR; GENE EXPRESSION REGULATION; GENETICS; LIFE EVENT; METABOLISM; PATHOLOGY;

CELL DIFFERENTIATION; CORTICOSTERONE; DEPRESSIVE DISORDER, MAJOR; DNA-BINDING PROTEINS; GENE EXPRESSION REGULATION; HUMANS; IMMEDIATE-EARLY PROTEINS; LIFE CHANGE EVENTS; NERVE TISSUE PROTEINS; OLIGODENDROGLIA; PROTEIN-SERINE-THREONINE KINASES; SCHIZOPHRENIA; TRANSCRIPTION FACTORS;

EID: 84924061142     PISSN: 23146133     EISSN: 23146141     Source Type: Journal    
DOI: 10.1155/2015/492367     Document Type: Article

References (84)

1. K. Miyoshi, A. Honda, K. Baba et al., "Disrupted-In-Schizophrenia 1, a candidate gene for schizophrenia, participates in neurite outgrowth," Molecular Psychiatry, vol. 8, no. 7, pp. 685-694, 2003.
2. T. Hattori, K. Baba, S. Matsuzaki et al., "A novel DISC1- interacting partner DISC1-Binding Zinc-finger protein: implication in the modulation of DISC1-dependent neurite outgrowth," Molecular Psychiatry, vol. 12, no. 4, pp. 398-407, 2007.
3. K. Miyoshi, M. Asanuma, I. Miyazaki et al., "DISC1 localizes to the centrosome by binding to kendrin," Biochemical and Biophysical Research Communications, vol. 317, no. 4, pp. 1195-1199, 2004.
4. S. Shimizu, S. Matsuzaki, T. Hattori et al., "DISC1-kendrin interaction is involved in centrosomal microtubule network formation," Biochemical and Biophysical Research Communications, vol. 377, no. 4, pp. 1051-1056, 2008.
5. T. Hattori, S. Shimizu, Y. Koyama et al., "DISC1 regulates cellcell adhesion, cell-matrix adhesion and neurite outgrowth," Molecular Psychiatry, vol. 15, no. 8, pp. 798-809, 2010.
6. J. K. Millar, S. Christie, S. Anderson et al., "Genomic structure and localisation within a linkage hotspot of Disrupted In Schizophrenia 1, a gene disrupted by a translocation segregating with schizophrenia,"Molecular Psychiatry, vol. 6, no. 2, pp. 173-178, 2001.
7. J. K. Millar, J. C. Wilson-Annan, S. Anderson et al., "Disruption of two novel genes by a translocation co-segregating with schizophrenia," Human Molecular Genetics, vol. 9, no. 9, pp. 1415-1423, 2000.
8. D. St Clair, D. Blackwood, W. Muir et al., "Association within a family of a balanced autosomal translocation withmajormental illness," The Lancet, vol. 336, no. 8706, pp. 13-16, 1990.
9. Q. Wang, E. I. Charych, V. L. Pulito et al., "The psychiatric disease risk factors DISC1 andTNIKinteract to regulate synapse composition and function,"Molecular Psychiatry, vol. 16, no. 10, pp. 1006-1023, 2011.
10. A. Hayashi-Takagi, M. Takaki, N. Graziane et al., "Disruptedin- Schizophrenia 1 (DISC1) regulates spines of the glutamate synapse via Rac1," Nature Neuroscience, vol. 13, no. 3, pp. 327-332, 2010.
11. A. Kamiya, K. Kubo, T. Tomoda et al., "A schizophreniaassociatedmutation of DISC1 perturbs cerebral cortex development," Nature Cell Biology, vol. 7, no. 12, pp. 1067-1078, 2005.
12. R. C. Roberts, "Schizophrenia in translation: disrupted in schizophrenia (DISC1): integrating clinical and basic findings," Schizophrenia Bulletin, vol. 33, no. 1, pp. 11-15, 2007.
13. Y. Mao, X. Ge, C. L. Frank et al., "Disrupted in schizophrenia 1 regulates neuronal progenitor proliferation via modulation of GSK3β/β-catenin signaling," Cell, vol. 136, no. 6, pp. 1017-1031, 2009.
14. X. Duan, J. H. Chang, S. Ge et al., "Disrupted-In-schizophrenia 1 regulates integration of newly generated neurons in the adult brain," Cell, vol. 130, no. 6, pp. 1146-1158, 2007.
15. D. J. Porteous, J. K. Millar, N. J. Brandon, and A. Sawa, "DISC1 at 10: connecting psychiatric genetics and neuroscience," Trends in Molecular Medicine, vol. 17, no. 12, pp. 699-706, 2011.
16. K. Ishizuka, A. Kamiya, E. C. Oh et al., "DISC1-dependent switch from progenitor proliferation to migration in the developing cortex," Nature, vol. 473, no. 7345, pp. 92-96, 2011.
17. K. Kuroda, S. Yamada, M. Tanaka et al., "Behavioral alterations associated with targeted disruption of exons 2 and 3 of the Disc1 gene in the mouse," Human Molecular Genetics, vol. 20, no. 23, Article ID ddr400, pp. 4666-4683, 2011.
18. T. Hikida,H. Jaaro-Peled, S. Seshadri et al., "Dominant-negative DISC1 transgenic mice display schizophrenia-associated phenotypes detected bymeasures translatable to humans," Proceedings of the National Academy of Sciences of the United States of America, vol. 104, no. 36, pp. 14501-14506, 2007.
19. S. Shimizu, Y. Koyama, T. Hattori et al., "DBZ, a CNS-specific DISC1 binding protein, positively regulates oligodendrocyte differentiation," GLIA, vol. 62, no. 5, pp. 709-724, 2014.
20. T. Hattori, S. Shimizu, Y. Koyama et al., "DISC1 (disrupted-inschizophrenia- 1) regulates differentiation of oligodendrocytes," PLoS ONE, vol. 9, no. 2,Article ID e88506, 2014.
21. P. Katsel, W. Tan, B. Abazyan et al., "Expression of mutant human DISC1 in mice supports abnormalities in differentiation of oligodendrocytes," Schizophrenia Research, vol. 130, no. 1-3, pp. 238-249, 2011.
22. N. Edgar and E. Sibille, "A putative functional role for oligodendrocytes in mood regulation," Translational Psychiatry, vol. 2, article e109, 2012.
23. R. D. Fields, "White matter in learning, cognition and psychiatric disorders," Trends in Neurosciences, vol. 31, no. 7, pp. 361-370, 2008.
24. N. Baumann, J.-C. Turpin, M. Lefevre, and B. Colsch, "Motor and psycho-cognitive clinical types in adult metachromatic leukodystrophy: genotype/phenotype relationships?" Journal of Physiology-Paris, vol. 96, no. 3-4, pp. 301-306, 2002.
25. M. H. Kosmidis, M. Giannakou, L. Messinis, and P. Papathanasopoulos, "Psychotic features associated with multiple sclerosis," International Review of Psychiatry, vol. 22, no. 1, pp. 55-66, 2010.
26. M. Walterfang, S. J. Wood, D. velakoulis, D. Copolov, and C. Pantelis, "Diseases of white matter and schizophrenia-like psychosis," Australian & New Zealand Journal of Psychiatry, vol. 39, no. 9, pp. 746-756, 2005.
27. S. Seshadri, A. Kamiya, Y. Yokota et al., "Disrupted-inschizophrenia- 1 expression is regulated by β-site amyloid precursor protein cleaving enzyme-1-neuregulin cascade," Proceedings of the National Academy of Sciences of the United States of America, vol. 107, no. 12, pp. 5622-5627, 2010.
28. N. Takahashi, T. Sakurai, K. L. Davis, and J.D. Buxbaum, "Linking oligodendrocyte and myelin dysfunction to neurocircuitry abnormalities in schizophrenia," Progress in Neurobiology, vol. 93, no. 1, pp. 13-24, 2011.
29. J. D. Wood, F. Bonath, S. Kumar, C. A. Ross, and V. T. Cunliffe, "Disrupted-in-schizophrenia 1 and neuregulin 1 are required for the specification of oligodendrocytes and neurones in the zebrafish brain," Human Molecular Genetics, vol. 18, no. 3, pp. 391-404, 2009.
30. V. Bartanusz,D. Jezova, L. T. Bertini, F. J. H. Tilders, J.M. Aubry, and J. Z. Kiss, "Stress-induced increase in vasopressin and corticotropin-releasing factor expression in hypophysiotrophic paraventricular neurons," Endocrinology, vol. 132, no. 2,pp. 895-902, 1993.
31. K. S. Kendler, L. M. Karkowski, and C. A. Prescott, "Causal relationship between stressful life events and the onset ofmajor depression," The American Journal of Psychiatry, vol. 156, no. 6, pp. 837-841, 1999.
32. G. Aguilera and C. Rabadan-Diehl, "vasopressinergic regulation of the hypothalamic-pituitary-adrenal axis: implications for stress adaptation," Regulatory Peptides, vol. 96, no. 1-2, pp. 23-29, 2000.
33. P. W. Gold and D. S. Charney, "Diseases of the mind and brain: depression: A disease of the mind, brain, and body," The American Journal of Psychiatry, vol. 159, no. 11, p. 1826, 2002.
34. B. S. McEwen, "Protection and damage from acute and chronic stress: allostasis and allostatic overload and relevance to the pathophysiology of psychiatric disorders," Annals of the New York Academy of Sciences, vol. 1032, pp. 1-7, 2004.
35. E. Holsboer-Trachsler, R. Stohler, and M. Hatzinger, "Repeated administration of the combined dexamethasone-human corticotropin releasing hormone stimulation test during treatment of depression," Psychiatry Research, vol. 38, no. 2, pp. 163-171, 1991.
36. J. W. Chu, D. F. Matthias, J. Belanoff, A. Schatzberg, A. R. Hoffman, and D. Feldman, "Successful long-term treatment of refractory Cushing's disease with high-dose mifepristone (RU 486),"TheJournal ofClinical Endocrinology andMetabolism, vol. 86, no. 8, pp. 3568-3573, 2001.
37. S. Miyata, Y. Koyama, K. Takemoto et al., "Plasma corticosterone activates SGK1 and induces morphological changes in oligodendrocytes in corpus callosum," PLoS ONE, vol. 6, no. 5, Article ID e19859, 2011.
38. W. G. Honer, P. Falkai, C. Chen, V. Arango, J. J. Mann, and A. J. Dwork, "Synaptic and plasticity-associated proteins in anterior frontal cortex in severemental illness," Neuroscience, vol. 91, no. 4, pp. 1247-1255, 1999.
39. A. L. T. Lacerda, P. Brambilla, R. B. Sassi et al., "Anatomical MRI study of corpus callosum in unipolar depression," Journal of Psychiatric Research, vol. 39, no. 4, pp. 347-354, 2005.
40. M. Hamidi, W. C. Drevets, and J. L. Price, "Glial reduction in amygdala in major depressive disorder is due to oligodendrocytes," Biological Psychiatry, vol. 55, no. 6, pp. 563-569, 2004.
41. C. Aston, L. Jiang, and B. P. Sokolov, "Transcriptional profiling reveals evidence for signaling and oligodendroglial abnormalities in the temporal cortex from patients with major depressive disorder,"Molecular Psychiatry, vol. 10, no. 3, pp. 309-322, 2005.
42. M. P. Leussis and S. L. Andersen, "Is adolescence a sensitive period for depression? Behavioral and neuroanatomical findings from a social stress model," Synapse, vol. 62, no. 1, pp. 22-30, 2008.
43. Y. Koyama, T. Hattori, S. Shimizu et al., "DBZ (DISC1-binding zinc finger protein)-deficient mice display abnormalities in basket cells in the somatosensory cortices," Journal of Chemical Neuroanatomy, vol. 53, pp. 1-10, 2013.
44. Q. Wang, X. Du, J. Meinkoth et al., "Characterization of Su48, a centrosome protein essential for cell division," Proceedings of the National Academy of Sciences of the United States of America, vol. 103, no. 17, pp. 6512-6517, 2006.
45. S. Mori and C. P. Leblond, "Electron microscopic identification of three classes of oligodendrocytes and a preliminary study of their proliferative activity in the corpus callosum of young rats," Journal of Comparative Neurology, vol. 139, no. 1, pp. 1-28, 1970.
46. S. Kuhlmann-Krieg, I. Sommer, and M. Schachner, "Ultrastructural features of cultured oligodendrocytes expressing stagespecific cell-surface antigens.," Brain Research, vol. 467, no. 2, pp. 269-280, 1988.
47. R. D. Fields, "White matter in learning, cognition and psychiatric disorders," Trends in Neurosciences, vol. 31, no. 7, pp. 361-370, 2008.
48. K. M. Spencer, P. G. Nestor, M. A. Niznikiewicz, D. F. Salisbury, M. E. Shenton, and R. W. McCarley, "Abnormal neural synchrony in schizophrenia," Journal of Neuroscience, vol. 23, no. 19, pp. 7407-7411, 2003.
49. Y. Hirohashi, Q. Wang, Q. Liu et al., "Centrosomal proteins Nde1 and Su48 form a complex regulated by phosphorylation," Oncogene, vol. 25, no. 45, pp. 6048-6055, 2006.
50. H.-G. Bernstein, J. Steiner, and B. Bogerts, "Glial cells in schizophrenia: pathophysiological significance and possible consequences for therapy," Expert Review of Neurotherapeutics, vol. 9, no. 7, pp. 1059-1071, 2009.
51. B. P. Sokolov, "Oligodendroglial abnormalities in schizophrenia, mood disorders and substance abuse. Comorbidity, shared traits, or molecular phenocopies?" International Journal of Neuropsychopharmacology, vol. 10, no. 4, pp. 547-555, 2007.
52. D. Tkachev, M. L. Mimmack, M. M. Ryan et al., "Oligodendrocyte dysfunction in schizophrenia and bipolar disorder,"The Lancet, vol. 362, no. 9386, pp. 798-805, 2003.
53. A. Anitha, K. Nakamura, K. Yamada et al., "Association studies and gene expression analyses of the DISC1-interacting molecules, pericentrin 2 (PCNT2) and DISC1-binding zinc finger protein (DBZ), with schizophrenia and with bipolar disorder," The American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics, vol. 150, no. 7, pp. 967-976, 2009.
54. L. N. Moens, P. de Rijk, J. Reumers et al., "Sequencing of DISC1 pathway genes reveals increased burden of raremissense variants in schizophrenia patients from a Northern Swedish population," PLoS ONE, vol. 6, no. 8,Article ID e23450, 2011.
55. T. Hattori, T. Katayama, T. Miyakawa et al., "Analysis of cortical development in mice lacking DBZ," Journal of Neurochemistry, vol. 125, supplement 1, p. 167, 2013.
56. P.W. Gold and D. S. Charney, "Diseases of the mind and brain: depression: a disease of the mind, brain, and body," American Journal of Psychiatry, vol. 159, no. 11, p. 1826, 2002.
57. B. S. McEwen, "Protection and damage from acute and chronic stress: Allostasis and allostatic overload and relevance to the pathophysiology of psychiatric disorders," Annals of the New York Academy of Sciences, vol. 1032, pp. 1-7, 2004.
58. T. Hattori, S. Miyata, A. Ito, T. Katayama, and M. Tohyama, "Psychosis and adhesion molecules," in Mental Illness/Book 1, InTech, 2012.
59. V. Bartanusz,D. Jezova, L. T. Bertini, F. J.H. Tilders, J.-M. Aubry, and J. Z. Kiss, "Stress-induced increase in vasopressin and corticotropin-releasing factor expression in hypophysiotrophic paraventricular neurons," Endocrinology, vol. 132, no. 2,pp. 895-902, 1993.
60. J. P. Herman, D. Adams, and C. Prewitt, "Regulatory changes in neuroendocrine stress-integrative circuitry produced by a variable stress paradigm," Neuroendocrinology, vol. 61, no. 2, pp. 180-190, 1995.
61. M. F. Dallman, N. C. Pecoraro, S. E. La Fleur et al., "Glucocorticoids, chronic stress, and obesity," Progress in Brain Research, vol. 153, pp. 75-105, 2006.
62. T. Kobayashi and P. Cohen, "Activation of serum- and glucocorticoid-regulated protein kinase by agonists that activate phosphatidylinositide 3-kinase is mediated by 3- phosphoinositide-dependent protein kinase-1 (PDK1) and PDK2," Biochemical Journal, vol. 339, no. 2, pp. 319-328, 1999.
63. T. Kobayashi, M. Deak, N. Morrice, and P. Cohen, "Characterization of the structure and regulation of two novel isoforms of serum- and glucocorticoid-induced protein kinase," Biochemical Journal, vol. 344, no. 1, pp. 189-197, 1999.
64. J. Park, M. L. L. Leong, P. Buse, A. C. Maiyar, G. L. Firestone, and B. A. Hemmings, "Serum and glucocorticoid-inducible kinase (SGK) is a target of the PI 3-kinase-stimulated signaling pathway," EMBO Journal, vol. 18, no. 11, pp. 3024-3033, 1999.
65. S.-I. Iwata, M. Nomoto, H. Morioka, and A. Miyata, "Gene expression profiling in the midbrain of striatal 6-hydroxydopamine- injected mice," Synapse, vol. 51, no. 4, pp. 279-286, 2004.
66. C. C. Stichel, B. Schoenebeck, M. Foguet et al., "sgk1, a member of an RNA cluster associated with cell death in a model of Parkinson's disease," European Journal of Neuroscience, vol. 21, no. 2, pp. 301-316, 2005.
67. B. Schoenebeck,V. Bader, R. Z. Xin, B. Schmitz,H. Lübbert, and C. C. Stichel, "Sgk1, a cell survival response in neurodegenerative diseases," Molecular and Cellular Neuroscience, vol. 30, no. 2, pp. 249-264, 2005.
68. H. Rangone, G. Poizat, J. Troncoso et al., "The serumand glucocorticoid-induced kinase SGK inhibits mutant huntingtin-induced toxicity by phosphorylating serine 421 of huntingtin," European Journal of Neuroscience, vol. 19, no. 2, pp. 273-279, 2004.
69. Y. Nishida, T. Nagata, Y. Takahashi, M. Sugahara-Kobayashi, A. Murata, and S. Asai, "Alteration of serum/glucocorticoid regulated kinase-1 (sgk-1) gene expression in rat hippocampus after transient global ischemia," Molecular Brain Research, vol. 123, no. 1-2, pp. 121-125, 2004.
70. M. Piechota, M. Korostynski, W. Solecki et al., "The dissection of transcriptional modules regulated by various drugs of abuse in the mouse striatum," Genome Biology, vol. 11, no. 5, article R48, 2010.
71. S. Waldegger, P. Barth, G. Raber, and F. Lang, "Cloning and characterization of a putative human serine/threonine protein kinase transcriptionally modified during anisotonic and isotonic alterations of cell volume," Proceedings of the National Academy of Sciences of the United States of America, vol. 94, no. 9, pp. 4440-4445, 1997.
72. F. Lang, K. Klingel, C. A. Wagner et al., "Deranged transcriptional regulation of cell-volume-sensitive kinase hSGK in diabetic nephropathy," Proceedings of the National Academy of Sciences of the United States of America, vol. 97, no. 14, pp. 8157-8162, 2000.
73. R. T. Cowling and H. C. Birnboim, "Expression of serum- and glucocorticoid-regulated kinase (sgk) mRNA is up-regulated by GM-CSF and other proinflammatory mediators in human granulocytes," Journal of Leukocyte Biology, vol. 67, no. 2, pp. 240-248, 2000.
74. F. Lang and P. Cohen, "Regulation and physiological roles of serum- and glucocorticoid-induced protein kinase isoforms," Science's STKE, no. 108, article RE17, 2001.
75. J. T. Murray, D. G. Campbell, N. Morrice et al., "Exploitation of KESTREL to identify NDRG family members as physiological substrates for SGK1 and GSK3," Biochemical Journal, vol. 384, no. 3, pp. 477-488, 2004.
76. J. Chun, T. Kwon, E. J. Lee et al., "14-3-3 protein mediates phosphorylation of microtubule-associated protein Tau by serumand glucocorticoid-induced protein kinase 1," Molecules and Cells, vol. 18, no. 3, pp. 360-368, 2004.
77. D. J. Tai, C.-C. Su, Y.-L. Ma, and E. H. Y. Lee, "SGK1 phosphorylation of IκB kinase α and p300 up-regulates NF-κB activity and increases N-methyl-D-aspartate receptor NR2A and NR2B expression,"The Journal of Biological Chemistry, vol. 284, no. 7, pp. 4073-4089, 2009.
78. T. Okuda, K. Kokame, and T. Miyata, "Differential expression patterns of NDRG family proteins in the central nervous system," Journal of Histochemistry and Cytochemistry, vol. 56, no. 2, pp. 175-182, 2008.
79. K. Imaizumi,M. Tsuda, A. Wanaka,M. Tohyama, and T. Takagi, "Differential expression of sgkmRNA, amember of the Ser/Thr protein kinase gene family, in rat brain after CNS injury," Molecular Brain Research, vol. 26, no. 1-2, pp. 189-196, 1994.
80. R. D. Hollister, K. J. Page, and B. T. Hyman, "Distribution of the messenger RNA for the extracellularly regulated kinases 1, 2 and 3 in rat brain: Effects of excitotoxic hippocampal lesions," Neuroscience, vol. 79, no. 4, pp. 1111-1119, 1997.
81. D. Rodriguez, A. Gelot, B. D. Gaspera et al., "Increased density of oligodendrocytes in childhood ataxia with diffuse central hypomyelination (CACH) syndrome: neuropathological and biochemical study of two cases," Acta Neuropathologica, vol. 97, no. 5, pp. 469-480, 1999.
82. M. M. Fraser, I. T. Bayazitov, S. S. Zakharenko, and S. J. Baker, "Phosphatase and tensin homolog, deleted on chromosome 10 deficiency in brain causes defects in synaptic structure, transmission and plasticity, and myelination abnormalities," Neuroscience, vol. 151, no. 2, pp. 476-488, 2008.
83. M. W. Tham, P. S. Woon, M. Y. Sum, T.-S. Lee, and K. Sim, "White matter abnormalities in major depression: evidence from post-mortem, neuroimaging and genetic studies," Journal of Affective Disorders, vol. 132, no. 1-2, pp. 26-36, 2011.
84. B. Czéh, J. I. H. Müller-Keuker, R. Rygula et al., "Chronic social stress inhibits cell proliferation in the adult medial prefrontal cortex: hemispheric asymmetry and reversal by fluoxetine treatment," Neuropsychopharmacology, vol. 32, no. 7, pp. 1490-1503, 2007.