Inhibition of eukaryotic elongation factor-2 confers to tumor suppression by a herbal formulation Huanglian-Jiedu decoction in human hepatocellular carcinoma

Journal of Ethnopharmacology

Volumn 164, Issue , 2015, Pages 309-318

  Wang, Ning ^a,b   Feng, Yibin ^a,b   Tan, Hor Yue ^a   Cheung, Fan ^a   Hong, Ming ^a   Lao, Lixing ^a   Nagamatsu, Tadashi ^c  

^a THE UNIVERSITY OF HONG KONG   (Hong Kong)

^b UNIVERSITY OF HONG KONG   (China)

^c MEIJO UNIVERSITY   (Japan)

Author keywords

AMPK; eEF2; Hepatocellular carcinoma; Huanglian Jiedu decoction; Nascent protein synthesis

Indexed keywords

ADENYLATE KINASE; ANTINEOPLASTIC AGENT; BAICALIN; BERBERINE; CHINESE DRUG; ELONGATION FACTOR 2; EUKARYOTIC ELONGATION FACTOR 2; GENIPOSIDE; HUANGLIAN JIEDU DECOCTION; INITIATION FACTOR; INITIATION FACTOR 4A; INITIATION FACTOR 4E; INITIATION FACTOR 4G; PALMATINE; UNCLASSIFIED DRUG; EEF2K PROTEIN, HUMAN; ELONGATION FACTOR 2 KINASE; FLAVONOID; HERBACEOUS AGENT; IRIDOID; ORENGEDOKU TO;

ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER INHIBITION; CANCER THERAPY; CELL EXPANSION; CELL PROLIFERATION; CELL VIABILITY ASSAY; CHEMICAL COMPOSITION; CHINESE MEDICINE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME INACTIVATION; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; FEMALE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; LIVER CELL CARCINOMA; MOUSE; NONHUMAN; PROTEIN EXPRESSION; PROTEIN SYNTHESIS; TUMOR VOLUME; TUMOR XENOGRAFT; UPREGULATION; ANIMAL; ANTAGONISTS AND INHIBITORS; BAGG ALBINO MOUSE; CARCINOMA, HEPATOCELLULAR; DRUG SCREENING; LIVER NEOPLASMS; METABOLISM; NEOVASCULARIZATION, PATHOLOGIC; NUDE MOUSE; PHYTOTHERAPY; TUMOR CELL LINE;

EUKARYOTA; MURINAE;

ANIMALS; ANTINEOPLASTIC AGENTS; BERBERINE; CARCINOMA, HEPATOCELLULAR; CELL LINE, TUMOR; DRUGS, CHINESE HERBAL; ELONGATION FACTOR 2 KINASE; FEMALE; FLAVONOIDS; HUMANS; IRIDOIDS; LIVER NEOPLASMS; MICE, INBRED BALB C; MICE, NUDE; NEOVASCULARIZATION, PATHOLOGIC; PHYTOTHERAPY; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84924060291     PISSN: 03788741     EISSN: 18727573     Source Type: Journal    
DOI: 10.1016/j.jep.2015.02.025     Document Type: Article

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