Inhibition of preadipocyte differentiation and lipid accumulation by orengedokuto treatment of 3T3-L1 cultures

Phytotherapy Research

Volumn 26, Issue 1, 2012, Pages 91-100

  Ikarashi, Nobutomo ^a   Tajima, Masataka ^a   Suzuki, Kunihiro ^a   Toda, Takahiro ^a   Ito, Kiyomi ^a   Ochiai, Wataru ^a   Sugiyama, Kiyoshi ^a  

^a HOSHI UNIVERSITY   (Japan)

Author keywords

3T3 L1 cell; berberine; C EBP ; Orengedokuto; PPARI

Indexed keywords

BERBERINE; CCAAT ENHANCER BINDING PROTEIN ALPHA; ORENGEDOKUTO; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; UNCLASSIFIED DRUG;

ADIPOCYTE; ANIMAL CELL; ARTICLE; CCAAT ENHANCER BINDING PROTEIN ALPHA GENE; CELL DIFFERENTIATION; CELL STRAIN 3T3; CHINESE MEDICINE; CONTROLLED STUDY; COPTIS; CORK TREE; DRUG MECHANISM; EMBRYO; GENE; GENE EXPRESSION; LIPID STORAGE; MOUSE; NONHUMAN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA GENE; PROADIPOCYTE; PROTEIN EXPRESSION;

3T3-L1 CELLS; ADIPOCYTES; ANIMALS; ANTI-OBESITY AGENTS; BERBERINE; CCAAT-ENHANCER-BINDING PROTEIN-ALPHA; CELL DIFFERENTIATION; CELL PROLIFERATION; COPTIS; DRUG EVALUATION, PRECLINICAL; DRUGS, CHINESE HERBAL; LIPID METABOLISM; MEDICINE, KAMPO; MICE; OBESITY; PHELLODENDRON; PHYTOTHERAPY; PLANT BARK; PPAR GAMMA; RHIZOME; RNA, MESSENGER;

EID: 84855645129     PISSN: 0951418X     EISSN: 10991573     Source Type: Journal    
DOI: 10.1002/ptr.3493     Document Type: Article

References (39)

1. Arakawa K, Saruta T, Abe, et al,. 2006. Improvement of accessory symptoms of hypertension by TSUMURA Orengedokuto Extract, a four herbal drugs containing Kampo-Medicine Granules for ethical use: a double-blind, placebo-controlled study. Phytomedicine 13: 1-10. (Pubitemid 41797584)
2. Bell A, Grunder L, Sorisky A,. 2000. Rapamycin inhibits human adipocyte differentiation in primary culture. Obes Res 8: 249-254.
3. Bradley RL, Mansfield JP, Maratos-Flier E, et al,. 2002. Melanin-concentrating hormone activates signaling pathways in 3T3-L1 adipocytes. Am J Physiol Endocrinol Metab 283: E584-E592. (Pubitemid 35230497)
4. Bray GA,. 2000. A concise review on the therapeutics of obesity. Nutrition 16: 953-960.
5. Choi BH, Ahn IS, Kim YH, et al,. 2006. Berberine reduces the expression of adipogenic enzymes and inflammatory molecules of 3T3-L1 adipocyte. Exp Mol Med 38: 599-605.
6. El Hadri K, Glorian M, Monsempes C, et al,. 2004. In vitro suppression of the lipogenic pathway by the nonnucleoside reverse transcriptase inhibitor efavirenz in 3T3 and human preadipocytes or adipocytes. J Biol Chem 279: 15130-15141. (Pubitemid 38618908)
7. Farrigan C, Pang K,. 2002. Obesity market overview. Nat Rev Drug Discov 1: 257-258.
8. Furuyashiki T, Nagayasu H, Aoki Y, et al,. 2004. Tea catechin suppresses adipocyte differentiation accompanied by down-regulation of PPARgamma2 and C/EBPalpha in 3T3-L1 cells. Biosci Biotechnol Biochem 68: 2353-2359. (Pubitemid 40033512)
9. Green H, Kehinde O,. 1975. An established preadipose cell line and its differentiation in culture. II. Factors affecting the adipose conversion. Cell 5: 19-27.
10. Green H, Meuth M,. 1974. An established pre-adipose cell line and its differentiation in culture. Cell 3: 127-133.
11. Green LM, Reade JL, Ware CF,. 1984. Rapid colorimetric assay for cell viability: application to the quantitation of cytotoxic and growth inhibitory lymphokines. J Immunol Methods 70: 257-268. (Pubitemid 14111307)
12. Hadvary P, Lengsfeld H, Wolfer H,. 1988. Inhibition of pancreatic lipase in vitro by the covalent inhibitor tetrahydrolipstatin. Biochem J 256: 357-361. (Pubitemid 19005994)
13. Halvorsen YD, Bond A, Sen A, et al,. 2001. Thiazolidinediones and glucocorticoids synergistically induce differentiation of human adipose tissue stromal cells: biochemical, cellular, and molecular analysis. Metabolism 50: 407-413. (Pubitemid 32327905)
14. Heal DJ, Aspley S, Prow MR, et al,. 1998. Sibutramine: a novel anti-obesity drug. A review of the pharmacological evidence to differentiate it from d -amphetamine and d -fenfluramine. Int J Obes Relat Metab Disord 22 (Suppl 1): S18-S28; discussion S29. (Pubitemid 128705406)
15. Hioki C, Yoshimoto K, Yoshida T,. 2004. Efficacy of bofu-tsusho-san, an oriental herbal medicine, in obese Japanese women with impaired glucose tolerance. Clin Exp Pharmacol Physiol 31: 614-619. (Pubitemid 39329764)
16. Huang C, Zhang Y, Gong Z, et al,. 2006. Berberine inhibits 3T3-L1 adipocyte differentiation through the PPARgamma pathway. Biochem Biophys Res Commun 348: 571-578. (Pubitemid 44209153)
17. Kamei Y, Kawada T, Mizukami J, et al,. 1994. The prevention of adipose differentiation of 3T3-L1 cells caused by retinoic acid is elicited through retinoic acid receptor alpha. Life Sci 55: PL307-PL312. (Pubitemid 124015897)
18. Kang K, Pariza MW,. 2001. trans-10,cis-12-Conjugated linoleic acid reduces leptin secretion from 3T3-L1 adipocytes. Biochem Biophys Res Commun 287: 377-382. (Pubitemid 32917608)
19. Kawada T, Aoki N, Kamei Y, et al,. 1990. Comparative investigation of vitamins and their analogues on terminal differentiation, from preadipocytes to adipocytes, of 3T3-L1 cells. Comp Biochem Physiol A Comp Physiol 96: 323-326. (Pubitemid 20228879)
20. Kim HS, Liang L, Dean RG, et al,. 2001. Inhibition of preadipocyte differentiation by myostatin treatment in 3T3-L1 cultures. Biochem Biophys Res Commun 281: 902-906. (Pubitemid 32917816)
21. Kim JK, So H, Youn MJ, et al,. 2007. Hibiscus sabdariffa L. water extract inhibits the adipocyte differentiation through the PI3-K and MAPK pathway. J Ethnopharmacol 114: 260-267. (Pubitemid 47539832)
22. Kopelman PG,. 2000. Obesity as a medical problem. Nature 404: 635-643. (Pubitemid 30205068)
23. Kozak LP, Jensen JT,. 1974. Genetic and developmental control of multiple forms of l -glycerol 3-phosphate dehydrogenase. J Biol Chem 249: 7775-7781.
24. Laemmli UK,. 1970. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227: 680-685.
25. Lagace DC, Nachtigal MW,. 2004. Inhibition of histone deacetylase activity by valproic acid blocks adipogenesis. J Biol Chem 279: 18851-18860. (Pubitemid 38623312)
26. Lee YS, Kim WS, Kim KH, et al,. 2006. Berberine, a natural plant product, activates AMP-activated protein kinase with beneficial metabolic effects in diabetic and insulin-resistant states. Diabetes 55: 2256-2264. (Pubitemid 44743622)
27. Levert KL, Waldrop GL, Stephens JM,. 2002. A biotin analog inhibits acetyl-CoA carboxylase activity and adipogenesis. J Biol Chem 277: 16347-16350. (Pubitemid 34967642)
28. Lowry OH, Rosebrough NJ, Farr AL, et al,. 1951. Protein measurement with the Folin phenol reagent. J Biol Chem 193: 265-275.
29. Miller CW, Casimir DA, Ntambi JM,. 1996. The mechanism of inhibition of 3T3-L1 preadipocyte differentiation by prostaglandin F2alpha. Endocrinology 137: 5641-5650.
30. Mosmann T,. 1983. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J Immunol Methods 65: 55-63. (Pubitemid 14203433)
31. Rosen ED, Hsu CH, Wang X, et al,. 2002. C/EBPalpha induces adipogenesis through PPARgamma: a unified pathway. Genes Dev 16: 22-26. (Pubitemid 34049634)
32. Sekiya N, Shibahara N, Sakakibara I, et al,. 2003. Inhibitory effects of Oren-Gedoku-To (Huanglian-Jie-Du-Tang) on free radical-induced lysis of human red blood cells. Phytother Res 17: 147-151. (Pubitemid 36262263)
33. Sen A, Lea-Currie YR, Sujkowska D, et al,. 2001. Adipogenic potential of human adipose derived stromal cells from multiple donors is heterogeneous. J Cell Biochem 81: 312-319. (Pubitemid 32298263)
34. Spiegelman BM, Flier JS,. 1996. Adipogenesis and obesity: rounding out the big picture. Cell 87: 377-389. (Pubitemid 26374313)
35. Takahata T, Kumano T, Ookawa K, et al,. 2004. Inhibition of 3T3-L1 adipocyte differentiation by 6-ethoxyzolamide: repressed peroxisome proliferator-activated receptor gamma mRNA and enhanced CCAAT/enhancer binding protein beta mRNA levels. Biochem Pharmacol 67: 1667-1675. (Pubitemid 38479845)
36. Tamori Y, Masugi J, Nishino N, et al,. 2002. Role of peroxisome proliferator-activated receptor-gamma in maintenance of the characteristics of mature 3T3-L1 adipocytes. Diabetes 51: 2045-2055. (Pubitemid 34729007)
37. Wise LS, Green H,. 1979. Participation of one isozyme of cytosolic glycerophosphate dehydrogenase in the adipose conversion of 3T3 cells. J Biol Chem 254: 273-275.
38. Wu Z, Rosen ED, Brun R, et al,. 1999. Cross-regulation of C/EBP alpha and PPAR gamma controls the transcriptional pathway of adipogenesis and insulin sensitivity. Mol Cell 3: 151-158. (Pubitemid 29292616)
39. Yoshida T, Sakane N, Wakabayashi Y, et al,. 1995. Thermogenic, anti-obesity effects of bofu-tsusho-san in MSG-obese mice. Int J Obes Relat Metab Disord 19: 717-722.