The janus face of α-toxin: A potent mediator of cytoprotection in staphylococci-infected macrophages

Journal of Innate Immunity

Volumn 7, Issue 2, 2015, Pages 187-198

  Koziel, Joanna ^a   Chmiest, Daniela ^a   Bryzek, Danuta ^a   Kmiecik, Katarzyna ^a   Mizgalska, Danuta ^a   Maciag Gudowska, Agnieszka ^a   Shaw, Lindsey N ^b   Potempa, Jan ^a,c  

^a JAGIELLONIAN UNIVERSITY   (Poland)

^b UNIVERSITY OF SOUTH FLORIDA   (United States)

^c UNIVERSITY OF LOUISVILLE SCHOOL OF MEDICINE   (United States)

Author keywords

Cytoprotection; Gene regulation; Macrophages; MCL 1; Staphylococcus aureus infection; Toxin

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 6; MYELOID LEUKEMIA FACTOR 1; STAPHYLOCOCCUS ALPHA TOXIN; TOLL LIKE RECEPTOR 2; BACTERIAL TOXIN; HEMOLYSIN; PROTEIN MCL 1; STAPHYLOCOCCAL ALPHA-TOXIN; TLR2 PROTEIN, HUMAN; VIRULENCE FACTOR;

APOPTOSIS; ARTICLE; BACTERIAL STRAIN; CELL PROTECTION; CONTROLLED STUDY; CYTOKINE RELEASE; HUMAN; HUMAN CELL; MACROPHAGE; NONHUMAN; PHAGOCYTOSIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; STAPHYLOCOCCUS AUREUS; UPREGULATION; CELL CULTURE; GENETICS; IMMUNE EVASION; IMMUNOLOGY; METABOLISM; MICROBIOLOGY; MUTATION; PATHOGENICITY; STAPHYLOCOCCUS INFECTION; TRANSMISSION;

BACTERIAL TOXINS; CELLS, CULTURED; CYTOPROTECTION; HEMOLYSIN PROTEINS; HUMANS; IMMUNE EVASION; INTERLEUKIN-6; MACROPHAGES; MUTATION; MYELOID CELL LEUKEMIA SEQUENCE 1 PROTEIN; NF-KAPPA B; PHAGOCYTOSIS; STAPHYLOCOCCAL INFECTIONS; STAPHYLOCOCCUS AUREUS; TOLL-LIKE RECEPTOR 2; VIRULENCE FACTORS;

EID: 84924043930     PISSN: 1662811X     EISSN: 16628128     Source Type: Journal    
DOI: 10.1159/000368048     Document Type: Article

References (23)

1. Freer JH, Arbuthnott JP: Toxins of Staphylococcus aureus. Pharmacol Ther 1982; 19: 55-106
2. Gray GS, Kehoe M: Primary sequence of the alpha-toxin gene from Staphylococcus aureus wood 46. Infect Immun 1984; 46: 615-618
3. Bhakdi S, Tranum-Jensen J: Alpha-toxin of Staphylococcus aureus. Microbiol Rev 1991; 55: 733-751
4. Walev I, Martin E, Jonas D, Mohamadzadeh M, Muller-Klieser W, Kunz L, Bhakdi S: Staphylococcal alpha-toxin kills human keratinocytes by permeabilizing the plasma membrane for monovalent ions. Infect Immun 1993; 61: 4972-4979
5. Bramley AJ, Patel AH, O'Reilly M, Foster R, Foster TJ: Roles of alpha-toxin and beta-toxin in virulence of Staphylococcus aureus for the mouse mammary gland. Infect Immun 1989; 57: 2489-2494
6. Jarry TM, Memmi G, Cheung AL: The expression of alpha-haemolysin is required for Staphylococcus aureus phagosomal escape after internalization in CFT-1 cells. Cell Microbiol 2008; 10: 1801-1814
7. Kubica M, Guzik K, Koziel J, Zarebski M, Richter W, Gajkowska B, Golda A, Maciag-Gudowska A, Brix K, Shaw L, Foster T, Potempa J: A potential new pathway for Staphylococcus aureus dissemination: the silent survival of S. aureus phagocytosed by human monocyte-derived macrophages. PLoS One 2008; 3:e1409
8. Hruz P, Zinkernagel AS, Jenikova G, Botwin GJ, Hugot JP, Karin M, Nizet V, Eckmann L: NOD2 contributes to cutaneous defense against Staphylococcus aureus through alpha-toxin-dependent innate immune activation. Proc Natl Acad Sci U S A 2009; 106: 12873-12878
9. Girardin SE, Boneca IG, Viala J, Chamaillard M, Labigne A, Thomas G, Philpott DJ, Sansonetti PJ: NOD2 is a general sensor of peptidoglycan through muramyl dipeptide (MDP) detection. J Biol Chem 2003; 278: 8869-8872
10. Deshmukh HS, Hamburger JB, Ahn SH, Mc-Cafferty DG, Yang SR, Fowler VG Jr: Critical role of NOD2 in regulating the immune response to Staphylococcus aureus. Infect Immun 2009; 77: 1376-1382
11. Ting JP, Davis BK: CATERPILLER: a novel gene family important in immunity, cell death, and diseases. Annu Rev Immunol 2005; 23: 387-414
12. Koziel J, Maciag-Gudowska A, Mikolajczyk T, Bzowska M, Sturdevant DE, Whitney AR, Shaw LN, DeLeo FR, Potempa J: Phagocytosis of Staphylococcus aureus by macrophages exerts cytoprotective effects manifested by the upregulation of antiapoptotic factors. PLoS One 2009; 4:e5210
13. Koziel J, Kmiecik K, Chmiest D, Maresz K, Mizgalska D, Maciag-Gudowska A, Mydel P, Potempa J: The role of Mcl-1 in S. aureusinduced cytoprotection of infected macrophages. Mediators Inflamm 2013; 2013: 427021
14. Livak KJ, Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods 2001; 25: 402-408
15. Giese B, Glowinski F, Paprotka K, Dittmann S, Steiner T, Sinha B, Fraunholz MJ: Expression of delta-toxin by Staphylococcus aureus mediates escape from phago-endosomes of human epithelial and endothelial cells in the presence of beta-toxin. Cell Microbiol 2011; 13: 316-329
16. Bantel H, Sinha B, Domschke W, Peters G, Schulze-Osthoff K, Janicke RU: alpha-Toxin is a mediator of Staphylococcus aureus-induced cell death and activates caspases via the intrinsic death pathway independently of death receptor signaling. J Cell Biol 2001; 155: 637-648
17. Haslinger B, Strangfeld K, Peters G, Schulze-Osthoff K, Sinha B: Staphylococcus aureus alpha-toxin induces apoptosis in peripheral blood mononuclear cells: role of endogenous tumour necrosis factor-alpha and the mitochondrial death pathway. Cell Microbiol 2003; 5: 729-741
18. Bayles KW, Wesson CA, Liou LE, Fox LK, Bohach GA, Trumble WR: Intracellular Staphylococcus aureus escapes the endosome and induces apoptosis in epithelial cells. Infect Immun 1998; 66: 336-342
19. Menzies BE, Kourteva I: Internalization of Staphylococcus aureus by endothelial cells induces apoptosis. Infect Immun 1998; 66: 5994-5998
20. Gurcel L, Abrami L, Girardin S, Tschopp J, van der Goot FG: Caspase-1 activation of lipid metabolic pathways in response to bacterial pore-forming toxins promotes cell survival. Cell 2006; 126: 1135-1145
21. Haugwitz U, Bobkiewicz W, Han SR, Beckmann E, Veerachato G, Shaid S, Biehl S, Dersch K, Bhakdi S, Husmann M: Pore-forming Staphylococcus aureus alpha-toxin triggers epidermal growth factor receptor-dependent proliferation. Cell Microbiol 2006; 8: 1591-1600
22. Husmann M, Dersch K, Bobkiewicz W, Beckmann E, Veerachato G, Bhakdi S: Differential role of p38 mitogen activated protein kinase for cellular recovery from attack by poreforming S. aureus alpha-toxin or streptolysin O. Biochem Biophys Res Commun 2006; 344: 1128-1134
23. Wilke GA, Bubeck Wardenburg J: Role of a disintegrin and metalloprotease 10 in Staphylococcus aureus alpha-hemolysin-mediated cellular injury. Proc Natl Acad Sci U S A 2010; 107: 13473-13478.