-
1
-
-
84857969863
-
Chipping away at the lung cancer genome
-
Pao W, Hutchinson KE. Chipping away at the lung cancer genome. Nat Med 2012;18:349-51.
-
(2012)
Nat Med
, vol.18
, pp. 349-351
-
-
Pao, W.1
Hutchinson, K.E.2
-
2
-
-
73349085919
-
Understanding the mechanisms behind trastuzumab therapy for human epidermal growth factor receptor 2-positive breast cancer
-
Spector NL, Blackwell KL. Understanding the mechanisms behind trastuzumab therapy for human epidermal growth factor receptor 2-positive breast cancer. J Clin Oncol 2009;27:5838-47.
-
(2009)
J Clin Oncol
, vol.27
, pp. 5838-5847
-
-
Spector, N.L.1
Blackwell, K.L.2
-
3
-
-
0037291769
-
EGF activates its receptor by removing interactions that autoinhibit ectodomain dimerization
-
Ferguson KM, Berger MB, Mendrola JM, et al. EGF activates its receptor by removing interactions that autoinhibit ectodomain dimerization. Mol Cell 2003;11:507-17.
-
(2003)
Mol Cell
, vol.11
, pp. 507-517
-
-
Ferguson, K.M.1
Berger, M.B.2
Mendrola, J.M.3
-
4
-
-
66249091930
-
The HER-2 receptor and breast cancer: ten years of targeted anti-HER-2 therapy and personalized medicine
-
Ross JS, Slodkowska EA, Symmans WF, et al. The HER-2 receptor and breast cancer: ten years of targeted anti-HER-2 therapy and personalized medicine. Oncologist 2009;14:320-68.
-
(2009)
Oncologist
, vol.14
, pp. 320-368
-
-
Ross, J.S.1
Slodkowska, E.A.2
Symmans, W.F.3
-
5
-
-
77956262693
-
Trastuzumab in combination with chemotherapy versus chemotherapy alone for treatment of HER2-positive advanced gastric or gastro-oesophageal junction cancer (ToGA): a phase 3, open-label, randomised controlled trial
-
Bang YJ, Van Cutsem E, Feyereislova A, et al. Trastuzumab in combination with chemotherapy versus chemotherapy alone for treatment of HER2-positive advanced gastric or gastro-oesophageal junction cancer (ToGA): a phase 3, open-label, randomised controlled trial. Lancet 2010;376:687-97.
-
(2010)
Lancet
, vol.376
, pp. 687-697
-
-
Bang, Y.J.1
Van Cutsem, E.2
Feyereislova, A.3
-
6
-
-
84890767985
-
Activating mutations in ERBB2 and their impact on diagnostics and treatment
-
Herter-Sprie GS, Greulich H, Wong KK. Activating mutations in ERBB2 and their impact on diagnostics and treatment. Front Oncol 2013;3:86.
-
(2013)
Front Oncol
, vol.3
, pp. 86
-
-
Herter-Sprie, G.S.1
Greulich, H.2
Wong, K.K.3
-
7
-
-
0037029712
-
Evaluation of HER-2/neu gene amplification and protein expression in non-small cell lung carcinomas
-
Hirsch FR, Varella-Garcia M, Franklin WA, et al. Evaluation of HER-2/neu gene amplification and protein expression in non-small cell lung carcinomas. Br J Cancer 2002;86:1449-56.
-
(2002)
Br J Cancer
, vol.86
, pp. 1449-1456
-
-
Hirsch, F.R.1
Varella-Garcia, M.2
Franklin, W.A.3
-
8
-
-
0242442020
-
HER2 status in non-small cell lung cancer: results from patient screening for enrollment to a phase II study of herceptin
-
Heinmöller P, Gross C, Beyser K, et al. HER2 status in non-small cell lung cancer: results from patient screening for enrollment to a phase II study of herceptin. Clin Cancer Res 2003;9:5238-43.
-
(2003)
Clin Cancer Res
, vol.9
, pp. 5238-5243
-
-
Heinmöller, P.1
Gross, C.2
Beyser, K.3
-
9
-
-
12144290704
-
Trastuzumab in combination with cisplatin and gemcitabine in patients with Her2-overexpressing, untreated, advanced non-small cell lung cancer: report of a phase II trial and findings regarding optimal identification of patients with Her2-overexpressing disease
-
Zinner RG, Glisson BS, Fossella FV, et al. Trastuzumab in combination with cisplatin and gemcitabine in patients with Her2-overexpressing, untreated, advanced non-small cell lung cancer: report of a phase II trial and findings regarding optimal identification of patients with Her2-overexpressing disease. Lung Cancer 2004;44:99-110.
-
(2004)
Lung Cancer
, vol.44
, pp. 99-110
-
-
Zinner, R.G.1
Glisson, B.S.2
Fossella, F.V.3
-
10
-
-
84867760241
-
HER2 amplification: a potential mechanism of acquired resistance to EGFR inhibition in EGFR-mutant lung cancers that lack the second-site EGFRT790M mutation
-
Takezawa K, Pirazzoli V, Arcila ME, et al. HER2 amplification: a potential mechanism of acquired resistance to EGFR inhibition in EGFR-mutant lung cancers that lack the second-site EGFRT790M mutation. Cancer Discov 2012;2:922-33.
-
(2012)
Cancer Discov
, vol.2
, pp. 922-933
-
-
Takezawa, K.1
Pirazzoli, V.2
Arcila, M.E.3
-
11
-
-
84877100240
-
Analysis of tumor specimens at the time of acquired resistance to EGFR-TKI therapy in 155 patients with EGFR-mutant lung cancers
-
Yu HA, Arcila ME, Rekhtman N, et al. Analysis of tumor specimens at the time of acquired resistance to EGFR-TKI therapy in 155 patients with EGFR-mutant lung cancers. Clin Cancer Res 2013;19:2240-7.
-
(2013)
Clin Cancer Res
, vol.19
, pp. 2240-2247
-
-
Yu, H.A.1
Arcila, M.E.2
Rekhtman, N.3
-
12
-
-
58849132314
-
HER2YVMA drives rapid development of adenosquamous lung tumors in mice that are sensitive to BIBW2992 and rapamycin combination therapy
-
Perera SA, Li D, Shimamura T, et al. HER2YVMA drives rapid development of adenosquamous lung tumors in mice that are sensitive to BIBW2992 and rapamycin combination therapy. Proc Natl Acad Sci U S A 2009;106:474-9.
-
(2009)
Proc Natl Acad Sci U S A
, vol.106
, pp. 474-479
-
-
Perera, S.A.1
Li, D.2
Shimamura, T.3
-
13
-
-
33746154236
-
Non-small-cell lung cancer and Ba/F3 transformed cells harboring the ERBB2 G776insV_G/C mutation are sensitive to the dual-specific epidermal growth factor receptor and ERBB2 inhibitor HKI-272
-
Shimamura T, Ji H, Minami Y, et al. Non-small-cell lung cancer and Ba/F3 transformed cells harboring the ERBB2 G776insV_G/C mutation are sensitive to the dual-specific epidermal growth factor receptor and ERBB2 inhibitor HKI-272. Cancer Res 2006;66:6487-91.
-
(2006)
Cancer Res
, vol.66
, pp. 6487-6491
-
-
Shimamura, T.1
Ji, H.2
Minami, Y.3
-
14
-
-
4944232647
-
Lung cancer: intragenic ERBB2 kinase mutations in tumours
-
Stephens P, Hunter C, Bignell G, et al. Lung cancer: intragenic ERBB2 kinase mutations in tumours. Nature 2004;431:525-6.
-
(2004)
Nature
, vol.431
, pp. 525-526
-
-
Stephens, P.1
Hunter, C.2
Bignell, G.3
-
15
-
-
84866360342
-
Prevalence, clinicopathologic associations, and molecular spectrum of ERBB2 (HER2) tyrosine kinase mutations in lung adenocarcinomas
-
Arcila ME, Chaft JE, Nafa K, et al. Prevalence, clinicopathologic associations, and molecular spectrum of ERBB2 (HER2) tyrosine kinase mutations in lung adenocarcinomas. Clin Cancer Res 2012;18:4910-8.
-
(2012)
Clin Cancer Res
, vol.18
, pp. 4910-4918
-
-
Arcila, M.E.1
Chaft, J.E.2
Nafa, K.3
-
16
-
-
20144386787
-
Somatic mutations of the HER2 kinase domain in lung adenocarcinomas
-
Shigematsu H, Takahashi T, Nomura M, et al. Somatic mutations of the HER2 kinase domain in lung adenocarcinomas. Cancer Res 2005;65:1642-6.
-
(2005)
Cancer Res
, vol.65
, pp. 1642-1646
-
-
Shigematsu, H.1
Takahashi, T.2
Nomura, M.3
-
17
-
-
80052558779
-
Prognostic and predictive implications of HER2/ERBB2/neu gene mutations in lung cancers
-
Tomizawa K, Suda K, Onozato R, et al. Prognostic and predictive implications of HER2/ERBB2/neu gene mutations in lung cancers. Lung Cancer 2011;74:139-44.
-
(2011)
Lung Cancer
, vol.74
, pp. 139-144
-
-
Tomizawa, K.1
Suda, K.2
Onozato, R.3
-
18
-
-
84880661427
-
Lung cancer that harbors an HER2 mutation: epidemiologic characteristics and therapeutic perspectives
-
Mazières J, Peters S, Lepage B, et al. Lung cancer that harbors an HER2 mutation: epidemiologic characteristics and therapeutic perspectives. J Clin Oncol 2013;31:1997-2003.
-
(2013)
J Clin Oncol
, vol.31
, pp. 1997-2003
-
-
Mazières, J.1
Peters, S.2
Lepage, B.3
-
19
-
-
84865994665
-
Functional analysis of receptor tyrosine kinase mutations in lung cancer identifies oncogenic extracellular domain mutations of ERBB2
-
Greulich H, Kaplan B, Mertins P, et al. Functional analysis of receptor tyrosine kinase mutations in lung cancer identifies oncogenic extracellular domain mutations of ERBB2. Proc Natl Acad Sci U S A 2012;109:14476-81.
-
(2012)
Proc Natl Acad Sci U S A
, vol.109
, pp. 14476-14481
-
-
Greulich, H.1
Kaplan, B.2
Mertins, P.3
-
20
-
-
84892666476
-
Novel germline mutation in the transmembrane domain of HER2 in familial lung adenocarcinomas
-
Yamamoto H, Higasa K, Sakaguchi M, et al. Novel germline mutation in the transmembrane domain of HER2 in familial lung adenocarcinomas. J Natl Cancer Inst 2014;106:djt338.
-
(2014)
J Natl Cancer Inst
, vol.106
-
-
Yamamoto, H.1
Higasa, K.2
Sakaguchi, M.3
-
21
-
-
16844375982
-
Lack of trastuzumab activity in nonsmall cell lung carcinoma with overexpression of erb-B2: 39810: a phase II trial of Cancer and Leukemia Group B
-
Clamon G, Herndon J, Kern J, et al. Lack of trastuzumab activity in nonsmall cell lung carcinoma with overexpression of erb-B2: 39810: a phase II trial of Cancer and Leukemia Group B. Cancer 2005;103:1670-5.
-
(2005)
Cancer
, vol.103
, pp. 1670-1675
-
-
Clamon, G.1
Herndon, J.2
Kern, J.3
-
22
-
-
0942287963
-
Randomized phase II trial of gemcitabine-cisplatin with or without trastuzumab in HER2-positive non-small-cell lung cancer
-
Gatzemeier U, Groth G, Butts C, et al. Randomized phase II trial of gemcitabine-cisplatin with or without trastuzumab in HER2-positive non-small-cell lung cancer. Ann Oncol 2004;15:19-27.
-
(2004)
Ann Oncol
, vol.15
, pp. 19-27
-
-
Gatzemeier, U.1
Groth, G.2
Butts, C.3
-
23
-
-
1542360632
-
Trastuzumab plus docetaxel in HER2/neu-positive non-small-cell lung cancer: a California Cancer Consortium screening and phase II trial
-
Lara PN Jr, Laptalo L, Longmate J, et al. Trastuzumab plus docetaxel in HER2/neu-positive non-small-cell lung cancer: a California Cancer Consortium screening and phase II trial. Clin Lung Cancer 2004;5:231-6.
-
(2004)
Clin Lung Cancer
, vol.5
, pp. 231-236
-
-
Lara, P.N.1
Laptalo, L.2
Longmate, J.3
-
24
-
-
2142762457
-
Trastuzumab in the treatment of advanced non-small-cell lung cancer: is there a rol?. Focus on Eastern Cooperative Oncology Group study 2598
-
Langer CJ, Stephenson P, Thor A, et al. Trastuzumab in the treatment of advanced non-small-cell lung cancer: is there a role? Focus on Eastern Cooperative Oncology Group study 2598. J Clin Oncol 2004;22:1180-7.
-
(2004)
J Clin Oncol
, vol.22
, pp. 1180-1187
-
-
Langer, C.J.1
Stephenson, P.2
Thor, A.3
-
25
-
-
77949694139
-
Randomized phase II multicenter trial of two schedules of lapatinib as first-or second-line monotherapy in patients with advanced or metastatic non-small cell lung cancer
-
Ross HJ, Blumenschein GR Jr, Aisner J, et al. Randomized phase II multicenter trial of two schedules of lapatinib as first-or second-line monotherapy in patients with advanced or metastatic non-small cell lung cancer. Clin Cancer Res 2010;16:1938-49.
-
(2010)
Clin Cancer Res
, vol.16
, pp. 1938-1949
-
-
Ross, H.J.1
Blumenschein, G.R.2
Aisner, J.3
-
26
-
-
84858002759
-
Clinical activity of afatinib (BIBW 2992) in patients with lung adenocarcinoma with mutations in the kinase domain of HER2/neu
-
De Grève J, Teugels E, Geers C, et al. Clinical activity of afatinib (BIBW 2992) in patients with lung adenocarcinoma with mutations in the kinase domain of HER2/neu. Lung Cancer 2012;76:123-7.
-
(2012)
Lung Cancer
, vol.76
, pp. 123-127
-
-
De Grève, J.1
Teugels, E.2
Geers, C.3
-
27
-
-
84884659720
-
Phase II study of afatinib, an irreversible ErbB family blocker, in demographically and genotypically defined non-small cell lung cancer (NSCLC) patients
-
De Greve J, Moran T, Graas MP, et al. Phase II study of afatinib, an irreversible ErbB family blocker, in demographically and genotypically defined non-small cell lung cancer (NSCLC) patients. J Clin Oncol 2013;31:abstr 8063.
-
(2013)
J Clin Oncol
, vol.31
-
-
De Greve, J.1
Moran, T.2
Graas, M.P.3
-
28
-
-
84894807977
-
Phase I study of neratinib in combination with temsirolimus in patients with human epidermal growth factor receptor 2-dependent and other solid tumors
-
Gandhi L, Bahleda R, Tolaney SM, et al. Phase I study of neratinib in combination with temsirolimus in patients with human epidermal growth factor receptor 2-dependent and other solid tumors. J Clin Oncol 2014;32:68-75.
-
(2014)
J Clin Oncol
, vol.32
, pp. 68-75
-
-
Gandhi, L.1
Bahleda, R.2
Tolaney, S.M.3
-
29
-
-
84927694072
-
Results with dacomitinib (PF-00299804), an irreversible pan-her tyrosine kinase inhibitor, in a phase II cohort of patients with her2-mutant or amplified lung cancers
-
Kris MG, Camidge DR, Giacone G, et al. Results with dacomitinib (PF-00299804), an irreversible pan-her tyrosine kinase inhibitor, in a phase II cohort of patients with her2-mutant or amplified lung cancers. J Thorac Oncol 2013;8:S609. Available online: http://journals.lww.com/jto/Citation/2013/11001/15th_World_Conference:on_Lung_Cancer.1.aspx
-
(2013)
J Thorac Oncol
, vol.8
, pp. S609
-
-
Kris, M.G.1
Camidge, D.R.2
Giacone, G.3
-
30
-
-
35949004420
-
Efficacy and safety of single-agent pertuzumab, a human epidermal receptor dimerization inhibitor, in patients with non small cell lung cancer
-
Herbst RS, Davies AM, Natale RB, et al. Efficacy and safety of single-agent pertuzumab, a human epidermal receptor dimerization inhibitor, in patients with non small cell lung cancer. Clin Cancer Res 2007;13:6175-81.
-
(2007)
Clin Cancer Res
, vol.13
, pp. 6175-6181
-
-
Herbst, R.S.1
Davies, A.M.2
Natale, R.B.3
|