Melatonin promotes Bax sequestration to mitochondria reducing cell susceptibility to apoptosis via the lipoxygenase metabolite 5-hydroxyeicosatetraenoic acid

Mitochondrion

Volumn 21, Issue , 2015, Pages 113-121

  Radogna, F ^a,b   Albertini, M C ^c   De Nicola, M ^a   Diederich, M ^d   Bejarano, I ^e   Ghibelli, L ^a  

^a UNIVERSITY OF ROME TOR VERGATA   (Italy)

^b LABORATOIRE DE BIOLOGIE MOLÉCULAIRE ET CELLULAIRE DU CANCER   (Luxembourg)

^c UNIVERSITY OF URBINO   (Italy)

^d Seoul National University   (South Korea)

^e KING ABDULLAH UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Saudi Arabia)

Author keywords

5 HETE; Apoptosis; Bax; Bcl 2; IP3; Melatonin

Indexed keywords

5 HYDROXYICOSATETRAENOIC ACID; CALMODULIN; LIPOXYGENASE; MELATONIN; PROTEIN BAX; PROTEIN BCL 2; 5-HYDROXY-6,8,11,14-EICOSATETRAENOIC ACID; ALOX5 PROTEIN, HUMAN; ARACHIDONATE 5 LIPOXYGENASE; HYDROXYICOSATETRAENOIC ACID;

APOPTOSIS; ARTICLE; BINDING AFFINITY; CELL VIABILITY; CONTROLLED STUDY; ENZYME ACTIVATION; HORMONE ACTION; HORMONE BINDING; HUMAN; HUMAN CELL; INTRACELLULAR SIGNALING; LEUKOCYTE; METABOLITE; MITOCHONDRION; PRIORITY JOURNAL; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; PROTEIN TARGETING; ANTAGONISTS AND INHIBITORS; CELL LINE; DRUG EFFECTS; METABOLISM; MONOCYTE; PHYSIOLOGY;

APOPTOSIS; ARACHIDONATE 5-LIPOXYGENASE; BCL-2-ASSOCIATED X PROTEIN; CELL LINE; HUMANS; HYDROXYEICOSATETRAENOIC ACIDS; MELATONIN; MITOCHONDRIA; MONOCYTES;

EID: 84923920035     PISSN: 15677249     EISSN: 18728278     Source Type: Journal    
DOI: 10.1016/j.mito.2015.02.003     Document Type: Article

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