A novel pyrazolone-based derivative induces apoptosis in human esophageal cells via reactive oxygen species (ROS) generation and caspase-dependent mitochondria-mediated pathway

Chemico-Biological Interactions

Volumn 231, Issue , 2015, Pages 1-9

  Zhao, Jing ^a   Zhang, Li ^a   Li, Jinyao ^a   Wu, Ting ^a   Wang, Meifang ^a   Xu, Guancheng ^a   Zhang, Fuchun ^a   Liu, Lang ^a   Yang, Jianhua ^a,b   Sun, Surong ^a  

^a XINJIANG UNIVERSITY   (China)

^b BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

Apoptosis; Cadmium; Eca 109 cells; Mitochondrial pathway; Pyrazolone based derivative

Indexed keywords

CASPASE; CASPASE 3; CASPASE 9; FLUORESCEIN ISOTHIOCYANATE; LIPOCORTIN 5; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PYRAZOLONE DERIVATIVE; REACTIVE OXYGEN METABOLITE; ANTINEOPLASTIC AGENT; CADMIUM; PYRAZOLONE;

ANTINEOPLASTIC ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; APOPTOSIS ASSAY; ARTICLE; CELL VIABILITY ASSAY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DNA FRAGMENTATION ASSAY; DRUG SYNTHESIS; ECA 109 CELL LINE; ENZYME ACTIVATION; ESOPHAGEAL CANCER CELL LINE; ESOPHAGUS CANCER; HUMAN; HUMAN CELL; IN VITRO STUDY; MITOCHONDRIAL MEMBRANE POTENTIAL; PROTEIN CLEAVAGE; TRANSMISSION ELECTRON MICROSCOPY; WESTERN BLOTTING; CHEMISTRY; DRUG EFFECTS; ESOPHAGEAL NEOPLASMS; ESOPHAGUS; METABOLISM; MITOCHONDRION; PATHOLOGY; SIGNAL TRANSDUCTION; TUMOR CELL LINE;

ANTINEOPLASTIC AGENTS; APOPTOSIS; CADMIUM; CASPASES; CELL LINE, TUMOR; ESOPHAGEAL NEOPLASMS; ESOPHAGUS; HUMANS; MITOCHONDRIA; PYRAZOLONES; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION;

EID: 84923915424     PISSN: 00092797     EISSN: 18727786     Source Type: Journal    
DOI: 10.1016/j.cbi.2015.02.004     Document Type: Article

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