Formulation and characterization of microspheres loaded with imatinib for sustained delivery

International Journal of Pharmaceutics

Volumn 482, Issue 1-2, 2015, Pages 123-130

  Ramazani, F ^a,b   Chen, W ^a   Van Nostrum, C F ^a   Storm, G ^a,c   Kiessling, F ^b   Lammers, T ^b,c   Hennink, W E ^a   Kok, R J ^a  

^a UTRECHT UNIVERSITY   (Netherlands)

^b RWTH AACHEN UNIVERSITY   (Germany)

^c UNIVERSITY OF TWENTE   (Netherlands)

Author keywords

Double emulsion (W1 O W2); drug release; Imatinib mesylate; Loading efficiency; log D; PLGA microspheres

Indexed keywords

COUNTERION; IMATINIB; MICROSPHERE; POLYGLACTIN; DELAYED RELEASE FORMULATION; DRUG CARRIER; LACTIC ACID; POLYGLYCOLIC ACID; POLYLACTIC ACID-POLYGLYCOLIC ACID COPOLYMER;

ALKALINITY; ARTICLE; DIFFERENTIAL SCANNING CALORIMETRY; DRUG DEGRADATION; DRUG DELIVERY SYSTEM; DRUG DIFFUSION; DRUG ELIMINATION; DRUG SOLUBILITY; EMULSION; ENCAPSULATION; GLASS TRANSITION TEMPERATURE; IN VITRO STUDY; MOLECULAR WEIGHT; PARTICLE SIZE; PH; POLYMERIZATION; PRIORITY JOURNAL; SCANNING ELECTRON MICROSCOPY; SURFACE PROPERTY; SUSTAINED RELEASE FORMULATION; CHEMISTRY; DELAYED RELEASE FORMULATION; DRUG RELEASE; SOLUBILITY; TIME;

DELAYED-ACTION PREPARATIONS; DRUG CARRIERS; DRUG LIBERATION; IMATINIB MESYLATE; LACTIC ACID; MICROSPHERES; PARTICLE SIZE; POLYGLYCOLIC ACID; SOLUBILITY; TIME FACTORS;

EID: 84923877293     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2015.01.043     Document Type: Article

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