Pharmacological tools for hydrogen sulphide research: A brief, introductory guide for beginners

British Journal of Pharmacology

Volumn 172, Issue 6, 2015, Pages 1633-1637

  Papapetropoulos, Andreas ^a   Whiteman, Matthew ^b   Cirino, Giuseppe ^c  

^a UNIVERSITY OF ATHENS   (Greece)

^b UNIVERSITY OF EXETER MEDICAL SCHOOL   (United Kingdom)

^c UNIVERSITY OF NAPLES FEDERICO II   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

3 MERCAPTOPYRUVATE SULFURTRANSFERASE; 3 MERCAPTOPYRUVIC ACID; 4 METHOXYPHENYL(MORPHOLINO)PHOSPHINODITHIOATE MORPHOLINIUM; AMINOETHOXYVINYLGLYCINE; AMINOOXYACETIC ACID; AMINOTRANSFERASE; BETA CYANO LEVOALANINE; CHEMICAL COMPOUND; CYSTATHIONINE BETA SYNTHASE; CYSTATHIONINE GAMMA LYASE; CYSTEINE; CYSTEINE 2 OXOGLUTARATE AMINOTRANSFERASE; DIALLYL DISULFIDE; DIALLYL TRISULFIDE; ENZYME INHIBITOR; GASOTRANSMITTER; HEMOGLOBIN; HOMOCYSTEINE; HYDROGEN SULFIDE; HYDROGEN SULFIDE DONOR; HYDROGEN SULFIDE INHIBITOR; HYDROXOCOBALAMIN; HYDROXYLAMINE; INORGANIC COMPOUND; ORGANIC COMPOUND; PROPARGYLGLYCINE; PYRIDOXAL 5 PHOSPHATE; SMALL INTERFERING RNA; SULFURTRANSFERASE; UNCLASSIFIED DRUG;

BIOLOGICAL ACTIVITY; BIOSYNTHESIS; CELL METABOLISM; CELL TRANSPORT; CELLULAR DISTRIBUTION; COLORIMETRY; CONCENTRATION RESPONSE; DRUG BINDING; DRUG POTENCY; DRUG SELECTIVITY; DRUG SYNTHESIS; DRUG TARGETING; DRUG TRANSFORMATION; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME SPECIFICITY; ENZYME SUBSTRATE COMPLEX; FLUOROMETRY; GENE SILENCING; HUMAN; HYDROGEN SULFIDE REMOVAL; NONHUMAN; PHARMACOLOGICAL BLOCKING; PRIORITY JOURNAL; REPRODUCIBILITY; REVIEW; RNA INTERFERENCE; SYNTHESIS; TISSUE DISTRIBUTION; ANIMAL; ANTAGONISTS AND INHIBITORS; CHEMICAL ANALYSIS; METABOLISM; PROCEDURES;

ANIMALS; CHEMISTRY TECHNIQUES, ANALYTICAL; HUMANS; HYDROGEN SULFIDE;

EID: 84923803897     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/bph.12806     Document Type: Review

References (28)

1. Alexander SPH, Benson HE, Faccenda E, Pawson AJ, Sharman JL, Spedding M, et al. (2013). The Concise Guide to PHARMACOLOGY 2013/14: Enzymes. Br J Pharmacol 170: 1797-1862.
2. Asimakopoulou A, Panopoulos P, Chasapis CT, Coletta C, Zhou Z, Cirino G, et al. (2013). Selectivity of commonly used pharmacological inhibitors for cystathionine beta synthase (CBS) and cystathionine gamma lyase (CSE). Br J Pharmacol 169: 922-932.
3. Banerjee R, Zou CG, (2005). Redox regulation and reaction mechanism of human cystathionine-beta-synthase: a PLP-dependent hemesensor protein. Arch Biochem Biophys 433: 144-156.
4. Benavides GA, Squadrito GL, Mills RW, Patel HD, Isbell TS, Patel RP, et al. (2007). Hydrogen sulfide mediates the vasoactivity of garlic. Proc Natl Acad Sci U S A 104: 17977-17982.
5. Bucci M, Papapetropoulos A, Vellecco V, Zhou Z, Zaid A, Giannogonas P, et al. (2012). cGMP-dependent protein kinase contributes to hydrogen sulfidestimulated vasorelaxation. PLoS ONE 7: e53319.
6. Di Salvo ML, Contestabile R, Safo MK, (2011). Vitamin B6 salvage enzymes: mechanism, structure and regulation. Biochim Biophys Acta 1814: 1597-1608.
7. Fu M, Zhang W, Wu L, Yang G, Li H, Wang R, (2012). Hydrogen sulfide (H2S) metabolism in mitochondria and its regulatory role in energy production. Proc Natl Acad Sci U S A 109: 2943-2948.
8. Ishii I, Akahoshi N, Yamada H, Nakano S, Izumi T, Suematsu MJ, (2010). Cystathionine gamma-Lyase-deficient mice require dietary cysteine to protect against acute lethal myopathy and oxidative injury. Biol Chem 285: 26358-26368.
9. Kashfi K, Olson KR, (2013). Biology and therapeutic potential of hydrogen sulfide and hydrogen sulfide-releasing chimeras. Biochem Pharmacol 85: 689-703.
10. Kimura H, (2011). Hydrogen sulfide: its production, release and functions. Amino Acids 41: 113-121.
11. Li L, Whiteman M, Guan YY, Neo KL, Cheng Y, Lee SW, et al. (2008). Characterization of a novel, water-soluble hydrogen sulfide-releasing molecule (GYY4137): new insights into the biology of hydrogen sulfide. Circulation 117: 2351-2360.
12. Li L, Rose P, Moore PK, (2011). Hydrogen sulfide and cell signaling. Annu Rev Pharmacol Toxicol 51: 169-187.
13. Lin VS, Chang CJ, (2012). Fluorescent probes for sensing and imaging biological hydrogen sulfide. Curr Opin Chem Biol 16: 595-601.
14. Meier M, Janosik M, Kery V, Kraus JP, Burkhard P, (2001). Structure of human cystathionine beta-synthase: a unique pyridoxal 5-phosphate-dependent heme protein. EMBO J 20: 3910-3916.
15. Nagahara N, Nagano M, Ito T, Shimamura K, Akimoto T, Suzuki H, (2013). Antioxidant enzyme, 3-mercaptopyruvate sulfurtransferase-knockout mice exhibit increased anxiety-like behaviors: a model for human mercaptolactate-cysteine disulfiduria. Sci Rep 3: 1986.
16. Nagy P, Pálinkás Z, Nagy A, Budai B, Tõth I, Vasas A, (2013). Chemical aspects of hydrogen sulfide measurements in physiological samples. Biochim Biophys Acta S0304-4165: 241-249.
17. Pawson AJ, Sharman JL, Benson HE, Faccenda E, Alexander SP, Buneman OP, et al. (2014). The IUPHAR/BPS Guide to PHARMACOLOGY: an expert-driven knowledgebase of drug targets and their ligands. Nucl Acids Res 42 (Database Issue): D1098-1106.
18. 2S biogenesis. Biochim Biophys Acta 1814: 1518-1527.
19. Stipanuk MH, Beck PW, (1982). Characterization of the enzymic capacity for cysteine desulphhydration in liver and kidney of the rat. Biochem J 206: 267-277.
20. Szabo C, (2007). Hydrogen sulfide and its therapeutic potential. Nat Rev Drug Discov 6: 917-935.
21. Teng H, Wu B, Zhao K, Yang G, Wu L, Wang R, (2013). Oxygen-sensitive mitochondrial accumulation of cystathionine β-synthase mediated by Lon protease. Proc Natl Acad Sci U S A 110: 12679-12684.
22. Ubuka T, (2002). Assay methods and biological roles of labile sulfur in animal tissues. J Chromatogr 781: 227-249.
23. Wang R, (2012). Physiological implications of hydrogen sulfide: a whiff exploration that blossomed. Physiol Rev 92: 791-896.
24. Watanabe M, Osada J, Aratani Y, Kluckman K, Reddick R, Malinow MR, et al. (1995). Mice deficient in cystathionine beta-synthase: animal models for mild and severe homocyst(e)inemia. Proc Natl Acad Sci U S A 92: 1585-1589.
25. Whiteman M, Le Trionnaire S, Chopra M, Fox B, Whatmore J, (2011). Emerging role of hydrogen sulfide in health and disease: critical appraisal of biomarkers and pharmacological tools. Clin Sci (Lond) 121: 459-488.
26. Wintner EA, Deckwerth TL, Langston W, Bengtsson A, Leviten D, Hill P, et al. (2010). A monobromobimane-based assay to measure the pharmacokinetic profile of reactive sulphide species in blood. Br J Pharmacol 160: 941-957.
27. Yang G, Wu L, Jiang B, Yang W, Qi J, Cao K, et al. (2008). H2S as a physiologic vasorelaxant: hypertension in mice with deletion of cystathionine gamma-lyase. Science 322: 587-590.
28. 2S-donors. Bioorg Med Chem 20: 2675-20678.