Saikosaponin a, an active compound of Radix Bupleuri, attenuates inflammation in hypertrophied 3T3-L1 adipocytes via ERK/NF-κB signaling pathways

International Journal of Molecular Medicine

Volumn 35, Issue 4, 2015, Pages 1126-1132

  Kim, Sung Ok ^a   Park, Ji Yeoung ^a   Jeon, Seo Young ^a   Yang, Chea Ha ^a   Kim, Mi Ryeo ^a  

^a Daegu Haany University   (South Korea)

Author keywords

Adipocytes; Hypertrophy; Inflammation; MAPK pathway; NF B; Saikosaponin a

Indexed keywords

CYCLOOXYGENASE 2; I KAPPA B ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 1BETA; INTERLEUKIN 6; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; NITRIC OXIDE; REAGENT; SAIKOSAPONIN A; TUMOR NECROSIS FACTOR ALPHA; ANTIINFLAMMATORY AGENT; AUTACOID; CYTOKINE; OLEANOLIC ACID; SAIKOSAPONIN; SAPONIN;

ADIPOCYTE; ANIMAL CELL; ARTICLE; BUPLEURUM; CELL VIABILITY; CONTROLLED STUDY; CYTOPLASM; CYTOTOXICITY; DISEASE ASSOCIATION; DOWN REGULATION; DRUG CYTOTOXICITY; EMBRYO; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; GENE TRANSLOCATION; HYPERTROPHY; IMMUNOBLOTTING; INFLAMMATION; MOUSE; MTT ASSAY; NONHUMAN; OBESITY; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SECRETION (PROCESS); SIGNAL TRANSDUCTION; 3T3 CELL LINE; ANALOGS AND DERIVATIVES; ANIMAL; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; METABOLISM;

3T3-L1 CELLS; ANIMALS; ANTI-INFLAMMATORY AGENTS; CYTOKINES; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; GENE EXPRESSION REGULATION; INFLAMMATION; INFLAMMATION MEDIATORS; MICE; NF-KAPPA B; NITRIC OXIDE; OLEANOLIC ACID; SAPONINS; SIGNAL TRANSDUCTION;

EID: 84923668984     PISSN: 11073756     EISSN: 1791244X     Source Type: Journal    
DOI: 10.3892/ijmm.2015.2093     Document Type: Article

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