Apolipoprotein E4 impairs in vivo hippocampal long-term synaptic plasticity by reducing the phosphorylation of CaMKIIα and CREB

Journal of Alzheimer's Disease

Volumn 41, Issue 4, 2014, Pages 1165-1176

  Qiao, Feng ^a   Gao, Xiu Ping ^b   Yuan, Li ^a   Cai, Hong Yan ^a   Qi, Jin Shun ^a  

^a SHANXI MEDICAL UNIVERSITY   (China)

^b MEDICAL COLLEGE OF WISCONSIN   (United States)

Author keywords

Apolipoprotein E4; Ca2+ calmodulin dependent protein kinase II (CaMKII); cAMP response element binding protein (CREB); hippocampus; late phase long term potentiation; synaptic plasticity

Indexed keywords

APOLIPOPROTEIN E4; CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE II; CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE II ALPHA; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; UNCLASSIFIED DRUG; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN BINDING PROTEIN; SERINE; THREONINE;

ANIMAL EXPERIMENT; ARTICLE; COGNITIVE DEFECT; CONTROLLED STUDY; EXCITATORY POSTSYNAPTIC POTENTIAL; HIPPOCAMPAL CA1 REGION; IMMUNOHISTOCHEMISTRY; IN VIVO STUDY; MALE; NERVE CELL PLASTICITY; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RAT; WESTERN BLOTTING; ANALYSIS OF VARIANCE; ANIMAL; BIOPHYSICS; DOSE RESPONSE; DRUG EFFECTS; ELECTROSTIMULATION; HIPPOCAMPUS; LONG TERM POTENTIATION; METABOLISM; PHOSPHORYLATION; SPRAGUE DAWLEY RAT;

ANALYSIS OF VARIANCE; ANIMALS; APOLIPOPROTEIN E4; BIOPHYSICS; CALCIUM-CALMODULIN-DEPENDENT PROTEIN KINASE TYPE 2; CREB-BINDING PROTEIN; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTRIC STIMULATION; HIPPOCAMPUS; LONG-TERM POTENTIATION; MALE; PHOSPHORYLATION; RATS; RATS, SPRAGUE-DAWLEY; SERINE; THREONINE;

EID: 84923650548     PISSN: 13872877     EISSN: 18758908     Source Type: Journal    
DOI: 10.3233/JAD-140375     Document Type: Article

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