Physicochemical characterization of asulacrine towards the development of an anticancer liposomal formulation via active drug loading: Stability, solubility, lipophilicity and ionization

International Journal of Pharmaceutics

Volumn 473, Issue 1-2, 2014, Pages 528-535

  See, Esther ^a   Zhang, Wenli ^a   Liu, Jianping ^b   Svirskis, Darren ^a   Baguley, Bruce C ^c   Shaw, John P ^a   Wang, Guangji ^b   Wu, Zimei ^a  

^a UNIVERSITY OF AUCKLAND   (New Zealand)

^b CHINA PHARMACEUTICAL UNIVERSITY   (China)

^c UNIVERSITY OF AUCKLAND   (New Zealand)

Author keywords

Asulacrine; Ionization constant; Lipophilicity; Liposomes; Post injection drug precipitation; Remote drug loading; Stability

Indexed keywords

ASULACRINE ISETHIONATE; LIPOSOME; AMSACRINE; ANTINEOPLASTIC AGENT; ASULACRINE;

ABSORPTION SPECTROSCOPY; ARTICLE; DILUTION; DRUG SOLUBILITY; DRUG SOLUTION; DRUG STABILITY; IONIZATION; LIPOPHILICITY; LIPOSOMAL DELIVERY; PH; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; ANALOGS AND DERIVATIVES; CHEMISTRY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MEDICINAL CHEMISTRY; SOLUBILITY;

AMSACRINE; ANTINEOPLASTIC AGENTS; CHEMISTRY, PHARMACEUTICAL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DRUG STABILITY; HYDROGEN-ION CONCENTRATION; LIPOSOMES; SOLUBILITY;

EID: 84905400903     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2014.07.033     Document Type: Article

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