Malondialdehyde-acetaldehyde adducts and anti-malondialdehyde-acetaldehyde antibodies in rheumatoid arthritis

Arthritis and Rheumatology

Volumn 67, Issue 3, 2015, Pages 645-655

  Thiele, Geoffrey M ^a,b   Duryee, Michael J ^a,b   Anderson, Daniel R ^b   Klassen, Lynell W ^a,b   Mohring, Stephen M ^b   Young, Kathleen A ^b   Benissan Messan, Dathe ^b   Sayles, Harlan ^b   Dusad, Anand ^b   Hunter, Carlos D ^b   Sokolove, Jeremy ^c   Robinson, William H ^c   O'Dell, James R ^a,b   Nicholas, Anthony P ^d   Tuma, Dean J ^a   Mikuls, Ted R ^a,b  

^a VA NEBRASKA WESTERN IOWA HEALTH CARE SYSTEM   (United States)

^b UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

^c STANFORD UNIVERSITY   (United States)

^d UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETALDEHYDE; ANTI MALONDIALDEHYDE ACETALDEHYDE ANTIBODY; AUTOANTIBODY; CD45 ANTIGEN; CYCLIC CITRULLINATED PEPTIDE ANTIBODY; HUMAN ALBUMIN; IMMUNOGLOBULIN A; IMMUNOGLOBULIN FC FRAGMENT; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; MALONALDEHYDE; RHEUMATOID FACTOR; UNCLASSIFIED DRUG; CYCLIC CITRULLINATED PEPTIDE; CYCLOPEPTIDE;

ADULT; ANTIBODY BLOOD LEVEL; ANTIBODY RESPONSE; ANTIGEN EXPRESSION; ANTIGEN SPECIFICITY; ARTICLE; CLINICAL ARTICLE; CLINICAL EVALUATION; COMPARATIVE STUDY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DISEASE ACTIVITY; DISEASE ASSOCIATION; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMAN; IMMUNE RESPONSE; MALE; OSTEOARTHRITIS; OXIDATIVE STRESS; PRIORITY JOURNAL; RHEUMATOID ARTHRITIS; SYNOVIUM; AGED; BLOOD; CROSS REACTION; IMMUNOHISTOCHEMISTRY; IMMUNOLOGY; MIDDLE AGED;

ACETALDEHYDE; ADULT; AGED; ARTHRITIS, RHEUMATOID; AUTOANTIBODIES; CROSS REACTIONS; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; MALONDIALDEHYDE; MIDDLE AGED; OSTEOARTHRITIS; PEPTIDES, CYCLIC; SYNOVIAL MEMBRANE;

EID: 84923579254     PISSN: 23265191     EISSN: 23265205     Source Type: Journal    
DOI: 10.1002/art.38969     Document Type: Article

References (41)

1. Freeman TL, Haver A, Duryee MJ, Tuma DJ, Klassen LW, Hamel FG, et al. Aldehydes in cigarette smoke react with the lipid peroxidation product malonaldehyde to form fluorescent protein adducts on lysines. Chem Res Toxicol 2005; 18: 817-24.
2. Hill GE, Miller JA, Baxter BT, Klassen LW, Duryee MJ, Tuma DJ, et al. Association of malondialdehyde-acetaldehyde (MAA) adducted proteins with atherosclerotic-induced vascular inflammatory injury. Atherosclerosis 1998; 141: 107-16.
3. Thiele GM, Klassen LW, Tuma DJ,. Formation and immunological properties of aldehyde-derived protein adducts following alcohol consumption. Methods Mol Biol 2008; 447: 235-57.
4. Rolla R, Vay D, Mottaran E, Parodi M, Traverso N, Arico S, et al. Detection of circulating antibodies against malondialdehyde-acetaldehyde adducts in patients with alcohol-induced liver disease. Hepatology 2000; 31: 878-84.
5. Holvoet P, Perez G, Zhao Z, Brouwers E, Bernar H, Collen D,. Malondialdehyde-modified low density lipoproteins in patients with atherosclerotic disease. J Clin Invest 1995; 95: 2611-9.
6. Uchida K,. Lipofuscin-like fluorophores originated from malondialdehyde. Free Radic Res 2006; 40: 1335-8.
7. Thiele GM, Tuma DJ, Willis MS, Miller JA, McDonald TL, Sorrell MF, et al. Soluble proteins modified with acetaldehyde and malondialdehyde are immunogenic in the absence of adjuvant. Alcohol Clin Exp Res 1998; 22: 1731-9.
8. Tuma DJ, Kearley ML, Thiele GM, Worrall S, Haver A, Klassen LW, et al. Elucidation of reaction scheme describing malondialdehyde-acetaldehyde-protein adduct formation. Chem Res Toxicol 2001; 14: 822-32.
9. Ishii T, Ito S, Kumazawa S, Sakurai T, Yamaguchi S, Mori T, et al. Site-specific modification of positively-charged surfaces on human serum albumin by malondialdehyde. Biochem Biophys Res Commun 2008; 371: 28-32.
10. Tuma DJ, Hoffman T, Sorrell MF,. The chemistry of acetaldehyde-protein adducts. Alcohol Alcohol Suppl 1991; 1: 271-6.
11. Desai PB, Manjunath S, Kadi S, Chetana K, Vanishree J,. Oxidative stress and enzymatic antioxidant status in rheumatoid arthritis: a case control study. Eur Rev Med Pharmacol Sci 2010; 14: 959-67.
12. Ozkan Y, Yardym-Akaydyn S, Sepici A, Keskin E, Sepici V, Simsek B,. Oxidative status in rheumatoid arthritis. Clin Rheumatol 2007; 26: 64-8.
13. Shah D, Wanchu A, Bhatnagar A,. Interaction between oxidative stress and chemokines: possible pathogenic role in systemic lupus erythematosus and rheumatoid arthritis. Immunobiology 2011; 216: 1010-7.
14. Vasanthi P, Nalini G, Rajasekhar G,. Status of oxidative stress in rheumatoid arthritis. Int J Rheum Dis 2009; 12: 29-33.
15. Mishra R, Singh A, Chandra V, Negi MP, Tripathy BC, Prakash J, et al. A comparative analysis of serological parameters and oxidative stress in osteoarthritis and rheumatoid arthritis. Rheumatol Int 2012; 32: 2377-82.
16. Ediz L, Hiz O, Ozkol H, Gulcu E, Toprak M, Ceylan MF,. Relationship between anti-CCP antibodies and oxidant and anti-oxidant activity in patients with rheumatoid arthritis. Int J Med Sci 2011; 8: 139-47.
17. Duryee MJ, Klassen LW, Schaffert CS, Tuma DJ, Hunter CD, Garvin RP, et al. Malondialdehyde-acetaldehyde adduct is the dominant epitope after MDA modification of proteins in atherosclerosis. Free Radic Biol Med 2010; 49: 1480-6.
18. Duryee MJ, Klassen LW, Freeman TL, Willis MS, Tuma DJ, Thiele GM,. Lipopolysaccharide is a cofactor for malondialdehyde-acetaldehyde adduct-mediated cytokine/chemokine release by rat sinusoidal liver endothelial and Kupffer cells. Alcohol Clin Exp Res 2004; 28: 1931-8.
19. Willis MS, Klassen LW, Tuma DJ, Sorrell MF, Thiele GM,. Adduction of soluble proteins with malondialdehyde-acetaldehyde (MAA) induces antibody production and enhances T-cell proliferation. Alcohol Clin Exp Res 2002; 26: 94-106.
20. Willis MS, Thiele GM, Tuma DJ, Klassen LW,. T cell proliferative responses to malondialdehyde-acetaldehyde haptenated protein are scavenger receptor mediated. Int Immunopharmacol 2003; 3: 1381-99.
21. Thiele GM, Duryee MJ, Willis MS, Tuma DJ, Radio SJ, Hunter CD, et al. Autoimmune hepatitis induced by syngeneic liver cytosolic proteins biotransformed by alcohol metabolites. Alcohol Clin Exp Res 2010; 34: 2126-36.
22. Mikuls TR, Fay BT, Michaud K, Sayles H, Thiele GM, Caplan L, et al. Associations of disease activity and treatments with mortality in men with rheumatoid arthritis: results from the VARA Registry. Rheumatology (Oxford) 2011; 50: 101-9.
23. Arnett FC, Edworthy SM, Bloch DA, McShane DJ, Fries JF, Cooper NS, et al. The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum 1988; 31: 315-24.
24. Mikuls TR, Payne JB, Reinhardt RA, Thiele GM, Maziarz E, Cannella AC, et al. Antibody responses to Porphyromonas gingivalis (P. gingivalis) in subjects with rheumatoid arthritis and periodontitis. Int Immunopharmacol 2009; 9: 38-42.
25. Kikugawa K, Kato T, Iwata A,. Determination of malonaldehyde in oxidized lipids by the Hantzsch fluorometric method. Anal Biochem 1988; 174: 512-21.
26. Nicholas AP, Whitaker JN,. Preparation of a monoclonal antibody to citrullinated epitopes: its characterization and some applications to immunohistochemistry in human brain. Glia 2002; 37: 328-36.
27. Tuma DJ, Thiele GM, Xu D, Klassen LW, Sorrell MF,. Acetaldehyde and malondialdehyde react together to generate distinct protein adducts in the liver during long-term ethanol administration. Hepatology 1996; 23: 872-80.
28. Lundberg K, Nijenhuis S, Vossenaar ER, Palmblad K, van Venrooij WJ, Klareskog L, et al. Citrullinated proteins have increased immunogenicity and arthritogenicity and their presence in arthritic joints correlates with disease severity. Arthritis Res Ther 2005; 7: R458-67.
29. Prevoo ML, van 't Hof MA, Kuper HH, van Leeuwen MA, van de Putte LB, van Riel PL,. Modified disease activity scores that include twenty-eight-joint counts: development and validation in a prospective longitudinal study of patients with rheumatoid arthritis. Arthritis Rheum 1995; 38: 44-8.
30. Kuhn KA, Kulik L, Tomooka B, Braschler KJ, Arend WP, Robinson WH, et al. Antibodies against citrullinated proteins enhance tissue injury in experimental autoimmune arthritis. J Clin Invest 2006; 116: 961-73.
31. Hueber W, Tomooka BH, Zhao X, Kidd BA, Drijfhout JW, Fries JF, et al. Proteomic analysis of secreted proteins in early rheumatoid arthritis: anti-citrulline autoreactivity is associated with up regulation of proinflammatory cytokines. Ann Rheum Dis 2007; 66: 712-9.
32. Wagner CA, Sokolove J, Lahey LJ, Bengtsson C, Saevarsdottir S, Alfredsson L, et al. Identification of anticitrullinated protein antibody reactivities in a subset of anti-CCP-negative rheumatoid arthritis: association with cigarette smoking and HLA-DRB1 'shared epitope' alleles. Ann Rheum Dis 2014. E-pub ahead of print.
33. Tusher VG, Tibshirani R, Chu G,. Significance analysis of microarrays applied to the ionizing radiation response. Proc Natl Acad Sci U S A 2001; 98: 5116-21.
34. Baka Z, Gyorgy B, Geher P, Buzas EI, Falus A, Nagy G,. Citrullination under physiological and pathological conditions. Joint Bone Spine 2012; 79: 431-6.
35. McCaskill ML, Kharbanda KK, Tuma DJ, Reynolds JD, DeVasure JM, Sisson JH, et al. Hybrid malondialdehyde and acetaldehyde protein adducts form in the lungs of mice exposed to alcohol and cigarette smoke. Alcohol Clin Exp Res 2011; 35: 1106-13.
36. Anderson DR, Duryee MJ, Hunter CD, Garvin RP, Shurmur SW, Klassen LW, et al. Differentiating normal coronary arteries, stable atheromatous lesions and unstable atheromatous lesions: MAA-protein adducts and anti-MAA antibodies isotypes in patients with atherosclerotic disease and acute myocardial infarction [abstract]. Arterioscler Thromb Vasc Biol 2012; 32 Suppl: A303.
37. Thiele GM, Duryee MJ, Freeman TL, Sorrell MF, Willis MS, Tuma DJ, et al. Rat sinusoidal liver endothelial cells (SECs) produce pro-fibrotic factors in response to adducts formed from the metabolites of ethanol. Biochem Pharmacol 2005; 79: 1593-600.
38. Willis MS, Klassen LW, Carlson DL, Brouse CF, Thiele GM,. Malondialdehyde-acetaldehyde haptenated protein binds macrophage scavenger receptor(s) and induces lysosomal damage. Int Immunopharmacol 2004; 4: 885-99.
39. Willis MS, Klassen LW, Tuma DJ, Sorrell MF, Thiele GM,. In vitro exposure to malondialdehyde-acetaldehyde adducted protein inhibits cell proliferation and viability. Alcohol Clin Exp Res 2002; 26: 158-64.
40. Duryee MJ, Klassen LW, Freeman TL, Willis MS, Tuma DJ, Thiele GM,. Chronic ethanol consumption impairs receptor-mediated endocytosis of MAA-modified albumin by liver endothelial cells. Biochem Pharmacol 2003; 66: 1045-54.
41. Duryee MJ, Klassen LW, Thiele GM,. Immunological response in alcoholic liver disease. World J Gastroenterol 2007; 13: 4938-46.