The new immunosuppressant, isogarcinol, binds directly to its target enzyme calcineurin, unlike cyclosporin A and tacrolimus

Biochimie

Volumn 111, Issue , 2015, Pages 119-124

  Cen, Juren ^a,b   Wang, Mengqi ^a   Jiang, Guohua ^a   Yin, Yanxia ^a   Su, Zhenyi ^a   Tong, Li ^a   Luo, Jing ^a   Ma, Yipeng ^a   Gao, Yadan ^a   Wei, Qun ^a  

^a BEIJING NORMAL UNIVERSITY   (China)

^b HAINAN UNIVERSITY   (China)

Author keywords

Calcineurin; Docking; Fluorescence spectroscopy; Isogarcinol; Isothermal titration calorimetry

Indexed keywords

CALCINEURIN; CYCLOSPORIN A; IMMUNOSUPPRESSIVE AGENT; ISOGARCINOL; TACROLIMUS; UNCLASSIFIED DRUG; BENZOPHENONE; BENZOPHENONE DERIVATIVE; CYCLOSPORIN; PROTEIN BINDING;

ARTICLE; DRUG BINDING SITE; DRUG INHIBITION; DRUG POTENCY; DRUG TARGETING; ENTHALPY; ENZYME INHIBITION; ENZYME KINETIC ASSAY; FLUORESCENCE RESONANCE ENERGY TRANSFER; FLUORESCENCE SPECTROSCOPY; HYDROGEN BOND; ISOTHERMAL TITRATION CALORIMETRY; MOLECULAR DOCKING; CHEMISTRY; GARCINIA; HUMAN; ISOLATION AND PURIFICATION;

GARCINIA MANGOSTANA;

BENZOPHENONES; CALCINEURIN; CYCLOSPORINE; GARCINIA; HUMANS; IMMUNOSUPPRESSIVE AGENTS; PROTEIN BINDING; TACROLIMUS;

EID: 84923536362     PISSN: 03009084     EISSN: 61831638     Source Type: Journal    
DOI: 10.1016/j.biochi.2015.02.004     Document Type: Article

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