메뉴 건너뛰기




Volumn 8, Issue 2, 2015, Pages 351-360

Production of 2-ketoisocaproate with Corynebacterium glutamicum strains devoid of plasmids and heterologous genes

Author keywords

[No Author keywords available]

Indexed keywords

2 OXOISOCAPROIC ACID; ACETOLACTATE SYNTHASE; ISOLEUCINE; ISOPENTYL ALCOHOL; ALPHA-KETOISOCAPROIC ACID; CULTURE MEDIUM; OXOACID; START CODON;

EID: 84923510321     PISSN: 17517907     EISSN: 17517915     Source Type: Journal    
DOI: 10.1111/1751-7915.12237     Document Type: Article
Times cited : (24)

References (56)
  • 1
    • 85008585468 scopus 로고
    • Taxonomical studies on glutamic acid-producing bacteria
    • Abe, S., Takayama, K.I., and Kinoshita, S. (1967) Taxonomical studies on glutamic acid-producing bacteria. J Gen Appl Microbiol 13: 279-301.
    • (1967) J Gen Appl Microbiol , vol.13 , pp. 279-301
    • Abe, S.1    Takayama, K.I.2    Kinoshita, S.3
  • 2
    • 84863164562 scopus 로고    scopus 로고
    • Keto acid therapy in predialysis chronic kidney disease patients: final consensus
    • Aparicio, M., Bellizzi, V., Chauveau, P., Cupisti, A., Ecder, T., Fouque, D., etal. (2012) Keto acid therapy in predialysis chronic kidney disease patients: final consensus. J Ren Nutr 22: S22-S24.
    • (2012) J Ren Nutr , vol.22 , pp. S22-S24
    • Aparicio, M.1    Bellizzi, V.2    Chauveau, P.3    Cupisti, A.4    Ecder, T.5    Fouque, D.6
  • 3
    • 84867209510 scopus 로고    scopus 로고
    • Systems and synthetic metabolic engineering for amino acid production - the heartbeat of industrial strain development
    • Becker, J., and Wittmann, C. (2012) Systems and synthetic metabolic engineering for amino acid production - the heartbeat of industrial strain development. Curr Opin Biotechnol 23: 718-726.
    • (2012) Curr Opin Biotechnol , vol.23 , pp. 718-726
    • Becker, J.1    Wittmann, C.2
  • 4
    • 77958566854 scopus 로고    scopus 로고
    • Systems level engineering of Corynebacterium glutamicum - reprogramming translational efficiency for superior production
    • Becker, J., Buschke, N., Bücker, R., and Wittmann, C. (2010) Systems level engineering of Corynebacterium glutamicum - reprogramming translational efficiency for superior production. Eng Life Sci 10: 430-438.
    • (2010) Eng Life Sci , vol.10 , pp. 430-438
    • Becker, J.1    Buschke, N.2    Bücker, R.3    Wittmann, C.4
  • 8
    • 76649136634 scopus 로고    scopus 로고
    • Pentanol isomer synthesis in engineered microorganisms
    • Cann, A.F., and Liao, J.C. (2010) Pentanol isomer synthesis in engineered microorganisms. Appl Microbiol Biotechnol 85: 893-899.
    • (2010) Appl Microbiol Biotechnol , vol.85 , pp. 893-899
    • Cann, A.F.1    Liao, J.C.2
  • 9
    • 33845552242 scopus 로고
    • Synthesis and properties of the α-keto acids
    • Cooper, A.J., Ginos, J.Z., and Meister, A. (1983) Synthesis and properties of the α-keto acids. Chem Rev 83: 321-358.
    • (1983) Chem Rev , vol.83 , pp. 321-358
    • Cooper, A.J.1    Ginos, J.Z.2    Meister, A.3
  • 11
    • 0023131480 scopus 로고
    • Regulation of acetohydroxy acid synthase in Corynebacterium glutamicum during fermentation of α-ketobutyrate to l-isoleucine
    • Eggeling, I., Cordes, C., Eggeling, L., and Sahm, H. (1987) Regulation of acetohydroxy acid synthase in Corynebacterium glutamicum during fermentation of α-ketobutyrate to l-isoleucine. Appl Microbiol Biotechnol 25: 346-351.
    • (1987) Appl Microbiol Biotechnol , vol.25 , pp. 346-351
    • Eggeling, I.1    Cordes, C.2    Eggeling, L.3    Sahm, H.4
  • 12
    • 77955284087 scopus 로고    scopus 로고
    • Leucine and α-ketoisocaproic acid, but not norleucine, stimulate skeletal muscle protein synthesis in neonatal pigs
    • Escobar, J., Frank, J.W., Suryawan, A., Nguyen, H.V., Van Horn, C.G., Hutson, S.M., and Davis, T.A. (2010) Leucine and α-ketoisocaproic acid, but not norleucine, stimulate skeletal muscle protein synthesis in neonatal pigs. J Nutr 140: 1418-1424.
    • (2010) J Nutr , vol.140 , pp. 1418-1424
    • Escobar, J.1    Frank, J.W.2    Suryawan, A.3    Nguyen, H.V.4    Van Horn, C.G.5    Hutson, S.M.6    Davis, T.A.7
  • 13
    • 37349123170 scopus 로고    scopus 로고
    • Co-ordinated regulation of gluconate catabolism and glucose uptake in Corynebacterium glutamicum by two functionally equivalent transcriptional regulators, GntR1 and GntR2
    • Frunzke, J., Engels, V., Hasenbein, S., Gätgens, C., and Bott, M. (2008) Co-ordinated regulation of gluconate catabolism and glucose uptake in Corynebacterium glutamicum by two functionally equivalent transcriptional regulators, GntR1 and GntR2. Mol Microbiol 67: 305-322.
    • (2008) Mol Microbiol , vol.67 , pp. 305-322
    • Frunzke, J.1    Engels, V.2    Hasenbein, S.3    Gätgens, C.4    Bott, M.5
  • 14
    • 0023093841 scopus 로고
    • Microbial production of l-leucine from α-ketoisocaproate by Corynebacterium glutamicum
    • Groeger, U., and Sahm, H. (1987) Microbial production of l-leucine from α-ketoisocaproate by Corynebacterium glutamicum. Appl Microbiol Biotechnol 25: 352-356.
    • (1987) Appl Microbiol Biotechnol , vol.25 , pp. 352-356
    • Groeger, U.1    Sahm, H.2
  • 15
    • 31444433490 scopus 로고    scopus 로고
    • Synthetic promoter libraries - tuning of gene expression
    • Hammer, K., Mijakovic, I., and Jensen, P.R. (2006) Synthetic promoter libraries - tuning of gene expression. Trends Biotechnol 24: 53-55.
    • (2006) Trends Biotechnol , vol.24 , pp. 53-55
    • Hammer, K.1    Mijakovic, I.2    Jensen, P.R.3
  • 16
    • 25144480541 scopus 로고    scopus 로고
    • Mechanism of the insulin-releasing action of α-ketoisocaproate and related α-keto acid anions
    • Heissig, H., Urban, K.A., Hastedt, K., Zunkler, B.J., and Panten, U. (2005) Mechanism of the insulin-releasing action of α-ketoisocaproate and related α-keto acid anions. Mol Pharmacol 68: 1097-1105.
    • (2005) Mol Pharmacol , vol.68 , pp. 1097-1105
    • Heissig, H.1    Urban, K.A.2    Hastedt, K.3    Zunkler, B.J.4    Panten, U.5
  • 17
    • 0042162924 scopus 로고    scopus 로고
    • The Corynebacterium glutamicum genome: features and impacts on biotechnological processes
    • Ikeda, M., and Nakagawa, S. (2003) The Corynebacterium glutamicum genome: features and impacts on biotechnological processes. Appl Microbiol Biotechnol 62: 99-109.
    • (2003) Appl Microbiol Biotechnol , vol.62 , pp. 99-109
    • Ikeda, M.1    Nakagawa, S.2
  • 18
    • 25444479070 scopus 로고    scopus 로고
    • Metabolic engineering of Corynebacterium glutamicum for fuel ethanol production under oxygen-deprivation conditions
    • Inui, M., Kawaguchi, H., Murakami, S., Vertes, A.A., and Yukawa, H. (2004) Metabolic engineering of Corynebacterium glutamicum for fuel ethanol production under oxygen-deprivation conditions. J Mol Microbiol Biotechnol 8: 243-254.
    • (2004) J Mol Microbiol Biotechnol , vol.8 , pp. 243-254
    • Inui, M.1    Kawaguchi, H.2    Murakami, S.3    Vertes, A.A.4    Yukawa, H.5
  • 19
    • 12444259324 scopus 로고    scopus 로고
    • The complete Corynebacterium glutamicum ATCC 13032 genome sequence and its impact on the production of l-aspartate-derived amino acids and vitamins
    • Kalinowski, J., Bathe, B., Bartels, D., Bischoff, N., Bott, M., Burkovski, A., etal. (2003) The complete Corynebacterium glutamicum ATCC 13032 genome sequence and its impact on the production of l-aspartate-derived amino acids and vitamins. J Biotechnol 104: 5-25.
    • (2003) J Biotechnol , vol.104 , pp. 5-25
    • Kalinowski, J.1    Bathe, B.2    Bartels, D.3    Bischoff, N.4    Bott, M.5    Burkovski, A.6
  • 20
    • 0027164654 scopus 로고
    • Isoleucine synthesis in Corynebacterium glutamicum: molecular analysis of the ilvB-ilvN-ilvC operon
    • Keilhauer, C., Eggeling, L., and Sahm, H. (1993) Isoleucine synthesis in Corynebacterium glutamicum: molecular analysis of the ilvB-ilvN-ilvC operon. J Bacteriol 175: 5595-5603.
    • (1993) J Bacteriol , vol.175 , pp. 5595-5603
    • Keilhauer, C.1    Eggeling, L.2    Sahm, H.3
  • 21
    • 0036299777 scopus 로고    scopus 로고
    • Export of l-isoleucine from Corynebacterium glutamicum: a two-gene-encoded member of a new translocator family
    • Kennerknecht, N., Sahm, H., Yen, M.R., Patek, M., Saier Jr, M.H., Jr, and Eggeling, L. (2002) Export of l-isoleucine from Corynebacterium glutamicum: a two-gene-encoded member of a new translocator family. J Bacteriol 184: 3947-3956.
    • (2002) J Bacteriol , vol.184 , pp. 3947-3956
    • Kennerknecht, N.1    Sahm, H.2    Yen, M.R.3    Patek, M.4    Saier Jr Jr, M.H.5    Eggeling, L.6
  • 22
    • 80052627582 scopus 로고    scopus 로고
    • Bio-based production of the platform chemical 1,5-diaminopentane
    • Kind, S., and Wittmann, C. (2011) Bio-based production of the platform chemical 1, 5-diaminopentane. Appl Microbiol Biotechnol 91: 1287-1296.
    • (2011) Appl Microbiol Biotechnol , vol.91 , pp. 1287-1296
    • Kind, S.1    Wittmann, C.2
  • 23
    • 0041429497 scopus 로고    scopus 로고
    • Tools for genetic engineering in the amino acid-producing bacterium Corynebacterium glutamicum
    • Kirchner, O., and Tauch, A. (2003) Tools for genetic engineering in the amino acid-producing bacterium Corynebacterium glutamicum. J Biotechnol 104: 287-299.
    • (2003) J Biotechnol , vol.104 , pp. 287-299
    • Kirchner, O.1    Tauch, A.2
  • 24
    • 84883267268 scopus 로고    scopus 로고
    • Complex regulation of the phosphoenolpyruvate carboxykinase gene pck and characterization of its GntR-type regulator IolR as a repressor of myo-inositol utilization genes in Corynebacterium glutamicum
    • Klaffl, S., Brocker, M., Kalinowski, J., Eikmanns, B.J., and Bott, M. (2013) Complex regulation of the phosphoenolpyruvate carboxykinase gene pck and characterization of its GntR-type regulator IolR as a repressor of myo-inositol utilization genes in Corynebacterium glutamicum. J Bacteriol 195: 4283-4296.
    • (2013) J Bacteriol , vol.195 , pp. 4283-4296
    • Klaffl, S.1    Brocker, M.2    Kalinowski, J.3    Eikmanns, B.J.4    Bott, M.5
  • 25
    • 78650404944 scopus 로고    scopus 로고
    • Metabolic engineering of Corynebacterium glutamicum for 2-ketoisovalerate production
    • Krause, F.S., Blombach, B., and Eikmanns, B.J. (2010) Metabolic engineering of Corynebacterium glutamicum for 2-ketoisovalerate production. Appl Environ Microbiol 76: 8053-8061.
    • (2010) Appl Environ Microbiol , vol.76 , pp. 8053-8061
    • Krause, F.S.1    Blombach, B.2    Eikmanns, B.J.3
  • 26
    • 0018507930 scopus 로고
    • Interactions of α-ketoisocaproate, glucose and arginine in the secretion of glucagon and insulin from the perfused rat pancreas
    • Leclercq-Meyer, V., Marchand, J., Leclercq, R., and Malaisse, W.J. (1979) Interactions of α-ketoisocaproate, glucose and arginine in the secretion of glucagon and insulin from the perfused rat pancreas. Diabetologia 17: 121-126.
    • (1979) Diabetologia , vol.17 , pp. 121-126
    • Leclercq-Meyer, V.1    Marchand, J.2    Leclercq, R.3    Malaisse, W.J.4
  • 27
    • 84861139695 scopus 로고    scopus 로고
    • Toward homosuccinate fermentation: metabolic engineering of Corynebacterium glutamicum for anaerobic production of succinate from glucose and formate
    • Litsanov, B., Brocker, M., and Bott, M. (2012a) Toward homosuccinate fermentation: metabolic engineering of Corynebacterium glutamicum for anaerobic production of succinate from glucose and formate. Appl Environ Microbiol 78: 3325-3337.
    • (2012) Appl Environ Microbiol , vol.78 , pp. 3325-3337
    • Litsanov, B.1    Brocker, M.2    Bott, M.3
  • 28
    • 83655197763 scopus 로고    scopus 로고
    • Efficient aerobic succinate production from glucose in minimal medium with Corynebacterium glutamicum
    • Litsanov, B., Kabus, A., Brocker, M., and Bott, M. (2012b) Efficient aerobic succinate production from glucose in minimal medium with Corynebacterium glutamicum. Microb Biotechnol 5: 116-128.
    • (2012) Microb Biotechnol , vol.5 , pp. 116-128
    • Litsanov, B.1    Kabus, A.2    Brocker, M.3    Bott, M.4
  • 29
    • 27744506829 scopus 로고    scopus 로고
    • Functional analysis of all aminotransferase proteins inferred from the genome sequence of Corynebacterium glutamicum
    • Marienhagen, J., Kennerknecht, N., Sahm, H., and Eggeling, L. (2005) Functional analysis of all aminotransferase proteins inferred from the genome sequence of Corynebacterium glutamicum. J Bacteriol 187: 7639-7646.
    • (2005) J Bacteriol , vol.187 , pp. 7639-7646
    • Marienhagen, J.1    Kennerknecht, N.2    Sahm, H.3    Eggeling, L.4
  • 30
    • 36148935215 scopus 로고    scopus 로고
    • Metabolic engineering of Corynebacterium glutamicum for cadaverine fermentation
    • Mimitsuka, T., Sawai, H., Hatsu, M., and Yamada, K. (2007) Metabolic engineering of Corynebacterium glutamicum for cadaverine fermentation. Biosci Biotechnol Biochem 71: 2130-2135.
    • (2007) Biosci Biotechnol Biochem , vol.71 , pp. 2130-2135
    • Mimitsuka, T.1    Sawai, H.2    Hatsu, M.3    Yamada, K.4
  • 31
    • 0029860181 scopus 로고    scopus 로고
    • l-Isoleucine production with Corynebacterium glutamicum: further flux increase and limitation of export
    • Morbach, S., Sahm, H., and Eggeling, L. (1996) l-Isoleucine production with Corynebacterium glutamicum: further flux increase and limitation of export. Appl Environ Microbiol 62: 4345-4351.
    • (1996) Appl Environ Microbiol , vol.62 , pp. 4345-4351
    • Morbach, S.1    Sahm, H.2    Eggeling, L.3
  • 32
    • 0026621920 scopus 로고
    • Functional and structural analyses of threonine dehydratase from Corynebacterium glutamicum
    • Möckel, B., Eggeling, L., and Sahm, H. (1992) Functional and structural analyses of threonine dehydratase from Corynebacterium glutamicum. J Bacteriol 174: 8065-8072.
    • (1992) J Bacteriol , vol.174 , pp. 8065-8072
    • Möckel, B.1    Eggeling, L.2    Sahm, H.3
  • 34
    • 56349093759 scopus 로고    scopus 로고
    • An efficient succinic acid production process in a metabolically engineered Corynebacterium glutamicum strain
    • Okino, S., Noburyu, R., Suda, M., Jojima, T., Inui, M., and Yukawa, H. (2008) An efficient succinic acid production process in a metabolically engineered Corynebacterium glutamicum strain. Appl Microbiol Biotechnol 81: 459-464.
    • (2008) Appl Microbiol Biotechnol , vol.81 , pp. 459-464
    • Okino, S.1    Noburyu, R.2    Suda, M.3    Jojima, T.4    Inui, M.5    Yukawa, H.6
  • 35
    • 79958763792 scopus 로고    scopus 로고
    • Citrate synthase in Corynebacterium glutamicum is encoded by two gltA transcripts which are controlled by RamA, RamB, and GlxR
    • van Ooyen, J., Emer, D., Bussmann, M., Bott, M., Eikmanns, B.J., and Eggeling, L. (2011) Citrate synthase in Corynebacterium glutamicum is encoded by two gltA transcripts which are controlled by RamA, RamB, and GlxR. J Biotechnol 154: 140-148.
    • (2011) J Biotechnol , vol.154 , pp. 140-148
    • van Ooyen, J.1    Emer, D.2    Bussmann, M.3    Bott, M.4    Eikmanns, B.J.5    Eggeling, L.6
  • 36
    • 84862689750 scopus 로고    scopus 로고
    • Improved l-lysine production with Corynebacterium glutamicum and systemic insight into citrate synthase flux and activity
    • van Ooyen, J., Noack, S., Bott, M., Reth, A., and Eggeling, L. (2012) Improved l-lysine production with Corynebacterium glutamicum and systemic insight into citrate synthase flux and activity. Biotechnol Bioeng 109: 2070-2081.
    • (2012) Biotechnol Bioeng , vol.109 , pp. 2070-2081
    • van Ooyen, J.1    Noack, S.2    Bott, M.3    Reth, A.4    Eggeling, L.5
  • 37
    • 84865972260 scopus 로고    scopus 로고
    • Extensive exometabolome analysis reveals extended overflow metabolism in various microorganisms
    • Paczia, N., Nilgen, A., Lehmann, T., Gätgens, J., Wiechert, W., and Noack, S. (2012) Extensive exometabolome analysis reveals extended overflow metabolism in various microorganisms. Microb Cell Fact 11: 122.
    • (2012) Microb Cell Fact , vol.11 , pp. 122
    • Paczia, N.1    Nilgen, A.2    Lehmann, T.3    Gätgens, J.4    Wiechert, W.5    Noack, S.6
  • 38
    • 74149089019 scopus 로고    scopus 로고
    • Fermentative production of branched chain amino acids: a focus on metabolic engineering
    • Park, J.H., and Lee, S.Y. (2010) Fermentative production of branched chain amino acids: a focus on metabolic engineering. Appl Microbiol Biotechnol 85: 491-506.
    • (2010) Appl Microbiol Biotechnol , vol.85 , pp. 491-506
    • Park, J.H.1    Lee, S.Y.2
  • 40
    • 0028052909 scopus 로고
    • Leucine synthesis in Corynebacterium glutamicum: enzyme activities, structure of leuA, and effect of leuA inactivation on lysine synthesis
    • Pátek, M., Krumbach, K., Eggeling, L., and Sahm, H. (1994) Leucine synthesis in Corynebacterium glutamicum: enzyme activities, structure of leuA, and effect of leuA inactivation on lysine synthesis. Appl Environ Microbiol 60: 133-140.
    • (1994) Appl Environ Microbiol , vol.60 , pp. 133-140
    • Pátek, M.1    Krumbach, K.2    Eggeling, L.3    Sahm, H.4
  • 41
    • 84923435248 scopus 로고    scopus 로고
    • Dissertation abstract. URL
    • Radespiel, T. (2010) Dissertation abstract. URL http://kups.ub.uni-koeln.de/id/eprint/3156.
    • (2010)
    • Radespiel, T.1
  • 42
    • 0036244782 scopus 로고    scopus 로고
    • Linking central metabolism with increased pathway flux: l-valine accumulation by Corynebacterium glutamicum
    • Radmacher, E., Vaitsikova, A., Burger, U., Krumbach, K., Sahm, H., and Eggeling, L. (2002) Linking central metabolism with increased pathway flux: l-valine accumulation by Corynebacterium glutamicum. Appl Environ Microbiol 68: 2246-2250.
    • (2002) Appl Environ Microbiol , vol.68 , pp. 2246-2250
    • Radmacher, E.1    Vaitsikova, A.2    Burger, U.3    Krumbach, K.4    Sahm, H.5    Eggeling, L.6
  • 43
    • 0028289983 scopus 로고
    • Small mobilizable multi-purpose cloning vectors derived from the Escherichia coli plasmids pK18 and pK19: selection of defined deletions in the chromosome of Corynebacterium glutamicum
    • Schäfer, A., Tauch, A., Jäger, W., Kalinowski, J., Thierbach, G., and Pühler, A. (1994) Small mobilizable multi-purpose cloning vectors derived from the Escherichia coli plasmids pK18 and pK19: selection of defined deletions in the chromosome of Corynebacterium glutamicum. Gene 145: 69-73.
    • (1994) Gene , vol.145 , pp. 69-73
    • Schäfer, A.1    Tauch, A.2    Jäger, W.3    Kalinowski, J.4    Thierbach, G.5    Pühler, A.6
  • 44
    • 84873964140 scopus 로고    scopus 로고
    • Secretory production of an FAD cofactor-containing cytosolic enzyme (sorbitol-xylitol oxidase from Streptomyces coelicolor) using the twin-arginine translocation (Tat) pathway of Corynebacterium glutamicum
    • Scheele, S., Oertel, D., Bongaerts, J., Evers, S., Hellmuth, H., Maurer, K.H., etal. (2013) Secretory production of an FAD cofactor-containing cytosolic enzyme (sorbitol-xylitol oxidase from Streptomyces coelicolor) using the twin-arginine translocation (Tat) pathway of Corynebacterium glutamicum. Microb Biotechnol 6: 202-206.
    • (2013) Microb Biotechnol , vol.6 , pp. 202-206
    • Scheele, S.1    Oertel, D.2    Bongaerts, J.3    Evers, S.4    Hellmuth, H.5    Maurer, K.H.6
  • 45
    • 79959256632 scopus 로고    scopus 로고
    • Biotechnological production of polyamines by bacteria: recent achievements and future perspectives
    • Schneider, J., and Wendisch, V.F. (2011) Biotechnological production of polyamines by bacteria: recent achievements and future perspectives. Appl Microbiol Biotechnol 91: 17-30.
    • (2011) Appl Microbiol Biotechnol , vol.91 , pp. 17-30
    • Schneider, J.1    Wendisch, V.F.2
  • 46
    • 77955665708 scopus 로고    scopus 로고
    • Engineering Corynebacterium glutamicum for isobutanol production
    • Smith, K.M., Cho, K.M., and Liao, J.C. (2010) Engineering Corynebacterium glutamicum for isobutanol production. Appl Microbiol Biotechnol 87: 1045-1055.
    • (2010) Appl Microbiol Biotechnol , vol.87 , pp. 1045-1055
    • Smith, K.M.1    Cho, K.M.2    Liao, J.C.3
  • 47
    • 0037048799 scopus 로고    scopus 로고
    • The alanine racemase gene alr is an alternative to antibiotic resistance genes in cloning systems for industrial Corynebacterium glutamicum strains
    • Tauch, A., Götker, S., Pühler, A., Kalinowski, J., and Thierbach, G. (2002) The alanine racemase gene alr is an alternative to antibiotic resistance genes in cloning systems for industrial Corynebacterium glutamicum strains. J Biotechnol 99: 79-91.
    • (2002) J Biotechnol , vol.99 , pp. 79-91
    • Tauch, A.1    Götker, S.2    Pühler, A.3    Kalinowski, J.4    Thierbach, G.5
  • 48
    • 18944362482 scopus 로고    scopus 로고
    • Characterization of methionine export in Corynebacterium glutamicum
    • Trötschel, C., Deutenberg, D., Bathe, B., Burkovski, A., and Krämer, R. (2005) Characterization of methionine export in Corynebacterium glutamicum. J Bacteriol 187: 3786-3794.
    • (2005) J Bacteriol , vol.187 , pp. 3786-3794
    • Trötschel, C.1    Deutenberg, D.2    Bathe, B.3    Burkovski, A.4    Krämer, R.5
  • 49
  • 50
    • 84892459391 scopus 로고    scopus 로고
    • Pushing product formation to its limit: metabolic engineering of Corynebacterium glutamicum for l-leucine overproduction
    • Vogt, M., Haas, S., Klaffl, S., Polen, T., Eggeling, L., van Ooyen, J., and Bott, M. (2014) Pushing product formation to its limit: metabolic engineering of Corynebacterium glutamicum for l-leucine overproduction. Metab Eng 22: 40-52.
    • (2014) Metab Eng , vol.22 , pp. 40-52
    • Vogt, M.1    Haas, S.2    Klaffl, S.3    Polen, T.4    Eggeling, L.5    van Ooyen, J.6    Bott, M.7
  • 51
    • 84873978248 scopus 로고    scopus 로고
    • Bio-based production of organic acids with Corynebacterium glutamicum
    • Wieschalka, S., Blombach, B., Bott, M., and Eikmanns, B.J. (2013) Bio-based production of organic acids with Corynebacterium glutamicum. Microb Biotechnol 6: 87-102.
    • (2013) Microb Biotechnol , vol.6 , pp. 87-102
    • Wieschalka, S.1    Blombach, B.2    Bott, M.3    Eikmanns, B.J.4
  • 52
    • 84867331983 scopus 로고    scopus 로고
    • Effect of transport proteins on l-isoleucine production with the l-isoleucine-producing strain Corynebacterium glutamicum YILW
    • Xie, X., Xu, L., Shi, J., Xu, Q., and Chen, N. (2012) Effect of transport proteins on l-isoleucine production with the l-isoleucine-producing strain Corynebacterium glutamicum YILW. J Ind Microbiol Biotechnol 39: 1549-1556.
    • (2012) J Ind Microbiol Biotechnol , vol.39 , pp. 1549-1556
    • Xie, X.1    Xu, L.2    Shi, J.3    Xu, Q.4    Chen, N.5
  • 55
    • 80051790539 scopus 로고    scopus 로고
    • Production of α-ketoisocaproate via free-whole-cell biotransformation by Rhodococcus opacus DSM 43250 with l-leucine as the substrate
    • Zhu, Y., Li, J., Liu, L., Du, G., and Chen, J. (2011) Production of α-ketoisocaproate via free-whole-cell biotransformation by Rhodococcus opacus DSM 43250 with l-leucine as the substrate. Enzyme Microb Technol 49: 321-325.
    • (2011) Enzyme Microb Technol , vol.49 , pp. 321-325
    • Zhu, Y.1    Li, J.2    Liu, L.3    Du, G.4    Chen, J.5
  • 56
    • 0027974098 scopus 로고
    • Quantitative discrimination of carrier-mediated excretion of isoleucine from uptake and diffusion in Corynebacterium glutamicum
    • Zittrich, S., and Krämer, R. (1994) Quantitative discrimination of carrier-mediated excretion of isoleucine from uptake and diffusion in Corynebacterium glutamicum. J Bacteriol 176: 6892-6899.
    • (1994) J Bacteriol , vol.176 , pp. 6892-6899
    • Zittrich, S.1    Krämer, R.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.