A novel therapeutic approach targeting rheumatoid arthritis by combined administration of morin, a dietary flavanol and non-steroidal anti-inflammatory drug indomethacin with reference to pro-inflammatory cytokines, inflammatory enzymes, RANKL and transcription factors

Chemico-Biological Interactions

Volumn 230, Issue , 2015, Pages 58-70

  Sultana, Farhath ^a   Rasool, Mahaboobkhan ^a  

^a VIT UNIVERSITY   (India)

Author keywords

Indomethacin; Inflammatory mediators; Morin; Pro inflammatory cytokines

Indexed keywords

ACETYLGLUCOSAMINIDASE; ACID PHOSPHATASE; BETA GALACTOSIDASE; CATALASE; CATHEPSIN D; CERULOPLASMIN; CYCLOOXYGENASE 2; ELASTASE; GLUTATHIONE; GLUTATHIONE PEROXIDASE 2; GLYCOPROTEIN; GLYCOSAMINOGLYCAN; HEXOSAMINE; HEXOSE; HYDROXYPROLINE; INDOMETACIN; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 1BETA; MESSENGER RNA; MONOCYTE CHEMOTACTIC PROTEIN 1; MORIN; OSTEOCLAST DIFFERENTIATION FACTOR; PROSTAGLANDIN E2; REACTIVE OXYGEN METABOLITE; SUPEROXIDE DISMUTASE; TRANSCRIPTION FACTOR AP 1; TRANSCRIPTION FACTOR RELA; TUMOR NECROSIS FACTOR ALPHA; VASCULOTROPIN; ANTIOXIDANT; AUTACOID; CYCLOOXYGENASE 2 INHIBITOR; CYTOKINE; ENZYME; FLAVONOID; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; NONSTEROID ANTIINFLAMMATORY AGENT; TRANSCRIPTION FACTOR;

ADJUVANT ARTHRITIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; BODY WEIGHT; BONE DEFECT; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG EFFICACY; DRUG MECHANISM; DRUG RESPONSE; DRUG TARGETING; ENZYME ACTIVITY; FEMALE; GENE EXPRESSION; IMMUNOCOMPETENT CELL; IMMUNOHISTOCHEMISTRY; LIPID PEROXIDATION; MALE; NONHUMAN; OXIDATIVE STRESS; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; PROTEIN FUNCTION; RAT; UPREGULATION; ANIMAL; ARTHRITIS, EXPERIMENTAL; ARTHRITIS, RHEUMATOID; ARTICULAR CARTILAGE; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; PATHOLOGY; WISTAR RAT;

RATTUS;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ANTIOXIDANTS; ARTHRITIS, EXPERIMENTAL; ARTHRITIS, RHEUMATOID; CARTILAGE, ARTICULAR; CYCLOOXYGENASE 2 INHIBITORS; CYTOKINES; ENZYMES; FEMALE; FLAVONOIDS; GENE EXPRESSION REGULATION; INDOMETHACIN; INFLAMMATION MEDIATORS; MALE; NF-KAPPA B; OXIDATIVE STRESS; RANK LIGAND; RATS, WISTAR; TRANSCRIPTION FACTORS;

EID: 84923348506     PISSN: 00092797     EISSN: 18727786     Source Type: Journal    
DOI: 10.1016/j.cbi.2015.02.007     Document Type: Article

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