SET overexpression in HEK293 cells regulates mitochondrial uncoupling proteins levels within a mitochondrial fission/reduced autophagic flux scenario

Biochemical and Biophysical Research Communications

Volumn 458, Issue 2, 2015, Pages 300-306

  Almeida, Luciana O ^a   Goto, Renata N ^a   Neto, Marinaldo P C ^a   Sousa, Lucas O ^a   Curti, Carlos ^a   Leopoldino, Andréia M ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Mitochondria; Mitochondrial fission; SET; UCPs

Indexed keywords

ADENOSINE TRIPHOSPHATE; CELL PROTEIN; CHLOROQUINE; MESSENGER RNA; OXIDIZING AGENT; PROTEIN DRP 1; PROTEIN FIS 1; PROTEIN LC3B; PROTEIN SET; TERT BUTYL HYDROPEROXIDE; UNCLASSIFIED DRUG; UNCOUPLING PROTEIN 1; UNCOUPLING PROTEIN 2; UNCOUPLING PROTEIN 3; VOLTAGE DEPENDENT ANION CHANNEL; CHAPERONE; ION CHANNEL; MITOCHONDRIAL PROTEIN; MITOCHONDRIAL UNCOUPLING PROTEIN; SET PROTEIN, HUMAN; TRANSCRIPTION FACTOR;

ARTICLE; AUTOPHAGY; CELL ORGANELLE; CONTROLLED STUDY; FIS1 GENE; GENE; HEK293 CELL LINE; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE; LIPID PEROXIDATION; LYSOSOME; MITOCHONDRIAL DYNAMICS; MITOCHONDRIAL FISSION; OXIDATIVE STRESS; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; REGULATORY MECHANISM; UPREGULATION; GENE EXPRESSION REGULATION; METABOLISM; MITOCHONDRION; PHYSIOLOGY;

AUTOPHAGY; GENE EXPRESSION REGULATION; HEK293 CELLS; HISTONE CHAPERONES; HUMANS; ION CHANNELS; MITOCHONDRIA; MITOCHONDRIAL DYNAMICS; MITOCHONDRIAL PROTEINS; OXIDATIVE STRESS; TRANSCRIPTION FACTORS; UP-REGULATION;

EID: 84923315789     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2015.01.104     Document Type: Article

References (38)

1. V. Azzu, M. Jastroch, A.S. Divakaruni, and M.D. Brand The regulation and turnover of mitochondrial uncoupling proteins Biochim. Biophys. Acta 1797 2010 785 791
2. V. Sosa, T. Moline, R. Somoza, R. Paciucci, H. Kondoh, and M.E. Lleonart Oxidative stress and cancer: an overview Ageing Res. Rev. 12 1 2013 Jan 376 390
3. J.S. Carew, and P. Huang Mitochondrial defects in cancer Mol. Cancer 1 2002 9
4. C. Cornelius, A. Trovato Salinaro, M. Scuto, V. Fronte, M.T. Cambria, M. Pennisi, R. Bella, P. Milone, A. Graziano, R. Crupi, S. Cuzzocrea, G. Pennisi, and V. Calabrese Cellular stress response, sirtuins and UCP proteins in Alzheimer disease: role of vitagenes Immun. Ageing 10 2013 41
5. R.J. Mailloux, and M.E. Harper Uncoupling proteins and the control of mitochondrial reactive oxygen species production Free Radic. Biol. Med. 51 2011 1106 1115
6. D. Robbins, and Y. Zhao New aspects of mitochondrial uncoupling proteins (UCPs) and their roles in tumorigenesis Int. J. Mol. Sci. 12 2011 5285 5293
7. I. Samudio, M. Fiegl, T. McQueen, K. Clise-Dwyer, and M. Andreeff The Warburg effect in leukemia-stroma cocultures is mediated by mitochondrial uncoupling associated with uncoupling protein 2 activation Cancer Res. 68 2008 5198 5205
8. W.P. Su, Y.C. Lo, J.J. Yan, I.C. Liao, P.J. Tsai, H.C. Wang, H.H. Yeh, C.C. Lin, H.H. Chen, W.W. Lai, and W.C. Su Mitochondrial uncoupling protein 2 regulates the effects of paclitaxel on Stat3 activation and cellular survival in lung cancer cells Carcinogenesis 33 2012 2065 2075
9. J. Sastre-Serra, A. Valle, M.M. Company, I. Garau, J. Oliver, and P. Roca Estrogen down-regulates uncoupling proteins and increases oxidative stress in breast cancer Free Radic. Biol. Med. 48 2010 506 512
10. D.G. Nicholls, and E. Rial A history of the first uncoupling protein, UCP1 J. Bioenerg. Biomembr. 31 1999 399 406
11. O. Boss, S. Samec, A. Paoloni-Giacobino, C. Rossier, A. Dulloo, J. Seydoux, P. Muzzin, and J.P. Giacobino Uncoupling protein-3: a new member of the mitochondrial carrier family with tissue-specific expression FEBS Lett. 408 1997 39 42
12. G. Baffy Uncoupling protein-2 and cancer Mitochondrion 10 2010 243 252
13. H. Gustafsson, L. Adamson, J. Hedander, E. Walum, and A. Forsby Insulin-like growth factor type 1 upregulates uncoupling protein 3 Biochem. Biophys. Res. Commun. 287 2001 1105 1111
14. S. Busquets, V. Almendro, E. Barreiro, M. Figueras, J.M. Argiles, and F.J. Lopez-Soriano Activation of UCPs gene expression in skeletal muscle can be independent on both circulating fatty acids and food intake. Involvement of ROS in a model of mouse cancer cachexia FEBS Lett. 579 2005 717 722
15. P. Facchinetti, E. Dorard, V. Contremoulins, M.C. Gaillard, N. Deglon, V. Sazdovitch, C. Guihenneuc-Jouyaux, E. Brouillet, C. Duyckaerts, and B. Allinquant SET translocation is associated with increase in caspase cleaved amyloid precursor protein in CA1 of Alzheimer and Down syndrome patients Neurobiol. Aging 35 2014 958 968
16. S.G. Carlson, E. Eng, E.G. Kim, E.J. Perlman, T.D. Copeland, and B.J. Ballermann Expression of SET, an inhibitor of protein phosphatase 2A, in renal development and Wilms' tumor J. Am. Soc. Nephrol. 9 1998 1873 1880
17. S. Sirma Ekmekci, C. G. Ekmekci, A. Kandilci, C. Gulec, M. Akbiyik, Z. Emrence, N. Abaci, Z. Karakas, L. Agaoglu, A. Unuvar, S. Anak, O. Devecioglu, D. Ustek, G. Grosveld, and U. Ozbek SET oncogene is upregulated in pediatric acute lymphoblastic leukemia Tumori 98 2012 252 256
18. A.M. Leopoldino, C.H. Squarize, C.B. Garcia, L.O. Almeida, C.R. Pestana, L.M. Sobral, S.A. Uyemura, E.H. Tajara, J. Silvio Gutkind, and C. Curti SET protein accumulates in HNSCC and contributes to cell survival: antioxidant defense, Akt phosphorylation and AVOs acidification Oral Oncol. 48 2012 1106 1113
19. M. Li, and Z. Damuni I1PP2A and I2PP2A. Two potent protein phosphatase 2A-specific inhibitor proteins Methods Mol. Biol. 93 1998 59 66
20. H.K. Arnold, and R.C. Sears Protein phosphatase 2A regulatory subunit B56alpha associates with c-myc and negatively regulates c-myc accumulation Mol. Cell. Biol. 26 2006 2832 2844
21. G.P. Liu, W. Wei, X. Zhou, Y. Zhang, H.H. Shi, J. Yin, X.Q. Yao, C.X. Peng, J. Hu, Q. Wang, H.L. Li, and J.Z. Wang I(2)(PP2A) regulates p53 and Akt correlatively and leads the neurons to abort apoptosis Neurobiol. Aging 33 2012 254 264
22. L.M. Sobral, L.O. Sousa, R.D. Coletta, H. Cabral, L.J. Greene, E.H. Tajara, J.S. Gutkind, C. Curti, and A.M. Leopoldino Stable SET knockdown in head and neck squamous cell carcinoma promotes cell invasion and the mesenchymal-like phenotype in vitro, as well as necrosis, cisplatin sensitivity and lymph node metastasis in xenograft tumor models Mol. Cancer 13 2014 32
23. J.P. ten Klooster, I. Leeuwen, N. Scheres, E.C. Anthony, and P.L. Hordijk Rac1-induced cell migration requires membrane recruitment of the nuclear oncogene SET EMBO J. 26 2007 336 345
24. Z.J. Yang, C.E. Chee, S. Huang, and F. Sinicrope Autophagy modulation for cancer therapy Cancer Biol. Ther. 11 2011 169 176
25. M. Karbowski Mitochondria on guard: role of mitochondrial fusion and fission in the regulation of apoptosis Adv. Exp. Med. Biol. 687 2010 131 142
26. A.M. Leopoldino, C.H. Squarize, C.B. Garcia, L.O. Almeida, C.R. Pestana, A.C. Polizello, S.A. Uyemura, E.H. Tajara, J.S. Gutkind, and C. Curti Accumulation of the SET protein in HEK293T cells and mild oxidative stress: cell survival or death signaling Mol. Cell. Biochem. 363 2012 65 74
27. L. He, P.F. Chinnery, S.E. Durham, E.L. Blakely, T.M. Wardell, G.M. Borthwick, R.W. Taylor, and D.M. Turnbull Detection and quantification of mitochondrial DNA deletions in individual cells by real-time PCR Nucleic Acids Res. 30 2002 e68
28. L.C. Gomes, and L. Scorrano Mitochondrial elongation during autophagy: a stereotypical response to survive in difficult times Autophagy 7 2011 1251 1253
29. M. Horimoto, M.B. Resnick, T.A. Konkin, J. Routhier, J.R. Wands, and G. Baffy Expression of uncoupling protein-2 in human colon cancer Clin. Cancer Res. 10 2004 6203 6207
30. H. Watanabe, J. Bohensky, T. Freeman, V. Srinivas, and I.M. Shapiro Hypoxic induction of UCP3 in the growth plate: UCP3 suppresses chondrocyte autophagy J. Cell. Physiol. 216 2008 419 425
31. L. Wan, G. Nie, J. Zhang, Y. Luo, P. Zhang, Z. Zhang, and B. Zhao beta-Amyloid peptide increases levels of iron content and oxidative stress in human cell and Caenorhabditis elegans models of Alzheimer disease Free Radic. Biol. Med. 50 2011 122 129
32. A. Negre-Salvayre, N. Auge, V. Ayala, H. Basaga, J. Boada, R. Brenke, S. Chapple, G. Cohen, J. Feher, T. Grune, G. Lengyel, G.E. Mann, R. Pamplona, G. Poli, M. Portero-Otin, Y. Riahi, R. Salvayre, S. Sasson, J. Serrano, O. Shamni, W. Siems, R.C. Siow, I. Wiswedel, K. Zarkovic, and N. Zarkovic Pathological aspects of lipid peroxidation Free Radic. Res. 44 2010 1125 1171
33. J. Hoeks, M.K. Hesselink, and P. Schrauwen Involvement of UCP3 in mild uncoupling and lipotoxicity Exp. Gerontol. 41 2006 658 662
34. D.C. Chan Fusion and fission: interlinked processes critical for mitochondrial health Annu Rev. Genet. 46 2012 265 287
35. J. Rehman, H.J. Zhang, P.T. Toth, Y. Zhang, G. Marsboom, Z. Hong, R. Salgia, A.N. Husain, C. Wietholt, and S.L. Archer Inhibition of mitochondrial fission prevents cell cycle progression in lung cancer FASEB J. 26 2012 2175 2186
36. M.N. Serasinghe, A.M. Seneviratne, A.V. Smrcka, and Y. Yoon Identification and characterization of unique proline-rich peptides binding to the mitochondrial fission protein hFis1 J. Biol. Chem. 285 2010 620 630
37. L.C. Gomes, and L. Scorrano High levels of Fis1, a pro-fission mitochondrial protein, trigger autophagy Biochim. Biophys. Acta 1777 2008 860 866
38. P.L. Pedersen Voltage dependent anion channels (VDACs): a brief introduction with a focus on the outer mitochondrial compartment's roles together with hexokinase-2 in the "Warburg effect" in cancer J. Bioenerg. Biomembr. 40 2008 123 126.