MiR-203 protects microglia mediated brain injury by regulating inflammatory responses via feedback to MyD88 in ischemia

Molecular Immunology

Volumn 65, Issue 2, 2015, Pages 293-301

  Yang, Zhao ^a   Zhong, Lina ^a   Zhong, Shanchuan ^a   Xian, Ronghua ^b   Yuan, Bangqing ^b  

^a CHONGQING MEDICAL UNIVERSITY   (China)

^b The 476th Hospital of PLA   (China)

Author keywords

Ischemia; Microglia; MiR 203; MyD88

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1 RECEPTOR; INTERLEUKIN 8; MESSENGER RNA; MICRORNA; MICRORNA 203; MYELOID DIFFERENTIATION FACTOR 88; SMALL INTERFERING RNA; TOLL LIKE RECEPTOR; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; MIRN203 MICRORNA, MOUSE; MYD88 PROTEIN, MOUSE;

3' UNTRANSLATED REGION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BRAIN FUNCTION; BRAIN INJURY; BRAIN ISCHEMIA; BRAIN PROTECTION; BRAIN WATER; CELL ACTIVATION; CELL PROTECTION; CELL VIABILITY; CONTROLLED STUDY; EMBRYO; GENE SILENCING; IN VIVO STUDY; MALE; MICROGLIA; MIDDLE CEREBRAL ARTERY OCCLUSION; MOUSE; NEGATIVE FEEDBACK; NERVOUS SYSTEM INFLAMMATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; UPREGULATION; WESTERN BLOTTING; ANIMAL; IMMUNOLOGY; INFLAMMATION; PATHOLOGY;

ANIMALS; BRAIN ISCHEMIA; GENE SILENCING; INFLAMMATION; MALE; MICE; MICROGLIA; MICRORNAS; MYELOID DIFFERENTIATION FACTOR 88; NF-KAPPA B; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTORS;

EID: 84923294667     PISSN: 01615890     EISSN: 18729142     Source Type: Journal    
DOI: 10.1016/j.molimm.2015.01.019     Document Type: Article

References (44)

1. Benbir G., Ince B., Kumral E., Ongen Z., Kultursay H., Tokgozoglu L., Oto A., Tuzun H. Antihypertensive drugs and inflammation in acute ischemic stroke as a predictor factor of future cardiovascular mortality. Inflammation 2012, 35:65-73.
2. Chen X.M., Splinter P.L., O'Hara S.P., LaRusso N.F. A cellular micro-RNA, let-7i, regulates Toll-like receptor 4 expression and contributes to cholangiocyte immune responses against Cryptosporidium parvum infection. J. Biol. Chem. 2007, 282:28929-28938.
3. Chen S., Martens-Lobenhoffer J., Weissenborn K., Kielstein J.T., Lichtinghagen R., Deb M., Li N., Tryc A.B., Goldbecker A., Dong Q., Bode-Boger S.M., Worthmann H. Association of dimethylarginines and mediators of inflammation after acute ischemic stroke. J. Neuroinflammation 2012, 9:251.
4. Chilana P., Sharma A., Arora V., Bhati J., Rai A. Computational identification and characterization of putative miRNAs in Heliothis virescens. Bioinformation 2013, 9:79-83.
5. Ciancarelli I., Di Massimo C., De Amicis D., Carolei A. Tozzi Ciancarelli MG. Evidence of redox unbalance in post-acute ischemic stroke patients. Curr. Neurovasc. Res. 2012, 9:85-90.
6. Correa-Costa M., Braga T.T., Semedo P., Hayashida C.Y., Bechara L.R., Elias R.M., Barreto C.R., Silva-Cunha C., Hyane M.I., Goncalves G.M., Brum P.C., Fujihara C., Zatz R., Pacheco-Silva A., Zamboni D.S., Camara N.O. Pivotal role of Toll-like receptors 2 and 4, its adaptor molecule MyD88, and inflammasome complex in experimental tubule-interstitial nephritis. PLoS One 2011, 6:e29004.
7. Deng Y., Lu J., Sivakumar V., Ling E.A., Kaur C. Amoeboid microglia in the periventricular white matter induce oligodendrocyte damage through expression of proinflammatory cytokines via MAP kinase signaling pathway in hypoxic neonatal rats. Brain Pathol. 2008, 18:387-400.
8. Frostig R.D., Lay C.C., Davis M.F. A rat's whiskers point the way toward a novel stimulus-dependent, protective stroke therapy. Neuroscientist 2013, 19:313-328.
9. Fumagalli S., Perego C., Ortolano F., De Simoni M.G. CX3CR1 deficiency induces an early protective inflammatory environment in ischemic mice. Glia 2013, 61:827-842.
10. Jayadev S., Case A., Alajajian B., Eastman A.J., Moller T., Garden G.A. Presenilin 2 influences miR146 level and activity in microglia. J. Neurochem. 2013, 127:592-599.
11. Jin X., Lu L., Su H., Lou Z., Wang F., Zheng Y., Xu G.T. Comparative analysis of known miRNAs across platyhelminths. FEBS J. 2013, 280:3944-3951.
12. Kim J.Y., Kim T.H., Kim S.S. Anti-inflammatory effect of a human prothrombin fragment-2-derived peptide, NSA9, in EOC2 microglia. Biochem. Biophys. Res. Commun. 2008, 368:779-785.
13. Kim J.H., Choi D.J., Jeong H.K., Kim J., Kim D.W., Choi S.Y., Park S.M., Suh Y.H., Jou I., Joe E.H. DJ-1 facilitates the interaction between STAT1 and its phosphatase, SHP-1, in brain microglia and astrocytes: a novel anti-inflammatory function of DJ-1. Neurobiol. Dis. 2013, 60:1-10.
14. Kim S.Y., Koo J.E., Song M.R., Lee J.Y. Retinol suppresses the activation of Toll-like receptors in MyD88- and STAT1-independent manners. Inflammation 2013, 36:426-433.
15. Lee J., Remold H.G., Ieong M.H., Kornfeld H. Macrophage apoptosis in response to high intracellular burden of Mycobacterium tuberculosis is mediated by a novel caspase-independent pathway. J. Immunol. 2006, 176:4267-4274.
16. Leistner S., Sander-Thoemmes T., Wabnitz H., Moeller M., Wachs M., Curio G., Macdonald R., Trahms L., Mackert B.M. Non-invasive simultaneous recording of neuronal and vascular signals in subacute ischemic stroke. Biomed. Tech. (Berl.) 2011, 56:85-90.
17. Lin S., Yin Q., Zhong Q., Lv F.L., Zhou Y., Li J.Q., Wang J.Z., Su B.Y., Yang Q.W. Heme activates TLR4-mediated inflammatory injury via MyD88/TRIF signaling pathway in intracerebral hemorrhage. J. Neuroinflammation 2012, 9:46.
18. Lu Q., Gao L., Huang L., Ruan L., Yang J., Huang W., Li Z., Zhang Y., Jin K., Zhuge Q. Inhibition of mammalian target of rapamycin improves neurobehavioral deficit and modulates immune response after intracerebral hemorrhage in rat. J. Neuroinflam. 2015, 11:44. in press.
19. Luheshi N.M., Kovacs K.J., Lopez-Castejon G., Brough D., Denes A. Interleukin-1alpha expression precedes IL-1beta after ischemic brain injury and is localised to areas of focal neuronal loss and penumbral tissues. J. Neuroinflammation 2011, 8:186.
20. Madinier A., Bertrand N., Rodier M., Quirie A., Mossiat C., Prigent-Tessier A., Marie C., Garnier P. Ipsilateral versus contralateral spontaneous post-stroke neuroplastic changes: involvement of BDNF. Neuroscience 2013, 231:169-181.
21. Maggi N., Arrigo P., Ruggiero C. Potential MiRNAs recognition site identification in 3' UTR regions by DSP methods. Conf. Proc. IEEE Eng. Med. Biol. Soc. 2012, 2012:5558-5561.
22. Melamed Z., Levy A., Ashwal-Fluss R., Lev-Maor G., Mekahel K., Atias N., Gilad S., Sharan R., Levy C., Kadener S., Ast G. Alternative splicing regulates biogenesis of miRNAs located across exon-intron junctions. Mol. Cell 2013, 50:869-881.
23. Montagner S., Orlandi E.M., Merante S., Monticelli S. The role of miRNAs in mast cells and other innate immune cells. Immunol. Rev. 2013, 253:12-24.
24. Morris G.P., Clark I.A., Zinn R., Vissel B. Microglia: a new frontier for synaptic plasticity, learning and memory, and neurodegenerative disease research. Neurobiol. Learn. Mem. 2013, 105:40-53.
25. Ormstad H., Verkerk R., Aass H.C., Amthor K.F., Sandvik L. Inflammation-induced catabolism of tryptophan and tyrosine in acute ischemic stroke. J. Mol. Neurosci. 2013, 51:893-902.
26. Owona B.A., Njayou N.F., Laufer S.A., Schluesener H.J., Moundipa P.F. Entada africana fraction CH(2)Cl(2)/MEOH 5% inhibits inducible nitric oxide synthase and pro-inflammatory cytokines gene expression induced by lipopolysaccharide in microglia. BMC Complement. Altern. Med. 2013, 13:254.
27. Primo M.N., Bak R.O., Schibler B., Mikkelsen J.G. Regulation of pro-inflammatory cytokines TNFalpha and IL24 by microRNA-203 in primary keratinocytes. Cytokine 2012, 60:741-748.
28. Qin X., Sun Z.Q., Dai X.J., Mao S.S., Zhang J.L., Jia M.X., Zhang Y.M. Toll-like receptor 4 signaling is involved in PACAP-induced neuroprotection in BV2 microglial cells under OGD/reoxygenation. Neurol. Res. 2012, 34:379-389.
29. Remenyi J., van den Bosch M.W., Palygin O., Mistry R.B., McKenzie C., Macdonald A., Hutvagner G., Arthur J.S., Frenguelli B.G., Pankratov Y. miR-132/212 knockout mice reveal roles for these miRNAs in regulating cortical synaptic transmission and plasticity. PLoS One 2013, 8:e62509.
30. Sethi P., Lukiw W.J. Micro-RNA abundance and stability in human brain: specific alterations in Alzheimer's disease temporal lobe neocortex. Neurosci. Lett. 2009, 459:100-104.
31. Sanchez-Jimenez C., Carrascoso I., Barrero J., Izquierdo J.M. Identification of a set of miRNAs differentially expressed in transiently TIA-depleted HeLa cells by genome-wide profiling. BMC Mol. Biol. 2013, 14:4.
32. Samimi H., Zaki Dizaji M., Ghadami M., Shahzadeh Fazeli A., Khashayar P., Soleimani M., Larijani B., Haghpanah V. MicroRNAs networks in thyroid cancers: focus on miRNAs related to the fascin. J. Diabetes Metab. Disord. 2013, 12:31.
33. Santos-Sierra S., Golenbock D.T., Henneke P. Toll-like receptor-dependent discrimination of streptococci. J. Endotoxin Res. 2006, 12:307-312.
34. Sheng W., Zong Y., Mohammad A., Ajit D., Cui J., Han D., Hamilton J.L., Simonyi A., Sun A.Y., Gu Z., Hong J.S., Weisman G.A., Sun G.Y. Pro-inflammatory cytokines and lipopolysaccharide induce changes in cell morphology, and upregulation of ERK1/2, iNOS and sPLA(2)-IIA expression in astrocytes and microglia. J. Neuroinflammation 2011, 8:121.
35. Smith J.A., Das A., Ray S.K., Banik N.L. Role of pro-inflammatory cytokines released from microglia in neurodegenerative diseases. Brain Res. Bull. 2012, 87:10-20.
36. Strassburger M., Braun H., Reymann K.G. Anti-inflammatory treatment with the p38 mitogen-activated protein kinase inhibitor SB239063 is neuroprotective, decreases the number of activated microglia and facilitates neurogenesis in oxygen-glucose-deprived hippocampal slice cultures. Eur. J. Pharmacol. 2008, 592:55-61.
37. Swardfager W., Winer D.A., Herrmann N., Winer S., Lanctot K.L. Interleukin-17 in post-stroke neurodegeneration. Neurosci. Biobehav. Rev. 2013, 37:436-447.
38. Toledano-Zarhi A., Tanne D., Carmeli E., Katz-Leurer M. Feasibility, safety and efficacy of an early aerobic rehabilitation program for patients after minor ischemic stroke: a pilot randomized controlled trial. NeuroRehabilitation 2011, 28:85-90.
39. Toubiana M., Gerdol M., Rosani U., Pallavicini A., Venier P., Roch P. Toll-like receptors and MyD88 adaptors in Mytilus: complete cds and gene expression levels. Dev. Comp. Immunol. 2013, 40:158-166.
40. Wang D.T., Ma Z.L., Li Y.L., Wang Y.Q., Zhao B.T., Wei J.L., Qi X., Zhao X.T., Jin Y.X. miR-150, p53 protein and relevant miRNAs consist of a regulatory network in NSCLC tumorigenesis. Oncol. Rep. 2013, 30:492-498.
41. Wei J., Huang X., Zhang Z., Jia W., Zhao Z., Zhang Y., Liu X., Xu G. MyD88 as a target of microRNA-203 in regulation of lipopolysaccharide or Bacille Calmette-Guerin induced inflammatory response of macrophage RAW264.7 cells. Mol. Immunol. 2013, 55:303-309.
42. Yang F., Wang Z., Wei X., Han H., Meng X., Zhang Y., Shi W., Li F., Xin T., Pang Q., Yi F. NLRP3 deficiency ameliorates neurovascular damage in experimental ischemic stroke. J. Cereb. Blood Flow Metab. 2014, 34:660-667.
43. Yoon H.M., Jang K.J., Han M.S., Jeong J.W., Kim G.Y., Lee J.H., Choi Y.H. Ganoderma lucidum ethanol extract inhibits the inflammatory response by suppressing the NF-kappaB and toll-like receptor pathways in lipopolysaccharide-stimulated BV2 microglial cells. Exp. Ther. Med. 2013, 5:957-963.
44. Zhang L., Dong L.Y., Li Y.J., Hong Z., Wei W.S. The microRNA miR-181c controls microglia-mediated neuronal apoptosis by suppressing tumor necrosis factor. J. Neuroinflammation 2015, 9:211. in press.