A nairovirus isolated from African bats causes haemorrhagic gastroenteritis and severe hepatic disease in mice

Nature Communications

Volumn 5, Issue , 2014, Pages

  Ishii, Akihiro ^a,b   Ueno, Keisuke ^a   Orba, Yasuko ^a   Sasaki, Michihito ^a   Moonga, Ladslav ^b   Hang'Ombe, Bernard M ^b   Mweene, Aaron S ^b   Umemura, Takashi ^c   Ito, Kimihito ^a   Hall, William W ^a,d,e   Sawa, Hirofumi ^a,b,e  

^a HOKKAIDO UNIVERSITY   (Japan)

^b UNIVERSITY OF ZAMBIA   (Zambia)

^c HOKKAIDO UNIVERSITY   (Japan)

^d UNIVERSITY COLLEGE DUBLIN   (Ireland)

^e Global Virus Network   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLYCOPROTEIN; VIRUS RNA;

BAT; DISEASE INCIDENCE; DISEASE VECTOR; GASTROENTERITIS; GENETIC ANALYSIS; PATHOGENICITY; RODENT; VIRAL DISEASE; VIRUS;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BAT; BUNYAVIRIDAE; CAVE; CLADISTICS; CONTROLLED STUDY; CRIMEAN CONGO HEMORRHAGIC FEVER VIRUS; DISEASE SEVERITY; FEMALE; GASTROENTERITIS; GASTROINTESTINAL HEMORRHAGE; GENOME; GENOME ANALYSIS; HIPPOSIDEROS GIGAS; LEOPARDS HILL VIRUS; LETHALITY; LIVER DISEASE; MOUSE; NAIROVIRUS; NAIROVIRUS INFECTION; NEXT GENERATION SEQUENCING; NONHUMAN; PHYLOGENY; PROTEIN PROCESSING; VIRUS IDENTIFICATION; VIRUS ISOLATION; VIRUS STRAIN; WEIGHT REDUCTION; ZAMBIA; ANIMAL; ANIMAL HEPATITIS; CRIMEAN CONGO HEMORRHAGIC FEVER; DISEASE MODEL; GENETICS; ISOLATION AND PURIFICATION; MOLECULAR GENETICS; NUCLEOTIDE SEQUENCE; VIROLOGY;

ZAMBIA;

CRIMEAN-CONGO HEMORRHAGIC FEVER VIRUS; HIPPOSIDEROS; MUS; NAIROVIRUS; ORTHOBUNYAVIRUS; PHYLLOSTOMIDAE;

ANIMALS; BASE SEQUENCE; CHIROPTERA; DISEASE MODELS, ANIMAL; GASTROENTERITIS; GASTROINTESTINAL HEMORRHAGE; HEMORRHAGIC FEVER, CRIMEAN; HEPATITIS, VIRAL, ANIMAL; MICE; MOLECULAR SEQUENCE DATA; NAIROVIRUS; RNA, VIRAL;

EID: 84923274764     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/ncomms6651     Document Type: Article

References (42)

1. Calisher, C. H., Childs, J. E., Field, H. E., Holmes, K. V. & Schountz, T. Bats: important reservoir hosts of emerging viruses. Clin. Microbiol. Rev. 19, 531-545 (2006).
2. Towner, J. S. et al. Marburg virus infection detected in a common African bat. PLoS ONE 2, e764 (2007).
3. Donaldson, E. F. et al. Metagenomic analysis of the viromes of three North American bat species: viral diversity among different bat species that share a common habitat. J. Virol. 84, 13004-13018 (2010).
4. Canuti, M. et al. Two novel parvoviruses in frugivorous New and Old World bats. PLoS ONE 6, e29140 (2011).
5. Drexler, J. F. et al. Bats host major mammalian paramyxoviruses. Nat. Commun. 3, 796 (2012).
6. Ge, X. et al. Metagenomic analysis of viruses from bat fecal samples reveals many novel viruses in insectivorous bats in China. J. Virol. 86, 4620-4630 (2012).
7. Tse, H. et al. Identification of a novel bat papillomavirus by metagenomics. PLoS ONE 7, e43986 (2012).
8. Peel, A. J. et al. Continent-wide panmixia of an African fruit bat facilitates transmission of potentially zoonotic viruses. Nat. Commun. 4, 2770 (2013).
9. Wu, Z. et al. Virome analysis for identification of novel mammalian viruses in bat species from Chinese provinces. J. Virol. 86, 10999-11012 (2012).
10. Kading, R. C. et al. Isolation and molecular characterization of Fikirini rhabdovirus, a novel virus from a Kenyan bat. J. Gen. Virol. 94, 2393-2398 (2013).
11. Dacheux, L. et al. A preliminary study of viral metagenomics of French bat species in contact with humans: identification of new mammalian viruses. PLoS ONE 9, e87194 (2014).
12. Briese, T. et al. Genetic detection and characterization of Lujo virus, a new haemorrhagic fever-associated arenavirus from southern Africa. PLoS Pathog. 5, e1000455 (2009).
13. Frame, J. D., Baldwin, Jr. J. M., Gocke, D. J. & Troup, J. M. Lassa fever, a new virus disease of man from West Africa. I. Clinical description and pathological findings. Am. J. Trop. Med. Hyg. 19, 670-676 (1970).
14. Paweska, J. T. et al. Nosocomial outbreak of novel arenavirus infection, southern Africa. Emerg. Infect. Dis. 15, 1598-1602 (2009).
15. Ishii, A. et al. Novel arenavirus, Zambia. Emerg. Infect. Dis. 17, 1921-1924 (2011).
16. Ishii, A. et al. Molecular surveillance and phylogenetic analysis of Old World arenaviruses in Zambia. J. Gen. Virol. 93, 2247-2251 (2012).
17. Whitehouse, C. A. Crimean-Congo haemorrhagic fever. Antiviral. Res. 64, 145-160 (2004).
18. Woodall, J. P., Williams, M. C. & Simpson, D. I. Congo virus: a hitherto undescribed virus occurring in Africa. II. Identification studies. East. Afr. Med. J. 44, 93-98 (1967).
19. Bente, D. A. et al. Crimean-Congo haemorrhagic fever: history, epidemiology, pathogenesis, clinical syndrome and genetic diversity. Antiviral. Res. 100, 159-189 (2013).
20. Honig, J. E., Osborne, J. C. & Nichol, S. T. The high genetic variation of viruses of the genus Nairovirus reflects the diversity of their predominant tick hosts. Virology 318, 10-16 (2004).
21. Frias-Staheli, N. et al. Ovarian tumor domain-containing viral proteases evade ubiquitin-and ISG15-dependent innate immune responses. Cell Host Microbe 2, 404-416 (2007).
22. Altamura, L. A. et al. Identification of a novel C-terminal cleavage of Crimean-Congo haemorrhagic fever virus PreGN that leads to generation of an NSM protein. J. Virol. 81, 6632-6642 (2007).
23. Sanchez, A. J., Vincent, M. J. & Nichol, S. T. Characterization of the glycoproteins of Crimean-Congo haemorrhagic fever virus. J. Virol. 76, 7263-7275 (2002).
24. Vincent, M. J. et al. Crimean-Congo haemorrhagic fever virus glycoprotein proteolytic processing by subtilase SKI-1. J. Virol. 77, 8640-8649 (2003).
25. Chastel, C. et al. Erve virus, a probable member of Bunyaviridae family isolated from shrews (Crocidura russula) in France. Acta Virol. 33, 270-280 (1989).
26. Dilcher, M. et al. Genetic characterization of Erve virus, a European Nairovirus distantly related to Crimean-Congo haemorrhagic fever virus. Virus Genes 45, 426-432 (2012).
27. Negredo, A. et al. Discovery of an ebolavirus-like filovirus in europe. PLoS Pathog. 7, e1002304 (2011).
28. Chamberlain, J. et al. Co-evolutionary patterns of variation in small and large RNA segments of Crimean-Congo haemorrhagic fever virus. J. Gen. Virol. 86, 3337-3341 (2005).
29. Swanepoel, R. et al. The clinical pathology of Crimean-Congo haemorrhagic fever. Rev. Infect. Dis. 11(Suppl 4): S794-S800 (1989).
30. Yu, X. J. et al. Fever with thrombocytopenia associated with a novel bunyavirus in China. N. Engl. J. Med. 364, 1523-1532 (2011).
31. Bente, D. A. et al. Pathogenesis and immune response of Crimean-Congo haemorrhagic fever virus in a STAT-1 knockout mouse model. J. Virol. 84, 11089-11100 (2010).
32. Boyd, A., Fazakerley, J. K. & Bridgen, A. Pathogenesis of Dugbe virus infection in wild-type and interferon-deficient mice. J. Gen. Virol. 87, 2005-2009 (2006).
33. Dowall, S. D. et al. Hazara virus infection is lethal for adult type I interferon receptor-knockout mice and may act as a surrogate for infection with the human-pathogenic Crimean-Congo haemorrhagic fever virus. J. Gen. Virol. 93, 560-564 (2012).
34. Smirnova, S. E. A comparative study of the Crimean haemorrhagic fever-Congo group of viruses. Arch. Virol. 62, 137-143 (1979).
35. Smirnova, S. E., Shestopalova, N. M., Reingold, V. N., Zubri, G. L. & Chumakov, M. P. Experimental Hazara Virus infection in mice. Acta Virol. 21, 128-132 (1977).
36. Zivcec, M. et al. Lethal Crimean-Congo haemorrhagic fever virus infection in interferon alpha/beta receptor knockout mice is associated with high viral loads, proinflammatory responses, and coagulopathy. J. Infect. Dis. 207, 1909-1921 (2013).
37. Yozwiak, N. L. et al. Virus identification in unknown tropical febrile illness cases using deep sequencing. PLoS Negl. Trop. Dis. 6, e1485 (2012).
38. Altschul, S. F., Gish, W., Miller, W., Myers, E. W. & Lipman, D. J. Basic local alignment search tool. J. Mol. Biol. 215, 403-410 (1990).
39. Huson, D. H., Auch, A. F., Qi, J. & Schuster, S. C. MEGAN analysis of metagenomic data. Genome Res. 17, 377-386 (2007).
40. Tamura, K. et al. MEGA5: molecular evolutionary genetics analysis using maximum likelihood, evolutionary distance, and maximum parsimony methods. Mol. Biol. Evol. 28, 2731-2739 (2011).
41. Jones, D. T., Taylor, W. R. & Thornton, J. M. The rapid generation of mutation data matrices from protein sequences. Comput. Appl. Biosci. 8, 275-282 (1992).
42. Seidah, N. G. & Chretien, M. Proprotein and prohormone convertases: a family of subtilases generating diverse bioactive polypeptides. Brain Res. 848, 45-62 (1999).