Structural analyses of Ca2+/CaM interaction with NaV channel C-termini reveal mechanisms of calcium-dependent regulation

Nature Communications

Volumn 5, Issue , 2014, Pages

  Wang, Chaojian ^a   Chung, Ben C ^a   Yan, Haidun ^a   Wang, Hong Gang ^a   Lee, Seok Yong ^a   Pitt, Geoffrey S ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM; CALMODULIN; FIBROBLAST GROWTH FACTOR; SODIUM CHANNEL NAV1.2; SODIUM CHANNEL NAV1.5; FIBROBLAST GROWTH FACTOR 14; PROTEIN BINDING; RECOMBINANT PROTEIN; SCN5A PROTEIN, HUMAN;

BIOCHEMICAL COMPOSITION; CARDIOLOGY; CARDIOVASCULAR DISEASE; CRYSTAL STRUCTURE; METABOLISM; MUTATION; SODIUM;

AFFINITY CHROMATOGRAPHY; ARTICLE; AUTISM; BRUGADA SYNDROME; CALORIMETRY; CARBOXY TERMINAL SEQUENCE; CHEMICAL ANALYSIS; CHILDHOOD ABSENCE EPILEPSY; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; CRYSTAL STRUCTURE; EMBRYO; ESCHERICHIA COLI; FEBRILE CONVULSION; GEL PERMEATION CHROMATOGRAPHY; HUMAN; HUMAN CELL; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; PROTEIN INTERACTION; REGULATORY MECHANISM; SEVERE MYOCLONIC EPILEPSY IN INFANCY; STOICHIOMETRY; AMINO ACID SEQUENCE; CHEMICAL STRUCTURE; CHEMISTRY; CYTOSOL; KINETICS; METABOLISM; MOLECULAR GENETICS; MUTATION; PROTEIN TERTIARY STRUCTURE; SEQUENCE HOMOLOGY; SITE DIRECTED MUTAGENESIS; X RAY CRYSTALLOGRAPHY;

AMINO ACID SEQUENCE; CALCIUM; CALMODULIN; CRYSTALLOGRAPHY, X-RAY; CYTOSOL; FIBROBLAST GROWTH FACTORS; HUMANS; KINETICS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; MUTATION; NAV1.2 VOLTAGE-GATED SODIUM CHANNEL; NAV1.5 VOLTAGE-GATED SODIUM CHANNEL; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT PROTEINS; SEQUENCE HOMOLOGY, AMINO ACID;

EID: 84923219800     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/ncomms5896     Document Type: Article

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