Comparative dendritic cell biology of veterinary mammals

Annual Review of Animal Biosciences

Volumn 3, Issue , 2015, Pages 533-557

  Summerfield, Artur ^a   Auray, Gael ^a   Ricklin, Meret ^a  

^a INSTITUTE OF VIROLOGY AND IMMUNOLOGY   (Switzerland)

Author keywords

bovine; canine; dendritic cells; equine; feline; macrophages; monocytes; ovine; porcine

Indexed keywords

BOS; BOVINAE; CANIS FAMILIARIS; EQUIDAE; FELIDAE; MAMMALIA; OVIS; OVIS ARIES; SUIDAE; SUS;

TRANSCRIPTOME;

ANIMAL; CELL DIFFERENTIATION; COMPARATIVE STUDY; CYTOLOGY; DENDRITIC CELL; DOMESTIC ANIMAL; IMMUNOLOGY; INNATE IMMUNITY;

ANIMALS; ANIMALS, DOMESTIC; CELL DIFFERENTIATION; DENDRITIC CELLS; IMMUNITY, INNATE; TRANSCRIPTOME;

EID: 84923169160     PISSN: 21658102     EISSN: 21658110     Source Type: Journal    
DOI: 10.1146/annurev-animal-022114-111009     Document Type: Article

References (125)

1. Murphy KM. 2013. Transcriptional control of dendritic cell development. Adv. Immunol. 120:239-67
2. Miller JC, Brown BD, Shay T, Gautier EL, Jojic V, et al. 2012. Deciphering the transcriptional network of the dendritic cell lineage. Nat. Immunol. 13:888-99
3. Robbins SH, Walzer T, Dembele D, Thibault C, Defays A, et al. 2008. Novel insights into the relationships between dendritic cell subsets in human and mouse revealed by genome-wide expression profiling. Genome Biol. 9:R17
4. Shay T, Jojic V, Zuk O, Rothamel K, Puyraimond-Zemmour D, et al. 2013. Conservation and divergence in the transcriptional programs of the human and mouse immune systems. PNAS 110:2946-51
5. Schlitzer A, Ginhoux F. 2014. Organization of the mouse and human DC network. Curr. Opin. Immunol. 26:90-99
6. Haniffa M, Collin M, Ginhoux F. 2013. Ontogeny and functional specialization of dendritic cells in human and mouse. Adv. Immunol. 120:1-49
7. Fitzgerald-Bocarsly P. 1993. Human natural interferon - a producing cells. Pharmacol. Ther. 60:39-62
8. Charley B, Lavenant L. 1990. Characterization of blood mononuclear cells producing IFN alpha following induction by coronavirus-infected cells (porcine transmissible gastroenteritis virus). Res. Immunol. 141:141-51
9. Siegal FP, Kadowaki N, Shodell M, Fitzgerald-Bocarsly PA, Shah K, et al. 1999. The nature of the principal type 1 interferon-producing cells in human blood. Science 284:1835-37
10. Asselin-Paturel C, Boonstra A, Dalod M, Durand I, Yessaad N, et al. 2001. Mouse type I IFN-producing cells are immature APCs with plasmacytoid morphology. Nat. Immunol. 2:1144-50
11. Summerfield A, Guzylack-Piriou L, Schaub A, Carrasco CP, Tache V, et al. 2003. Porcine peripheral blood dendritic cells and natural interferon-producing cells. Immunology 110:440-49
12. + dendritic cells (DCs) represent a unique myeloid DC subset that cross-presents necrotic cell antigens. J. Exp. Med. 207:1247-60
13. + dendritic cells. J. Exp. Med. 207:1273-81
14. +dendritic cells. J. Exp. Med. 207:1283-92
15. Merad M, Sathe P, Helft J, Miller J, Mortha A. 2013. The dendritic cell lineage: ontogeny and function of dendritic cells and their subsets in the steady state and the inflamed setting. Annu. Rev. Immunol. 31:563-604
16. Sathe P, Metcalf D, Vremec D, Naik SH, Langdon WY, et al. 2014. Lymphoid tissue and plasmacytoid dendritic cells and macrophages do not share a commonmacrophage-dendritic cell-restricted progenitor. Immunity 41:104-15
17. Guilliams M, Ginhoux F, Jakubzick C, Naik SH, Onai N, et al. 2014. Dendritic cells, monocytes and macrophages: a unified nomenclature based on ontogeny. Nat. Rev. Immunol. 14:571-78
18. Tamoutounour S, Guilliams M, Montanana Sanchis F, Liu H, Terhorst D, et al. 2013. Origins and functional specialization of macrophages and of conventional and monocyte-derived dendritic cells in mouse skin. Immunity 39:925-38
19. Varol C, Vallon-Eberhard A, Elinav E, Aychek T, Shapira Y, et al. 2009. Intestinal lamina propria dendritic cell subsets have different origin and functions. Immunity 31:502-12
20. Varol C, Landsman L, Fogg DK, Greenshtein L, Gildor B, et al. 2007. Monocytes give rise to mucosal, but not splenic, conventional dendritic cells. J. Exp. Med. 204:171-80
21. Mildner A, Yona S, Jung S. 2013. A close encounter of the third kind: monocyte-derived cells. Adv. Immunol. 120:69-103
22. Ginhoux F, Jung S. 2014. Monocytes and macrophages: developmental pathways and tissue homeostasis. Nat. Rev. Immunol. 14:392-404
23. Seillet C, Belz GT. 2013. Terminal differentiation of dendritic cells. Adv. Immunol. 120:185-210
24. Watchmaker PB, Lahl K, Lee M, Baumjohann D, Morton J, et al. 2014. Comparative transcriptional and functional profiling defines conserved programs of intestinal DC differentiation in humans and mice. Nat. Immunol. 15:98-108
25. Iwasaki A. 2007. Mucosal dendritic cells. Annu. Rev. Immunol. 25:381-418
26. Saurer L, McCullough KC, SummerfieldA. 2007. In vitro induction of mucosa-type dendritic cells by alltrans retinoic acid. J. Immunol. 179:3504-14
27. + T cell responses in vivo. Eur. J. Immunol. 22:3057-61
28. Howard CJ, Sopp P, Brownlie J, Kwong LS, Parsons KR, Taylor G. 1997. Identification of two distinct populations of dendritic cells in afferent lymph that vary in their ability to stimulate T cells. J. Immunol. 159:5372-82
29. Howard CJ, Brooke GP, Werling D, Sopp P, Hope JC, et al. 1999. Dendritic cells in cattle: phenotype and function. Vet. Immunol. Immunopathol. 72:119-24
30. Gliddon DR, Howard CJ. 2002. CD26 is expressed on a restricted subpopulation of dendritic cells in vivo. Eur. J. Immunol. 32:1472-81
31. Contreras V, Urien C, Guiton R, Alexandre Y, Vu Manh TP, et al. 2010. Existence of CD8a-like dendritic cells with a conserved functional specialization and a common molecular signature in distant mammalian species. J. Immunol. 185:3313-25
32. + type. J. Immunol. 187:4411-15
33. Guzylack-Piriou L, Alves MP, McCullough KC, Summerfield A. 2010. Porcine Flt3 ligand and its receptor: generation of dendritic cells and identification of a new marker for porcine dendritic cells. Dev. Comp. Immunol. 34:455-64
34. Summerfield A, McCullough KC. 2009. The porcine dendritic cell family. Dev. Comp. Immunol. 33:299-309
35. Bimczok D, Sowa EN, Faber-Zuschratter H, Pabst R, Rothkötter HJ. 2005. Site-specific expression of CD11b and SIRPa (CD172a) on dendritic cells: implications for their migration patterns in the gut immune system. Eur. J. Immunol. 35:1418-27
36. Reid E, Juleff N, Gubbins S, Prentice H, Seago J, Charleston B. 2011. Bovine plasmacytoid dendritic cells are the major source of type I interferon in response to foot-and-mouth disease virus in vitro and in vivo. J. Virol. 85:4297-308
37. Pascale F, Contreras V, Bonneau M, Courbet A, Chilmonczyk S, et al. 2008. Plasmacytoid dendritic cells migrate in afferent skin lymph. J. Immunol. 180:5963-72
38. Calzada-Nova G, Schnitzlein W, Husmann R, Zuckermann FA. 2010. Characterization of the cytokine and maturation responses of pure populations of porcine plasmacytoid dendritic cells to porcine viruses and toll-like receptor agonists. Vet. Immunol. Immunopathol. 135:20-33
39. Baumann A, Mateu E, Murtaugh MP, Summerfield A. 2013. Impact of genotype 1 and 2 of porcine reproductive and respiratory syndrome viruses on interferon-a responses by plasmacytoid dendritic cells. Vet. Res. 44:33
40. Fiebach AR, Guzylack-Piriou L, Python S, Summerfield A, Ruggli N. 2011. Classical Swine Fever virus Npro limits type I interferon induction in plasmacytoid dendritic cells by interacting with interferon regulatory factor 7. J. Virol. 85:8002-11
41. Guzylack-Piriou L, Balmelli C, McCullough KC, Summerfield A. 2004. Type-A CpG oligonucleotides activate exclusively porcine natural interferon-producing cells to secrete interferon-a, tumour necrosis factor-a and interleukin-12. Immunology 112:28-37
42. Guzylack-Piriou L, Bergamin F, Gerber M, McCullough KC, Summerfield A. 2006. Plasmacytoid dendritic cell activation by foot-and-mouth disease virus requires immune complexes. Eur. J. Immunol. 36:1674-83
43. Balmelli C, Vincent IE, Rau H, Guzylack-Piriou L, McCullough K, Summerfield A. 2005. FcgRIIdependent sensitisation of natural interferon-producing cells for viral infection and interferon-a responses. Eur. J. Immunol. 35:2406-15
44. rns. PLOS Pathog. 9:e1003412
45. Sallusto F, Lanzavecchia A. 1994. Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor a. J. Exp. Med. 179:1109-18
46. Werling D, Hope JC, Chaplin P, Collins RA, Taylor G, Howard CJ. 1999. Involvement of caveolae in the uptake of respiratory syncytial virus antigen by dendritic cells. J. Leukoc. Biol. 66:50-58
47. Mackenzie-Dyck S, Attah-Poku S, Juillard V, Babiuk LA, van Drunen Littel-van den Hurk S. 2011. The synthetic peptides bovine enteric b-defensin (EBD), bovine neutrophil b-defensin (BNBD) 9 andBNBD 3 are chemotactic for immature bovine dendritic cells. Vet. Immunol. Immunopathol. 143:87-107
48. Bajer AA, Garcia-Tapia D, Jordan KR, Haas KM, Werling D, et al. 2003. Peripheral blood-derived bovine dendritic cells promote IgG1-restricted B cell responses in vitro. J. Leukoc. Biol. 73:100-6
49. Mirkovitch J, König A, Sauter KS, Brcic M, Hope JC, et al. 2006. Single-cell analysis divides bovine monocyte-derived dendritic cells into subsets expressing either high or low levels of inducible nitric oxide synthase. Vet. Immunol. Immunopathol. 114:1-14
50. Hope JC, Whelan AO, Hewinson RG, Vordermeier M, Howard CJ. 2003. Maturation of bovine dendritic cells by lipopeptides. Vet. Immunol. Immunopathol. 95:21-31
51. Norimatsu M, Harris J, Chance V, Dougan G, Howard CJ, Villarreal-Ramos B. 2003. Differential response of bovine monocyte-derived macrophages and dendritic cells to infection with Salmonella typhimurium in a low-dose model in vitro. Immunology 108:55-61
52. Hope JC, Thom ML, McCormick PA, Howard CJ. 2004. Interaction of antigen presenting cells with mycobacteria. Vet. Immunol. Immunopathol. 100:187-95
53. Werling D, Hope JC, Howard CJ, Jungi TW. 2004. Differential production of cytokines, reactive oxygen and nitrogen by bovine macrophages and dendritic cells stimulated with Toll-like receptor agonists. Immunology 111:41-52
54. Willcocks S, YamakawaY, Stalker A, Coffey TJ, Goldammer T, Werling D. 2006. Identification and gene expression of the bovine C-type lectin Dectin-1. Vet. Immunol. Immunopathol. 113:234-42
55. Pinchuk LM, Boyd BL, Kruger EF, Roditi I, Furger A. 2003. Bovine dendritic cells generated from monocytes and bone marrow progenitors regulate immunoglobulin production in peripheral blood B cells. Comp. Immunol. Microbiol. Infect. Dis. 26:233-49
56. Hope JC, Werling D, Collins RA, Mertens B, Howard CJ. 2000. Flt-3 ligand, in combination with bovine granulocyte-macrophage colony-stimulating factor and interleukin-4, promotes the growth of bovine bone marrow derived dendritic cells. Scand. J. Immunol. 51:60-66
57. + T-cell responses to Mycobacterium bovis and M. avium antigens in Bacille Calmette Guérin vaccinated and nonvaccinated cattle. Scand. J. Immunol. 52:285-91
58. Chan SS, McConnell I, Blacklaws BA. 2002. Generation and characterization of ovine dendritic cells derived from peripheral blood monocytes. Immunology 107:366-72
59. Bonneau M, Epardaud M, Payot F, Niborski V, Thoulouze MI, et al. 2006. Migratory monocytes and granulocytes are major lymphatic carriers of Salmonella from tissue to draining lymph node. J. Leukoc. Biol. 79:268-76
60. Fach SJ, Brockmeier SL, Hobbs LA, Lehmkuhl HD, Sacco RE. 2006. Pulmonary dendritic cells isolated from neonatal and adult ovine lung tissue. Vet. Immunol. Immunopathol. 112:171-82
61. Foulon E, Foucras G. 2008. Two populations of ovine bone marrow-derived dendritic cells can be generated with recombinant GM-CSF and separated on CD11b expression. J. Immunol. Methods 339:1-10
62. Ezquerra A, Revilla C, Alvarez B, Pérez C, Alonso F, Domínguez J. 2009. Porcine myelomonocytic markers and cell populations. Dev. Comp. Immunol. 33:284-98
63. Moreno S, Alvarez B, Poderoso T, Revilla C, Ezquerra A, et al. 2010. Porcine monocyte subsets differ in the expression of CCR2 and in their responsiveness to CCL2. Vet. Res. 41:76
64. + monocytes into functional dendritic cells. Immunobiology 209:57-65
65. Alvarez B, Poderoso T, Alonso F, Ezquerra A, Domínguez J, Revilla C. 2013. Antigen targeting to APC: from mice to veterinary species. Dev. Comp. Immunol. 41:153-63
66. Huang YW, Dryman BA, Li W, Meng XJ. 2009. Porcine DC-SIGN: molecular cloning, gene structure, tissue distribution and binding characteristics. Dev. Comp. Immunol. 33:464-80
67. Auray G, Facci MR, van Kessel J, Buchanan R, Babiuk LA, Gerdts V. 2010. Differential activation and maturation of two porcine DC populations following TLR ligand stimulation. Mol. Immunol. 47:2103-11
68. Facci MR, Auray G, Buchanan R, van Kessel J, Thompson DR, et al. 2010. A comparison between isolated blood dendritic cells and monocyte-derived dendritic cells in pigs. Immunology 129:396-405
69. Carrasco CP, Rigden RC, Schaffner R, Gerber H, Neuhaus V, et al. 2001. Porcine dendritic cells generated in vitro: morphological, phenotypic and functional properties. Immunology 104:175-84
70. Dominguez J, Alvarez B, Alonso F, Thacker E, Haverson K, et al. 2001. Workshop studies on monoclonal antibodies in the myeloid panel with CD11 specificity. Vet. Immunol. Immunopathol. 80:111-19
71. Haverson K, Bailey M, Higgins VR, Bland PW, Stokes CR. 1994. Characterization of monoclonal antibodies specific for monocytes, macrophages and granulocytes from porcine peripheral blood and mucosal tissues. J. Immunol. Methods 170:233-45
72. Whittall JT, Parkhouse RM. 1997. Monoclonal antibodies defining differentiation antigens of swine lymphoid and myeloid cells. Vet. Immunol. Immunopathol. 60:149-60
73. Ricklin Gutzwiller ME, Moulin HR, Zurbriggen A, Roosje P, Summerfield A. 2010. Comparative analysis of canine monocyte- and bone-marrow-derived dendritic cells. Vet. Res. 41:40
74. Bonnefont-Rebeix C, de Carvalho CM, Bernaud J, Chabanne L, Marchal T, Rigal D. 2006. CD86 molecule is a specific marker for canine monocyte-derived dendritic cells. Vet. Immunol. Immunopathol. 109:167-76
75. Bonnefont-Rebeix C, Marchal T, Bernaud J, Pin JJ, Leroux C, et al. 2007. Toll-like receptor 3 (TLR3): a new marker of canine monocytes-derived dendritic cells (cMo-DC). Vet. Immunol. Immunopathol. 118:134-39
76. Qeska V, Baumgartner W, Beineke A. 2013. Species-specific properties and translational aspects of canine dendritic cells. Vet. Immunol. Immunopathol. 151:181-92
77. Bienzle D, Reggeti F, Clark ME, Chow C. 2003. Immunophenotype and functional properties of feline dendritic cells derived from blood and bone marrow. Vet. Immunol. Immunopathol. 96:19-30
78. Freer G, Matteucci D, Mazzetti P, Bozzacco L, Bendinelli M. 2005. Generation of feline dendritic cells derived from peripheral blood monocytes for in vivo use. Clin. Diagn. Lab. Immunol. 12:1202-8
79. Sprague WS, Pope M, Hoover EA. 2005. Culture and comparison of feline myeloid dendritic cells vs. macrophages. J. Comp. Pathol. 133:136-45
80. Mauel S, Steinbach F, Ludwig H. 2006. Monocyte-derived dendritic cells from horses differ from dendritic cells of humans and mice. Immunology 117:463-73
81. Moyo NA, Marchi E, Steinbach F. 2013. Differentiation and activation of equine monocyte-derived dendritic cells are not correlated with CD206 or CD83 expression. Immunology 139:472-83
82. Renjifo X, Howard C, Kerkhofs P, Denis M, Urbain J, et al. 1997. Purification and characterization of bovine dendritic cells from peripheral blood. Vet. Immunol. Immunopathol. 60:77-88
83. Miyazawa K, Aso H, Honda M, Kido T, Minashima T, et al. 2006. Identification of bovine dendritic cell phenotype from bovine peripheral blood. Res. Vet. Sci. 81:40-45
84. + dendritic cells resident in the spleen. Clin. Vaccine Immunol. 13:1064-69
85. Mielcarek M, Kucera KA, Nash R, Torok-Storb B, McKenna HJ. 2007. Identification and characterization of canine dendritic cells generated in vivo. Biol. Blood Marrow Transplant. 13:1286-93
86. Hope JC, Howard CJ, Prentice H, Charleston B. 2006. Isolation and purification of afferent lymph dendritic cells that drain the skin of cattle. Nat. Protoc. 1:982-87
87. Gliddon DR, Hope JC, Brooke GP, Howard CJ. 2004. DEC-205 expression on migrating dendritic cells in afferent lymph. Immunology 111:262-72
88. Hope JC, Guzman E, Cubillos-Zapata C, Stephens SA, Gilbert SC, et al. 2012. Migratory subpopulations of afferent lymphatic dendritic cells differ in their interactions with Mycobacterium bovis Bacille Calmette Guerin. Vaccine 30:2357-67
89. + T cell responses by subpopulations of dendritic cells from afferent lymph are related to IL-1a secretion. J. Leukoc. Biol. 69:271-79
90. Cubillos-Zapata C, Guzman E, Turner A, Gilbert SC, Prentice H, et al. 2011. Differential effects of viral vectors on migratory afferent lymph dendritic cells in vitro predict enhanced immunogenicity in vivo. J. Virol. 85:9385-94
91. Stephens SA, Brownlie J, Charleston B, Howard CJ. 2003. Differences in cytokine synthesis by the subpopulations of dendritic cells from afferent lymph. Immunology 110:48-57
92. Bujdoso R, Hopkins J, DutiaBM, Young P, McConnell I. 1989. Characterization of sheep afferent lymph dendritic cells and their role in antigen carriage. J. Exp. Med. 170:1285-301
93. hi SIRPsubset in lymph dendritic cells from the upper aero-digestive tract. J. Leukoc. Biol. 76:553-61
94. Geherin SA, Fintushel SR, Lee MH, Wilson RP, Patel RT, et al. 2012. The skin, a novel niche for recirculating B cells. J. Immunol. 188:6027-35
95. Ryan S, Tiley L, McConnell I, Blacklaws B. 2000. Infection of dendritic cells by the Maedi-Visna lentivirus. J. Virol. 74:10096-103
96. + DCs. J. Exp. Med. 206:3115-30
97. Marquet F, Bonneau M, Pascale F, Urien C, Kang C, et al. 2011. Characterization of dendritic cells subpopulations in skin and afferent lymph in the swine model. PLOS ONE 6:e16320
98. Maxymiv NG, Bharathan M, Mullarky IK. 2012. Bovine mammary dendritic cells: a heterogeneous population, distinct from macrophages and similar in phenotype to afferent lymph veiled cells. Comp. Immunol. Microbiol. Infect. Dis. 35:31-38
99. Jamin A, Gorin S, Le Potier MF, Kuntz-Simon G. 2006. Characterization of conventional and plasmacytoid dendritic cells in swine secondary lymphoid organs and blood. Vet. Immunol. Immunopathol. 114:224-37
100. Naessens J, Howard CJ, Hopkins J. 1997. Nomenclature and characterization of leukocyte differentiation antigens in ruminants. Immunol. Today 18:365-68
101. Rhind SM, Hopkins J, Grant ES. 2000. Differential expression of ovine CD1. Immunology 101:452-57
102. MacHugh ND, Bensaid A, Davis WC, Howard CJ, Parsons KR, et al. 1988. Characterization of a bovine thymic differentiation antigen analogous to CD1 in the human. Scand. J. Immunol. 27:541-47
103. Nfon CK, Dawson H, Toka FN, Golde WT. 2008. Langerhans cells in porcine skin. Vet. Immunol. Immunopathol. 126:236-47
104. Ricklin ME, Roosje P, SummerfieldA. 2010. Characterization of canine dendritic cells in healthy, atopic, and non-allergic inflamed skin. J. Clin. Immunol. 30:845-54
105. Woo JC, Moore PF. 1997. A feline homologue of CD1 is defined using a feline-specific monoclonal antibody. Tissue Antigens 49:244-51
106. Arzi B, Murphy B, Baumgarth N, Vapniarsky N, Nemec A, et al. 2011. Analysis of immune cells within the healthy oral mucosa of specific pathogen-free cats. Anat. Histol. Embryol. 40:1-10
107. Saint-André Marchal I, Dezutter-Dambuyant C, Willett BJ, Woo JC, Moore PF, et al. 1997. Immunophenotypic characterization of feline Langerhans cells. Vet. Immunol. Immunopathol. 58:1-16
108. Åkesson CP, Press CMcL, Espenes A, Aleksandersen M. 2008. Phenotypic characterisation of intestinal dendritic cells in sheep. Dev. Comp. Immunol. 32:837-49
109. McNeilly TN, Brown JK, Harkiss G. 2006. Differential expression of cell surface markers by ovine respiratory tract dendritic cells. J. Histochem. Cytochem. 54:1021-30
110. Haverson K, Singha S, Stokes CR, Bailey M. 2000. Professional and non-professional antigen-presenting cells in the porcine small intestine. Immunology 101:492-500
111. Inman CF, Singha S, Lewis M, Bradley B, Stokes C, Bailey M. 2010. Dendritic cells interact with CD4 T cells in intestinal mucosa. J. Leukoc. Biol. 88:571-78
112. + intestinal antigen presenting cells and antigen-specific immune responses, leading to a prolonged intestinal ETEC infection. Vet. Res. 40:40
113. + antigen-presenting cells isolated from small intestinal mucosa mature but lose their T cell stimulatory function in response to cholera toxin treatment. Vet. Immunol. Immunopathol. 134:239-48
114. Zhang W, Wen K, Azevedo MSP, Gonzalez A, Saif LJ, et al. 2008. Lactic acid bacterial colonization and human rotavirus infection influence distribution and frequencies of monocytes/macrophages and dendritic cells in neonatal gnotobiotic pigs. Vet. Immunol. Immunopathol. 121:222-31
115. Vlasova AN, Chattha KS, Kandasamy S, Siegismund CS, Saif LJ. 2013. Prenatally acquired vitamin A deficiency alters innate immune responses to human rotavirus in a gnotobiotic pig model. J. Immunol. 190:4742-53
116. Vlasova AN, Chattha KS, Kandasamy S, Liu Z, Esseili M, et al. 2013. Lactobacilli and bifidobacteria promote immune homeostasis by modulating innate immune responses to human rotavirus in neonatal gnotobiotic pigs. PLOS ONE 8:e76962
117. Gonzalez AM, Azevedo MS, Jung K, Vlasova A, Zhang W, Saif LJ. 2010. Innate immune responses to human rotavirus in the neonatal gnotobiotic piglet disease model. Immunology 131:242-56
118. Riffault S, Carrat C, van Reeth K, Pensaert M, Charley B. 2001. Interferon-alpha-producing cells are localized in gut-associated lymphoid tissues in transmissible gastroenteritis virus (TGEV) infected piglets. Vet. Res. 32:71-79
119. Summerfield A. 2011. Viewpoint: factors involved in type I interferon responses during porcine virus infections. Vet. Immunol. Immunopathol. 148:168-71
120. Meurens F, Summerfield A, Nauwynck H, Saif L, Gerdts V. 2012. The pig: a model for human infectious diseases. Trends Microbiol. 20:50-57
121. Waters WR, Palmer MV, Thacker TC, Davis WC, Sreevatsan S, et al. 2011. Tuberculosis immunity: opportunities from studies with cattle. Clin. Dev. Immunol. 2011:768542
122. Watkins C, Lau S, Thistlethwaite R, Hopkins J, Harkiss GD. 1999. Analysis of reporter gene expression in ovine dermis and afferent lymph dendritic cells in vitro and in vivo. Vet. Immunol. Immunopathol. 72:125-33
123. Gamvrellis A, Walsh K, Tatarczuch L, Smooker P, Plebanski M, Scheerlinck JP. 2013. Phenotypic analysis of ovine antigen presenting cells loaded with nanoparticles migrating from the site of vaccination. Methods 60:257-63
124. Hemati B, Contreras V, Urien C, Bonneau M, Takamatsu HH, et al. 2009. Bluetongue virus targets conventional dendritic cells in skin lymph. J. Virol. 83:8789-99
125. Mair KH, Sedlak C, Kaser T, Pasternak A, Levast B, et al. 2014. The porcine innate immune system: an update. Dev. Comp. Immunol. 45:321-43