Adipogenesis and epicardial adipose tissue: A novel fate of the epicardium induced by mesenchymal transformation and PPARγ activation

Proceedings of the National Academy of Sciences of the United States of America

Volumn 112, Issue 7, 2015, Pages 2070-2075

  Yamaguchi, Yukiko ^a   Cavallero, Susana ^a   Patterson, Michaela ^a   Shen, Hua ^a   Xu, Jian ^b   Kumar, S Ram ^a   Sucov, Henry M ^a  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^b UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

EAT; Epicardial adipose tissue; Epicardium to mesenchymal transformation; PPAR

Indexed keywords

PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA;

ADIPOCYTE; ADIPOGENESIS; ADIPOSE TISSUE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; EPICARDIUM; EPITHELIAL MESENCHYMAL TRANSITION; FIBROBLAST; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; SMOOTH MUSCLE FIBER; AGONISTS; ANIMAL; CELL LINEAGE; CYTOLOGY; MESODERM; PERICARDIUM; TRANSFORMED CELL LINE;

MAMMALIA; MUS;

ADIPOGENESIS; ANIMALS; CELL LINE, TRANSFORMED; CELL LINEAGE; HUMANS; MESODERM; MICE; PERICARDIUM; PPAR GAMMA;

EID: 84923166412     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1417232112     Document Type: Article

References (33)

1. Iacobellis G, Bianco AC (2011) Epicardial adipose tissue: Emerging physiological, pathophysiological and clinical features. Trends Endocrinol Metab 22(11): 450-457.
2. Rabkin SW (2007) Epicardial fat: Properties, function and relationship to obesity. Obes Rev 8(3):253-261.
3. Sacks HS, Fain JN (2007) Human epicardial adipose tissue: A review. Am Heart J 153(6): 907-917.
4. Fletcher BD, Jacobstein MD, Abramowsky CR, Anderson RH (1987) Right atrioventricular valve atresia: Anatomic evaluation with MR imaging. AJR Am J Roentgenol 148(4):671-674.
5. Jornet A, Reig J, Ruiz C, Uson M, Petit M (1990) The intervenous tubercle (of lower): Morphological characteristics and changes in relation to age. Arch Anat Histol Embryol 73:21-32.
6. Marchington JM, Mattacks CA, Pond CM (1989) Adipose tissue in the mammalian heart and pericardium: Structure, foetal development and biochemical properties. Comp Biochem Physiol B 94(2):225-232.
7. Bedford E (1972) The story of fatty heart. A disease of Victorian times. Br Heart J 34(1): 23-28.
8. Bayes-Genis A, et al. (2010) Human progenitor cells derived from cardiac adipose tissue ameliorate myocardial infarction in rodents. J Mol Cell Cardiol 49(5):771-780.
9. Virágh S, Challice CE (1981) The origin of the epicardium and the embryonic myocardial circulation in the mouse. Anat Rec 201(1):157-168.
10. Sucov HM, Gu Y, Thomas S, Li P, Pashmforoush M (2009) Epicardial control of myocardial proliferation and morphogenesis. Pediatr Cardiol 30(5):617-625.
11. Riley PR (2012) An epicardial floor plan for building and rebuilding the mammalian heart. Curr Top Dev Biol 100:233-251.
12. Acharya A, et al. (2012) The bHLH transcription factor Tcf21 is required for lineagespecific EMT of cardiac fibroblast progenitors. Development 139(12):2139-2149.
13. Sacks HS, et al. (2009) Uncoupling protein-1 and related messenger ribonucleic acids in human epicardial and other adipose tissues: Epicardial fat functioning as brown fat. J Clin Endocrinol Metab 94(9):3611-3615.
14. Cai CL, et al. (2008) A myocardial lineage derives from Tbx18 epicardial cells. Nature 454(7200):104-108.
15. Chen T, et al. (2002) Epicardial induction of fetal cardiomyocyte proliferation via a retinoic acid-inducible trophic factor. Dev Biol 250(1):198-207.
16. Spiegelman BM, Hu E, Kim JB, Brun R (1997) PPAR gamma and the control of adipogenesis. Biochimie 79(2-3):111-112.
17. Molnár F, Matilainen M, Carlberg C (2005) Structural determinants of the agonistindependent association of human peroxisome proliferator-activated receptors with coactivators. J Biol Chem 280(28):26543-26556.
18. Dobson ME, et al. (2011) Pioglitazone induces a proadipogenic antitumor response in mice with PAX8-PPARgamma fusion protein thyroid carcinoma. Endocrinology 152(11): 4455-4465.
19. Zhou B, Pu WT (2011) Epicardial epithelial-to-mesenchymal transition in injured heart. J Cell Mol Med 15(12):2781-2783.
20. Chau YY, et al. (2014) Visceral and subcutaneous fat have different origins and evidence supports a mesothelial source. Nat Cell Biol 16(4):367-375.
21. Liu Q, et al. (2014) Epicardium-to-fat transition in injured heart. Cell Res 24(11): 1367-1369.
22. Christoffels VM, et al. (2009) Tbx18 and the fate of epicardial progenitors. Nature 458(7240)E8-E9; discussion E9-E10.
23. Christoffels VM, et al. (2006) Formation of the venous pole of the heart from an Nkx2-5-negative precursor population requires Tbx18. Circ Res 98(12):1555-1563.
24. Anghel SI, Wahli W (2007) Fat poetry: A kingdom for PPAR gamma. Cell Res 17(6): 486-511.
25. Tansey DK, Aly Z, Sheppard MN (2005) Fat in the right ventricle of the normal heart. Histopathology 46(1):98-104.
26. Iyer VR, Chin AJ (2013) Arrhythmogenic right ventricular cardiomyopathy/dysplasia (ARVC/D). Am J Med Genet C Semin Med Genet 163C(3):185-197.
27. Garcia-Gras E, et al. (2006) Suppression of canonical Wnt/beta-catenin signaling by nuclear plakoglobin recapitulates phenotype of arrhythmogenic right ventricular cardiomyopathy. J Clin Invest 116(7):2012-2021.
28. Kisanuki YY, et al. (2001) Tie2-Cre transgenic mice: A new model for endothelial celllineage analysis in vivo. Dev Biol 230(2):230-242.
29. Soriano P (1999) Generalized lacZ expression with the ROSA26 Cre reporter strain. Nat Genet 21(1):70-71.
30. He W, et al. (2003) Adipose-specific peroxisome proliferator-activated receptor gamma knockout causes insulin resistance in fat and liver but not in muscle. Proc Natl Acad Sci USA 100(26):15712-15717.
31. Li P, et al. (2011) IGF signaling directs ventricular cardiomyocyte proliferation during embryonic heart development. Development 138(9):1795-1805.
32. Hazra S, et al. (2004) Peroxisome proliferator-activated receptor gamma induces a phenotypic switch from activated to quiescent hepatic stellate cells. J Biol Chem 279(12):11392-11401.
33. Leferovich JM, et al. (2001) Heart regeneration in adult MRL mice. Proc Natl Acad Sci USA 98(17):9830-9835.