Epicardial epithelial-to-mesenchymal transition in injured heart

Journal of Cellular and Molecular Medicine

Volumn 15, Issue 12, 2011, Pages 2781-2783

  Zhou, Bin ^a,b   Pu, William T ^b  

^a Shanghai Jiao Tong University Affiliated Sixth People s Hospital   (China)

^b HARVARD UNIVERSITY   (United States)

Author keywords

EMT; Epicardium; Myocardial infarction; Regeneration

Indexed keywords

CRE RECOMBINASE; INTEGRASE;

ANIMAL; ARTICLE; CELL DIFFERENTIATION; CELL LINEAGE; EPITHELIAL MESENCHYMAL TRANSITION; HEART; HEART INFARCTION; METABOLISM; MOUSE; MOUSE MUTANT; PATHOPHYSIOLOGY; PERICARDIUM; SIGNAL TRANSDUCTION;

ANIMALS; CELL DIFFERENTIATION; CELL LINEAGE; EPITHELIAL-MESENCHYMAL TRANSITION; HEART; INTEGRASES; MICE; MICE, MUTANT STRAINS; MYOCARDIAL INFARCTION; PERICARDIUM; SIGNAL TRANSDUCTION;

EID: 82455186684     PISSN: 15821838     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1582-4934.2011.01450.x     Document Type: Article

References (15)

1. Olivey HE, Svensson EC. Epicardial-myocardial signaling directing coronary vasculogenesis. Circ Res. 2010; 106: 818-32.
2. Limana F, Zacheo A, Mocini D, et al. Identification of myocardial and vascular precursor cells in human and mouse epicardium. Circ Res. 2007; 101: 1255-65.
3. Cai CL, Martin JC, Sun Y, et al. A myocardial lineage derives from Tbx18 epicardial cells. Nature. 2008; 454: 104-8.
4. Zhou B, Ma Q, Rajagopal S, et al. Epicardial progenitors contribute to the cardiomyocyte lineage in the developing heart. Nature. 2008; 454: 109-13.
5. Christoffels VM, Grieskamp T, Norden J, et al. Tbx18 and the fate of epicardial progenitors. Nature. 2009; 458: E8-9; discussion E9-10.
6. Lavine KJ, Yu K, White AC, et al. Endocardial and epicardial derived FGF signals regulate myocardial proliferation and differentiationin vivo. Dev Cell. 2005; 8: 85-95.
7. Lavine KJ, White AC, Park C, et al. Fibroblast growth factor signals regulate a wave of Hedgehog activation that is essential for coronary vascular development. Genes Dev. 2006; 20: 1651-66.
8. Hamdi H, Planat-Benard V, Bel A, et al. Epicardial adipose stem cell sheets results in greater post-infarction survival than intramyocardial injections. Cardiovasc Res. 2011; 91: 483-91.
9. Limana F, Capogrossi McGermani A. The epicardium in cardiac repair: from the stem cell view. Pharmacol Ther. 2011; 129: 82-96.
10. Lepilina A, Coon AN, Kikuchi K, et al. A dynamic epicardial injury response supports progenitor cell activity during zebrafish heart regeneration. Cell. 2006; 127: 607-19.
11. Zhou B, Honor LB, He H, et al. Adult mouse epicardium modulates myocardial injury by secreting paracrine factors. J Clin Invest. 2011; 121: 1894-904.
12. Smart N, Bollini S, Dube KN, et al. De novocardiomyocytes from within the activated adult heart after injury. Nature. 2011; 474: 640-4.
13. Gherghiceanu M, Popescu LM. Human epicardium: ultrastructural ancestry of mesothelium and mesenchymal cells. J Cell Mol Med. 2009; 13: 2949-51.
14. Gherghiceanu M, Popescu LM. Cardiomyocyte precursors and telocytes in epicardial stem cell niche: electron microscope images. J Cell Mol Med. 2010; 14: 871-7.
15. Popescu LM, Gherghiceanu M, Manole CG, et al. Cardiac renewing: interstitial Cajal-like cells nurse cardiomyocyte progenitors in epicardial stem cell niches. J Cell Mol Med. 2009; 13: 866-86.