Comparative effects of intraduodenal protein and lipid on ghrelin, peptide YY, and leptin release in healthy men

American Journal of Physiology - Regulatory Integrative and Comparative Physiology

Volumn 308, Issue 4, 2015, Pages R300-R304

  Ullrich, Sina S ^a,b   Otto, Bärbel ^c   Hutchison, Amy T ^a,b   Luscombe Marsh, Natalie D ^a,b,d   Horowitz, Michael ^a,b   Feinle Bisset, Christine ^a,b  

^a UNIVERSITY OF ADELAIDE   (Australia)

^b NATIONAL HEALTH AND MEDICAL RESEARCH COUNCIL   (Australia)

^c LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

^d CSIRO   (Australia)

Author keywords

Food intake; Gastrointestinal function; Gut hormones; Humans

Indexed keywords

GHRELIN; LEPTIN; LIPID; PEPTIDE YY; PROTEIN; SODIUM CHLORIDE; FAT INTAKE; GHRL PROTEIN, HUMAN; MILK PROTEIN; PROTEIN HYDROLYSATE; PROTEIN INTAKE; TRIACYLGLYCEROL; WHEY PROTEIN;

ADULT; ARTICLE; BLOOD SAMPLING; CALORIC INTAKE; CONTROLLED STUDY; ENERGY BALANCE; HORMONE BLOOD LEVEL; HORMONE RELEASE; HUMAN; MALE; MEAL; NORMAL HUMAN; PRIORITY JOURNAL; ADMINISTRATION AND DOSAGE; ADOLESCENT; BLOOD; COMPARATIVE STUDY; CONTROLLED CLINICAL TRIAL; CROSSOVER PROCEDURE; DOUBLE BLIND PROCEDURE; DRUG EFFECTS; DUODENUM; EATING; ENERGY METABOLISM; FAT INTAKE; METABOLISM; POSTPRANDIAL STATE; PROTEIN INTAKE; TIME; YOUNG ADULT;

ADOLESCENT; ADULT; CROSS-OVER STUDIES; DIETARY FATS; DIETARY PROTEINS; DOUBLE-BLIND METHOD; DUODENUM; EATING; ENERGY METABOLISM; GHRELIN; HEALTHY VOLUNTEERS; HUMANS; LEPTIN; MALE; MILK PROTEINS; PEPTIDE YY; POSTPRANDIAL PERIOD; PROTEIN HYDROLYSATES; TIME FACTORS; TRIGLYCERIDES; YOUNG ADULT;

EID: 84923163676     PISSN: 03636119     EISSN: 15221490     Source Type: Journal    
DOI: 10.1152/ajpregu.00504.2014     Document Type: Article

References (36)

1. Al Awar R, Obeid O, Hwalla N, Azar S. Postprandial acylated ghrelin status following fat and protein manipulation of meals in healthy young women. Clin Sci (Lond) 109: 405–411, 2005.
2. Barrachina MD, Martínez V, Wang L, Wei JY, Taché Y. Synergistic interaction between leptin and cholecystokinin to reduce short-term food intake in lean#mice. Proc Natl Acad Sci USA 94: 10,455–10,460, 1997.
3. Batterham RL, Cowley MA, Small CJ, Herzog H, Cohen MA, Dakin CL, Wren AM, Brynes AE, Low MJ, Ghatei MA, Cone RD, Bloom SR. Gut hormone PYY(3–36) physiologically inhibits food intake. Nature 418: 650–654, 2002.
4. Batterham RL, Heffron H, Kapoor S, Chivers JE, Chandarana K, Herzog H, Le Roux CW, Thomas EL, Bell JD, Withers DJ. Critical role for peptide YY in protein-mediated satiation and body-weight regulation. Cell Metab 4: 223–233, 2006.
5. Beglinger C, Degen L, Matzinger D, D’Amato M, Drewe J. Loxiglumide, a CCK-A receptor antagonist, stimulates calorie intake and hunger feelings in humans. Am J Physiol Regul Integr Comp Physiol 280: R1149–R1154, 2001.
6. Blouet C, Schwartz GJ. Brainstem nutrient sensing in the nucleus of the solitary tract inhibits feeding. Cell Metab 16: 579–587, 2012.
7. Brennan IM, Luscombe-Marsh ND, Seimon RV, Otto B, Horowitz M, Wishart JM, Feinle-Bisset C. Effects of fat, protein, and carbohydrate and protein load on appetite, plasma cholecystokinin, peptide YY, and ghrelin, and energy intake in lean and obese men. Am J Physiol Gastrointest Liver Physiol 303: G129–G140, 2012.
8. Cota D, Proulx K, Smith KA, Kozma SC, Thomas G, Woods SC, Seeley RJ. Hypothalamic mTOR signaling regulates food intake. Science 312: 927–930, 2006.
9. Date Y, Kojima M, Hosoda H, Sawaguchi A, Mondal MS, Suganuma T, Matsukura S, Kangawa K, Nakazato M. Ghrelin, a novel growth hormone-releasing acylated peptide, is synthesized in a distinct endocrine cell type in the gastrointestinal tracts of rats and humans. Endocrinology 141: 4255–4261, 2000.
10. Degen L, Oesch S, Casanova M, Graf S, Ketterer S, Drewe J, Beglinger C. Effect of peptide YY3–36 on food intake in humans. Gastroenterology 129: 1430–1436, 2005.
11. Feinle-Bisset C, Patterson M, Ghatei MA, Bloom SR, Horowitz M. Fat digestion is required for suppression of ghrelin and stimulation of peptide YY and pancreatic polypeptide secretion by intraduodenal lipid. Am J Physiol Endocrinol Metab 289: E948–E953, 2005.
12. Feltrin KL, Little TJ, Meyer JH, Horowitz M, Smout AJ, Wishart J, Pilichiewicz AN, Rades T, Chapman IM, Feinle-Bisset C. Effects of intraduodenal fatty acids on appetite, antropyloroduodenal motility, and plasma CCK and GLP-1 in humans vary with their chain length. Am J Physiol Regul Integr Comp Physiol 287: R524–R533, 2004.
13. Feltrin KL, Patterson M, Ghatei MA, Bloom SR, Meyer JH, Horowitz M, Feinle-Bisset C. Effect of fatty acid chain length on suppression of ghrelin and stimulation of PYY, GLP-2 and PP secretion in healthy men. Peptides 27: 1638–1643, 2006.
14. Flint A, Raben A, Astrup A, Holst JJ. Glucagon-like peptide 1 promotes satiety and suppresses energy intake in humans. J Clin Invest 101: 515–520, 1998.
15. Foster-Schubert KE, Overduin J, Prudom CE, Liu J, Callahan HS, Gaylinn BD, Thorner MO, Cummings DE. Acyl and total ghrelin are suppressed strongly by ingested proteins, weakly by lipids, and biphasically by carbohydrates. J Clin Endocrinol Metab 93: 1971–1979, 2008.
16. Geary N, Kissileff HR, Pi-Sunyer FX, Hinton V. Individual, but not simultaneous, glucagon and cholecystokinin infusions inhibit feeding in men. Am J Physiol Regul Integr Comp Physiol 262: R975–R980, 1992.
17. Imbeault P, Doucet E, Mauriège P, St-Pierre S, Couillard C, Alméras N, Després JP, Tremblay A. Difference in leptin response to a high-fat meal between lean and obese men. Clin Sci 101: 359–365, 2001.
18. Kentish SJ, O’Donnell TA, Isaacs NJ, Young RL, Li H, Harrington AM, Brierley SM, Wittert GA, Blackshaw LA, Page AJ. Gastric vagal afferent modulation by leptin is influenced by food intake status. J Physiol 591: 1921–1934, 2013.
19. Korbonits M, Trainer PJ, Little JA, Edwards R, Kopelman PG, Besser GM, Svec F, Grossman AB. Leptin levels do not change acutely with food administration in normal or obese subjects, but are negatively correlated with pituitary-adrenal activity. Clin Endocrinol (Oxf) 46: 751–757, 1997.
20. Little TJ, Luscombe-Marsh ND, Gentilcore D, Brook EJ, Feinle-Bisset C. Effects of varying the inter-meal interval on relationships between antral area, gut hormones and energy intake following a nutrient drink in healthy lean humans. Physiol Behav 135: 34–43, 2014.
21. MacIntosh CG, Morley JE, Wishart J, Morris H, Jansen JB, Horowitz M, Chapman IM. Effect of exogenous cholecystokinin (CCK)-8 on food intake and plasma CCK, leptin, and insulin concentrations in older and young adults: evidence for increased CCK activity as a cause of the anorexia of aging. J Clin Endocrinol Metab 86: 5830–5837, 2001.
22. Parker BA, Doran S, Wishart J, Horowitz M, Chapman IM. Effects of small intestinal and gastric glucose administration on the suppression of plasma ghrelin concentrations in healthy older men and women. Clin Endocrinol (Oxf) 62: 539–546, 2005.
23. Pilichiewicz AN, Papadopoulos P, Brennan IM, Little TJ, Meyer JH, Wishart JM, Horowitz M, Feinle-Bisset C. Load-dependent effects of duodenal lipid on antropyloroduodenal motility, plasma CCK and PYY, and energy intake in healthy men. Am J Physiol Regul Integr Comp Physiol 293: R2170–R2178, 2007.
24. Poppitt SD, McCormack D, Buffenstein R. Short-term effects of macronutrient preloads on appetite and energy intake in lean women. Physiol Behav 64: 279–285, 1998.
25. Rolls BJ, Kim-Harris S, Fischman MW, Foltin RW, Moran TH, Stoner SA. Satiety after preloads with different amounts of fat and carbohydrate: implications for obesity. Am J Clin Nutr 60: 476–487, 1994.
26. Romon M, Lebel P, Fruchart JC, Dallongeville J. Postprandial leptin response to carbohydrate and fat meals in obese women. J Am Coll Nutr 22: 247–251, 2003.
27. Romon M, Lebel P, Velly C, Marecaux N, Fruchart JC, Dallongeville J. Leptin response to carbohydrate or fat meal and association with subsequent satiety and energy intake. Am J Physiol Endocrinol Metab 277: E855–E861, 1999.
28. Ryan AT, Feinle-Bisset C, Kallas A, Wishart JM, Clifton PM, Horowitz M, Luscombe-Marsh ND. Intraduodenal protein modulates antropyloroduodenal motility, hormone release, glycemia, appetite, and energy intake in lean men. Am J Clin Nutr 96: 474–482, 2012.
29. Ryan AT, Luscombe-Marsh ND, Saies AA, Little TJ, Standfield S, Horowitz M, Feinle-Bisset C. Effects of intraduodenal lipid and protein on gut motility and hormone release, glycemia, appetite, and energy intake in lean men. Am J Clin Nutr 98: 300–311, 2013.
30. Seimon RV, Lange K, Little TJ, Brennan IM, Pilichiewicz AN, Feltrin KL, Smeets AJ, Horowitz M, Feinle-Bisset C. Pooled-data analysis identifies pyloric pressures and plasma cholecystokinin concentrations as major determinants of acute energy intake in healthy, lean men. Am J Clin Nutr 92: 61–68, 2010.
31. Steinert RE, Luscombe-Marsh ND, Little TJ, Standfield S, Otto B, Horowitz M, Feinle-Bisset C. Effects of intraduodenal infusion of Ltryptophan on ad libitum eating, antropyloroduodenal motility, glycemia, insulinemia, and gut peptide secretion in healthy men. J Clin Endocrinol Metab 99: 3275–3284, 2014.
32. Steinert RE, Schirra J, Meyer-Gerspach AC, Kienle P, Fischer H, Schulte F, Goeke B, Beglinger C. Effect of glucagon-like peptide-1 receptor antagonism on appetite and food intake in healthy men. Am J Clin Nutr 100: 514–523, 2014.
33. Stunkard AJ, Messick S. The three-factor eating questionnaire to measure dietary restraint, disinhibition and hunger. J Psychosom Res 29: 71–83, 1985.
34. Weigle DS, Duell PB, Connor WE, Steiner RA, Soules MR, Kuijper JL. Effect of fasting, refeeding, and dietary fat restriction on plasma leptin levels. J Clin Endocrinol Metab 82: 561–565, 1997.
35. Williams DL, Baskin DG, Schwartz MW. Hindbrain leptin receptor stimulation enhances the anorexic response to cholecystokinin. Am J Physiol Regul Integr Comp Physiol 297: R1238–R1246, 2009.
36. Wren AM, Seal LJ, Cohen MA, Brynes AE, Frost GS, Murphy KG, Dhillo WS, Ghatei MA, Bloom SR. Ghrelin enhances appetite and increases food intake in humans. J Clin Endocrinol Metab 86: 5992–5995, 2001.