MicroRNA-7 inhibits metastasis and invasion through targeting focal adhesion kinase in cervical cancer

International Journal of Clinical and Experimental Medicine

Volumn 8, Issue 1, 2015, Pages 480-487

  Hao, Zhenfeng ^a   Yang, Jishi ^a   Wang, Chenghai ^b   Li, Yaoyao ^a   Zhang, Yu ^a   Dong, Xiaoyun ^a   Zhou, Liulin ^a   Liu, Jing ^a   Zhang, Yanqing ^b   Qian, Jing ^a  

^a YANGZHOU UNIVERSITY   (China)

^b CLINICAL MEDICAL COLLEGE OF YANGZHOU UNIVERSITY   (China)

Author keywords

Cervical cancer; Focal adhesion kinase; Invasion; Metastasis; MicroRNA; MiR 7

Indexed keywords

FOCAL ADHESION KINASE; MICRORNA; MICRORNA 7; UNCLASSIFIED DRUG;

3' UNTRANSLATED REGION; ARTICLE; CELL INVASION ASSAY; CELL MIGRATION ASSAY; CONTROLLED STUDY; DOWN REGULATION; GENE EXPRESSION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; HUMAN TISSUE; LUCIFERASE ASSAY; METASTASIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SEQUENCE ANALYSIS; TRANSWELL MIGRATION ASSAY; TUMOR INVASION; UPREGULATION; UTERINE CERVIX CANCER; WESTERN BLOTTING;

EID: 84923126131     PISSN: None     EISSN: 19405901     Source Type: Journal    
DOI: None     Document Type: Article

References (29)

1. Fabian MR, Sonenberg N and Filipowicz W. Regulation of mRNA translation and stability by microRNAs. Annu Rev Biochem 2010; 79: 351-379.
2. Guo H, Ingolia NT, Weissman JS and Bartel DP. Mammalian microRNAs predominantly act to decrease target mRNA levels. Nature 2010; 466: 835-840.
3. Bartel DP. MicroRNAs: genomics, biogenesis, mechanism, and function. Cell 2004; 116: 281-297.
4. Farazi TA, Spitzer JI, Morozov P and Tuschl T. miRNAs in human cancer. J Pathol 2011; 223: 102-115.
5. Tao K, Yang J, Guo Z, Hu Y, Sheng H, Gao H and Yu H. Prognostic value of miR-221-3p, miR-342-3p and miR-491-5p expression in colon cancer. Am J Transl Res 2014; 6: 391-401.
6. Yu H, Li H, Qian H, Jiao X, Zhu X, Jiang X, Dai G and Huang J. Upregulation of miR-301a correlates with poor prognosis in triple-negative breast cancer. Med Oncol 2014; 31: 283.
7. Jemal A, Bray F, Center MM, Ferlay J, Ward E and Forman D. Global cancer statistics. CA Cancer J Clin 2011; 61: 69-90.
8. Sharma G, Dua P and Agarwal SM. A Comprehensive Review of Dysregulated miRNAs Involved in Cervical Cancer. Curr Genomics 2014; 15: 310-323.
9. Villegas-Ruiz V, Juarez-Mendez S, Perez-Gonzalez OA, Arreola H, Paniagua-Garcia L, Parra-Melquiadez M, Peralta-Rodriguez R, Lopez-Romero R, Monroy-Garcia A, Mantilla-Morales A, Gomez-Gutierrez G, Roman-Bassaure E and Salcedo M. Heterogeneity of microRNAs expression in cervical cancer cells: over-expression of miR-196a. Int J Clin Exp Pathol 2014; 7: 1389-1401.
10. Wang N, Zhou Y, Zheng L and Li H. MiR-31 is an independent prognostic factor and functions as an oncomir in cervical cancer via targeting ARID1A. Gynecol Oncol 2014; 134: 129-137.
11. Yuan W, Xiaoyun H, Haifeng Q, Jing L, Weixu H, Ruofan D, Jinjin Y and Zongji S. MicroRNA-218 enhances the radiosensitivity of human cervical cancer via promoting radiation induced apoptosis. Int J Med Sci 2014; 11: 691-696.
12. Zhang B, Chen J, Ren Z, Chen Y, Li J, Miao X, Song Y, Zhao T, Li Y, Shi Y, Ren D and Liu J. A specific miRNA signature promotes radioresistance of human cervical cancer cells. Cancer Cell Int 2013; 13: 118.
13. Zhou X, Hu Y, Dai L, Wang Y, Zhou J, Wang W, Di W and Qiu L. MicroRNA-7 inhibits tumor metastasis and reverses epithelial-mesenchymal transition through AKT/ERK1/2 inactivation by targeting EGFR in epithelial ovarian cancer. PLoS One 2014; 9: e96718.
14. Xie J, Chen M, Zhou J, Mo MS, Zhu LH, Liu YP, Gui QJ, Zhang L and Li GQ. miR-7 inhibits the invasion and metastasis of gastric cancer cells by suppressing epidermal growth factor receptor expression. Oncol Rep 2014; 31: 1715-1722.
15. Li Q, Tang Y, Cheng X, Ji J, Zhang J and Zhou X. EGFR protein expression and gene amplification in squamous intraepithelial lesions and squamous cell carcinomas of the cervix. Int J Clin Exp Pathol 2014; 7: 733-741.
16. Yu Z, Ni L, Chen D, Zhang Q, Su Z, Wang Y, Yu W, Wu X, Ye J, Yang S, Lai Y and Li X. Identification of miR-7 as an oncogene in renal cell carcinoma. J Mol Histol 2013; 44: 669-677.
17. Liu S, Zhang P, Chen Z, Liu M, Li X and Tang H. MicroRNA-7 downregulates XIAP expression to suppress cell growth and promote apoptosis in cervical cancer cells. FEBS Lett 2013; 587: 2247-2253.
18. Kong X, Li G, Yuan Y, He Y, Wu X, Zhang W, Wu Z, Chen T, Wu W, Lobie PE and Zhu T. MicroRNA-7 inhibits epithelial-to-mesenchymal transition and metastasis of breast cancer cells via targeting FAK expression. PLoS One 2012; 7: e41523.
19. Wu DG, Wang YY, Fan LG, Luo H, Han B, Sun LH, Wang XF, Zhang JX, Cao L, Wang XR, You YP and Liu N. MicroRNA-7 regulates glioblastoma cell invasion via targeting focal adhesion kinase expression. Chin Med J (Engl) 2011; 124: 2616-2621.
20. Junn E, Lee KW, Jeong BS, Chan TW, Im JY and Mouradian MM. Repression of alpha-synuclein expression and toxicity by microRNA-7. Proc Natl Acad Sci U S A 2009; 106: 13052-13057.
21. Wang Y, Liu J, Liu C, Naji A and Stoffers DA. MicroRNA-7 regulates the mTOR pathway and proliferation in adult pancreatic beta-cells. Diabetes 2013; 62: 887-895.
22. Reddy SD, Ohshiro K, Rayala SK and Kumar R. MicroRNA-7, a homeobox D10 target, inhibits p21-activated kinase 1 and regulates its functions. Cancer Res 2008; 68: 8195-8200.
23. Zhang H, Cai K, Wang J, Wang X, Cheng K, Shi F, Jiang L, Zhang Y and Dou J. MiR-7, Inhibited Indirectly by LincRNA HOTAIR, Directly Inhibits SETDB1 and Reverses the EMT of Breast Cancer Stem Cells by Downregulating the STAT3 Pathway. Stem Cells 2014; 32: 2858-2868.
24. Chen Y, Xia X, Wang S, Wu X, Zhang J, Zhou Y, Tan Y, He S, Qiang F, Li A, Roe OD and Zhou J. High FAK combined with low JWA expression: clinical prognostic and predictive role for adjuvant fluorouracil-leucovorin-oxaliplatin treatment in resectable gastric cancer patients. J Gastroenterol 2013; 48: 1034-1044.
25. Garouniatis A, Zizi-Sermpetzoglou A, Rizos S, Kostakis A, Nikiteas N and Papavassiliou AG. FAK, CD44v6, c-Met and EGFR in colorectal cancer parameters: tumour progression, metastasis, patient survival and receptor crosstalk. Int J Colorectal Dis 2013; 28: 9-18.
26. Zhan Q, Huang RF, Liang XH, Ge MX, Jiang JW, Lin H and Zhou XL. FRAS1 knockdown reduces A549 cells migration and invasion through downregulation of FAK signaling. Int J Clin Exp Med 2014; 7: 1692-1697.
27. Dai Z, Zhou SL, Zhou ZJ, Bai DS, Xu XY, Fu XT, Chen Q, Zhao YM, Zhu K, Yu L, Yang GH, Wang Z, Wu WZ, Zhou J and Fan J. Capn4 contributes to tumour growth and metastasis of hepatocellular carcinoma by activation of the FAK-Src signalling pathways. J Pathol 2014; 234: 316-328.
28. Luedde T. MicroRNA-151 and its hosting gene FAK (focal adhesion kinase) regulate tumor cell migration and spreading of hepatocellular carcinoma. Hepatology 2010; 52: 1164-1166.
29. Golubovskaya VM and Cance WG. Focal adhesion kinase and p53 signaling in cancer cells. Int Rev Cytol 2007; 263: 103-153.