-
2
-
-
35448986170
-
The replication of beta cells in normal physiology, in disease and for therapy
-
Butler PC, Meier JJ, Butler AE, Bhushan A. The replication of beta cells in normal physiology, in disease and for therapy. Nat Clin Pract Endocrinol Metab 2007;3:758-768
-
(2007)
Nat Clin Pract Endocrinol Metab
, vol.3
, pp. 758-768
-
-
Butler, P.C.1
Meier, J.J.2
Butler, A.E.3
Bhushan, A.4
-
3
-
-
77954277549
-
Beta-cell replication is increased in donor organs from young patients after prolonged life support
-
In't Veld P, De Munck N, Van Belle K, et al. Beta-cell replication is increased in donor organs from young patients after prolonged life support. Diabetes 2010;59:1702-1708
-
(2010)
Diabetes
, vol.59
, pp. 1702-1708
-
-
In't Veld, P.1
De Munck, N.2
Van Belle, K.3
-
4
-
-
24144473869
-
Very slow turnover of beta-cells in aged adult mice
-
Teta M, Long SY, Wartschow LM, Rankin MM, Kushner JA. Very slow turnover of beta-cells in aged adult mice. Diabetes 2005;54:2557-2567
-
(2005)
Diabetes
, vol.54
, pp. 2557-2567
-
-
Teta, M.1
Long, S.Y.2
Wartschow, L.M.3
Rankin, M.M.4
Kushner, J.A.5
-
5
-
-
77957787230
-
Significant human beta-cell turnover is limited to the first three decades of life as determined by in vivo thymidine analog incorporation and radiocarbon dating
-
Perl S, Kushner JA, Buchholz BA, et al. Significant human beta-cell turnover is limited to the first three decades of life as determined by in vivo thymidine analog incorporation and radiocarbon dating. J Clin Endocrinol Metab 2010;95:E234-E239
-
(2010)
J Clin Endocrinol Metab
, vol.95
-
-
Perl, S.1
Kushner, J.A.2
Buchholz, B.A.3
-
6
-
-
61449258391
-
Impaired islet turnover in human donor pancreata with aging
-
Reers C, Erbel S, Esposito I, et al. Impaired islet turnover in human donor pancreata with aging. Eur J Endocrinol 2009;160:185-191
-
(2009)
Eur J Endocrinol
, vol.160
, pp. 185-191
-
-
Reers, C.1
Erbel, S.2
Esposito, I.3
-
7
-
-
80054991835
-
PDGF signalling controls age-dependent proliferation in pancreatic b-cells
-
Chen H, Gu X, Liu Y, et al. PDGF signalling controls age-dependent proliferation in pancreatic b-cells. Nature 2011;478:349-355
-
(2011)
Nature
, vol.478
, pp. 349-355
-
-
Chen, H.1
Gu, X.2
Liu, Y.3
-
8
-
-
35148833815
-
Regulation of beta-cell mass and function by the Akt/protein kinase B signalling pathway
-
Elghazi L, Rachdi L, Weiss AJ, Cras-Méneur C, Bernal-Mizrachi E. Regulation of beta-cell mass and function by the Akt/protein kinase B signalling pathway. Diabetes Obes Metab 2007;9(Suppl. 2):147-157
-
(2007)
Diabetes Obes Metab
, vol.9
, Issue.SUPPL. 2
, pp. 147-157
-
-
Elghazi, L.1
Rachdi, L.2
Weiss, A.J.3
Cras-Méneur, C.4
Bernal-Mizrachi, E.5
-
9
-
-
80052099673
-
MicroRNAs in b-cell biology, insulin resistance, diabetes and its complications
-
Fernandez-Valverde SL, Taft RJ, Mattick JS. MicroRNAs in b-cell biology, insulin resistance, diabetes and its complications. Diabetes 2011;60:1825-1831
-
(2011)
Diabetes
, vol.60
, pp. 1825-1831
-
-
Fernandez-Valverde, S.L.1
Taft, R.J.2
Mattick, J.S.3
-
10
-
-
78649378267
-
MicroRNA functions in stress responses
-
Leung AK, Sharp PA. MicroRNA functions in stress responses. Mol Cell 2010;40:205-215
-
(2010)
Mol Cell
, vol.40
, pp. 205-215
-
-
Leung, A.K.1
Sharp, P.A.2
-
11
-
-
78751474118
-
Non-coding RNAs as regulators of embryogenesis
-
Pauli A, Rinn JL, Schier AF. Non-coding RNAs as regulators of embryogenesis. Nat Rev Genet 2011;12:136-149
-
(2011)
Nat Rev Genet
, vol.12
, pp. 136-149
-
-
Pauli, A.1
Rinn, J.L.2
Schier, A.F.3
-
12
-
-
36248978699
-
MicroRNA expression is required for pancreatic islet cell genesis in the mouse
-
Lynn FC, Skewes-Cox P, Kosaka Y, McManus MT, Harfe BD, German MS. MicroRNA expression is required for pancreatic islet cell genesis in the mouse. Diabetes 2007;56:2938-2945
-
(2007)
Diabetes
, vol.56
, pp. 2938-2945
-
-
Lynn, F.C.1
Skewes-Cox, P.2
Kosaka, Y.3
McManus, M.T.4
Harfe, B.D.5
German, M.S.6
-
13
-
-
79952259862
-
MiRNAs control insulin content in pancreatic b-cells via downregulation of transcriptional repressors
-
Melkman-Zehavi T, Oren R, Kredo-Russo S, et al. miRNAs control insulin content in pancreatic b-cells via downregulation of transcriptional repressors. EMBO J 2011;30:835-845
-
(2011)
EMBO J
, vol.30
, pp. 835-845
-
-
Melkman-Zehavi, T.1
Oren, R.2
Kredo-Russo, S.3
-
14
-
-
34547126004
-
MicroRNA-124a regulates Foxa2 expression and intracellular signaling in pancreatic beta-cell lines
-
Baroukh N, Ravier MA, Loder MK, et al. MicroRNA-124a regulates Foxa2 expression and intracellular signaling in pancreatic beta-cell lines. J Biol Chem 2007;282:19575-19588
-
(2007)
J Biol Chem
, vol.282
, pp. 19575-19588
-
-
Baroukh, N.1
Ravier, M.A.2
Loder, M.K.3
-
15
-
-
9144270691
-
A pancreatic islet-specific micro-RNA regulates insulin secretion
-
Poy MN, Eliasson L, Krutzfeldt J, et al. A pancreatic islet-specific micro-RNA regulates insulin secretion. Nature 2004;432:226-230
-
(2004)
Nature
, vol.432
, pp. 226-230
-
-
Poy, M.N.1
Eliasson, L.2
Krutzfeldt, J.3
-
16
-
-
79960322580
-
Rutter GA. miR-29a and miR-29b contribute to pancreatic beta-cell-specific silencing of monocarboxylate transporter 1 (Mct1)
-
Pullen TJ, da Silva Xavier G, Kelsey G, Rutter GA. miR-29a and miR-29b contribute to pancreatic beta-cell-specific silencing of monocarboxylate transporter 1 (Mct1). Mol Cell Biol 2011;31:3182-3194
-
(2011)
Mol Cell Biol
, vol.31
, pp. 3182-3194
-
-
Pullen, T.J.1
Da Silva Xavier, G.2
Kelsey, G.3
-
17
-
-
78650510609
-
Sabatini DM. mTOR: From growth signal integration to cancer, diabetes and ageing
-
Zoncu R, Efeyan A, Sabatini DM. mTOR: From growth signal integration to cancer, diabetes and ageing. Nat Rev Mol Cell Biol 2011;12:21-35
-
(2011)
Nat Rev Mol Cell Biol
, vol.12
, pp. 21-35
-
-
Zoncu, R.1
Efeyan, A.2
-
18
-
-
84859117806
-
Rapamycin-induced insulin resistance is mediated by mTORC2 loss and uncoupled from longevity
-
Lamming DW, Ye L, Katajisto P, et al. Rapamycin-induced insulin resistance is mediated by mTORC2 loss and uncoupled from longevity. Science 2012;335:1638-1643
-
(2012)
Science
, vol.335
, pp. 1638-1643
-
-
Lamming, D.W.1
Ye, L.2
Katajisto, P.3
-
19
-
-
9444234587
-
Signaling elements involved in the metabolic regulation of mTOR by nutrients, incretins, and growth factors in islets
-
Kwon G, Marshall CA, Pappan KL, Remedi MS, McDaniel ML. Signaling elements involved in the metabolic regulation of mTOR by nutrients, incretins, and growth factors in islets. Diabetes 2004;53(Suppl. 3):S225-S232
-
(2004)
Diabetes
, vol.53
, Issue.SUPPL. 3
-
-
Kwon, G.1
Marshall, C.A.2
Pappan, K.L.3
Remedi, M.S.4
McDaniel, M.L.5
-
20
-
-
65549130128
-
MTORC1 activation regulates beta-cell mass and proliferation by modulation of cyclin D2 synthesis and stability
-
Balcazar N, Sathyamurthy A, Elghazi L, et al. mTORC1 activation regulates beta-cell mass and proliferation by modulation of cyclin D2 synthesis and stability. J Biol Chem 2009;284:7832-7842
-
(2009)
J Biol Chem
, vol.284
, pp. 7832-7842
-
-
Balcazar, N.1
Sathyamurthy, A.2
Elghazi, L.3
-
21
-
-
0035210374
-
Islet beta cell expression of constitutively active Akt1/PKB alpha induces striking hypertrophy, hyperplasia, and hyperinsulinemia
-
Bernal-Mizrachi E, Wen W, Stahlhut S, Welling CM, Permutt MA. Islet beta cell expression of constitutively active Akt1/PKB alpha induces striking hypertrophy, hyperplasia, and hyperinsulinemia. J Clin Invest 2001;108: 1631-1638
-
(2001)
J Clin Invest
, vol.108
, pp. 1631-1638
-
-
Bernal-Mizrachi, E.1
Wen, W.2
Stahlhut, S.3
Welling, C.M.4
Permutt, M.A.5
-
22
-
-
48249146208
-
Disruption of Tsc2 in pancreatic beta cells induces beta cell mass expansion and improved glucose tolerance in a TORC1-dependent manner
-
Rachdi L, Balcazar N, Osorio-Duque F, et al. Disruption of Tsc2 in pancreatic beta cells induces beta cell mass expansion and improved glucose tolerance in a TORC1-dependent manner. Proc Natl Acad Sci USA 2008; 105:9250-9255
-
(2008)
Proc Natl Acad Sci USA
, vol.105
, pp. 9250-9255
-
-
Rachdi, L.1
Balcazar, N.2
Osorio-Duque, F.3
-
23
-
-
66649096458
-
Upregulation of the mammalian target of rapamycin complex 1 pathway by Ras homolog enriched in brain in pancreatic beta-cells leads to increased beta-cell mass and prevention of hyperglycemia
-
Hamada S, Hara K, Hamada T, et al. Upregulation of the mammalian target of rapamycin complex 1 pathway by Ras homolog enriched in brain in pancreatic beta-cells leads to increased beta-cell mass and prevention of hyperglycemia. Diabetes 2009;58:1321-1332
-
(2009)
Diabetes
, vol.58
, pp. 1321-1332
-
-
Hamada, S.1
Hara, K.2
Hamada, T.3
-
24
-
-
0034700456
-
Hypoinsulinaemia, glucose intolerance and diminished beta-cell size in S6K1-deficient mice
-
Pende M, Kozma SC, Jaquet M, et al. Hypoinsulinaemia, glucose intolerance and diminished beta-cell size in S6K1-deficient mice. Nature 2000;408:994-997
-
(2000)
Nature
, vol.408
, pp. 994-997
-
-
Pende, M.1
Kozma, S.C.2
Jaquet, M.3
-
25
-
-
37549021902
-
Quantitative differential expression analysis reveals miR-7 as major islet microRNA
-
Bravo-Egana V, Rosero S, Molano RD, et al. Quantitative differential expression analysis reveals miR-7 as major islet microRNA. Biochem Biophys Res Commun 2008;366:922-926
-
(2008)
Biochem Biophys Res Commun
, vol.366
, pp. 922-926
-
-
Bravo-Egana, V.1
Rosero, S.2
Molano, R.D.3
-
26
-
-
61349122608
-
MicroRNA miR-7 is preferentially expressed in endocrine cells of the developing and adult human pancreas
-
Correa-Medina M, Bravo-Egana V, Rosero S, et al. MicroRNA miR-7 is preferentially expressed in endocrine cells of the developing and adult human pancreas. Gene Expr Patterns 2009;9:193-199
-
(2009)
Gene Expr Patterns
, vol.9
, pp. 193-199
-
-
Correa-Medina, M.1
Bravo-Egana, V.2
Rosero, S.3
-
27
-
-
45549089973
-
MicroRNA-7 inhibits the epidermal growth factor receptor and the Akt pathway and is down-regulated in glioblastoma
-
Kefas B, Godlewski J, Comeau L, et al. microRNA-7 inhibits the epidermal growth factor receptor and the Akt pathway and is down-regulated in glioblastoma. Cancer Res 2008;68:3566-3572
-
(2008)
Cancer Res
, vol.68
, pp. 3566-3572
-
-
Kefas, B.1
Godlewski, J.2
Comeau, L.3
-
28
-
-
65549120766
-
Regulation of epidermal growth factor receptor signaling in human cancer cells by microRNA-7
-
Webster RJ, Giles KM, Price KJ, Zhang PM, Mattick JS, Leedman PJ. Regulation of epidermal growth factor receptor signaling in human cancer cells by microRNA-7. J Biol Chem 2009;284:5731-5741
-
(2009)
J Biol Chem
, vol.284
, pp. 5731-5741
-
-
Webster, R.J.1
Giles, K.M.2
Price, K.J.3
Zhang, P.M.4
Mattick, J.S.5
Leedman, P.J.6
-
29
-
-
78649728328
-
MicroRNA-7 targets IGF1R (insulin-like growth factor 1 receptor) in tongue squamous cell carcinoma cells
-
Jiang L, Liu X, Chen Z, et al. MicroRNA-7 targets IGF1R (insulin-like growth factor 1 receptor) in tongue squamous cell carcinoma cells. Biochem J 2010;432:199-205
-
(2010)
Biochem J
, vol.432
, pp. 199-205
-
-
Jiang, L.1
Liu, X.2
Chen, Z.3
-
30
-
-
79551527320
-
MiRNA-7 attenuation in Schwannoma tumors stimulates growth by upregulating three oncogenic signaling pathways
-
Saydam O, Senol O,Würdinger T, et al. miRNA-7 attenuation in Schwannoma tumors stimulates growth by upregulating three oncogenic signaling pathways. Cancer Res 2011;71:852-861
-
(2011)
Cancer Res
, vol.71
, pp. 852-861
-
-
Saydam, O.1
Senol, O.2
Würdinger, T.3
-
31
-
-
84856258714
-
MicroRNA profiling identifies miR-29 as a regulator of disease-associated pathways in experimental biliary atresia
-
Hand NJ, Horner AM, Master ZR, et al. MicroRNA profiling identifies miR-29 as a regulator of disease-associated pathways in experimental biliary atresia. J Pediatr Gastroenterol Nutr 2012;54:186-192
-
(2012)
J Pediatr Gastroenterol Nutr
, vol.54
, pp. 186-192
-
-
Hand, N.J.1
Horner, A.M.2
Master, Z.R.3
-
32
-
-
78650535338
-
Three-amino-acid-loopextension homeodomain factor Meis3 regulates cell survival via PDK1
-
Liu J, Wang Y, Birnbaum MJ, Stoffers DA. Three-amino-acid-loopextension homeodomain factor Meis3 regulates cell survival via PDK1. Proc Natl Acad Sci USA 2010;107:20494-20499
-
(2010)
Proc Natl Acad Sci USA
, vol.107
, pp. 20494-20499
-
-
Liu, J.1
Wang, Y.2
Birnbaum, M.J.3
Stoffers, D.A.4
-
33
-
-
78651320424
-
The UCSC Genome Browser database: Update 2011
-
Database issue
-
Fujita PA, Rhead B, Zweig AS, et al. The UCSC Genome Browser database: Update 2011. Nucleic Acids Res 2011;39(Database issue):D876-D882
-
(2011)
Nucleic Acids Res
, vol.39
-
-
Fujita, P.A.1
Rhead, B.2
Zweig, A.S.3
-
34
-
-
0346094457
-
Prediction of mammalian microRNA targets
-
Lewis BP, Shih IH, Jones-Rhoades MW, Bartel DP, Burge CB. Prediction of mammalian microRNA targets. Cell 2003;115:787-798
-
(2003)
Cell
, vol.115
, pp. 787-798
-
-
Lewis, B.P.1
Shih, I.H.2
Jones-Rhoades, M.W.3
Bartel, D.P.4
Burge, C.B.5
-
35
-
-
78751477191
-
Gene silencing by microRNAs: Contributions of translational repression and mRNA decay
-
Huntzinger E, Izaurralde E. Gene silencing by microRNAs: Contributions of translational repression and mRNA decay. Nat Rev Genet 2011;12:99-110
-
(2011)
Nat Rev Genet
, vol.12
, pp. 99-110
-
-
Huntzinger, E.1
Izaurralde, E.2
-
36
-
-
33749076673
-
SIN1/MIP1 maintains rictor-mTOR complex integrity and regulates Akt phosphorylation and substrate specificity
-
Jacinto E, Facchinetti V, Liu D, et al. SIN1/MIP1 maintains rictor-mTOR complex integrity and regulates Akt phosphorylation and substrate specificity. Cell 2006;127:125-137
-
(2006)
Cell
, vol.127
, pp. 125-137
-
-
Jacinto, E.1
Facchinetti, V.2
Liu, D.3
-
37
-
-
0036713778
-
TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling
-
Inoki K, Li Y, Zhu T, Wu J, Guan KL. TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling. Nat Cell Biol 2002;4:648-657
-
(2002)
Nat Cell Biol
, vol.4
, pp. 648-657
-
-
Inoki, K.1
Li, Y.2
Zhu, T.3
Wu, J.4
Guan, K.L.5
-
38
-
-
0034668203
-
Phosphorylation of the cap-binding protein eIF4E by the MAPK-activated protein kinase Mnk1
-
Pyronnet S. Phosphorylation of the cap-binding protein eIF4E by the MAPK-activated protein kinase Mnk1. Biochem Pharmacol 2000;60:1237-1243
-
(2000)
Biochem Pharmacol
, vol.60
, pp. 1237-1243
-
-
Pyronnet, S.1
-
39
-
-
3242719457
-
Mnk2 and Mnk1 are essential for constitutive and inducible phosphorylation of eukaryotic initiation factor 4E but not for cell growth or development
-
Ueda T, Watanabe-Fukunaga R, Fukuyama H, Nagata S, Fukunaga R. Mnk2 and Mnk1 are essential for constitutive and inducible phosphorylation of eukaryotic initiation factor 4E but not for cell growth or development. Mol Cell Biol 2004;24:6539-6549
-
(2004)
Mol Cell Biol
, vol.24
, pp. 6539-6549
-
-
Ueda, T.1
Watanabe-Fukunaga, R.2
Fukuyama, H.3
Nagata, S.4
Fukunaga, R.5
-
40
-
-
0037219411
-
Betacell deficit and increased beta-cell apoptosis in humans with type 2 diabetes
-
Butler AE, Janson J, Bonner-Weir S, Ritzel R, Rizza RA, Butler PC. Betacell deficit and increased beta-cell apoptosis in humans with type 2 diabetes. Diabetes 2003;52:102-110
-
(2003)
Diabetes
, vol.52
, pp. 102-110
-
-
Butler, A.E.1
Janson, J.2
Bonner-Weir, S.3
Ritzel, R.4
Rizza, R.A.5
Butler, P.C.6
-
41
-
-
36649000083
-
Proliferation of sorted human and rat beta cells
-
Parnaud G, Bosco D, Berney T, et al. Proliferation of sorted human and rat beta cells. Diabetologia 2008;51:91-100
-
(2008)
Diabetologia
, vol.51
, pp. 91-100
-
-
Parnaud, G.1
Bosco, D.2
Berney, T.3
-
42
-
-
84864305807
-
Pancreas-enriched miRNA refines endocrine cell differentiation
-
Kredo-Russo S, Mandelbaum AD, Ness A, et al. Pancreas-enriched miRNA refines endocrine cell differentiation. Development 2012;139: 3021-3031
-
(2012)
Development
, vol.139
, pp. 3021-3031
-
-
Kredo-Russo, S.1
Mandelbaum, A.D.2
Ness, A.3
-
43
-
-
84861567957
-
MicroRNA-7 inhibits tumor growth and metastasis by targeting the phosphoinositide 3-kinaseakt pathway in hepatocellular carcinoma
-
Fang YX, Xue JL, Shen Q, Chen J, Tian L. MicroRNA-7 inhibits tumor growth and metastasis by targeting the phosphoinositide 3-kinase/Akt pathway in hepatocellular carcinoma. Hepatology 2012;55:1852-1862
-
(2012)
Hepatology
, vol.55
, pp. 1852-1862
-
-
Fang, Y.X.1
Xue, J.L.2
Shen, Q.3
Chen, J.4
Tian, L.5
-
44
-
-
84868132259
-
Antisense miR-7 impairs insulin expression in developing pancreas and in cultured pancreatic buds
-
Nieto M, Hevia P, Garcia E, et al. Antisense miR-7 impairs insulin expression in developing pancreas and in cultured pancreatic buds. Cell Transplant 2012;21:1761-1774
-
(2012)
Cell Transplant
, vol.21
, pp. 1761-1774
-
-
Nieto, M.1
Hevia, P.2
Garcia, E.3
-
45
-
-
84856511715
-
L-leucine alters pancreatic b-cell differentiation and function via the mTor signaling pathway
-
Rachdi L, Aïello V, Duvillié B, Scharfmann R. L-leucine alters pancreatic b-cell differentiation and function via the mTor signaling pathway. Diabetes 2012;61:409-417
-
(2012)
Diabetes
, vol.61
, pp. 409-417
-
-
Rachdi, L.1
Aïello, V.2
Duvillié, B.3
Scharfmann, R.4
-
46
-
-
64649104150
-
Survey of the human pancreatic beta-cell G1/S proteome reveals a potential therapeutic role for cdk-6 and cyclin D1 in enhancing human beta-cell replication and function in vivo
-
Fiaschi-Taesch N, Bigatel TA, Sicari B, et al. Survey of the human pancreatic beta-cell G1/S proteome reveals a potential therapeutic role for cdk-6 and cyclin D1 in enhancing human beta-cell replication and function in vivo. Diabetes 2009;58:882-893
-
(2009)
Diabetes
, vol.58
, pp. 882-893
-
-
Fiaschi-Taesch, N.1
Bigatel, T.A.2
Sicari, B.3
-
47
-
-
0028963533
-
A selective decrease in the beta cell mass of human islets transplanted into diabetic nude mice
-
Davalli AM, Ogawa Y, Ricordi C, Scharp DW, Bonner-Weir S, Weir GC. A selective decrease in the beta cell mass of human islets transplanted into diabetic nude mice. Transplantation 1995;59:817-820
-
(1995)
Transplantation
, vol.59
, pp. 817-820
-
-
Davalli, A.M.1
Ogawa, Y.2
Ricordi, C.3
Scharp, D.W.4
Bonner-Weir, S.5
Weir, G.C.6
-
48
-
-
38449086256
-
Partial pancreatectomy in adult humans does not provoke beta-cell regeneration
-
Menge BA, Tannapfel A, Belyaev O, et al. Partial pancreatectomy in adult humans does not provoke beta-cell regeneration. Diabetes 2008;57:142-149
-
(2008)
Diabetes
, vol.57
, pp. 142-149
-
-
Menge, B.A.1
Tannapfel, A.2
Belyaev, O.3
-
49
-
-
20044384383
-
Gene transfer of constitutively active Akt markedly improves human islet transplant outcomes in diabetic severe combined immunodeficient mice
-
Rao P, Roccisana J, Takane KK, et al. Gene transfer of constitutively active Akt markedly improves human islet transplant outcomes in diabetic severe combined immunodeficient mice. Diabetes 2005;54:1664-1675
-
(2005)
Diabetes
, vol.54
, pp. 1664-1675
-
-
Rao, P.1
Roccisana, J.2
Takane, K.K.3
|